Microbiota-derived short chain fatty acids modulate microglia and promote Aβ plaque deposition

Loss of NPC1 enhances phagocytic uptake and impairs lipid trafficking in microglia

(2021) Alessio Colombo et al.   Nature Communications

Fibrillar Aβ triggers microglial proteome alterations and dysfunction in Alzheimer mouse models

(2020) Laura Sebastian Monasor et al.   eLife

Short-Chain Fatty Acids and Lipopolysaccharide as Mediators Between Gut Dysbiosis and Amyloid Pathology in Alzheimer’s Disease

(2020) Moira Marizzoni et al.   JOURNAL OF ALZHEIMERS DISEASE

Emerging Microglia Biology Defines Novel Therapeutic Approaches for Alzheimer’s Disease

(2020) Joseph W. Lewcock et al.   NEURON

Sex-specific effects of microbiome perturbations on cerebral Aβ amyloidosis and microglia phenotypes

(2019) Hemraj B. Dodiya et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The role of short-chain fatty acids in microbiota–gut–brain communication

(2019) Boushra Dalile et al.   Nature Reviews Gastroenterology & Hepatology

Alzheimer’s Disease Microbiome Is Associated with Dysregulation of the Anti-Inflammatory P-Glycoprotein Pathway

(2019) John P. Haran et al.   mBio

The Major Risk Factors for Alzheimer’s Disease: Age, Sex, and Genes Modulate the Microglia Response to Aβ Plaques

(2019) Carlo Sala Frigerio et al.   Cell Reports

The Microbiota-Gut-Brain Axis

(2019) John F. Cryan et al.   PHYSIOLOGICAL REVIEWS

Modified Mediterranean-ketogenic diet modulates gut microbiome and short-chain fatty acids in association with Alzheimer's disease markers in subjects with mild cognitive impairment

(2019) Ravinder Nagpal et al.   EBioMedicine

Alzheimer Disease: An Update on Pathobiology and Treatment Strategies

(2019) Justin M. Long et al.   CELL

Sustained microglial depletion with CSF1R inhibitor impairs parenchymal plaque development in an Alzheimer’s disease model

(2019) Elizabeth Spangenberg et al.   Nature Communications

Short-Chain Fatty Acids Improve Poststroke Recovery via Immunological Mechanisms

(2019) Rebecca Sadler et al.   JOURNAL OF NEUROSCIENCE

The microbiome-gut-brain axis in acute and chronic brain diseases

(2019) Corinne Benakis et al.   CURRENT OPINION IN NEUROBIOLOGY

BACE1 inhibition more effectively suppresses initiation than progression of β-amyloid pathology

(2018) Finn Peters et al.   ACTA NEUROPATHOLOGICA

The gut microbiome primes a cerebroprotective immune response after stroke

(2018) Vikramjeet Singh et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Short-chain fatty acids: microbial metabolites that alleviate stress-induced brain-gut axis alterations

(2018) Marcel van de Wouw et al.   JOURNAL OF PHYSIOLOGY-LONDON

Emerging Role of Diet and Microbiota Interactions in Neuroinflammation

(2018) Mathangi Janakiraman et al.   Frontiers in Immunology

Microbiome–microglia connections via the gut–brain axis

(2018) Reem Abdel-Haq et al.   JOURNAL OF EXPERIMENTAL MEDICINE

T cells in the post-ischemic brain: Troopers or paramedics?

(2018) Julia V. Cramer et al.   JOURNAL OF NEUROIMMUNOLOGY

Loss of TREM2 function increases amyloid seeding but reduces plaque-associated ApoE

(2018) Samira Parhizkar et al.   NATURE NEUROSCIENCE

Protective roles of intestinal microbiota derived short chain fatty acids in Alzheimer’s disease-type beta-amyloid neuropathological mechanisms

(2017) Lap Ho et al.   Expert Review of Neurotherapeutics

Butyrate reduces appetite and activates brown adipose tissue via the gut-brain neural circuit

(2017) Zhuang Li et al.   GUT

Altered Gut Microbiome Composition and Tryptic Activity of the 5xFAD Alzheimer’s Mouse Model

(2017) Carolin Brandscheid et al.   JOURNAL OF ALZHEIMERS DISEASE

Microglia in Alzheimer’s disease

(2017) David V. Hansen et al.   JOURNAL OF CELL BIOLOGY

Microglia in Alzheimer’s disease

(2017) Heela Sarlus et al.   JOURNAL OF CLINICAL INVESTIGATION

Microglia-derived ASC specks cross-seed amyloid-β in Alzheimer’s disease

(2017) Carmen Venegas et al.   NATURE

Diverse Requirements for Microglial Survival, Specification, and Function Revealed by Defined-Medium Cultures

