AgRP/NPY and POMC neurons in the arcuate nucleus and their potential role in treatment of obesity

Brain-specific chemokine FAM19A5 induces hypothalamic inflammation

(2020) Dasol Kang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

C1q/TNF-related Protein 4 Induces Signal Transducer and Activator of Transcription 3 Pathway and Modulates Food Intake

(2020) Yuejie Li et al.   NEUROSCIENCE

Neuroprotective and Neuromodulatory Effects Induced by Cannabidiol and Cannabigerol in Rat Hypo-E22 cells and Isolated Hypothalamus

(2020) Viviana di Giacomo et al.   Antioxidants

Tanycyte ablation in the arcuate nucleus and median eminence increases obesity susceptibility by increasing body fat content in male mice

(2020) Sooyeon Yoo et al.   GLIA

Amyloid beta peptide is an endogenous negative allosteric modulator of leptin receptor

(2020) Erika Cecon et al.   NEUROENDOCRINOLOGY

Ciliary Neurotrophic Factor Acts on Distinctive Hypothalamic Arcuate Neurons and Promotes Leptin Entry Into and Action on the Mouse Hypothalamus

(2020) Wiebe Venema et al.   Frontiers in Cellular Neuroscience

FGF21 Mimics a Fasting-Induced Metabolic State and Increases Appetite in Zebrafish

(2020) Ayelén Melisa Blanco et al.   Scientific Reports

ARCAgRP/NPY Neuron Activity Is Required for Acute Exercise-Induced Food Intake in Un-Trained Mice

(2020) Wyatt Bunner et al.   Frontiers in Physiology

Vulnerability to psychological stress‐induced anorexia in female mice depends on blockade of ghrelin signal in nucleus tractus solitarius

(2020) Chihiro Yamada et al.   BRITISH JOURNAL OF PHARMACOLOGY

Deletion of liver kinase B1 in POMC neurons predisposes to diet-induced obesity

(2020) Zhaoxia Wu et al.   LIFE SCIENCES

Glial Endozepines Reverse High-Fat Diet-Induced Obesity by Enhancing Hypothalamic Response to Peripheral Leptin

(2020) Florent Guillebaud et al.   MOLECULAR NEUROBIOLOGY

A leptin–BDNF pathway regulating sympathetic innervation of adipose tissue

(2020) Putianqi Wang et al.   NATURE

Hypothalamic tanycytes generate acute hyperphagia through activation of the arcuate neuronal network

(2020) Matei Bolborea et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Peripheral Spexin Inhibited Food Intake in Mice

(2020) Shuangyu Lv et al.   International Journal of Endocrinology

Cafeteria diet-induced obesity reduces leptin-stimulated NADPH-diaphorase reactivity in the hypothalamic arcuate nucleus of rats

(2020) Milen Hristov et al.   ACTA HISTOCHEMICA

Organophosphate Flame Retardants Excite Arcuate Melanocortin Circuitry and Increase Neuronal Sensitivity to Ghrelin in Adult Mice

(2020) Gwyndolin M Vail et al.   ENDOCRINOLOGY

Long Chain Fatty Acids Differentially Regulate Sub-populations of Arcuate POMC and NPY Neurons

(2020) Natalie J. Michael et al.   NEUROSCIENCE

GPR101 drives growth hormone hypersecretion and gigantism in mice via constitutive activation of Gs and Gq/11

(2020) Dayana Abboud et al.   Nature Communications

Overexpression of Smad7 in hypothalamic POMC neurons disrupts glucose balance by attenuating central insulin signaling

(2020) Feixiang Yuan et al.   Molecular Metabolism

Hypothalamic mechanisms associated with corticotropin-releasing factor-induced anorexia in chicks

(2019) Jinxin Wang et al.   NEUROPEPTIDES

Obesity: global epidemiology and pathogenesis

(2019) Matthias Blüher   Nature Reviews Endocrinology

Vertical sleeve gastrectomy improves liver and hypothalamic functions in obese mice

(2019) Peixin Li et al.   JOURNAL OF ENDOCRINOLOGY

Anti-obesity Effects of Ginsenosides in High-Fat Diet-Fed Rats

(2019) Hyun-Jung Park et al.   Chinese Journal of Integrative Medicine

Effect of agmatine on food intake in mandarin fish (Siniperca chuatsi)

(2019) Liyuan Lv et al.   FISH PHYSIOLOGY AND BIOCHEMISTRY

The melanocortin pathway and control of appetite-progress and therapeutic implications

(2019) Giulia Baldini et al.   JOURNAL OF ENDOCRINOLOGY

Epigenetic regulation of POMC; implications for nutritional programming, obesity and metabolic disease

(2019) T. Candler et al.   FRONTIERS IN NEUROENDOCRINOLOGY

Antiobesity Effect of Flaxseed Polysaccharide via Inducing Satiety due to Leptin Resistance Removal and Promoting Lipid Metabolism through the AMP-Activated Protein Kinase (AMPK) Signaling Pathway

(2019) Jianming Luo et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Ghrelin receptor in agouti‐related peptide neurones regulates metabolic adaptation to calorie restriction

(2019) Chia‐Shan Wu et al.   JOURNAL OF NEUROENDOCRINOLOGY

Direct and indirect effects of liraglutide on hypothalamic POMC and NPY/AgRP neurons – Implications for energy balance and glucose control

(2019) Zhenyan He et al.   Molecular Metabolism

Pharmacological Modulation of Ghrelin to Induce Weight Loss: Successes and Challenges

