E3 ligases and deubiquitinating enzymes regulating the MAPK signaling pathway in cancers
出版年份 2022 全文链接
标题
E3 ligases and deubiquitinating enzymes regulating the MAPK signaling pathway in cancers
作者
关键词
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出版物
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
Volume 1877, Issue 3, Pages 188736
出版商
Elsevier BV
发表日期
2022-05-17
DOI
10.1016/j.bbcan.2022.188736
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注意：仅列出部分参考文献，下载原文获取全部文献信息。- Pro-apoptotic and anti-apoptotic regulation mediated by deubiquitinating enzymes
- (2022) Hae-Seul Choi et al. CELLULAR AND MOLECULAR LIFE SCIENCES
- Functional Roles of JNK and p38 MAPK Signaling in Nasopharyngeal Carcinoma
- (2022) Lesley Jia Wei Pua et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- PROTAC targeted protein degraders: the past is prologue
- (2022) Miklós Békés et al. NATURE REVIEWS DRUG DISCOVERY
- Dissection of the MKK3 Functions in Human Cancer: A Double-Edged Sword?
- (2022) Valentina Piastra et al. Cancers
- Clinical Significance and Regulation of ERK5 Expression and Function in Cancer
- (2022) Matilde Monti et al. Cancers
- Beyond K48 and K63: non-canonical protein ubiquitination
- (2021) Michal Tracz et al. CELLULAR & MOLECULAR BIOLOGY LETTERS
- Emerging functions of branched ubiquitin chains
- (2021) Michael E. French et al. Cell Discovery
- c-Jun N-terminal kinase 2 suppresses pancreatic cancer growth and invasion and is opposed by c-Jun N-terminal kinase 1
- (2021) Xiaodong Tian et al. CANCER GENE THERAPY
- MAPK signaling regulates c‐MYC for melanoma cell adaptation to asparagine restriction
- (2021) Gaurav Pathria et al. EMBO REPORTS
- Delta-like 1 homolog (DLK1) as a possible therapeutic target and its application to radioimmunotherapy using 125I-labelled anti-DLK1 antibody in lung cancer models (HOT1801 and FIGHT004)
- (2021) Hironori Takagi et al. LUNG CANCER
- PROTACs in Treatment of Cancer: A review
- (2021) Poonam Arora et al. MINI-REVIEWS IN MEDICINAL CHEMISTRY
- ARAF mutations confer resistance to the RAF inhibitor belvarafenib in melanoma
- (2021) Ivana Yen et al. NATURE
- MDM2 induces EMT via the B‑Raf signaling pathway through 14‑3‑3
- (2021) Mengting Ou et al. ONCOLOGY REPORTS
- MEKK1 Regulates Chemokine Expression in Mammary Fibroblasts: Implications for the Breast Tumor Microenvironment
- (2021) Saverio Gentile et al. Frontiers in Oncology
- Inhibitory feedback control of NF-κB signalling in health and disease
- (2021) Jack A. Prescott et al. BIOCHEMICAL JOURNAL
- Research progress of MEK1/2 inhibitors and degraders in the treatment of cancer
- (2021) Chao Wang et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Proteomic analysis of ubiquitination substrates reveals a CTLH E3 ligase complex‐dependent regulation of glycolysis
- (2021) Matthew E. R. Maitland et al. FASEB JOURNAL
- The MEK5/ERK5 Pathway in Health and Disease
- (2021) Rupesh Paudel et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Regulation of Cancer Metabolism by Deubiquitinating Enzymes: The Warburg Effect
- (2021) So-Hee Kim et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Emerging strategies to target RAS signaling in human cancer therapy
- (2021) Kun Chen et al. Journal of Hematology & Oncology
- Clinical Positioning of the IAP Antagonist Tolinapant (ASTX660) in Colorectal Cancer
- (2021) Nyree Crawford et al. MOLECULAR CANCER THERAPEUTICS
- K29-linked ubiquitin signaling regulates proteotoxic stress response and cell cycle
- (2021) Yuanyuan Yu et al. Nature Chemical Biology
- Current Perspectives and Novel Strategies of NRAS-Mutant Melanoma
- (2021) Alejandro Garcia-Alvarez et al. OncoTargets and Therapy
- Targeting Protein Kinases Degradation by PROTACs
- (2021) Fei Yu et al. Frontiers in Chemistry
- Clinical, genetic and pharmacological data support targeting the MEK5/ERK5 module in lung cancer
