Microbial-derived metabolites as a risk factor of age-related cognitive decline and dementia
出版年份 2022 全文链接
标题
Microbial-derived metabolites as a risk factor of age-related cognitive decline and dementia
作者
关键词
-
出版物
Molecular Neurodegeneration
Volume 17, Issue 1, Pages -
出版商
Springer Science and Business Media LLC
发表日期
2022-06-17
DOI
10.1186/s13024-022-00548-6
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- Role of Microbiota-Gut-Brain Axis in Regulating Dopaminergic Signaling
- (2022) Sevag Hamamah et al. Biomedicines
- Neuronal Mitophagy: Friend or Foe?
- (2021) Christina Doxaki et al. Frontiers in Cell and Developmental Biology
- Age-related cognitive decline is associated with microbiota-gut-brain axis disorders and neuroinflammation in mice
- (2021) Mei-Ling Wu et al. BEHAVIOURAL BRAIN RESEARCH
- Going with the grain: Fiber, cognition, and the microbiota-gut-brain-axis
- (2021) Kirsten Berding et al. EXPERIMENTAL BIOLOGY AND MEDICINE
- Mining Microbes for Mental Health: Determining the Role of Microbial Metabolic Pathways in Human Brain Health and Disease
- (2021) Simon Spichak et al. NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
- Impaired eIF5A function causes a Mendelian disorder that is partially rescued in model systems by spermidine
- (2021) Víctor Faundes et al. Nature Communications
- Mitochondrial Dysfunction and Oxidative Stress in Alzheimer’s Disease
- (2021) Afzal Misrani et al. Frontiers in Aging Neuroscience
- Structural and Functional Dysbiosis of Fecal Microbiota in Chinese Patients With Alzheimer's Disease
- (2021) Zongxin Ling et al. Frontiers in Cell and Developmental Biology
- Diet quality, gut microbiota, and microRNAs associated with mild cognitive impairment in middle-aged and elderly Chinese population
- (2021) Xiaona Zhang et al. AMERICAN JOURNAL OF CLINICAL NUTRITION
- Can Natural Products Exert Neuroprotection without Crossing the Blood–Brain Barrier?
- (2021) Manon Leclerc et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Untargeted Stable Isotope Probing of the Gut Microbiota Metabolome Using 13C-Labeled Dietary Fibers
- (2021) Pan Deng et al. JOURNAL OF PROTEOME RESEARCH
- Dietary spermidine improves cognitive function
- (2021) Sabrina Schroeder et al. Cell Reports
- Microbiota-derived short chain fatty acids modulate microglia and promote Aβ plaque deposition
- (2021) Alessio Vittorio Colombo et al. eLife
- Plasma TMAO increase after healthy diets: results from 2 randomized controlled trials with dietary fish, polyphenols, and whole-grain cereals
- (2021) Giuseppina Costabile et al. AMERICAN JOURNAL OF CLINICAL NUTRITION
- Tryptophan-metabolizing gut microbes regulate adult neurogenesis via the aryl hydrocarbon receptor
- (2021) George Zhang Wei et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- In vivo and neuropathology data support locus coeruleus integrity as indicator of Alzheimer’s disease pathology and cognitive decline
- (2021) Heidi I. L. Jacobs et al. Science Translational Medicine
- Review: microbial transformations of human bile acids
- (2021) Douglas V. Guzior et al. Microbiome
- Neuroinflammation and the Kynurenine Pathway in CNS Disease: Molecular Mechanisms and Therapeutic Implications
- (2021) Mustafa N. Mithaiwala et al. Cells
- Association of small intestinal bacterial overgrowth with nonalcoholic fatty liver disease in children: A meta-analysis
- (2021) Linghan Kuang et al. PLoS One
- Regulation of blood–brain barrier integrity by microbiome-associated methylamines and cognition by trimethylamine N-oxide
- (2021) Lesley Hoyles et al. Microbiome
- Concomitant memantine and Lactobacillus plantarum treatment attenuates cognitive impairments in APP/PS1 mice
- (2020) Qiu-Jun Wang et al. Aging-US
- Spermidine in dementia
- (2020) Thomas Pekar et al. WIENER KLINISCHE WOCHENSCHRIFT
- Spermidine and spermine delay brain aging by inducing autophagy in SAMP8 mice
- (2020) Ting-Ting Xu et al. Aging-US
- Aryl Hydrocarbon Receptor in Post-Mortem Hippocampus and in Serum from Young, Elder, and Alzheimer’s Patients
- (2020) Nicte Alaide Ramos-García et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Gut‐brain axis serotonergic responses to acute stress exposure are microbiome‐dependent
- (2020) Joshua M. Lyte et al. NEUROGASTROENTEROLOGY AND MOTILITY
- Role of Gut Microbiota in Neuroendocrine Regulation of Carbohydrate and Lipid Metabolism via the Microbiota-Gut-Brain-Liver Axis
- (2020) Shu-Zhi Wang et al. Microorganisms
- Developmental Signatures of Microbiota-Derived Metabolites in the Mouse Brain
- (2020) Jonathan R. Swann et al. Metabolites
- P-cresol Alters Brain Dopamine Metabolism and Exacerbates Autism-Like Behaviors in the BTBR Mouse
- (2020) Tiziana Pascucci et al. Brain Sciences
- Mechanisms by which autophagy regulates memory capacity in ageing
- (2020) Maria De Risi et al. AGING CELL
- Microbial Imidazole Propionate Affects Responses to Metformin through p38γ-Dependent Inhibitory AMPK Phosphorylation