(2017) Christopher J. Bohlen et al.   NEURON

Protective roles of intestinal microbiota derived short chain fatty acids in Alzheimer’s disease-type beta-amyloid neuropathological mechanisms

(2017) Lap Ho et al.   Expert Review of Neurotherapeutics

Reduction of Abeta amyloid pathology in APPPS1 transgenic mice in the absence of gut microbiota

(2017) T. Harach et al.   Scientific Reports

Antibiotic-induced perturbations in microbial diversity during post-natal development alters amyloid pathology in an aged APPSWE/PS1ΔE9 murine model of Alzheimer’s disease

(2017) Myles R. Minter et al.   Scientific Reports

Gut microbiome alterations in Alzheimer’s disease

(2017) Nicholas M. Vogt et al.   Scientific Reports

Gut Microbiota Regulate Motor Deficits and Neuroinflammation in a Model of Parkinson’s Disease

(2016) Timothy R. Sampson et al.   CELL

Young microglia restore amyloid plaque clearance of aged microglia

(2016) Anna Daria et al.   EMBO JOURNAL

Microbiota Dysbiosis Controls the Neuroinflammatory Response after Stroke

(2016) V. Singh et al.   JOURNAL OF NEUROSCIENCE

Complement and microglia mediate early synapse loss in Alzheimer mouse models

(2016) S. Hong et al.   SCIENCE

Antibiotic-induced perturbations in gut microbial diversity influences neuro-inflammation and amyloidosis in a murine model of Alzheimer’s disease

(2016) Myles R. Minter et al.   Scientific Reports

Dietary Fatty Acids Directly Impact Central Nervous System Autoimmunity via the Small Intestine

(2015) Aiden Haghikia et al.   IMMUNITY

Host microbiota constantly control maturation and function of microglia in the CNS

(2015) Daniel Erny et al.   NATURE NEUROSCIENCE

ClustVis: a web tool for visualizing clustering of multivariate data using Principal Component Analysis and heatmap

(2015) Tauno Metsalu et al.   NUCLEIC ACIDS RESEARCH

Innate Immunity Fights Alzheimer's Disease

(2015) Marie-Victoire Guillot-Sestier et al.   TRENDS IN NEUROSCIENCES

Murine versus human apolipoprotein E4: differential facilitation of and co-localization in cerebral amyloid angiopathy and amyloid plaques in APP transgenic mouse models

(2015) Fan Liao et al.   Acta Neuropathologica Communications

Identification of a unique TGF-β–dependent molecular and functional signature in microglia

(2013) Oleg Butovsky et al.   NATURE NEUROSCIENCE

A Shortened Barnes Maze Protocol Reveals Memory Deficits at 4-Months of Age in the Triple-Transgenic Mouse Model of Alzheimer's Disease

(2013) Aida Attar et al.   PLoS One

The Microbial Metabolites, Short-Chain Fatty Acids, Regulate Colonic Treg Cell Homeostasis

(2013) P. M. Smith et al.   SCIENCE

Apolipoprotein E and Apolipoprotein E Receptors: Normal Biology and Roles in Alzheimer Disease

(2013) D. M. Holtzman et al.   Cold Spring Harbor Perspectives in Medicine

Generation of Alzheimer Disease-associated Amyloid β42/43Peptide by γ-Secretase Can Be Inhibited Directly by Modulation of Membrane Thickness

(2012) Edith Winkler et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

NLRP3 is activated in Alzheimer’s disease and contributes to pathology in APP/PS1 mice

(2012) Michael T. Heneka et al.   NATURE

Significance of Short Chain Fatty Acid Transport by Members of the Monocarboxylate Transporter Family (MCT)

(2012) Ivano Moschen et al.   NEUROCHEMICAL RESEARCH

Butyrate and Propionate Protect against Diet-Induced Obesity and Regulate Gut Hormones via Free Fatty Acid Receptor 3-Independent Mechanisms

(2012) Hua V. Lin et al.   PLoS One

Short chain fatty acids and their receptors: new metabolic targets

(2012) Brian T. Layden et al.   Translational Research

Long-Term In Vivo Imaging of  -Amyloid Plaque Appearance and Growth in a Mouse Model of Cerebral  -Amyloidosis

(2011) J. K. Hefendehl et al.   JOURNAL OF NEUROSCIENCE

The microbiome-gut-brain axis: from bowel to behavior

(2011) J. F. Cryan et al.   NEUROGASTROENTEROLOGY AND MOTILITY

The Toll-Like Receptor 2 Pathway Establishes Colonization by a Commensal of the Human Microbiota

(2011) J. L. Round et al.   SCIENCE

Regulatory T cells are key cerebroprotective immunomodulators in acute experimental stroke

(2009) Arthur Liesz et al.   NATURE MEDICINE