- (2021) Adrián Sánchez-Fdez et al. npj Precision Oncology
- The role of delta-like non-canonical Notch ligand 1 (DLK1) in cancer
- (2021) James F H Pittaway et al. ENDOCRINE-RELATED CANCER
- Inhibition of ubiquitin-specific protease 13-mediated degradation of Raf1 kinase by Spautin-1 has opposing effects in naïve and primed pluripotent stem cells
- (2021) Xin Wang et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Clonal dynamics of BRAF-driven drug resistance in EGFR-mutant lung cancer
- (2021) Diana Schaufler et al. npj Precision Oncology
- TNF-α-induced E3 ligase, TRIM15 inhibits TNF-α-regulated NF-κB pathway by promoting turnover of K63 linked ubiquitination of TAK1
- (2021) Milton Roy et al. CELLULAR SIGNALLING
- The MEK5-ERK5 kinase axis controls lipid metabolism in small cell lung cancer
- (2020) Sandra Cristea et al. CANCER RESEARCH
- USP15 potentiates NF‐κB activation by differentially stabilizing TAB2 and TAB3
- (2020) Qiaoqiao Zhou et al. FEBS Journal
- Targeting MAPK Signaling in Cancer: Mechanisms of Drug Resistance and Sensitivity
- (2020) Shannon Lee et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Selective inhibitors for JNK signalling: a potential targeted therapy in cancer
- (2020) Qinghua Wu et al. JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY
- OTUD1 Negatively Regulates Type I IFN Induction by Disrupting Noncanonical Ubiquitination of IRF3
- (2020) Zeming Zhang et al. JOURNAL OF IMMUNOLOGY
- Role of oncogenic KRAS in the diagnosis, prognosis and treatment of pancreatic cancer
- (2020) Louis Buscail et al. Nature Reviews Gastroenterology & Hepatology
- Targeted Avenues for Cancer Treatment: The MEK5–ERK5 Signaling Pathway
- (2020) Diane M. Pereira et al. TRENDS IN MOLECULAR MEDICINE
- The ubiquitin ligase HERC1 regulates cell migration via RAF-dependent regulation of MKK3/p38 signaling
- (2020) Leonardo Pedrazza et al. Scientific Reports
- Extracellular signal regulated kinase 5 promotes cell migration, invasion and lung metastasis in a FAK-dependent manner
- (2020) Weiwei Jiang et al. Protein & Cell
- Current Advances in the Treatment of BRAF-Mutant Melanoma
- (2020) Hima Patel et al. Cancers
- Mutations That Confer Drug-Resistance, Oncogenicity and Intrinsic Activity on the ERK MAP Kinases—Current State of the Art
- (2020) Karina Smorodinsky-Atias et al. Cells
- Overcoming Resistance to Therapies Targeting the MAPK Pathway in BRAF-Mutated Tumours
- (2020) Emily L. Paton et al. Journal of Oncology
- TNFAIP3 Interacting Protein 3 Overexpression Suppresses Nonalcoholic Steatohepatitis by Blocking TAK1 Activation
- (2020) Dan Liu et al. Cell Metabolism
- TAK1 is a pivotal therapeutic target for tumor progression and bone destruction in myeloma
- (2020) Jumpei Teramachi et al. HAEMATOLOGICA
- SUMOylation Is Required for ERK5 Nuclear Translocation and ERK5-Mediated Cancer Cell Proliferation
- (2020) Tatiana Erazo et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- The p38 Pathway: From Biology to Cancer Therapy
- (2020) Adrián Martínez-Limón et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Understanding MAPK Signaling Pathways in Apoptosis
- (2020) Jicheng Yue et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Proteolysis-targeting chimera (PROTAC) for targeted protein degradation and cancer therapy
- (2020) Xin Li et al. Journal of Hematology & Oncology
- PROteolysis TArgeting Chimeras (PROTACs) as emerging anticancer therapeutics
- (2020) Sajid Khan et al. ONCOGENE
- MLK3 is a newly identified microRNA-520b target that regulates liver cancer cell migration
- (2020) Fei Zhang et al. PLoS One
- RAS, wanted dead or alive: Advances in targeting RAS mutant cancers
- (2020) Clint A. Stalnecker et al. Science Signaling
- Nonproteolytic K29-Linked Ubiquitination of the PB2 Replication Protein of Influenza A Viruses by Proviral Cullin 4-Based E3 Ligases
