In vivo and neuropathology data support locus coeruleus integrity as indicator of Alzheimer’s disease pathology and cognitive decline

The cortical origin and initial spread of medial temporal tauopathy in Alzheimer’s disease assessed with positron emission tomography

(2021) Justin S. Sanchez et al.   Science Translational Medicine

β-amyloid redirects norepinephrine signaling to activate the pathogenic GSK3β/tau cascade

(2020) Fang Zhang et al.   Science Translational Medicine

The presubiculum links incipient amyloid and tau pathology to memory function in older persons

(2020) Heidi I.L. Jacobs et al.   NEUROLOGY

Magnetic resonance imaging of noradrenergic neurons

(2019) Takashi Watanabe et al.   Brain Structure & Function

Alzheimer’s disease pathology: pathways between central norepinephrine activity, memory, and neuropsychiatric symptoms

(2019) Heidi I. L. Jacobs et al.   MOLECULAR PSYCHIATRY

Locus coeruleus imaging as a biomarker for noradrenergic dysfunction in neurodegenerative diseases

(2019) Matthew J Betts et al.   BRAIN

Neuromelanin, aging, and neuronal vulnerability in Parkinson's disease

(2019) Miquel Vila   MOVEMENT DISORDERS

Rapid Reconfiguration of the Functional Connectome after Chemogenetic Locus Coeruleus Activation

(2019) Valerio Zerbi et al.   NEURON

An experimental model of Braak’s pretangle proposal for the origin of Alzheimer’s disease: the role of locus coeruleus in early symptom development

(2019) Abhinaba Ghosh et al.   Alzheimers Research & Therapy

Tau seeding activity begins in the transentorhinal/entorhinal regions and anticipates phospho-tau pathology in Alzheimer’s disease and PART

(2018) Sarah K. Kaufman et al.   ACTA NEUROPATHOLOGICA

Spreading of Tau Pathology in Sporadic Alzheimer’s Disease Along Cortico-cortical Top-Down Connections

(2018) Heiko Braak et al.   CEREBRAL CORTEX

Religious Orders Study and Rush Memory and Aging Project

(2018) David A. Bennett et al.   JOURNAL OF ALZHEIMERS DISEASE

18F-Flortaucipir Binding in Choroid Plexus: Related to Race and Hippocampus Signal

(2018) Christopher M. Lee et al.   JOURNAL OF ALZHEIMERS DISEASE

The Revised National Alzheimer’s Coordinating Center’s Neuropathology Form—Available Data and New Analyses

(2018) Lilah M Besser et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Structural tract alterations predict downstream tau accumulation in amyloid-positive older individuals

(2018) Heidi I. L. Jacobs et al.   NATURE NEUROSCIENCE

Locus coeruleus integrity in old age is selectively related to memories linked with salient negative events

(2018) Dorothea Hämmerer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

On the origin of tau seeding activity in Alzheimer’s disease

(2018) Helmut Heinsen et al.   ACTA NEUROPATHOLOGICA

In vivo visualization of age-related differences in the locus coeruleus

(2018) Kathy Y. Liu et al.   NEUROBIOLOGY OF AGING

Association Between Elevated Brain Amyloid and Subsequent Cognitive Decline Among Cognitively Normal Persons

(2017) Michael C. Donohue et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Locus coeruleus ablation exacerbates cognitive deficits, neuropathology, and lethality in P301S tau transgenic mice

(2017) Termpanit Chalermpalanupap et al.   JOURNAL OF NEUROSCIENCE

Harvard Aging Brain Study: Dataset and accessibility

(2017) Alexander Dagley et al.   NEUROIMAGE

TOMM40 ′523 variant and cognitive decline in older persons with APOE ε3/3 genotype

(2017) Lei Yu et al.   NEUROLOGY

Quantifying the accretion of hyperphosphorylated tau in the locus coeruleus and dorsal raphe nucleus: the pathological building blocks of early Alzheimer's disease

(2017) A. J. Ehrenberg et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Interactions of iron, dopamine and neuromelanin pathways in brain aging and Parkinson's disease

