期刊
NATURE CELL BIOLOGY
卷 14, 期 10, 页码 987-989出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/ncb2599
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- Medical Research Council [G0800784] Funding Source: Medline
- Wellcome Trust [092096, 079249] Funding Source: Medline
- MRC [G0800784] Funding Source: UKRI
- Medical Research Council [G0800784B, G0800784] Funding Source: researchfish
Given the important role of the hypothalamus in regulating feeding and metabolism, there has been considerable interest in a possible function for hypothalamic stem cells in modulating body weight in health and disease. Mice given a high-fat diet develop inflammation in the hypothalamus and lose key types of neurons. It now appears that another effect of a high-fat diet is to reduce neural stem cell numbers, as well as their ability to make new neurons effects that are associated with activation of the IKK beta/NF-kappa B pathway thereby - exacerbating the primary loss of neurons and resulting in altered feeding behaviour and obesity.
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