- (2020) Ara Koh et al. Cell Metabolism
- Dementia prevention, intervention, and care: 2020 report of the Lancet Commission
- (2020) Gill Livingston et al. LANCET
- Gut Metabolite TMAO Induces Synaptic Plasticity Deficits by Promoting Endoplasmic Reticulum Stress
- (2020) Manoj Govindarajulu et al. Frontiers in Molecular Neuroscience
- Microbiome definition re-visited: old concepts and new challenges
- (2020) Gabriele Berg et al. Microbiome
- Increase in blood–brain barrier leakage in healthy, older adults
- (2020) Inge C. M. Verheggen et al. GeroScience
- ROS Generation in Microglia: Understanding Oxidative Stress and Inflammation in Neurodegenerative Disease
- (2020) Dominic S. A. Simpson et al. Antioxidants
- p-Cresol Sulfate Caused Behavior Disorders and Neurodegeneration in Mice with Unilateral Nephrectomy Involving Oxidative Stress and Neuroinflammation
- (2020) Chiao-Yin Sun et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Short-Chain Fatty Acids and Lipopolysaccharide as Mediators Between Gut Dysbiosis and Amyloid Pathology in Alzheimer’s Disease
- (2020) Moira Marizzoni et al. JOURNAL OF ALZHEIMERS DISEASE
- Gut Microbiota and Dysbiosis in Alzheimer’s Disease: Implications for Pathogenesis and Treatment
- (2020) Shan Liu et al. MOLECULAR NEUROBIOLOGY
- Gut microbial metabolites as multi-kingdom intermediates
- (2020) Kimberly A. Krautkramer et al. NATURE REVIEWS MICROBIOLOGY
- Gut microbial molecules in behavioural and neurodegenerative conditions
- (2020) Brittany D. Needham et al. NATURE REVIEWS NEUROSCIENCE
- Trimethylamine N-Oxide, a Gut Microbiota-Dependent Metabolite, is Associated with Frailty in Older Adults with Cardiovascular Disease
- (2020) Wei He et al. Clinical Interventions in Aging
- Gut mycobiome and its interaction with diet, gut bacteria and alzheimer's disease markers in subjects with mild cognitive impairment: A pilot study
- (2020) Ravinder Nagpal et al. EBioMedicine
- The gut microbiome–derived metabolite trimethylamine N-oxide modulates neuroinflammation and cognitive function with aging
- (2020) Vienna E. Brunt et al. GeroScience
- Results from a pilot study: The effects of nicotinamide riboside on mild cognitive impairment
- (2020) Miranda E. Orr et al. Alzheimers & Dementia
- Nutraceutical Approaches of Autophagy and Neuroinflammation in Alzheimer’s Disease: A Systematic Review
- (2020) Reinhard Gruendler et al. MOLECULES
- The positive effect of spermidine in older adults suffering from dementia
- (2020) Thomas Pekar et al. WIENER KLINISCHE WOCHENSCHRIFT
- Imidazole propionate is increased in diabetes and associated with dietary patterns and altered microbial ecology
- (2020) Antonio Molinaro et al. Nature Communications
- Urinary metabolic phenotyping for Alzheimer’s disease
- (2020) Natalja Kurbatova et al. Scientific Reports
- Blood–Brain Barrier Leakage Is Increased in Parkinson’s Disease
- (2020) Sarah Al-Bachari et al. Frontiers in Physiology
- Gut bacterial tyrosine decarboxylases restrict levels of levodopa in the treatment of Parkinson’s disease
- (2019) Sebastiaan P. van Kessel et al. Nature Communications
- The Relationships Between Vitamin K and Cognition: A Review of Current Evidence
- (2019) Ludovico Alisi et al. Frontiers in Neurology
- Gut Microbe to Brain Signaling: What Happens in Vagus…
- (2019) Christine Fülling et al. NEURON
- The Role of Gut Microbiota in Pathogenesis of Alzheimer's Disease
- (2019) Mehmet Bostanciklioğlu JOURNAL OF APPLIED MICROBIOLOGY
- Altered microbiomes distinguish Alzheimer’s disease from amnestic mild cognitive impairment and health in a Chinese cohort
- (2019) Ping Liu et al. BRAIN BEHAVIOR AND IMMUNITY
- Polyamines and eIF5A Hypusination Modulate Mitochondrial Respiration and Macrophage Activation
- (2019) Daniel J. Puleston et al. Cell Metabolism
- APOE genotype influences the gut microbiome structure and function in humans and mice: relevance for Alzheimer’s disease pathophysiology
- (2019) Tam T. T. Tran et al. FASEB JOURNAL
- Epigenetic mechanisms related to cognitive decline during aging
- (2019) María F. Harman et al. JOURNAL OF NEUROSCIENCE RESEARCH
- The kynurenine pathway: a finger in every pie
- (2019) Jonathan Savitz MOLECULAR PSYCHIATRY
- Alzheimer’s Disease Microbiome Is Associated with Dysregulation of the Anti-Inflammatory P-Glycoprotein Pathway
- (2019) John P. Haran et al. mBio
- Effects of spermidine supplementation on cognition and biomarkers in older adults with subjective cognitive decline (SmartAge)—study protocol for a randomized controlled trial
- (2019) Miranka Wirth et al. Alzheimers Research & Therapy
- Tryptophan Metabolic Pathways and Brain Serotonergic Activity: A Comparative Review
- (2019) Erik Höglund et al. Frontiers in Endocrinology
- Alzheimer’s disease: pathogenesis, diagnostics, and therapeutics
- (2019) Sneham Tiwari et al. International Journal of Nanomedicine