(2019) Martha A. Schalla et al.   Current Diabetes Reports

Glucose Increase DAGLα Levels in Tanycytes and Its Inhibition Alters Orexigenic and Anorexigenic Neuropeptides Expression in Response to Glucose

(2019) Alejandra Palma-Chavez et al.   Frontiers in Endocrinology

Effects of a Flavonoid-Rich Extract from Citrus sinensis Juice on a Diet-Induced Obese Zebrafish

(2019) Giuseppe Montalbano et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Irisin increases the expression of anorexigenic and neurotrophic genes in mouse brain

(2019) Annalisa Natalicchio et al.   DIABETES-METABOLISM RESEARCH AND REVIEWS

Leptin Modulates the Expression of miRNAs-Targeting POMC mRNA by the JAK2-STAT3 and PI3K-Akt Pathways

(2019) Adel Derghal et al.   Journal of Clinical Medicine

Targeting AgRP neurons to maintain energy balance: Lessons from animal models

(2018) Sebastián Zagmutt et al.   BIOCHEMICAL PHARMACOLOGY

TCPTP Regulates Insulin Signaling in AgRP Neurons to Coordinate Glucose Metabolism With Feeding

(2018) Garron T. Dodd et al.   DIABETES

Does obestatin modulate the hypothalamic appetite-regulating network in peripubertal sheep?

(2018) M. Szlis et al.   JOURNAL OF ANIMAL PHYSIOLOGY AND ANIMAL NUTRITION

Insulin and leptin excite anorexigenic pro-opiomelanocortin neurones via activation of TRPC5 channels

(2018) J. Qiu et al.   JOURNAL OF NEUROENDOCRINOLOGY

Fluoxetine Modulates the Activity of Hypothalamic POMC Neurons via mTOR Signaling

(2018) Ilaria Barone et al.   MOLECULAR NEUROBIOLOGY

An insurmountable NPY Y5 receptor antagonist exhibits superior anti-obesity effects in high-fat diet-induced obese mice

(2018) Yumiko Fukasaka et al.   NEUROPEPTIDES

Reduced gene expression of sirtuins and active AMPK levels in children and adolescents with obesity and insulin resistance

(2018) Zahra Arab Sadeghabadi et al.   Obesity Research & Clinical Practice

Ghrelin regulation of glucose metabolism

(2018) Anne-Laure Poher et al.   PEPTIDES

Regulation of feeding by somatostatin neurons in the tuberal nucleus

(2018) Sarah Xinwei Luo et al.   SCIENCE

The anti-obesity effect of starch in a whole grain-like structural form

(2018) Kaiyun Luo et al.   Food & Function

Improvement of Adipose Macrophage Polarization in High Fat Diet-Induced Obese GHSR Knockout Mice

(2018) Fang Yuan et al.   Biomed Research International

POMC neurons expressing leptin receptors coordinate metabolic responses to fasting via suppression of leptin levels

(2018) Alexandre Caron et al.   eLife

Progress and challenges in anti-obesity pharmacotherapy

(2018) Daniel H Bessesen et al.   Lancet Diabetes & Endocrinology

Ghrelin mediates exercise endurance and the feeding response post-exercise

(2018) Bharath K. Mani et al.   Molecular Metabolism

Deficiency of leptin receptor in myeloid cells disrupts hypothalamic metabolic circuits and causes body weight increase

(2018) Yuanqing Gao et al.   Molecular Metabolism

Ghrelin, a gastrointestinal hormone, regulates energy balance and lipid metabolism

(2018) You Lv et al.   BIOSCIENCE REPORTS

Pharmacological Effects and Regulatory Mechanisms of Tobacco Smoking Effects on Food Intake and Weight Control

(2018) Tongyuan Hu et al.   Journal of Neuroimmune Pharmacology

Insulin transport across the blood-brain barrier can occur independently of the insulin receptor

(2018) Elizabeth M. Rhea et al.   JOURNAL OF PHYSIOLOGY-LONDON

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(2018) Yu Chung Chooi et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Seasonal consumption of polyphenol-rich fruits affects the hypothalamic leptin signaling system in a photoperiod-dependent mode

(2018) Maria Ibars et al.   Scientific Reports

Insulin regulates POMC neuronal plasticity to control glucose metabolism

(2018) Garron T Dodd et al.   eLife

The increasing burden of diabetes and variations among the states of India: the Global Burden of Disease Study 1990–2016

(2018) Nikhil Tandon et al.   Lancet Global Health

Body composition, biochemical, behavioral and molecular alterations in overfed rats after chronic exposure to SSRI

(2018) Aline Isabel da Silva et al.   BEHAVIOURAL BRAIN RESEARCH

MicroRNAs are involved in the hypothalamic leptin sensitivity

(2018) Adel Derghal et al.   Epigenetics

Ectopic lipid deposition mediates insulin resistance in adipose specific 11β-Hydroxysteroid dehydrogenase type 1 transgenic mice

(2018) Abudukadier Abulizi et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Effects of RVD-hemopressin (α) on feeding and body weight after standard or cafeteria diet in rats

(2018) Sheila Leone et al.   NEUROPEPTIDES

Phenethyl isothiocyanate activates leptin signaling and decreases food intake

(2018) Miho Yagi et al.   PLoS One

Central Dicer-miR-103/107 controls developmental switch of POMC progenitors into NPY neurons and impacts glucose homeostasis

(2018) Sophie Croizier et al.   eLife

Natural anti-obesity agents and their therapeutic role in management of obesity: A future trend perspective

(2018) Sravani Karri et al.   BIOMEDICINE & PHARMACOTHERAPY

Suppression of GHS-R in AgRP Neurons Mitigates Diet-Induced Obesity by Activating Thermogenesis

