High fat induces acute and chronic inflammation in the hypothalamus: effect of high-fat diet, palmitate and TNF-α on appetite-regulating NPY neurons

A Stereological Analysis of NPY, POMC, Orexin, GFAP Astrocyte, and Iba1 Microglia Cell Number and Volume in Diet-Induced Obese Male Mice

(2015) Moyra B. Lemus et al.   ENDOCRINOLOGY

Dietary triglycerides act on mesolimbic structures to regulate the rewarding and motivational aspects of feeding

(2014) C Cansell et al.   MOLECULAR PSYCHIATRY

Tumor Necrosis Factor–Neuropeptide Y Cross Talk Regulates Inflammation, Epithelial Barrier Functions, and Colonic Motility

(2013) Bindu Chandrasekharan et al.   INFLAMMATORY BOWEL DISEASES

Opposite effects of a high-fat diet and calorie restriction on ciliary neurotrophic factor signaling in the mouse hypothalamus

(2013) Ilenia Severi et al.   Frontiers in Neuroscience

Glucagon-Like Peptide-1 Receptor Agonist, Exendin-4, Regulates Feeding-Associated Neuropeptides in Hypothalamic Neuronsin Vivoandin Vitro

(2012) Prasad S. Dalvi et al.   ENDOCRINOLOGY

AgRP and NPY Expression in the Human Hypothalamic Infundibular Nucleus Correlate with Body Mass Index, Whereas Changes in αMSH Are Related to Type 2 Diabetes

(2012) Anneke Alkemade et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Cellular Leptin Resistance Impairs the Leptin-Mediated Suppression of Neuropeptide Y Secretion in Hypothalamic Neurons

(2011) Sandeep S. Dhillon et al.   ENDOCRINOLOGY

Lipid-induced insulin resistance mediated by the proinflammatory receptor TLR4 requires saturated fatty acid–induced ceramide biosynthesis in mice

(2011) William L. Holland et al.   JOURNAL OF CLINICAL INVESTIGATION

Obesity is associated with hypothalamic injury in rodents and humans

(2011) Joshua P. Thaler et al.   JOURNAL OF CLINICAL INVESTIGATION

Heat shock protein 70 together with its co-chaperone CHIP inhibits TNF-α induced apoptosis by promoting proteasomal degradation of apoptosis signal-regulating kinase1

(2010) Yanhong Gao et al.   APOPTOSIS

Modulation of hypothalamic PTP1B in the TNF-α-induced insulin and leptin resistance

(2010) Paty Karoll Picardi et al.   FEBS LETTERS

Astrocytes: biology and pathology

(2009) Michael V. Sofroniew et al.   ACTA NEUROPATHOLOGICA

Microglial Physiology: Unique Stimuli, Specialized Responses

(2009) Richard M. Ransohoff et al.   Annual Review of Immunology

Palmitate Attenuates Insulin Signaling and Induces Endoplasmic Reticulum Stress and Apoptosis in Hypothalamic Neurons: Rescue of Resistance and Apoptosis through Adenosine 5′ Monophosphate-Activated Protein Kinase Activation

(2009) Christopher M. Mayer et al.   ENDOCRINOLOGY

Ciliary neurotrophic factor recruitment of glucagon-like peptide-1 mediates neurogenesis, allowing immortalization of adult murine hypothalamic neurons

(2009) Denise D. Belsham et al.   FASEB JOURNAL

Palmitic acid mediates hypothalamic insulin resistance by altering PKC-θ subcellular localization in rodents

(2009) Stephen C. Benoit et al.   JOURNAL OF CLINICAL INVESTIGATION

Saturated Fatty Acids Produce an Inflammatory Response Predominantly through the Activation of TLR4 Signaling in Hypothalamus: Implications for the Pathogenesis of Obesity

(2009) M. Milanski et al.   JOURNAL OF NEUROSCIENCE

Central Administration of an Endoplasmic Reticulum Stress Inducer Inhibits the Anorexigenic Effects of Leptin and Insulin

(2009) Jong Chul Won et al.   Obesity

High-Fat Diet Induces Apoptosis of Hypothalamic Neurons

(2009) Juliana C. Moraes et al.   PLoS One

Molecular dissection of reactive astrogliosis and glial scar formation

(2009) Michael V. Sofroniew   TRENDS IN NEUROSCIENCES

Hypothalamic IKKβ/NF-κB and ER Stress Link Overnutrition to Energy Imbalance and Obesity

(2008) Xiaoqing Zhang et al.   CELL

Shared Principles in NF-κB Signaling

(2008) Matthew S. Hayden et al.   CELL