- Role of Tryptophan in Microbiota-Induced Depressive-Like Behavior: Evidence From Tryptophan Depletion Study
- (2019) Iva Lukić et al. Frontiers in Behavioral Neuroscience
- Mild cognitive impairment has similar alterations as Alzheimer's disease in gut microbiota
- (2019) Binyin Li et al. Alzheimers & Dementia
- Exploratory analysis of covariation of microbiota-derived vitamin K and cognition in older adults
- (2019) Angela McCann et al. AMERICAN JOURNAL OF CLINICAL NUTRITION
- Higher Circulating Trimethylamine N-oxide Sensitizes Sevoflurane-Induced Cognitive Dysfunction in Aged Rats Probably by Downregulating Hippocampal Methionine Sulfoxide Reductase A
- (2019) Liang Zhao et al. NEUROCHEMICAL RESEARCH
- Association of plasma trimethylamine-N-oxide levels with post-stroke cognitive impairment: a 1-year longitudinal study
- (2019) Chen Zhu et al. NEUROLOGICAL SCIENCES
- The Microbiota-Gut-Brain Axis
- (2019) John F. Cryan et al. PHYSIOLOGICAL REVIEWS
- Gut microbes and metabolites as modulators of blood-brain barrier integrity and brain health
- (2019) Aimée Parker et al. Gut Microbes
- Decreased levels of circulating trimethylamine N-oxide alleviate cognitive and pathological deterioration in transgenic mice: a potential therapeutic approach for Alzheimer’s disease
- (2019) Qiang Gao et al. Aging-US
- Higher cerebrospinal fluid to plasma ratio of p-cresol sulfate and indoxyl sulfate in patients with Parkinson’s disease
- (2019) Bartłomiej Sankowski et al. CLINICA CHIMICA ACTA
- Decreased plasmatic spermidine and increased spermine in mild cognitive impairment and Alzheimer’s disease patients
- (2019) HELENA P. G. JOAQUIM et al. Archives of Clinical Psychiatry
- Interplay between the human gut microbiome and host metabolism
- (2019) Alessia Visconti et al. Nature Communications
- The relationship between the gut microbiome and mild cognitive impairment in patients without dementia: a cross-sectional study conducted in Japan
- (2019) Naoki Saji et al. Scientific Reports
- Spermidine protects from age-related synaptic alterations at hippocampal mossy fiber-CA3 synapses
- (2019) Marta Maglione et al. Scientific Reports
- Trimethylamine-N -oxide promotes brain aging and cognitive impairment in mice
- (2018) Dang Li et al. AGING CELL
- Safety and tolerability of spermidine supplementation in mice and older adults with subjective cognitive decline
- (2018) Claudia Schwarz et al. Aging-US
- The cholinergic system in the pathophysiology and treatment of Alzheimer’s disease
- (2018) Harald Hampel et al. BRAIN
- Sodium butyrate abolishes lipopolysaccharide-induced depression-like behaviors and hippocampal microglial activation in mice
- (2018) Yosuke Yamawaki et al. BRAIN RESEARCH
- Neurotransmitter modulation by the gut microbiota
- (2018) Philip Strandwitz BRAIN RESEARCH
- Gut Microbiota Regulation of Tryptophan Metabolism in Health and Disease
- (2018) Allison Agus et al. Cell Host & Microbe
- A randomized controlled trial on the efficacy of resistant dextrin, as functional food, in women with type 2 diabetes: Targeting the hypothalamic–pituitary–adrenal axis and immune system
- (2018) Mahdieh Abbasalizad Farhangi et al. CLINICAL NUTRITION
- Dysregulated bile acid synthesis and dysbiosis are implicated in Western diet–induced systemic inflammation, microglial activation, and reduced neuroplasticity
- (2018) Prasant Kumar Jena et al. FASEB JOURNAL
- Protein-bounded uremic toxin p-cresylsulfate induces vascular permeability alternations
- (2018) Wei-Hua Tang et al. HISTOCHEMISTRY AND CELL BIOLOGY
- Aryl Hydrocarbon Receptor Activation Modulates Intestinal Epithelial Barrier Function by Maintaining Tight Junction Integrity
- (2018) Min Yu et al. International Journal of Biological Sciences
- Vascular Cognitive Impairment and the Gut Microbiota
- (2018) Sinian Li et al. JOURNAL OF ALZHEIMERS DISEASE
- Gut Microbiota is Altered in Patients with Alzheimer’s Disease
- (2018) Zhen-Qian Zhuang et al. JOURNAL OF ALZHEIMERS DISEASE
- The Gut Microbiome Alterations and Inflammation-Driven Pathogenesis of Alzheimer’s Disease—a Critical Review
- (2018) Marta Sochocka et al. MOLECULAR NEUROBIOLOGY
- Blood–brain barrier breakdown in Alzheimer disease and other neurodegenerative disorders
- (2018) Melanie D. Sweeney et al. Nature Reviews Neurology
- Sodium butyrate triggers a functional elongation of microglial process via Akt-small RhoGTPase activation and HDACs inhibition
- (2018) Peng Wang et al. NEUROBIOLOGY OF DISEASE
- Phenyl sulfate, indoxyl sulfate and p-cresyl sulfate decrease glutathione level to render cells vulnerable to oxidative stress in renal tubular cells
- (2018) Takeo Edamatsu et al. PLoS One
- Spermidine in health and disease
- (2018) Frank Madeo et al. SCIENCE
- Vitamin K Deficiency Induced by Warfarin Is Associated With Cognitive and Behavioral Perturbations, and Alterations in Brain Sphingolipids in Rats
- (2018) Sahar Tamadon-Nejad et al. Frontiers in Aging Neuroscience