(2017) Chia-Shan Wu et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Therapeutic Potential of Targeting the Ghrelin Pathway

(2017) Gustav Colldén et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The agouti-related peptide binds heparan sulfate through segments critical for its orexigenic effects

(2017) Rafael Palomino et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hypothalamic inflammation in obesity and metabolic disease

(2017) Alexander Jais et al.   JOURNAL OF CLINICAL INVESTIGATION

Genetics of non-syndromic childhood obesity and the use of high-throughput DNA sequencing technologies

(2017) Ana Carolina Proença da Fonseca et al.   JOURNAL OF DIABETES AND ITS COMPLICATIONS

Asprosin is a centrally acting orexigenic hormone

(2017) Clemens Duerrschmid et al.   NATURE MEDICINE

A molecular census of arcuate hypothalamus and median eminence cell types

(2017) John N Campbell et al.   NATURE NEUROSCIENCE

Biochemical and cellular properties of insulin receptor signalling

(2017) Rebecca A. Haeusler et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Dynamics of Gut-Brain Communication Underlying Hunger

(2017) Lisa R. Beutler et al.   NEURON

One-week exposure to a free-choice high-fat high-sugar diet does not disrupt blood–brain barrier permeability in fed or overnight fasted rats

(2017) M. Rijnsburger et al.   NUTRITIONAL NEUROSCIENCE

Obesity: a chronic relapsing progressive disease process. A position statement of the World Obesity Federation

(2017) G.A. Bray et al.   Obesity Reviews

Direct versus indirect actions of ghrelin on hypothalamic NPY neurons

(2017) Hiroshi Hashiguchi et al.   PLoS One

Ghrelin as a Survival Hormone

(2017) Bharath K. Mani et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

TNFα drives mitochondrial stress in POMC neurons in obesity

(2017) Chun-Xia Yi et al.   Nature Communications

Antagonistic modulation of NPY/AgRP and POMC neurons in the arcuate nucleus by noradrenalin

(2017) Lars Paeger et al.   eLife

The Role of MicroRNA in the Modulation of the Melanocortinergic System

(2017) Adel Derghal et al.   Frontiers in Neuroscience

Development and Function of the Blood-Brain Barrier in the Context of Metabolic Control

(2017) Roberta Haddad-Tóvolli et al.   Frontiers in Neuroscience

The role of ghrelin-responsive mediobasal hypothalamic neurons in mediating feeding responses to fasting

(2017) Bharath K. Mani et al.   Molecular Metabolism

Cholinergic neurons in the dorsomedial hypothalamus regulate food intake

(2017) Jae Hoon Jeong et al.   Molecular Metabolism

Mitochondrial uncoupling in the melanocortin system differentially regulates NPY and POMC neurons to promote weight-loss

(2017) Natalie Jane Michael et al.   Molecular Metabolism

Heterogeneity of hypothalamic pro-opiomelanocortin-expressing neurons revealed by single-cell RNA sequencing

(2017) Brian Y.H. Lam et al.   Molecular Metabolism

Predicting obesity rate and obesity-related healthcare costs using data analytics

(2017) Stephanie Revels et al.   Health Policy and Technology

The Leptin Receptor Complex: Heavier Than Expected?

(2017) Joris Wauman et al.   Frontiers in Endocrinology

Fibroblast growth factor 21, assisted by elevated glucose, activates paraventricular nucleus NUCB2/Nesfatin-1 neurons to produce satiety under fed states

(2017) Putra Santoso et al.   Scientific Reports

Pathways for insulin access to the brain: the role of the microvascular endothelial cell

(2016) Rick I. Meijer et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Central ghrelin increases food foraging/hoarding that is blocked by GHSR antagonism and attenuates hypothalamic paraventricular nucleus neuronal activation

(2016) Michael A. Thomas et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

MicroRNAs in the hypothalamus

(2016) Mohammed Taouis   BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM

Making sense of the sensory regulation of hunger neurons

(2016) Yiming Chen et al.   BIOESSAYS

Asprosin, a Fasting-Induced Glucogenic Protein Hormone

(2016) Chase Romere et al.   CELL

Microbiota-Produced Succinate Improves Glucose Homeostasis via Intestinal Gluconeogenesis

(2016) Filipe De Vadder et al.   Cell Metabolism

Adult NG2-Glia Are Required for Median Eminence-Mediated Leptin Sensing and Body Weight Control

(2016) Tina Djogo et al.   Cell Metabolism

Leptin signalling pathways in hypothalamic neurons

(2016) Obin Kwon et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Neuronal Deletion of Ghrelin Receptor Almost Completely Prevents Diet-Induced Obesity

(2016) Jong Han Lee et al.   DIABETES

Maternal Obesity in the Mouse Compromises the Blood-Brain Barrier in the Arcuate Nucleus of Offspring

(2016) Dong Won Kim et al.   ENDOCRINOLOGY

Proanthocyanidins potentiate hypothalamic leptin/STAT3 signalling and Pomc gene expression in rats with diet-induced obesity

(2016) M Ibars et al.   INTERNATIONAL JOURNAL OF OBESITY

The long road to leptin

(2016) Jeffrey Friedman   JOURNAL OF CLINICAL INVESTIGATION

60 YEARS OF POMC: Biosynthesis, trafficking, and secretion of pro-opiomelanocortin-derived peptides

(2016) Niamh X Cawley et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

The effect of physical exercise on orexigenic and anorexigenic peptides and its role on long-term feeding control

