期刊
INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE
卷 69, 期 -, 页码 1-9出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.ijdevneu.2018.06.001
关键词
Astroglial cells; Risperidone; Haloperidol; Inflammatory response; Glutathione
资金
- Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq)
- Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES)
- Fundacao de Amparo a Pesquisa do Estado do Rio Grande do Sul (FAPERGS)
- Universidade Federal do Rio Grande do Sul
- Instituto Nacional de Ciencia e Tecnologia para Excitotoxicidade e Neuroprotecao (INCTEN/CNPq)
Astrocytes are glial cells that are essential for the maintenance of central nervous system functions, modulating neurotransmitters, providing metabolic, trophic and antioxidant support, and producing a wide range of cytokines to modulate the inflammatory response. These cells can be targets for antipsychotics, medications used in the treatment of neuropsychiatric disorders. In this regard, several studies have shown that antipsychotics are able to modulate peripheral cytokine release, but their effects on astroglial inflammatory response need to be further investigated. In this study, we evaluated the effects of risperidone and haloperidol, common atypical and typical antipsychotics, respectively, on cytokine release and redox status in C6 astroglial cells, an astrocyte-like cell line. Risperidone showed an anti-inflammatory activity, decreasing the release of tumor necrosis factor alpha (TNF-alpha), interleukins 1 beta (IL-1 beta) and 6 (IL-6), and increasing interleukin 10 (IL-10). This atypical antipsychotic was also able to decrease the transcriptional activity of nuclear factor kappa B (NF kappa B) and improve glutathione content. However, haloperidol induced a pro-inflammatory response, increasing the extracellular levels of TNF-alpha and IL-1 beta, in addition to decreasing IL-10. This typical antipsychotic could induce an inflammatory response by activating p38 mitogen-activated protein kinase (p38 MAPK)/NF kappa B pathways. In summary, our results suggest that risperidone and haloperidol present different effects on astroglial cells, in this way being able to differentially affect the neuroinflammation associated with neuropsychiatric disorders.
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