- Impact of the Gut Microbiota on Intestinal Immunity Mediated by Tryptophan Metabolism
- (2018) Jing Gao et al. Frontiers in Cellular and Infection Microbiology
- The Vagus Nerve at the Interface of the Microbiota-Gut-Brain Axis
- (2018) Bruno Bonaz et al. Frontiers in Neuroscience
- Neurally Released GABA Acts via GABAC Receptors to Modulate Ca2+ Transients Evoked by Trains of Synaptic Inputs, but Not Responses Evoked by Single Stimuli, in Myenteric Neurons of Mouse Ileum
- (2018) Katerina Koussoulas et al. Frontiers in Physiology
- Polyamines: Bio-Molecules with Diverse Functions in Plant and Human Health and Disease
- (2018) Avtar K. Handa et al. Frontiers in Chemistry
- A Neural Circuit for Gut-Induced Reward
- (2018) Wenfei Han et al. CELL
- The IDO Inhibitor Coptisine Ameliorates Cognitive Impairment in a Mouse Model of Alzheimer's Disease
- (2018) Dan Yu et al. JOURNAL OF ALZHEIMERS DISEASE
- Cultivable butyrate-producing bacteria of elderly Japanese diagnosed with Alzheimer’s disease
- (2018) Thi Thuy Tien Nguyen et al. JOURNAL OF MICROBIOLOGY
- Microbial tryptophan catabolites in health and disease
- (2018) Henrik M. Roager et al. Nature Communications
- Healthy Aging and Dementia: Two Roads Diverging in Midlife?
- (2018) Katie Irwin et al. Frontiers in Aging Neuroscience
- Gut microbiota, cognitive frailty and dementia in older individuals: a systematic review
- (2018) Andrea Ticinesi et al. Clinical Interventions in Aging
- Bile Acid Synthesis: From Nature to the Chemical Modification and Synthesis and Their Applications as Drugs and Nutrients
- (2018) Tanja M. Šarenac et al. Frontiers in Pharmacology
- Altered bile acid profile in mild cognitive impairment and Alzheimer's disease: Relationship to neuroimaging and CSF biomarkers
- (2018) Kwangsik Nho et al. Alzheimers & Dementia
- Altered bile acid profile associates with cognitive impairment in Alzheimer's disease—An emerging role for gut microbiome
- (2018) Siamak MahmoudianDehkordi et al. Alzheimers & Dementia
- Spermidine: a physiological autophagy inducer acting as an anti-aging vitamin in humans?
- (2018) Frank Madeo et al. Autophagy
- The kynurenine pathway and cognitive performance in community-dwelling older adults. The Hordaland Health Study
- (2018) Stein-Erik Hafstad Solvang et al. BRAIN BEHAVIOR AND IMMUNITY
- Microbially Produced Imidazole Propionate Impairs Insulin Signaling through mTORC1
- (2018) Ara Koh et al. CELL
- Dopamine: Functions, Signaling, and Association with Neurological Diseases
- (2018) Marianne O. Klein et al. CELLULAR AND MOLECULAR NEUROBIOLOGY
- The effect of spermidine on memory performance in older adults at risk for dementia: A randomized controlled trial
- (2018) Miranka Wirth et al. CORTEX
- Activation of Nrf2/ARE pathway alleviates the cognitive deficits in PS1V97L-Tg mouse model of Alzheimer’s disease through modulation of oxidative stress
- (2018) Yuanruhua Tian et al. JOURNAL OF NEUROSCIENCE RESEARCH
- Vitamin K status and inflammation are associated with cognition in older Irish adults
- (2018) A. Kiely et al. NUTRITIONAL NEUROSCIENCE
- Low Serum Tryptophan Levels as an Indicator of Global Cognitive Performance in Nondemented Women over 50 Years of Age
- (2018) L. A. Ramos-Chávez et al. Oxidative Medicine and Cellular Longevity
- Implication of Trimethylamine N-Oxide (TMAO) in Disease: Potential Biomarker or New Therapeutic Target
- (2018) Manuel Janeiro et al. Nutrients
- Trimethylamine-N-oxide (TMAO) as Novel Potential Biomarker of Early Predictors of Metabolic Syndrome
- (2018) Luigi Barrea et al. Nutrients
- The gut microbiota-derived metabolite trimethylamine N-oxide is elevated in Alzheimer’s disease
- (2018) Nicholas M. Vogt et al. Alzheimers Research & Therapy
- GABA-modulating bacteria of the human gut microbiota
- (2018) Philip Strandwitz et al. Nature Microbiology
- Gut microbiota functions: metabolism of nutrients and other food components
- (2017) Ian Rowland et al. EUROPEAN JOURNAL OF NUTRITION
- Protective roles of intestinal microbiota derived short chain fatty acids in Alzheimer’s disease-type beta-amyloid neuropathological mechanisms
- (2017) Lap Ho et al. Expert Review of Neurotherapeutics
- Probiotic Bifidobacterium longum NCC3001 Reduces Depression Scores and Alters Brain Activity: A Pilot Study in Patients With Irritable Bowel Syndrome
- (2017) Maria Ines Pinto-Sanchez et al. GASTROENTEROLOGY
- TUDCA: An Agonist of the Bile Acid Receptor GPBAR1/TGR5 With Anti-Inflammatory Effects in Microglial Cells
- (2017) Natalia Yanguas-Casás et al. JOURNAL OF CELLULAR PHYSIOLOGY
- The vicious circle of hypometabolism in neurodegenerative diseases: Ways and mechanisms of metabolic correction
- (2017) Yuri Zilberter et al. JOURNAL OF NEUROSCIENCE RESEARCH
- Mass spectrometry-based metabolomics: Targeting the crosstalk between gut microbiota and brain in neurodegenerative disorders
- (2017) Hemi Luan et al. MASS SPECTROMETRY REVIEWS
