Article
Environmental Sciences
Qiang Ma, Houguo Xu, Samwel Mchele Limbu, Yuliang Wei, Mengqing Liang
Summary: In this study, the ability of fish to utilize carbohydrates was evaluated by intraperitoneal injection or oral administration of glucose or fructose to tiger puffer and turbot. The results showed that glucose and fructose stimulated insulin secretion and improved hypoxia tolerance in the two marine fishes.
FRONTIERS IN MARINE SCIENCE
(2023)
Article
Health Care Sciences & Services
Andrea Foppiani, Fabiana Ciciriello, Arianna Bisogno, Silvia Bricchi, Carla Colombo, Federico Alghisi, Vincenzina Lucidi, Maria Ausilia Catena, Mariacristina Lucanto, Andrea Mari, Giorgio Bedogni, Alberto Battezzati
Summary: This study aimed to describe the distribution and provide reference quartiles of OGTT-related variables in the Italian cystic fibrosis population. The results showed the deterioration of glucose tolerance and insulin secretion with age according to sex and pancreatic insufficiency, highlighting a deviation from linearity for patients 35 years of age.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Immunology
Li Li, Eun-Seon Yoo, Xiujuan Li, Steven C. Wyler, Xiameng Chen, Rong Wan, Amanda G. Arnold, Shari G. Birnbaum, Lin Jia, Jong-Woo Sohn, Chen Liu
Summary: Atypical antipsychotics like risperidone and olanzapine can cause drug-induced metabolic syndrome by inhibiting hypothalamic Mc4r neuronal activity, leading to hyperphagia and weight gain.
JOURNAL OF EXPERIMENTAL MEDICINE
(2021)
Article
Endocrinology & Metabolism
Vasudha Ahuja, Pasi Aronen, T. A. Pramodkumar, Helen Looker, Angela Chetrit, Aini H. Bloigu, Auni Juutilainen, Cristina Bianchi, Lucia La Sala, Ranjit Mohan Anjana, Rajendra Pradeepa, Ulagamadesan Venkatesan, Sarvanan Jebarani, Viswanathan Baskar, Teresa Vanessa Fiorentino, Patrick Timpel, Ralph A. DeFronzo, Antonio Ceriello, Stefano Del Prato, Muhammad Abdul-Ghani, Sirkka Keinanen-Kiukaanniemi, Rachel Dankner, Peter H. Bennett, William C. Knowler, Peter Schwarz, Giorgio Sesti, Rie Oka, Viswanathan Mohan, Leif Groop, Jaakko Tuomilehto, Samuli Ripatti, Michael Bergman, Tiinamaija Tuomi
Summary: The 1-h PG of >= 11.6 mmol/L during OGTT has good sensitivity and specificity for detecting type 2 diabetes. Prescreening with a diabetes-specific risk calculator is suggested to reduce the proportion of false-positive cases, with further studies needed for other ethnic groups and complication risk assessment.
Article
Multidisciplinary Sciences
Suguru Fujita, Yasuaki Karasawa, Ken-ichi Hironaka, Y. -h. Taguchi, Shinya Kuroda
Summary: High-throughput omics technologies allow for the profiling of entire biological systems. In this study, tensor decomposition was applied to a dataset of blood molecule concentrations to extract features in a non-biased manner without the need for hypothesis generation. The results showed that tensor decomposition can extract similar features obtained by hypothesis-driven analysis, but with a shorter processing time.
Article
Endocrinology & Metabolism
Kim K. B. Clemmensen, Annemarie Koster, Johannes T. H. Nielen, Pieter C. Dagnelie, Coen D. A. Stehouwer, Hans Bosma, Anke Wesselius, Kristine Faerch, Simone J. P. M. Eussen
Summary: The timing of sleep, physical activity, and dietary intake varies between weekends and weekdays, potentially leading to impaired glucose and lipid regulation on Mondays. This study found that fasting glucose, insulin, and triglyceride concentrations were slightly higher on Mondays compared to other weekdays. There was a pronounced association between Monday and insulin concentrations in men, but not in women. The associations with glucose and triglycerides were only seen in individuals with known type 2 diabetes.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Neurosciences
Julia E. R. Nickols, Serdar M. Dursun, Anna M. W. Taylor
Summary: Opioid addiction is characterized by changes in the dopamine system, and the use of dopamine partial agonists like brexpiprazole may help restore dopamine signaling during drug withdrawal. In a mouse model, brexpiprazole treatment was found to attenuate locomotor sensitization, abolish morphine place preference, and prevent the expression of opioid-induced hyperalgesia.