(2016) Sandra Aparecida Benite-Ribeiro et al.   MEDICAL HYPOTHESES

Modulation of leptin resistance by food compounds

(2016) Gerard Aragonès et al.   MOLECULAR NUTRITION & FOOD RESEARCH

The pathophysiology of defective proteostasis in the hypothalamus — from obesity to ageing

(2016) Cláudia Cavadas et al.   Nature Reviews Endocrinology

Body Fatness and Cancer — Viewpoint of the IARC Working Group

(2016) Béatrice Lauby-Secretan et al.   NEW ENGLAND JOURNAL OF MEDICINE

Vagal Blocking for Obesity Control: a Possible Mechanism-Of-Action

(2016) Helene Johannessen et al.   OBESITY SURGERY

Enhanced responsiveness ofGhsrQ343Xrats to ghrelin results in enhanced adiposity without increased appetite

(2016) Yacine Chebani et al.   Science Signaling

Obesity Impairs the Action of the Neuroendocrine Ghrelin System

(2016) Jeffrey M. Zigman et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Divergent effects of central melanocortin signalling on fat and sucrose preference in humans

(2016) Agatha A. van der Klaauw et al.   Nature Communications

Enhanced responsiveness ofGhsrQ343Xrats to ghrelin results in enhanced adiposity without increased appetite

(2016) Yacine Chebani et al.   Science Signaling

The suppression of ghrelin signaling mitigates age-associated thermogenic impairment

(2016) Ligen Lin et al.   Aging-US

Insulin enhanced leptin-induced STAT3 signaling by inducing GRP78

(2016) Mina Thon et al.   Scientific Reports

Inhibition of hypothalamic MCT1 expression increases food intake and alters orexigenic and anorexigenic neuropeptide expression

(2016) Roberto Elizondo-Vega et al.   Scientific Reports

mTORC1 signaling in Agrp neurons mediates circadian expression of Agrp and NPY but is dispensable for regulation of feeding behavior

(2015) Verena Albert et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Network of hypothalamic neurons that control appetite

(2015) Jong-Woo Sohn   BMB Reports

Sensory Detection of Food Rapidly Modulates Arcuate Feeding Circuits

(2015) Yiming Chen et al.   CELL

Leptin and Insulin Act on POMC Neurons to Promote the Browning of White Fat

(2015) Garron T. Dodd et al.   CELL

Palatability Can Drive Feeding Independent of AgRP Neurons

(2015) Raphaël G.P. Denis et al.   Cell Metabolism

Neuronal Regulation of Energy Homeostasis: Beyond the Hypothalamus and Feeding

(2015) Michael J. Waterson et al.   Cell Metabolism

Gpr17 in AgRP Neurons Regulates Feeding and Sensitivity to Insulin and Leptin

(2015) Hongxia Ren et al.   DIABETES

Enhancement of Hypothalamic STAT3 Acetylation by Nuclear Receptor Nur77 Dictates Leptin Sensitivity

(2015) Yan Chen et al.   DIABETES

Central Sirt1 Regulates Body Weight and Energy Expenditure Along With the POMC-Derived Peptide α-MSH and the Processing Enzyme CPE Production in Diet-Induced Obese Male Rats

(2015) Nicole E. Cyr et al.   ENDOCRINOLOGY

Neonatal ghrelin programs development of hypothalamic feeding circuits

(2015) Sophie M. Steculorum et al.   JOURNAL OF CLINICAL INVESTIGATION

Erythropoietin regulates POMC expression via STAT3 and potentiates leptin response

(2015) Soumyadeep Dey et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

Pro-Opiomelanocortin (POMC) Neurones, POMC-Derived Peptides, Melanocortin Receptors and Obesity: How Understanding of this System has Changed Over the Last Decade

(2015) K. G. Mountjoy   JOURNAL OF NEUROENDOCRINOLOGY

Hypothalamic POMC neurons promote cannabinoid-induced feeding

(2015) Marco Koch et al.   NATURE

Nicotine Attenuates Disruption of Blood–Brain Barrier Induced by Saturated-Fat Feeding in Wild-Type Mice

(2015) Mina Elahy et al.   NICOTINE & TOBACCO RESEARCH

Protein Tyrosine Phosphatases in Hypothalamic Insulin and Leptin Signaling

(2015) Zhong-Yin Zhang et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Anti-Obesity and Anti-Hyperglycemic Effects of Cinnamaldehyde via altered Ghrelin Secretion and Functional impact on Food Intake and Gastric Emptying

(2015) Susana Camacho et al.   Scientific Reports

Arcuate hypothalamic AgRP and putative POMC neurons show opposite changes in spiking across multiple timescales

(2015) Yael Mandelblat-Cerf et al.   eLife

Ghrelin

(2015) T.D. Müller et al.   Molecular Metabolism

Age-Associated Weight Gain, Leptin, and SIRT1: A Possible Role for Hypothalamic SIRT1 in the Prevention of Weight Gain and Aging through Modulation of Leptin Sensitivity

(2015) Tsutomu Sasaki   Frontiers in Endocrinology

The hypothalamic arcuate nucleus and the control of peripheral substrates

(2014) Aurélie Joly-Amado et al.   BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM

Phenethyl isothiocyanate: A comprehensive review of anti-cancer mechanisms

(2014) Parul Gupta et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

Central Neural Regulation of Brown Adipose Tissue Thermogenesis and Energy Expenditure

(2014) Shaun F. Morrison et al.   Cell Metabolism

Xbp1s in Pomc Neurons Connects ER Stress with Energy Balance and Glucose Homeostasis