- Bile acid quantification of 20 plasma metabolites identifies lithocholic acid as a putative biomarker in Alzheimer’s disease
- (2017) Josef Marksteiner et al. Metabolomics
- Association of brain amyloidosis with pro-inflammatory gut bacterial taxa and peripheral inflammation markers in cognitively impaired elderly
- (2017) Annamaria Cattaneo et al. NEUROBIOLOGY OF AGING
- L-Tryptophan-kynurenine pathway enzymes are therapeutic target for neuropsychiatric diseases: Focus on cell type differences
- (2017) Hidetsugu Fujigaki et al. NEUROPHARMACOLOGY
- Recent evidence for an expanded role of the kynurenine pathway of tryptophan metabolism in neurological diseases
- (2017) Michael D. Lovelace et al. NEUROPHARMACOLOGY
- The relationship between obesity and cognitive health and decline
- (2017) Louise Dye et al. PROCEEDINGS OF THE NUTRITION SOCIETY
- Lactobacillus reuteriinduces gut intraepithelial CD4+CD8αα+T cells
- (2017) Luisa Cervantes-Barragan et al. SCIENCE
- Unconjugated bile acids in rat brain: Analytical method based on LC/ESI-MS/MS with chemical derivatization and estimation of their origin by comparison to serum levels
- (2017) Tatsuya Higashi et al. STEROIDS
- The Gut Microbial Metabolite Trimethylamine-N-Oxide Is Present in Human Cerebrospinal Fluid
- (2017) Daniele Del Rio et al. Nutrients
- The Neuroprotective Effects of Phenolic Acids: Molecular Mechanism of Action
- (2017) et al. Nutrients
- Protein-bound uremic toxins impaired mitochondrial dynamics and functions
- (2017) Chiao-Yin Sun et al. Oncotarget
- Protective roles of intestinal microbiota derived short chain fatty acids in Alzheimer’s disease-type beta-amyloid neuropathological mechanisms
- (2017) Lap Ho et al. Expert Review of Neurotherapeutics
- Trimethylamine‐N‐Oxide Induces Vascular Inflammation by Activating the NLRP3 Inflammasome Through the SIRT3‐SOD2‐mtROS Signaling Pathway
- (2017) Ming‐liang Chen et al. Journal of the American Heart Association
- Bile Acid Signaling Pathways from the Enterohepatic Circulation to the Central Nervous System
- (2017) Kim L. Mertens et al. Frontiers in Neuroscience
- Blood Trimethylamine-N-Oxide Originates from Microbiota Mediated Breakdown of Phosphatidylcholine and Absorption from Small Intestine
- (2017) Wolfgang Stremmel et al. PLoS One
- Hepatic alterations are accompanied by changes to bile acid transporter-expressing neurons in the hypothalamus after traumatic brain injury
- (2017) Damir Nizamutdinov et al. Scientific Reports
- Functional Coupling of Human Microphysiology Systems: Intestine, Liver, Kidney Proximal Tubule, Blood-Brain Barrier and Skeletal Muscle
- (2017) Lawrence Vernetti et al. Scientific Reports
- Gut microbiome alterations in Alzheimer’s disease
- (2017) Nicholas M. Vogt et al. Scientific Reports
- Blood metabolite markers of preclinical Alzheimer's disease in two longitudinally followed cohorts of older individuals
- (2016) Ramon Casanova et al. Alzheimers & Dementia
- Age-related changes in gut microbiota composition from newborn to centenarian: a cross-sectional study
- (2016) Toshitaka Odamaki et al. BMC MICROBIOLOGY
- Towards understanding brain-gut-microbiome connections in Alzheimer’s disease
- (2016) Rong Xu et al. BMC Systems Biology
- Cognitive impairment by antibiotic-induced gut dysbiosis: Analysis of gut microbiota-brain communication
- (2016) Esther E. Fröhlich et al. BRAIN BEHAVIOR AND IMMUNITY
- Sodium butyrate exerts neuroprotective effects by restoring the blood-brain barrier in traumatic brain injury mice
- (2016) Haixiao Li et al. BRAIN RESEARCH
- Gut Microbial Metabolite TMAO Enhances Platelet Hyperreactivity and Thrombosis Risk
- (2016) Weifei Zhu et al. CELL
- Alzheimer's disease: Targeting the Cholinergic System
- (2016) Talita H. Ferreira-Vieira et al. Current Neuropharmacology
- Effects of bile acids on neurological function and disease
- (2016) Matthew McMillin et al. FASEB JOURNAL
- Chitosan oligosaccharides alleviate cognitive deficits in an amyloid-β1–42-induced rat model of Alzheimer's disease
- (2016) Shiliang Jia et al. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
- Growing up in a Bubble: Using Germ-Free Animals to Assess the Influence of the Gut Microbiota on Brain and Behavior
- (2016) Pauline Luczynski et al. INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY
- Increased dietary vitamin K intake is associated with less severe subjective memory complaint among older adults
- (2016) Anne Soutif-Veillon et al. MATURITAS
- HDAC Inhibitor Sodium Butyrate-Mediated Epigenetic Regulation Enhances Neuroprotective Function of Microglia During Ischemic Stroke
- (2016) Radhika Patnala et al. MOLECULAR NEUROBIOLOGY
- Type I interferons and microbial metabolites of tryptophan modulate astrocyte activity and central nervous system inflammation via the aryl hydrocarbon receptor
- (2016) Veit Rothhammer et al. NATURE MEDICINE
- The neuropharmacology of butyrate: The bread and butter of the microbiota-gut-brain axis?
