期刊
WIENER KLINISCHE WOCHENSCHRIFT
卷 132, 期 1-2, 页码 42-46出版社
SPRINGER WIEN
DOI: 10.1007/s00508-019-01588-7
关键词
Dementia; Alzheimer's disease; Spermidine; Memory performance; CERAD Plus
资金
- University of Applied Sciences Wiener Neustadt (FHWN)
Previous studies have highlighted that spermidine has the ability to trigger the important process of dissolving amyloid-beta plaques by autophagy. This manuscript focuses on the correlation of serum spermidine levels between age and between performance in mini-mental state examinations. It will serve as a premise for an ongoing multicentric placebo-controlled study, which focuses on the effect of oral spermidine supplementation on memory performance. Memory tests were carried out on 80 subjects aged 60-96 years old in 6 nursing homes in Styria. Blood samples were taken for the determination of spermidine concentration. The results showed a significant correlation between the spermidine concentration and the mini-mental state examination score (p= 0.025). On the basis of the dependence demonstrated it can be concluded that spermidine might be suitable as a biomarker for the diagnosis of neurocognitive changes (senile dementia or Alzheimer's disease).
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