(2017) Fabio A. Zucca et al.   PROGRESS IN NEUROBIOLOGY

Tau pathology spread in PS19 tau transgenic mice following locus coeruleus (LC) injections of synthetic tau fibrils is determined by the LC’s afferent and efferent connections

(2015) Michiyo Iba et al.   ACTA NEUROPATHOLOGICA

Validating novel tau positron emission tomography tracer [F-18]-AV-1451 (T807) on postmortem brain tissue

(2015) Marta Marquié et al.   ANNALS OF NEUROLOGY

Tau positron emission tomographic imaging in aging and early Alzheimer disease

(2015) Keith A. Johnson et al.   ANNALS OF NEUROLOGY

The preclinical phase of the pathological process underlying sporadic Alzheimer’s disease

(2015) Heiko Braak et al.   BRAIN

Histologic validation of locus coeruleus MRI contrast in post-mortem tissue

(2015) Noam I. Keren et al.   NEUROIMAGE

Temporal course and pathologic basis of unawareness of memory loss in dementia

(2015) Robert S. Wilson et al.   NEUROLOGY

Residual decline in cognition after adjustment for common neuropathologic conditions.

(2015) Lei Yu et al.   NEUROPSYCHOLOGY

The coeruleus/subcoeruleus complex in rapid eye movement sleep behaviour disorders in Parkinson’s disease

(2013) Daniel García-Lorenzo et al.   BRAIN

Overview and Findings from the Religious Orders Study

(2013) David A. Bennett et al.   Current Alzheimer Research

Overview and Findings from the Rush Memory and Aging Project

(2013) David A. Bennett et al.   Current Alzheimer Research

Cortical surface-based analysis reduces bias and variance in kinetic modeling of brain PET data

(2013) Douglas N. Greve et al.   NEUROIMAGE

Life-span cognitive activity, neuropathologic burden, and cognitive aging

(2013) R. S. Wilson et al.   NEUROLOGY

Neural reserve, neuronal density in the locus ceruleus, and cognitive decline

(2013) R. S. Wilson et al.   NEUROLOGY

Environmental Novelty Activates β2-Adrenergic Signaling to Prevent the Impairment of Hippocampal LTP by Aβ Oligomers

(2013) Shaomin Li et al.   NEURON

Correlation of Alzheimer Disease Neuropathologic Changes With Cognitive Status: A Review of the Literature

(2012) Peter T. Nelson et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Locus coeruleus neuron density and parkinsonism in older adults without Parkinson's disease

(2012) Aron S. Buchman et al.   MOVEMENT DISORDERS

Propagation of Tau Pathology in a Model of Early Alzheimer's Disease

(2012) Alix de Calignon et al.   NEURON

National Institute on Aging–Alzheimer’s Association guidelines for the neuropathologic assessment of Alzheimer’s disease: a practical approach

(2011) Thomas J. Montine et al.   ACTA NEUROPATHOLOGICA

Stages of the Pathologic Process in Alzheimer Disease: Age Categories From 1 to 100 Years

(2011) Heiko Braak et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

The pathological process underlying Alzheimer’s disease in individuals under thirty

(2010) Heiko Braak et al.   ACTA NEUROPATHOLOGICA

Locus ceruleus controls Alzheimer's disease pathology by modulating microglial functions through norepinephrine

(2010) M. T. Heneka et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Alzheimerʼs Disease Centersʼ Uniform Data Set (UDS)

(2009) Sandra Weintraub et al.   ALZHEIMER DISEASE & ASSOCIATED DISORDERS

Locus Coeruleus Activation Facilitates Memory Encoding and Induces Hippocampal LTD that Depends on  -Adrenergic Receptor Activation

(2009) N. Lemon et al.   CEREBRAL CORTEX

The locus coeruleus and noradrenergic modulation of cognition

(2009) Susan J. Sara   NATURE REVIEWS NEUROSCIENCE

Evaluation of 14 nonlinear deformation algorithms applied to human brain MRI registration

(2009) Arno Klein et al.   NEUROIMAGE