- (2016) Roman M. Stilling et al. NEUROCHEMISTRY INTERNATIONAL
- Effects of scFOS on the composition of fecal microbiota and anxiety in patients with irritable bowel syndrome: a randomized, double blind, placebo controlled study
- (2016) F. Azpiroz et al. NEUROGASTROENTEROLOGY AND MOTILITY
- Modulation of learning and memory by natural polyamines
- (2016) Gustavo Petri Guerra et al. PHARMACOLOGICAL RESEARCH
- p-Cresyl sulfate affects the oxidative burst, phagocytosis process, and antigen presentation of monocyte-derived macrophages
- (2016) M.L.V. Azevedo et al. TOXICOLOGY LETTERS
- Influence of Tryptophan and Serotonin on Mood and Cognition with a Possible Role of the Gut-Brain Axis
- (2016) Trisha Jenkins et al. Nutrients
- Trimethylamine N-Oxide: The Good, the Bad and the Unknown
- (2016) Manuel Velasquez et al. Toxins
- Trimethylamine N‐Oxide Promotes Vascular Inflammation Through Signaling of Mitogen‐Activated Protein Kinase and Nuclear Factor‐κB
- (2016) Marcus M. Seldin et al. Journal of the American Heart Association
- Serum Trimethylamine-N-Oxide Is Strongly Related to Renal Function and Predicts Outcome in Chronic Kidney Disease
- (2016) Catharina Missailidis et al. PLoS One
- Impact of diabetes on cognitive function and brain structure
- (2015) Amir Moheet et al. Annals of the New York Academy of Sciences
- Gut microbiota depletion from early adolescence in mice: Implications for brain and behaviour
- (2015) Lieve Desbonnet et al. BRAIN BEHAVIOR AND IMMUNITY
- The roles of peripheral serotonin in metabolic homeostasis
- (2015) Rabih El-Merahbi et al. FEBS LETTERS
- Gut permeability, its interaction with gut microflora and effects on metabolic health are mediated by the lymphatics system, liver and bile acid
- (2015) Cuong D Tran et al. Future Microbiology
- Modulation of Gut Microbiota–Brain Axis by Probiotics, Prebiotics, and Diet
- (2015) Xiaofei Liu et al. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
- Role of intestinal microbiota in the generation of polyphenol-derived phenolic acid mediated attenuation of Alzheimer's disease β-amyloid oligomerization
- (2015) Dongjie Wang et al. MOLECULAR NUTRITION & FOOD RESEARCH
- Gut biogeography of the bacterial microbiota
- (2015) Gregory P. Donaldson et al. NATURE REVIEWS MICROBIOLOGY
- Amyloid-β pathology is attenuated by tauroursodeoxycholic acid treatment in APP/PS1 mice after disease onset
- (2015) Pedro A. Dionísio et al. NEUROBIOLOGY OF AGING
- TMAO: A small molecule of great expectations
- (2015) Marcin Ufnal et al. NUTRITION
- Gut microbiota and aging
- (2015) P. W. OToole et al. SCIENCE
- What has serotonin to do with depression?
- (2015) Philip J. Cowen et al. World Psychiatry
- Mild cognitive impairment and its management in older people
- (2015) Sima Ataollahi Eshkoor et al. Clinical Interventions in Aging
- Plasma 24-metabolite Panel Predicts Preclinical Transition to Clinical Stages of Alzheimer’s Disease
- (2015) Massimo S. Fiandaca et al. Frontiers in Neurology
- Antidepressant-Like Effect of Sodium Butyrate is Associated with an Increase in TET1 and in 5-Hydroxymethylation Levels in the Bdnf Gene
- (2015) Y. B. Wei et al. INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY
- Adaptation of the human aryl hydrocarbon receptor to sense microbiota-derived indoles
- (2015) Troy D. Hubbard et al. Scientific Reports
- Measurement of trimethylamine-N-oxide by stable isotope dilution liquid chromatography tandem mass spectrometry
- (2014) Zeneng Wang et al. ANALYTICAL BIOCHEMISTRY
- Role of Monocarboxylate Transporters in Drug Delivery to the Brain
- (2014) Nisha Vijay et al. CURRENT PHARMACEUTICAL DESIGN
- Bile acids permeabilize the blood brain barrier after bile duct ligation in rats via Rac1-dependent mechanisms
- (2014) Matthew Quinn et al. DIGESTIVE AND LIVER DISEASE
- Arsenic Exposure Perturbs the Gut Microbiome and Its Metabolic Profile in Mice: An Integrated Metagenomics and Metabolomics Analysis
- (2014) Kun Lu et al. ENVIRONMENTAL HEALTH PERSPECTIVES
- Dietary trimethylamine N-oxide exacerbates impaired glucose tolerance in mice fed a high fat diet
- (2014) Xiang Gao et al. JOURNAL OF BIOSCIENCE AND BIOENGINEERING
- Gut Microbes and the Brain: Paradigm Shift in Neuroscience
- (2014) E. A. Mayer et al. JOURNAL OF NEUROSCIENCE
- Prognostic Value of Elevated Levels of Intestinal Microbe-Generated Metabolite Trimethylamine-N-Oxide in Patients With Heart Failure
- (2014) W.H. Wilson Tang et al. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
- The gut microbiota influences blood-brain barrier permeability in mice
- (2014) V. Braniste et al. Science Translational Medicine
- Upregulation of colonic luminal polyamines produced by intestinal microbiota delays senescence in mice
- (2014) Ryoko Kibe et al. Scientific Reports
- White matter microstructure in late middle-age: Effects of apolipoprotein E4 and parental family history of Alzheimer's disease
- (2014) Nagesh Adluru et al. NeuroImage-Clinical
- The kynurenine pathway as a therapeutic target in cognitive and neurodegenerative disorders
- (2013) Trevor W Stone et al. BRITISH JOURNAL OF PHARMACOLOGY
- Serotonin – Kynurenine Hypothesis of Depression: Historical Overview and Recent Developments
- (2013) Gregory Oxenkrug CURRENT DRUG TARGETS