(2014) Kevin W. Williams et al.   Cell Metabolism

Induced Ablation of Ghrelin Cells in Adult Mice Does Not Decrease Food Intake, Body Weight, or Response to High-Fat Diet

(2014) Matthew R. McFarlane et al.   Cell Metabolism

Insulin Excites Anorexigenic Proopiomelanocortin Neurons via Activation of Canonical Transient Receptor Potential Channels

(2014) Jian Qiu et al.   Cell Metabolism

Hypothalamic Tanycytes Are an ERK-Gated Conduit for Leptin into the Brain

(2014) Eglantine Balland et al.   Cell Metabolism

Hypothalamic Tanycytes: Gatekeepers to Metabolic Control

(2014) Yuanqing Gao et al.   Cell Metabolism

Functional foods to promote weight loss and satiety

(2014) Candida Rebello et al.   CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE

GLP-1 Agonism Stimulates Brown Adipose Tissue Thermogenesis and Browning Through Hypothalamic AMPK

(2014) D. Beiroa et al.   DIABETES

Erythropoietin Action in Stress Response, Tissue Maintenance and Metabolism

(2014) Yuanyuan Zhang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Resveratrol Attenuates High-Fat Diet-Induced Disruption of the Blood–Brain Barrier and Protects Brain Neurons from Apoptotic Insults

(2014) Huai-Chia Chang et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

An excitatory paraventricular nucleus to AgRP neuron circuit that drives hunger

(2014) Michael J. Krashes et al.   NATURE

Sirt1 rescues the obesity induced by insulin-resistant constitutively-nuclear FoxO1 in POMC neurons of male mice

(2014) Vina Yanti Susanti et al.   Obesity

Ablation of AgRP neurons impairs adaption to restricted feeding

(2014) Keith Tan et al.   Molecular Metabolism

Inactivation of SOCS3 in leptin receptor-expressing cells protects mice from diet-induced insulin resistance but does not prevent obesity

(2014) João A.B. Pedroso et al.   Molecular Metabolism

Retrograde study of CART- or NPY-neuronal projection from the hypothalamic arcuate nucleus to the dorsal raphe and/or the locus coeruleus in the rat

(2013) Ye S. Yoon et al.   BRAIN RESEARCH

Parallel, Redundant Circuit Organization for Homeostatic Control of Feeding Behavior

(2013) J. Nicholas Betley et al.   CELL

Mitofusin 2 in POMC Neurons Connects ER Stress with Leptin Resistance and Energy Imbalance

(2013) Marc Schneeberger et al.   CELL

Moderate physical exercise attenuates the alterations of feeding behaviour induced by social stress in female rats

(2013) Sandra Aparecida Benite-Ribeiro et al.   CELL BIOCHEMISTRY AND FUNCTION

Rapid versus Delayed Stimulation of Feeding by the Endogenously Released AgRP Neuron Mediators GABA, NPY, and AgRP

(2013) Michael J. Krashes et al.   Cell Metabolism

Tanycytic VEGF-A Boosts Blood-Hypothalamus Barrier Plasticity and Access of Metabolic Signals to the Arcuate Nucleus in Response to Fasting

(2013) Fanny Langlet et al.   Cell Metabolism

Hypothalamic Ceramide Levels Regulated by CPT1C Mediate the Orexigenic Effect of Ghrelin

(2013) S. Ramirez et al.   DIABETES

Hypothalamic SIRT1 prevents age-associated weight gain by improving leptin sensitivity in mice

(2013) Tsutomu Sasaki et al.   DIABETOLOGIA

Neuronal Sirt1 Deficiency Increases Insulin Sensitivity in Both Brain and Peripheral Tissues

(2013) Min Lu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Tanycyte-like cells form a blood-cerebrospinal fluid barrier in the circumventricular organs of the mouse brain

(2013) Fanny Langlet et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Forkhead box class O transcription factors in liver function and disease

(2013) Irina Tikhanovich et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

The Beneficial Effects of Early Short-Term Exercise in the Offspring of Obese Mothers are Accompanied by Alterations in the Hypothalamic Gene Expression of Appetite Regulators and FTO (Fat Mass and Obesity Associated) Gene

(2013) V. Caruso et al.   JOURNAL OF NEUROENDOCRINOLOGY

Neonatal Leptin Exposure Specifies Innervation of Presympathetic Hypothalamic Neurons and Improves the Metabolic Status of Leptin-Deficient Mice

(2013) K. Bouyer et al.   JOURNAL OF NEUROSCIENCE

Leptin Signaling in GABA Neurons, But Not Glutamate Neurons, Is Required for Reproductive Function

(2013) W. A. Zuure et al.   JOURNAL OF NEUROSCIENCE

Acute and Long-Term Suppression of Feeding Behavior by POMC Neurons in the Brainstem and Hypothalamus, Respectively

(2013) C. Zhan et al.   JOURNAL OF NEUROSCIENCE

Functional neuroanatomy of the central noradrenergic system

(2013) Elemer Szabadi   JOURNAL OF PSYCHOPHARMACOLOGY

Ghrelin-induced food intake and adiposity depend on central mTORC1/S6K1 signaling

(2013) Darko Stevanovic et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Postnatal Ablation of POMC Neurons Induces an Obese Phenotype Characterized by Decreased Food Intake and Enhanced Anxiety-Like Behavior

(2013) Yona Greenman et al.   MOLECULAR ENDOCRINOLOGY

Cellular Insulin Resistance Disrupts Leptin-Mediated Control of Neuronal Signaling and Transcription

(2013) Anaies Nazarians-Armavil et al.   MOLECULAR ENDOCRINOLOGY

Anthocyanins attenuate body weight gain via modulating neuropeptide Y and GABAB1 receptor in rats hypothalamus

