Article
Clinical Neurology
Benjamin Davidson, David Eapen-John, Karim Mithani, Jennifer S. Rabin, Ying Meng, Xingshan Cao, Christopher B. Pople, Peter Giacobbe, Clement Hamani, Nir Lipsman
Summary: This study conducted a systematic review and meta-analysis of the long-term effects of ablative neurosurgical procedures on psychiatric symptoms, showing significant improvements in depression, obsessive-compulsive symptoms, anxiety, and clinical global impression. There was significant heterogeneity in the effect sizes for anxiety symptoms between different procedure types.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2022)
Article
Psychiatry
Ping Qin, Sadia Syeda, Silvia Sara Canetto, Vikas Arya, Baopeng Liu, Vikas Menon, Bob Lew, Stephen Platt, Paul Yip, David Gunnell
Summary: Midlife suicide is strongly associated with socioeconomic difficulties and common physical and psychiatric illnesses in this age group. Investigations in the future should consider interactions between risk factors, as well as sex and ethnicity intersectionality and data from low- and middle-income countries.
JOURNAL OF PSYCHIATRIC RESEARCH
(2022)
Article
Multidisciplinary Sciences
Xinyao Meng, Ji-Long Zheng, Mao-Ling Sun, Hai-Yun Lai, Bao-Jie Wang, Jun Yao, Hongbo Wang
Summary: This meta-analysis investigated the relationship between MTHFR gene polymorphisms and psychiatric disorders. The findings suggested that certain MTHFR polymorphisms were associated with the occurrence of specific disorders.
Review
Psychiatry
Matthew Modini, Amy Burton, Maree J. Abbott
Summary: Inpatient psychiatric hospitals have been a standard aspect of mental health treatment for centuries. A meta-review was conducted to examine factors affecting inpatients' perceptions of psychiatric hospitals, revealing key factors including relationships on the ward, the ward environment, coercive measures, legal status, autonomy, feeling deserving of care, and expectations of care at admission and discharge. Therapeutic rapport was consistently referenced as the most important factor.
JOURNAL OF PSYCHIATRIC RESEARCH
(2021)
Review
Behavioral Sciences
Emily Dudek, David Dodell-Feder
Summary: A meta-analysis of rtfMRI-NF for psychiatric disorders shows that it has a positive impact on brain activity during training, a large effect after training without feedback, and small effects on behavioral outcomes. More research is needed to understand the mechanisms, target population, and conditions of rtfMRI-NF.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2021)
Article
Biochemistry & Molecular Biology
Mankun Wei, Uli Nurjanah, Arin Herkilini, Can Huang, Yanjun Li, Makoto Miyagishi, Shourong Wu, Vivi Kasim
Summary: XBP1-u promotes tumor growth in hepatocellular carcinoma cells by enhancing cholesterol biosynthesis through the XBP1-u/SREBP2/HMGCR axis. The stabilization of SREBP2 by XBP1-u leads to increased transcription of HMGCR, the rate-limiting enzyme in cholesterol biosynthesis.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Review
Psychology, Clinical
Xue-Lei Fu, Yan Qian, Xiao-Hong Jin, Hai-Rong Yu, Hua Wu, Lin Du, Hong-Lin Chen, Ya-Qin Shi
Summary: This study quantified the suicide rates among people with serious mental illness (bipolar disorder, major depression, or schizophrenia). The findings showed high suicide rates, especially among individuals with major depression. Male patients were found to have a higher risk of suicide compared to females. Poisoning was the most common method of suicide. The study highlights the need for increased psychological assessment and monitoring, as well as further research on regional and age differences in suicide among this population.