- Tryptophan Catabolites from Microbiota Engage Aryl Hydrocarbon Receptor and Balance Mucosal Reactivity via Interleukin-22
- (2013) Teresa Zelante et al. IMMUNITY
- Altered profile of human gut microbiome is associated with cirrhosis and its complications
- (2013) Jasmohan S. Bajaj et al. JOURNAL OF HEPATOLOGY
- The role of short-chain fatty acids in the interplay between diet, gut microbiota, and host energy metabolism
- (2013) Gijs den Besten et al. JOURNAL OF LIPID RESEARCH
- The role of serotonin in cognitive function: evidence from recent studies and implications for understanding depression
- (2013) Philip Cowen et al. JOURNAL OF PSYCHOPHARMACOLOGY
- Major phenylpropanoid-derived metabolites in the human gut can arise from microbial fermentation of protein
- (2013) Wendy R. Russell et al. MOLECULAR NUTRITION & FOOD RESEARCH
- Richness of human gut microbiome correlates with metabolic markers
- (2013) Emmanuelle Le Chatelier et al. NATURE
- Intestinal microbiota metabolism of l-carnitine, a nutrient in red meat, promotes atherosclerosis
- (2013) Robert A Koeth et al. NATURE MEDICINE
- The immune marker CD68 correlates with cognitive impairment in normally aged rats
- (2013) Mark Farso et al. NEUROBIOLOGY OF AGING
- Quinolinic Acid: An Endogenous Neurotoxin with Multiple Targets
- (2013) Rafael Lugo-Huitrón et al. Oxidative Medicine and Cellular Longevity
- Commensal Bacteria-Dependent Indole Production Enhances Epithelial Barrier Function in the Colon
- (2013) Yosuke Shimada et al. PLoS One
- Dopamine Signaling in reward-related behaviors
- (2013) Ja-Hyun Baik Frontiers in Neural Circuits
- Metabolic profiling of Alzheimer's disease brains
- (2013) Koichi Inoue et al. Scientific Reports
- Alterations in metabolic pathways and networks in Alzheimer’s disease
- (2013) R Kaddurah-Daouk et al. Translational Psychiatry
- Toward a unified biological hypothesis for the BDNF Val66Met-associated memory deficits in humans: a model of impaired dendritic mRNA trafficking
- (2013) Gabriele Baj et al. Frontiers in Neuroscience
- Colonic mucosal microbiome differs from stool microbiome in cirrhosis and hepatic encephalopathy and is linked to cognition and inflammation
- (2012) Jasmohan S. Bajaj et al. AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
- Critical role of gut microbiota in the production of biologically active, free catecholamines in the gut lumen of mice
- (2012) Yasunari Asano et al. AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
- The association between cognitive function and white matter lesion location in older adults: a systematic review
- (2012) Niousha Bolandzadeh et al. BMC Neurology
- Tryptophan depletion in depressed patients occurs independent of kynurenine pathway activation
- (2012) Martina M. Hughes et al. BRAIN BEHAVIOR AND IMMUNITY
- Modulation of Inflammatory Cytokines and Mitogen-activated Protein Kinases by Acetate in Primary Astrocytes
- (2012) Mahmoud L. Soliman et al. Journal of Neuroimmune Pharmacology
- Acetate supplementation modulates brain histone acetylation and decreases interleukin-1β expression in a rat model of neuroinflammation
- (2012) Mahmoud L Soliman et al. Journal of Neuroinflammation
- TUDCA, a Bile Acid, Attenuates Amyloid Precursor Protein Processing and Amyloid-β Deposition in APP/PS1 Mice
- (2012) Ana F. Nunes et al. MOLECULAR NEUROBIOLOGY
- The microbiome-gut-brain axis during early life regulates the hippocampal serotonergic system in a sex-dependent manner
- (2012) G Clarke et al. MOLECULAR PSYCHIATRY
- Brain endogenous liver X receptor ligands selectively promote midbrain neurogenesis
- (2012) Spyridon Theofilopoulos et al. Nature Chemical Biology
- Kynurenines in the mammalian brain: when physiology meets pathology
- (2012) Robert Schwarcz et al. NATURE REVIEWS NEUROSCIENCE
- Gray matter network associated with risk for Alzheimer's disease in young to middle-aged adults
- (2012) Gene E. Alexander et al. NEUROBIOLOGY OF AGING
- Microbial conversion of choline to trimethylamine requires a glycyl radical enzyme
- (2012) S. Craciun et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Host-Gut Microbiota Metabolic Interactions
- (2012) J. K. Nicholson et al. SCIENCE
- Impact of Intestinal Microbiota on Intestinal Luminal Metabolome
- (2012) Mitsuharu Matsumoto et al. Scientific Reports
- Linkage of gut microbiome with cognition in hepatic encephalopathy
- (2011) Jasmohan S. Bajaj et al. AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
- Deoxycholic and chenodeoxycholic bile acids induce apoptosis via oxidative stress in human colon adenocarcinoma cells
- (2011) Juan Ignacio Barrasa et al. APOPTOSIS
- Role of pro-inflammatory cytokines released from microglia in neurodegenerative diseases
- (2011) Joshua A. Smith et al. BRAIN RESEARCH BULLETIN
- Kynurenine 3-Monooxygenase Inhibition in Blood Ameliorates Neurodegeneration
- (2011) Daniel Zwilling et al. CELL
- Nontraditional Risk Factors and Biomarkers for Cardiovascular Disease: Mechanistic, Research, and Clinical Considerations for Youth
- (2011) Prabhakaran (Babu) Balagopal et al. CIRCULATION
- The Intestinal Microbiota Affect Central Levels of Brain-Derived Neurotropic Factor and Behavior in Mice
- (2011) Premysl Bercik et al. GASTROENTEROLOGY
- Mechanism of acute tryptophan depletion: is it only serotonin?