(2013) Haroon Badshah et al.   NEUROPEPTIDES

Peripheral chemerin administration modulates hypothalamic control of feeding

(2013) Luigi Brunetti et al.   PEPTIDES

Involvement of Hypothalamic AMP-Activated Protein Kinase in Leptin-Induced Sympathetic Nerve Activation

(2013) Mamoru Tanida et al.   PLoS One

The Dipeptidyl Peptidase-4 Inhibitor Des-Fluoro-Sitagliptin Regulates Brown Adipose Tissue Uncoupling Protein Levels in Mice with Diet-Induced Obesity

(2013) Takanobu Shimasaki et al.   PLoS One

Modulation of AgRP-neuronal function by SOCS3 as an initiating event in diet-induced hypothalamic leptin resistance

(2013) L. E. Olofsson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Loss of Function of the Melanocortin 2 Receptor Accessory Protein 2 Is Associated with Mammalian Obesity

(2013) M. Asai et al.   SCIENCE

Arcuate AgRP neurons mediate orexigenic and glucoregulatory actions of ghrelin

(2013) Qian Wang et al.   Molecular Metabolism

Identification of a novel and orally available benzimidazole derivative as an NPY Y5 receptor antagonist with in vivo efficacy

(2012) Yuusuke Tamura et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Identification of a novel benzimidazole derivative as a highly potent NPY Y5 receptor antagonist with an anti-obesity profile

(2012) Yuusuke Tamura et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

FoxO1 Target Gpr17 Activates AgRP Neurons to Regulate Food Intake

(2012) Hongxia Ren et al.   CELL

Different vascular permeability between the sensory and secretory circumventricular organs of adult mouse brain

(2012) Shoko Morita et al.   CELL AND TISSUE RESEARCH

p70S6 Kinase Phosphorylates AMPK on Serine 491 to Mediate Leptin's Effect on Food Intake

(2012) Yossi Dagon et al.   Cell Metabolism

Modulation of Leptin Resistance by Protein Tyrosine Phosphatases

(2012) Julie St-Pierre et al.   Cell Metabolism

Leptin and insulin pathways in POMC and AgRP neurons that modulate energy balance and glucose homeostasis

(2012) Luis Varela et al.   EMBO REPORTS

PTP1B and TCPTP - nonredundant phosphatases in insulin signaling and glucose homeostasis

(2012) Tony Tiganis   FEBS Journal

GOAT induced ghrelin acylation regulates hedonic feeding

(2012) J.F. Davis et al.   HORMONES AND BEHAVIOR

Necdin Controls Foxo1 Acetylation in Hypothalamic Arcuate Neurons to Modulate the Thyroid Axis

(2012) K. Hasegawa et al.   JOURNAL OF NEUROSCIENCE

Ligand-Induced Architecture of the Leptin Receptor Signaling Complex

(2012) Liliya V. Mancour et al.   MOLECULAR CELL

Central nervous system control of metabolism

(2012) Martin G. Myers et al.   NATURE

Deciphering a neuronal circuit that mediates appetite

(2012) Qi Wu et al.   NATURE

Tanycytes of the hypothalamic median eminence form a diet-responsive neurogenic niche

(2012) Daniel A Lee et al.   NATURE NEUROSCIENCE

Rho-kinase regulates energy balance by targeting hypothalamic leptin receptor signaling

(2012) Hu Huang et al.   NATURE NEUROSCIENCE

Evidence suggesting that ghrelin O-acyl transferase inhibitor acts at the hypothalamus to inhibit hypothalamo-pituitary-adrenocortical axis function in the rat

(2012) Marcin Rucinski et al.   PEPTIDES

Thinking about Eating Food Activates Visual Cortex with Reduced Bilateral Cerebellar Activation in Females with Anorexia Nervosa: An fMRI Study

(2012) Samantha J. Brooks et al.   PLoS One

Y1 and Y5 Receptors Are Both Required for the Regulation of Food Intake and Energy Homeostasis in Mice

(2012) Amy D. Nguyen et al.   PLoS One

Hypothalamic mTOR Signaling Mediates the Orexigenic Action of Ghrelin

(2012) Luís Martins et al.   PLoS One

In vitro selection of a peptide antagonist of growth hormone secretagogue receptor using cDNA display

(2012) S. Ueno et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Paravascular Pathway Facilitates CSF Flow Through the Brain Parenchyma and the Clearance of Interstitial Solutes, Including Amyloid  

(2012) J. J. Iliff et al.   Science Translational Medicine

Regulation of lipid metabolism by p53 – fighting two villains with one sword

(2012) Ido Goldstein et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Ablation of ghrelin receptor reduces adiposity and improves insulin sensitivity during aging by regulating fat metabolism in white and brown adipose tissues

(2011) Ligen Lin et al.   AGING CELL

Leptin in human physiology and pathophysiology

(2011) Christos S. Mantzoros et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Third ventricular coinjection of subthreshold doses of NPY and AgRP stimulate food hoarding and intake and neural activation

(2011) Brett J. W. Teubner et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

NPY receptors as potential targets for anti-obesity drug development

(2011) Ernie Yulyaningsih et al.   BRITISH JOURNAL OF PHARMACOLOGY

Hunger States Switch a Flip-Flop Memory Circuit via a Synaptic AMPK-Dependent Positive Feedback Loop

(2011) Yunlei Yang et al.   CELL

The effect of age on glucose uptake and GLUT1 and GLUT4 expression in rat skeletal muscle