Article
Medicine, General & Internal
Cecilia Johansson, Lina Ortendahl, Marcus M. Lind, Jonas Andersson, Lars Johansson, Mattias Brunstrom
Summary: This study investigated the association between diabetes and different prediabetic states as independent risk factors for atrial fibrillation (AF). The results showed a significant association between glycemic status and AF in all groups except the impaired glucose tolerance group. However, this association disappeared after controlling for potential confounders.
JOURNAL OF INTERNAL MEDICINE
(2023)
Article
Medicine, General & Internal
Hyun-Hwa Cha, Won Ki Lee, Sujeong Kim, Hyun Mi Kim, Mi Ju Kim, Won Joon Seong
Summary: We aimed to determine the upper and lower cutoff values to simplify the diagnosis of gestational diabetes mellitus (GDM). By investigating OGTT results, we found the cutoff values for confirming and excluding GDM, and discovered a method to simplify the diagnostic steps.
Article
Plant Sciences
Arman Syah Goli, Vilasinee Hirunpanich Sato, Hitoshi Sato, Savita Chewchinda, Jiraporn Leanpolchareanchai, Jannarin Nontakham, Jantana Yahuafai, Thavaree Thilavech, Pongsatorn Meesawatsom, Metawee Maitree
Summary: This study demonstrates the antidiabetic and antioxidant effects of aqueous extract of Lysiphyllum strychnifolium (LS) leaves in vivo and in vitro.
PHARMACEUTICAL BIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Viola Zywicki, Paola Capozza, Paolo Caravelli, Stefano Del Prato, Raffaele De Caterina
Summary: Impaired glucose tolerance (IGT) has been associated with adverse cardiovascular outcomes. This study found that among non-diabetic ACS patients, only those with elevated 1-hour and 2-hour plasma glucose levels had more severe myocardial injury and longer hospitalization. 1-hour plasma glucose is important in assessing post-ACS cardiac risk.
CARDIOVASCULAR DIABETOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Antonio Del Casale, Maurizio Simmaco, Martina Nicole Modesti, Clarissa Zocchi, Jan Francesco Arena, Irene Bilotta, Alessandro Alcibiade, Giuseppe Sarli, Lorenzo Cutillo, Giulia Antonelli, Enrico La Spina, Ottavia De Luca, Robert Preissner, Marina Borro, Giovanna Gentile, Paolo Girardi, Maurizio Pompili
Summary: This study investigates the correlation between DRD2, DRD3, and HTR2A genes and resistance to antipsychotic medication, and finds that a diagnosis of schizophrenia and specific genotypes are significantly associated with high treatment resistance.
Article
Endocrinology & Metabolism
Kathryn J. Potter, Quitterie Reynaud, Valerie Boudreau, Florence Racine, Francois Tremblay, Annick Lavoie, Maite Carricart, Genevieve Mailhot, Isabelle Durieu, Peter A. Senior, Remi Rabasa-Lhoret
Summary: Patients meeting both criteria of indeterminate glycemia and impaired glucose tolerance have an increased risk of developing diabetes, suggesting the need for closer monitoring.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Medicine, Research & Experimental
Teresa Mezza, Pietro Manuel Ferraro, Gianfranco Di Giuseppe, Simona Moffa, Chiara M. A. Cefalo, Francesca Cinti, Flavia Impronta, Umberto Capece, Giuseppe Quero, Alfredo Pontecorvi, Andrea Mari, Sergio Alfieri, Andrea Giaccari
Summary: This study aimed to verify the acute effect of reduced beta cell mass on the development of hyperglycemia. The research found that reduced first-phase insulin secretion and glucose sensitivity were predictors of eventual development of impaired glucose tolerance and diabetes. Thus, these functional alterations may play a key role in the pathogenesis of type 2 diabetes (T2DM).
JOURNAL OF CLINICAL INVESTIGATION
(2021)
Article
Agriculture, Dairy & Animal Science
M. Duplessis, C. L. Girard
Summary: The study aimed to evaluate the glucose and insulin metabolism in cows with supplementation of biotin, folic acid, and vitamin B-12 during the transition period. Results showed that cows receiving a biotin supplement had reduced insulin sensitivity in early lactation, while cows supplemented with folic acid and vitamin B-12 had a faster insulin response, though this did not lead to further improvements after a glucose challenge.
JOURNAL OF DAIRY SCIENCE
(2021)