- (2011) E L van Donkelaar et al. MOLECULAR PSYCHIATRY
- Converging evidence for central 5-HT effects in acute tryptophan depletion
- (2011) M J Crockett et al. MOLECULAR PSYCHIATRY
- The anxiolytic effect of Bifidobacterium longum NCC3001 involves vagal pathways for gut-brain communication
- (2011) P. Bercik et al. NEUROGASTROENTEROLOGY AND MOTILITY
- Age-related changes in the default mode network are more advanced in Alzheimer disease
- (2011) D. T. Jones et al. NEUROLOGY
- Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve
- (2011) J. A. Bravo et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Normal gut microbiota modulates brain development and behavior
- (2011) R. D. Heijtz et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Cognitive dysfunction with aging and the role of inflammation
- (2011) Arthur A. Simen et al. Therapeutic Advances in Chronic Disease
- Kynurenine and its metabolites in Alzheimer's disease patients
- (2010) E Gulaj et al. Advances in Medical Sciences
- The APOE ɛ4 allele modulates brain white matter integrity in healthy adults
- (2010) V Heise et al. MOLECULAR PSYCHIATRY
- Reduced anxiety-like behavior and central neurochemical change in germ-free mice
- (2010) K. M. Neufeld et al. NEUROGASTROENTEROLOGY AND MOTILITY
- Neuroinflammation and Cognitive Aging
- (2010) Raymond L. Ownby Current Psychiatry Reports
- A Gut Feeling about GABA: Focus on GABAB Receptors
- (2010) Niall P. Hyland et al. Frontiers in Pharmacology
- Small-intestinal bacterial overgrowth in cirrhosis is related to the severity of liver disease
- (2009) C. PANDE et al. ALIMENTARY PHARMACOLOGY & THERAPEUTICS
- Mitochondrial dysfunction is a trigger of Alzheimer's disease pathophysiology
- (2009) Paula I. Moreira et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
- Meta-Analysis of Alzheimer's Disease Risk with Obesity, Diabetes, and Related Disorders
- (2009) Louis A. Profenno et al. BIOLOGICAL PSYCHIATRY
- Age-associated cognitive decline
- (2009) I. J. Deary et al. BRITISH MEDICAL BULLETIN
- Proinflammatory cytokine interferon-γ increases induction of indoleamine 2,3-dioxygenase in monocytic cells primed with amyloid β peptide 1-42: implications for the pathogenesis of Alzheimer’s disease
- (2009) Akiko Yamada et al. JOURNAL OF NEUROCHEMISTRY
- Effect of quinolinic acid on human astrocytes morphology and functions: implications in Alzheimer's disease
- (2009) Ka Ting et al. Journal of Neuroinflammation
- Structure and function of the blood–brain barrier
- (2009) N. Joan Abbott et al. NEUROBIOLOGY OF DISEASE
- The Excitotoxin Quinolinic Acid Induces Tau Phosphorylation in Human Neurons
- (2009) Abdur Rahman et al. PLoS One
- Metabolomics analysis reveals large effects of gut microflora on mammalian blood metabolites
- (2009) W. R. Wikoff et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The bacterial signal indole increases epithelial-cell tight-junction resistance and attenuates indicators of inflammation
- (2009) T. Bansal et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Bile acids as endogenous etiologic agents in gastrointestinal cancer
- (2009) Harris Bernstein et al. WORLD JOURNAL OF GASTROENTEROLOGY
- Effects of Hypertension and Hypercholesterolemia on Cognitive Functioning in Patients With Alzheimer Disease
- (2008) Felicia C. Goldstein et al. ALZHEIMER DISEASE & ASSOCIATED DISORDERS
- The role of luminal factors in the recovery of gastric function and behavioral changes after chronic Helicobacter pylori infection
- (2008) Elena F. Verdu et al. AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
- Subcellular localization of transporters along the rat blood–brain barrier and blood–cerebral-spinal fluid barrier by in vivo biotinylation
- (2008) L.M. Roberts et al. NEUROSCIENCE
- Effects of the gut microbiota on host adiposity are modulated by the short-chain fatty-acid binding G protein-coupled receptor, Gpr41
- (2008) B. S. Samuel et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExploreAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started