Possible Integrative Actions of Leptin and Insulin Signaling in the Hypothalamus Targeting Energy Homeostasis

Pathways for insulin access to the brain: the role of the microvascular endothelial cell

(2016) Rick I. Meijer et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Discovery of novel, high potent, ABC type PTP1B inhibitors with TCPTP selectivity and cellular activity

(2016) Peihong Liu et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Neuronal Rap1 Regulates Energy Balance, Glucose Homeostasis, and Leptin Actions

(2016) Kentaro Kaneko et al.   Cell Reports

Saturated Fatty Acids Engage an IRE1α-Dependent Pathway to Activate the NLRP3 Inflammasome in Myeloid Cells

(2016) Megan M. Robblee et al.   Cell Reports

Insulin enhanced leptin-induced STAT3 signaling by inducing GRP78

(2016) Mina Thon et al.   Scientific Reports

Endoplasmic Reticulum Stress Impairs Insulin Receptor Signaling in the Brains of Obese Rats

(2015) Lina Liang et al.   PLoS One

Insulin Regulates Brain Function, but How Does It Get There?

(2014) S. M. Gray et al.   DIABETES

PTP1B inhibitors for type 2 diabetes treatment: a patent review (2011 – 2014)

(2014) Akhilesh Kumar Tamrakar et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Leptin induced GRP78 expression through the PI3K-mTOR pathway in neuronal cells

(2014) Mina Thon et al.   Scientific Reports

Inactivation of SOCS3 in leptin receptor-expressing cells protects mice from diet-induced insulin resistance but does not prevent obesity

(2014) João A.B. Pedroso et al.   Molecular Metabolism

Brain-wide pathway for waste clearance captured by contrast-enhanced MRI

(2013) Jeffrey J. Iliff et al.   JOURNAL OF CLINICAL INVESTIGATION

Cellular Insulin Resistance Disrupts Leptin-Mediated Control of Neuronal Signaling and Transcription

(2013) Anaies Nazarians-Armavil et al.   MOLECULAR ENDOCRINOLOGY

Small molecule tools for functional interrogation of protein tyrosine phosphatases

(2012) Rongjun He et al.   FEBS Journal

A Paravascular Pathway Facilitates CSF Flow Through the Brain Parenchyma and the Clearance of Interstitial Solutes, Including Amyloid  

(2012) J. J. Iliff et al.   Science Translational Medicine

Expression of leptin and leptin receptor isoforms in the rat and human carotid body

(2011) Andrea Porzionato et al.   BRAIN RESEARCH

Sodium Phenylbutyrate, a Drug With Known Capacity to Reduce Endoplasmic Reticulum Stress, Partially Alleviates Lipid-Induced Insulin Resistance and β-Cell Dysfunction in Humans

(2011) Changting Xiao et al.   DIABETES

Overexpression of GRP78 protects glial cells from endoplasmic reticulum stress

(2011) Kaori Suyama et al.   NEUROSCIENCE LETTERS

IL-1β induces ER stress in a JNK dependent manner that determines cell death in human pancreatic epithelial MIA PaCa-2 cells

(2010) Gaurav Verma et al.   APOPTOSIS

Functional Role of Suppressor of Cytokine Signaling 3 Upregulation in Hypothalamic Leptin Resistance and Long-Term Energy Homeostasis

(2010) A. S. Reed et al.   DIABETES

Insulin modulates induction of glucose-regulated protein 78 during endoplasmic reticulum stress via augmentation of ATF4 expression in human neuroblastoma cells

(2010) Kiyoshi Inageda   FEBS LETTERS

Endoplasmic Reticulum Stress Plays a Central Role in Development of Leptin Resistance

(2009) Lale Ozcan et al.   Cell Metabolism

Grp78 Heterozygosity Promotes Adaptive Unfolded Protein Response and Attenuates Diet-Induced Obesity and Insulin Resistance

(2009) R. Ye et al.   DIABETES

Enhanced Stat3 Activation in POMC Neurons Provokes Negative Feedback Inhibition of Leptin and InsulinSignaling in Obesity

(2009) M. B. Ernst et al.   JOURNAL OF NEUROSCIENCE

The obesity susceptibility gene Cpe links FoxO1 signaling in hypothalamic pro-opiomelanocortin neurons with regulation of food intake

(2009) Leona Plum et al.   NATURE MEDICINE

Central Administration of an Endoplasmic Reticulum Stress Inducer Inhibits the Anorexigenic Effects of Leptin and Insulin

(2009) Jong Chul Won et al.   Obesity

Insulin Resistance and Alzheimers Disease: Molecular Links & Clinical Implications

(2008) Karen Neumann et al.   Current Alzheimer Research

Obesity and Free Fatty Acids

(2008) Guenther Boden   ENDOCRINOLOGY AND METABOLISM CLINICS OF NORTH AMERICA

Endoplasmic Reticulum Stress Induces Leptin Resistance

(2008) T. Hosoi et al.   MOLECULAR PHARMACOLOGY

Specific Physiological Roles for Signal Transducer and Activator of Transcription 3 in Leptin Receptor-Expressing Neurons

(2007) Merisa L. Piper et al.   MOLECULAR ENDOCRINOLOGY