(2011) J. M. Santos et al.   CELL BIOCHEMISTRY AND FUNCTION

Elevated Hypothalamic TCPTP in Obesity Contributes to Cellular Leptin Resistance

(2011) Kim Loh et al.   Cell Metabolism

A small molecule antagonist of ghrelin O-acyltransferase (GOAT)

(2011) Amanda L. Garner et al.   CHEMICAL COMMUNICATIONS

Ablation of the Leptin Receptor in the Hypothalamic Arcuate Nucleus Abrogates Leptin-Induced Sympathetic Activation

(2011) Shannon M. Harlan et al.   CIRCULATION RESEARCH

Mediobasal Hypothalamic SIRT1 Is Essential for Resveratrol’s Effects on Insulin Action in Rats

(2011) Colette M. Knight et al.   DIABETES

The Central Sirtuin 1/p53 Pathway Is Essential for the Orexigenic Action of Ghrelin

(2011) D. A. Velasquez et al.   DIABETES

GABAergic signaling by AgRP neurons prevents anorexia via a melanocortin-independent mechanism

(2011) Qi Wu et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Leptin receptor signaling: pathways to leptin resistance

(2011) Joris Wauman   Frontiers in Bioscience-Landmark

Rapid, reversible activation of AgRP neurons drives feeding behavior in mice

(2011) Michael J. Krashes et al.   JOURNAL OF CLINICAL INVESTIGATION

Functional implications of limited leptin receptor and ghrelin receptor coexpression in the brain

(2011) Mario Perello et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Peroxisome proliferation–associated control of reactive oxygen species sets melanocortin tone and feeding in diet-induced obesity

(2011) Sabrina Diano et al.   NATURE MEDICINE

AGRP neurons are sufficient to orchestrate feeding behavior rapidly and without training

(2011) Yexica Aponte et al.   NATURE NEUROSCIENCE

Engaging neuroscience to advance translational research in brain barrier biology

(2011) Edward A. Neuwelt et al.   NATURE REVIEWS NEUROSCIENCE

Body mass index in midlife and late-life as a risk factor for dementia: a meta-analysis of prospective studies

(2011) K. J. Anstey et al.   Obesity Reviews

Effects of vaspin, chemerin and omentin-1 on feeding behavior and hypothalamic peptide gene expression in the rat

(2011) Luigi Brunetti et al.   PEPTIDES

Role of the AMP-activated protein kinase (AMPK) signaling pathway in the orexigenic effects of endogenous ghrelin

(2011) P.J. Verhulst et al.   REGULATORY PEPTIDES

Disrupted erythropoietin signalling promotes obesity and alters hypothalamus proopiomelanocortin production

(2011) Ruifeng Teng et al.   Nature Communications

PDK-1/FoxO1 pathway in POMC neurons regulates Pomc expression and food intake

(2010) Kristy Iskandar et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Mechanism of attenuation of leptin signaling under chronic ligand stimulation

(2010) Holger Knobelspies et al.   BMC BIOCHEMISTRY

Disruption of Protein Arginine N -Methyltransferase 2 Regulates Leptin Signaling and Produces Leanness In Vivo Through Loss of STAT3 Methylation

(2010) Hiroaki Iwasaki et al.   CIRCULATION RESEARCH

Functional Role of Suppressor of Cytokine Signaling 3 Upregulation in Hypothalamic Leptin Resistance and Long-Term Energy Homeostasis

(2010) A. S. Reed et al.   DIABETES

Induction of Hypothalamic Sirt1 Leads to Cessation of Feeding via Agouti-Related Peptide

(2010) Tsutomu Sasaki et al.   ENDOCRINOLOGY

Ghrelin effects on neuropeptides in the rat hypothalamus depend on fatty acid metabolism actions on BSX but not on gender

(2010) Ricardo Lage et al.   FASEB JOURNAL

Hypothalamic malonyl-CoA and CPT1c in the treatment of obesity

(2010) Michael J. Wolfgang et al.   FEBS Journal

Induction ofSirt1by Mechanical Stretch of Skeletal Muscle through the Early Response Factor EGR1 Triggers an Antioxidative Response

(2010) Patricia S. Pardo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Obesity-induced Hypertension: Role of Sympathetic Nervous System, Leptin, and Melanocortins

(2010) John E. Hall et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PTP1B and SHP2 in POMC neurons reciprocally regulate energy balance in mice

(2010) Ryoichi Banno et al.   JOURNAL OF CLINICAL INVESTIGATION

Agrp Neurons Mediate Sirt1's Action on the Melanocortin System and Energy Balance: Roles for Sirt1 in Neuronal Firing and Synaptic Plasticity

(2010) M. O. Dietrich et al.   JOURNAL OF NEUROSCIENCE

Segregation of Acute Leptin and Insulin Effects in Distinct Populations of Arcuate Proopiomelanocortin Neurons

(2010) K. W. Williams et al.   JOURNAL OF NEUROSCIENCE

The design of barriers in the hypothalamus allows the median eminence and the arcuate nucleus to enjoy private milieus: The former opens to the portal blood and the latter to the cerebrospinal fluid

(2010) Esteban M. Rodríguez et al.   PEPTIDES

NPY Neuron-Specific Y2 Receptors Regulate Adipose Tissue and Trabecular Bone but Not Cortical Bone Homeostasis in Mice

(2010) Yan-Chuan Shi et al.   PLoS One

Recent advances in understanding leptin signaling and leptin resistance

(2009) David L. Morris et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Loss of GABAergic Signaling by AgRP Neurons to the Parabrachial Nucleus Leads to Starvation

