Quinolinic Acid: An Endogenous Neurotoxin with Multiple Targets

Connecting inflammation with glutamate agonism in suicidality

(2013) Sophie Erhardt et al.   NEUROPSYCHOPHARMACOLOGY

Oxidative Stress Is Related to the Deleterious Effects of Heme Oxygenase-1 in anIn VivoNeuroinflammatory Rat Model

(2013) Claire Tronel et al.   Oxidative Medicine and Cellular Longevity

Quinolinic acid: neurotoxicity

(2012) Gilles J. Guillemin   FEBS Journal

The role of kynurenines in the pathomechanism of amyotrophic lateral sclerosis and multiple sclerosis: therapeutic implications

(2012) Judit Füvesi et al.   JOURNAL OF NEURAL TRANSMISSION

Selenium-induced antioxidant protection recruits modulation of thioredoxin reductase during excitotoxic/pro-oxidant events in the rat striatum

(2012) Perla D. Maldonado et al.   NEUROCHEMISTRY INTERNATIONAL

NAD+metabolism and oxidative stress: the golden nucleotide on a crown of thorns

(2012) Hassina Massudi et al.   REDOX REPORT

Signaling mechanisms downstream of quinolinic acid targeting the cytoskeleton of rat striatal neurons and astrocytes

(2011) Paula Pierozan et al.   EXPERIMENTAL NEUROLOGY

Regulation of quinolinic acid neosynthesis in mouse, rat and human brain by iron and iron chelators in vitro

(2011) Erin K. Stachowski et al.   JOURNAL OF NEURAL TRANSMISSION

Severe depression is associated with increased microglial quinolinic acid in subregions of the anterior cingulate gyrus: Evidence for an immune-modulated glutamatergic neurotransmission?

(2011) Johann Steiner et al.   Journal of Neuroinflammation

Suppressing inflammatory cascade by cyclo-oxygenase inhibitors attenuates quinolinic acid induced Huntington's disease-like alterations in rats

(2011) Harikesh Kalonia et al.   LIFE SCIENCES

Licofelone attenuates quinolinic acid induced Huntington like symptoms: Possible behavioral, biochemical and cellular alterations

(2011) Harikesh Kalonia et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Kynurenine and its metabolites in Alzheimer's disease patients

(2010) E Gulaj et al.   Advances in Medical Sciences

Quinolinate phosphoribosyl transferase, a key enzyme in de novo NAD+ synthesis, suppresses spontaneous cell death by inhibiting overproduction of active-caspase-3

(2010) Kazumi Ishidoh et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Acute intrastriatal administration of quinolinic acid provokes hyperphosphorylation of cytoskeletal intermediate filament proteins in astrocytes and neurons of rats

(2010) Paula Pierozan et al.   EXPERIMENTAL NEUROLOGY

Characterization of the kynurenine pathway in NSC-34 cell line: implications for amyotrophic lateral sclerosis

(2010) Yiquan Chen et al.   JOURNAL OF NEUROCHEMISTRY

Time-course correlation of early toxic events in three models of striatal damage: Modulation by proteases inhibition

(2010) Verónica Pérez-De La Cruz et al.   NEUROCHEMISTRY INTERNATIONAL

Protective effect of montelukast against quinolinic acid/malonic acid induced neurotoxicity: possible behavioral, biochemical, mitochondrial and tumor necrosis factor-α level alterations in rats

(2010) H. Kalonia et al.   NEUROSCIENCE

Protective effect of rofecoxib and nimesulide against intra-striatal quinolinic acid-induced behavioral, oxidative stress and mitochondrial dysfunctions in rats

(2010) Harikesh Kalonia et al.   NEUROTOXICOLOGY

Pioglitazone ameliorates behavioral, biochemical and cellular alterations in quinolinic acid induced neurotoxicity: Possible role of peroxisome proliferator activated receptor-ϒ (PPARϒ) in Huntington's disease

(2010) Harikesh Kalonia et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

p53 induction contributes to excitotoxic neuronal death in rat striatum through apoptotic and autophagic mechanisms

(2009) Yan Wang et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Neuroprotective effects of naturally occurring polyphenols on quinolinic acid-induced excitotoxicity in human neurons

(2009) Nady Braidy et al.   FEBS Journal

Effect of quinolinic acid on human astrocytes morphology and functions: implications in Alzheimer's disease

(2009) Ka Ting et al.   Journal of Neuroinflammation

Mechanism for Quinolinic Acid Cytotoxicity in Human Astrocytes and Neurons

(2009) Nady Braidy et al.   NEUROTOXICITY RESEARCH

The Kynurenine Pathway and Inflammation in Amyotrophic Lateral Sclerosis

(2009) Yiquan Chen et al.   NEUROTOXICITY RESEARCH

The Excitotoxin Quinolinic Acid Induces Tau Phosphorylation in Human Neurons

(2009) Abdur Rahman et al.   PLoS One

Effects of caffeic acid, rofecoxib, and their combination against quinolinic acid-induced behavioral alterations and disruption in glutathione redox status

(2009) Harikesh Kalonia et al.   Neuroscience Bulletin

Early nerve ending rescue from oxidative damage and energy failure by l-carnitine as post-treatment in two neurotoxic models in rat: recovery of antioxidant and reductive capacities

(2009) Diana Elinos-Calderón et al.   EXPERIMENTAL BRAIN RESEARCH

Targeting oxidative/nitrergic stress ameliorates motor impairment, and attenuates synaptic mitochondrial dysfunction and lipid peroxidation in two models of Huntington's disease

(2008) Verónica Pérez-De La Cruz et al.   BEHAVIOURAL BRAIN RESEARCH

Cytoplasmic calcium mediates oxidative damage in an excitotoxic /energetic deficit synergic model in rats

(2008) Verónica Pérez-De La Cruz et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

AAV–BDNF mediated attenuation of quinolinic acid-induced neuropathology and motor function impairment

(2008) A P Kells et al.   GENE THERAPY

Excitotoxic damage, disrupted energy metabolism, and oxidative stress in the rat brain: antioxidant and neuroprotective effects of l-carnitine

(2008) Daniela Silva-Adaya et al.   JOURNAL OF NEUROCHEMISTRY

Quinolinate-induced Rat Striatal Excitotoxicity Impairs Endoplasmic Reticulum Ca2+-ATPase Function

(2008) Anna M. A. P. Fernandes et al.   NEUROCHEMICAL RESEARCH

Iron porphyrinate Fe(TPPS) reduces brain cell damage in rats intrastriatally lesioned by quinolinate

(2008) Carolina González-Cortés et al.   NEUROTOXICOLOGY AND TERATOLOGY