PSYCHOLOGICAL MEDICINE
(2023)
Review
Medicine, General & Internal
Ricardo Irizarry, Amelia Winczura, Omar Dimassi, Navpreet Dhillon, Annu Minhas, Jeanpaul Larice
Summary: Psilocybin has shown potential as a therapy for psychiatric illnesses. Microdosing with psilocybin has been found to improve symptoms in patients with anxiety, depression, obsessive-compulsive disorder, post-traumatic stress disorder, and substance abuse. However, further research is needed to determine the efficacy and safety of psilocybin microdosing and its general use in psychiatry.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2022)
Article
Psychiatry
Frank van den Boogert, Katharina Klein, Pascalle Spaan, Bram Sizoo, Yvonne H. A. Bouman, Witte J. G. Hoogendijk, Sabine J. Roza
Summary: Many individuals with psychiatric disorders experience difficulties in sensory processing. This meta-analysis examined the sensory processing patterns of adolescent and adult individuals with different psychiatric conditions. The findings suggest that sensory processing difficulties are a non-specific transdiagnostic phenotype associated with a broad spectrum of psychiatric disorders.
JOURNAL OF PSYCHIATRIC RESEARCH
(2022)
Article
Psychiatry
Mara Eyllon, Alexander P. Dang, J. Ben Barnes, John Buresh, Gabrielle D. Peloquin, Annika C. Hogan, Scott T. Shimotsu, Susan R. Sama, Samuel S. Nordberg
Summary: Psychiatric patients exhibit significant rates of vaccine hesitancy, with substance use disorders and tobacco use being positively associated with vaccine hesitancy, while bipolar disorder shows a significant negative association with vaccine hesitancy. Interventions may be necessary to improve vaccination rates in these populations.
PSYCHIATRY RESEARCH
(2022)
Review
Biochemistry & Molecular Biology
Xinxin Luo, Leader Alfason, Mankun Wei, Shourong Wu, Vivi Kasim
Summary: X-box binding protein 1 (XBP1) is a transcription factor involved in unfolded protein response and other physiological pathways. Its spliced isoform XBP1-s plays a critical role in inflammation, neurodegenerative diseases, and tumor progression. Meanwhile, the unspliced isoform XBP1-u also plays a key role in autophagy and tumorigenesis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Psychiatry
Gayatri Bhatia, Shravan Patel, Badalkumar Paladiya
Summary: The aim of this study was to analyze the content and scientific accuracy of Bollywood movies depicting psychiatric illnesses in the last two decades. A Google search was conducted to compile a list of Bollywood movies portraying psychiatric illnesses. Each movie was examined for character details, symptoms, diagnosis, and accuracy of depiction. The results showed that 28 movies were analyzed, with most characters being middle-aged, unmarried, employed, and affluent. The most common symptom was aggression, and the diagnosis was often schizophrenia. Treatment-seeking was low, and the common outcome was deterioration. In conclusion, the depiction of psychiatric illnesses in Bollywood differs from research evidence in many aspects, highlighting the need for greater alignment between cinematic portrayal and research evidence.
ASIAN JOURNAL OF PSYCHIATRY
(2023)
Review
Clinical Neurology
Kwonmok Ko, Emma I. Kopra, Anthony J. Cleare, James J. Rucker
Summary: Psychedelic therapy shows promising therapeutic effects on depressive symptoms according to recent clinical research. Psilocybin, ayahuasca, and LSD demonstrated significant reduction of symptoms in both short-term and long-term treatment.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Health Policy & Services
Anil Srivastava, Rajesh Nair
Summary: This study explored the utility of medical clearance among adult psychiatric patients, finding that investigations had relatively low yield, while history and physical examination had significantly higher yield, especially in disoriented, agitated, or older patients.
PSYCHIATRIC SERVICES
(2022)
Article
Genetics & Heredity
Kyoko Watanabe, Philip R. Jansen, Jeanne E. Savage, Priyanka Nandakumar, Xin Wang, David A. Hinds, Joel Gelernter, Daniel F. Levey, Renato Polimanti, Murray B. Stein, Eus J. W. Van Someren, August B. Smit, Danielle Posthuma
Summary: Genome-wide association meta-analysis identified 554 risk loci for insomnia in a sample size of almost 600,000 cases and 1.8 million controls, and implicated specific biological pathways through gene prioritization.