(2009) Qi Wu et al.   CELL

Endoplasmic Reticulum Stress Plays a Central Role in Development of Leptin Resistance

(2009) Lale Ozcan et al.   Cell Metabolism

Divergent Regulation of Energy Expenditure and Hepatic Glucose Production by Insulin Receptor in Agouti-Related Protein and POMC Neurons

(2009) H. V. Lin et al.   DIABETES

Ghrelin restores ‘lean-type’ hunger and energy expenditure profiles in morbidly obese subjects but has no effect on postgastrectomy subjects

(2009) M S B Huda et al.   INTERNATIONAL JOURNAL OF OBESITY

Differential distribution of tight junction proteins suggests a role for tanycytes in blood-hypothalamus barrier regulation in the adult mouse brain

(2009) Amandine Mullier et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Enhanced Stat3 Activation in POMC Neurons Provokes Negative Feedback Inhibition of Leptin and InsulinSignaling in Obesity

(2009) M. B. Ernst et al.   JOURNAL OF NEUROSCIENCE

Inhibition of hypothalamic Foxo1 expression reduced food intake in diet-induced obesity rats

(2009) Eduardo R. Ropelle et al.   JOURNAL OF PHYSIOLOGY-LONDON

The obesity susceptibility gene Cpe links FoxO1 signaling in hypothalamic pro-opiomelanocortin neurons with regulation of food intake

(2009) Leona Plum et al.   NATURE MEDICINE

GOAT links dietary lipids with the endocrine control of energy balance

(2009) Henriette Kirchner et al.   NATURE MEDICINE

SIRT1 and insulin resistance

(2009) Fengxia Liang et al.   Nature Reviews Endocrinology

Central Administration of an Endoplasmic Reticulum Stress Inducer Inhibits the Anorexigenic Effects of Leptin and Insulin

(2009) Jong Chul Won et al.   Obesity

Hypothalamic Sirt1 Regulates Food Intake in a Rodent Model System

(2009) Işin Çakir et al.   PLoS One

HF diets increase hypothalamic PTP1B and induce leptin resistance through both leptin-dependent and -independent mechanisms

(2008) Christy L. White et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Intragastric administration of evodiamine suppresses NPY and AgRP gene expression in the hypothalamus and decreases food intake in rats

(2008) Jinghong Shi et al.   BRAIN RESEARCH

Identification of the Acyltransferase that Octanoylates Ghrelin, an Appetite-Stimulating Peptide Hormone

(2008) Jing Yang et al.   CELL

PDK1 Deficiency in POMC-Expressing Cells Reveals FOXO1-Dependent and -Independent Pathways in Control of Energy Homeostasis and Stress Response

(2008) Bengt F. Belgardt et al.   Cell Metabolism

Mediobasal Hypothalamic p70 S6 Kinase 1 Modulates the Control of Energy Homeostasis

(2008) Clémence Blouet et al.   Cell Metabolism

Hypothalamic ERK Mediates the Anorectic and Thermogenic Sympathetic Effects of Leptin

(2008) K. Rahmouni et al.   DIABETES

Reduction of Hypothalamic Protein Tyrosine Phosphatase Improves Insulin and Leptin Resistance in Diet-Induced Obese Rats

(2008) Paty Karoll Picardi et al.   ENDOCRINOLOGY

Bsx, a Novel Hypothalamic Factor Linking Feeding with Locomotor Activity, Is Regulated by Energy Availability

(2008) Ruben Nogueiras et al.   ENDOCRINOLOGY

Brain SIRT1: Anatomical Distribution and Regulation by Energy Availability

(2008) G. Ramadori et al.   JOURNAL OF NEUROSCIENCE

Ablation of Neurons Expressing Agouti-Related Protein Activates Fos and Gliosis in Postsynaptic Target Regions

(2008) Q. Wu et al.   JOURNAL OF NEUROSCIENCE

Endoplasmic Reticulum Stress Induces Leptin Resistance

(2008) T. Hosoi et al.   MOLECULAR PHARMACOLOGY

UCP2 mediates ghrelin’s action on NPY/AgRP neurons by lowering free radicals

(2008) Zane B. Andrews et al.   NATURE

The Orexigenic Effect of Ghrelin Is Mediated through Central Activation of the Endogenous Cannabinoid System

(2008) Blerina Kola et al.   PLoS One

Loss of Cytokine-STAT5 Signaling in the CNS and Pituitary Gland Alters Energy Balance and Leads to Obesity

(2008) Ji-Yeon Lee et al.   PLoS One

Ghrelin octanoylation mediated by an orphan lipid transferase

(2008) J. A. Gutierrez et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

AMPK: a metabolic gauge regulating whole-body energy homeostasis

(2008) Ricardo Lage et al.   TRENDS IN MOLECULAR MEDICINE

Mechanisms of Leptin Action and Leptin Resistance

(2007) Martin G. Myers et al.   Annual Review of Physiology

Ghrelin raises [Ca2+]i via AMPK in hypothalamic arcuate nucleus NPY neurons

(2007) Daisuke Kohno et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Characterization of Adult Ghrelin and Ghrelin Receptor Knockout Mice under Positive and Negative Energy Balance

(2007) Yuxiang Sun et al.   ENDOCRINOLOGY

Insulin Receptor Substrate 4 Couples the Leptin Receptor to Multiple Signaling Pathways

(2007) Joris Wauman et al.   MOLECULAR ENDOCRINOLOGY

Specific Physiological Roles for Signal Transducer and Activator of Transcription 3 in Leptin Receptor-Expressing Neurons

(2007) Merisa L. Piper et al.   MOLECULAR ENDOCRINOLOGY