- (2020) Marwah Karim et al. mBio
- The JNK Signaling Pathway in Inflammatory Skin Disorders and Cancer
- (2020) Manel B. Hammouda et al. Cells
- Tipifarnib in recurrent, metastatic HRAS‐mutant salivary gland cancer
- (2020) Glenn J. Hanna et al. CANCER
- Regulation of Wnt Signaling through Ubiquitination and Deubiquitination in Cancers
- (2020) Hong-Beom Park et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Specificity in Ubiquitination Triggered by Virus Infection
- (2020) Haidong Gu et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Proteolysis targeting chimeras (PROTACs) are emerging therapeutics for hematologic malignancies
- (2020) Yonghan He et al. Journal of Hematology & Oncology
- Opposing Oncogenic Functions of p38 Mitogen-activated Protein Kinase Alpha and Beta in Human Pancreatic Cancer Cells
- (2020) XIAODONG TIAN et al. ANTICANCER RESEARCH
- TRIM28 Regulates Dlk1 Expression in Adipogenesis
- (2020) Hsin-Pin Lu et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Arabidopsis E3 ligase KEG associates with and ubiquitinates MKK4 and MKK5 to regulate plant immunity
- (2020) Chenyang Gao et al. Journal of Integrative Plant Biology
- Loss of FBXW7-mediated degradation of BRAF elicits resistance to BET inhibitors in adult T cell leukemia cells
- (2020) Chien-Hung Yeh et al. Molecular Cancer
- Functions of p38 MAP Kinases in the Central Nervous System
- (2020) Prita R. Asih et al. Frontiers in Molecular Neuroscience
- JNK3 as Therapeutic Target and Biomarker in Neurodegenerative and Neurodevelopmental Brain Diseases
- (2020) Clara Alice Musi et al. Cells
- Potent and Selective Mitogen-Activated Protein Kinase Kinase 1/2 (MEK1/2) Heterobifunctional Small-molecule Degraders
- (2020) Jianping Hu et al. JOURNAL OF MEDICINAL CHEMISTRY
- Visualizing ubiquitination in mammalian cells
- (2019) Sjoerd JL van Wijk et al. EMBO REPORTS
- Differential PROTAC substrate specificity dictated by orientation of recruited E3 ligase
- (2019) Blake E. Smith et al. Nature Communications
- Targeting Alterations in the RAF–MEK Pathway
- (2019) Rona Yaeger et al. Cancer Discovery
- The IAP antagonist birinapant potentiates bortezomib anti-myeloma activity in vitro and in vivo
- (2019) Liang Zhou et al. Journal of Hematology & Oncology
- Impact of ERK5 on the Hallmarks of Cancer
- (2019) Barbara Stecca et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Regulation of c-Raf Stability through the CTLH Complex
- (2019) Christina McTavish et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- MAPK/ERK Signaling in Regulation of Renal Differentiation
- (2019) Kurtzeborn et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- p38γ is essential for cell cycle progression and liver tumorigenesis
- (2019) Antonia Tomás-Loba et al. NATURE
- K27-linked ubiquitination of BRAF by ITCH engages cytokine response to maintain MEK-ERK signaling
- (2019) Qing Yin et al. Nature Communications
- MLK 3 silence induces cervical cancer cell apoptosis via the Notch‐1/autophagy network
- (2019) Liya Ma et al. CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY
- CRAF mutations in lung cancer can be oncogenic and predict sensitivity to combined type II RAF and MEK inhibition
- (2019) Amir Noeparast et al. ONCOGENE
- Branching Out: Improved Signaling by Heterotypic Ubiquitin Chains
- (2019) Diane L. Haakonsen et al. TRENDS IN CELL BIOLOGY
- Overexpression of MAP3K3 promotes tumour growth through activation of the NF-κB signalling pathway in ovarian carcinoma
- (2019) Ying Zhang et al. Scientific Reports
- BRAF Mutations Classes I, II, and III in NSCLC Patients Included in the SLLIP Trial: The Need for a New Pre-Clinical Treatment Rationale
- (2019) Jillian Wilhelmina Paulina Bracht et al. Cancers
- Advances in Discovering Deubiquitinating Enzyme (DUB) Inhibitors
- (2019) Nathan J. Schauer et al. JOURNAL OF MEDICINAL CHEMISTRY
- Discovery of a First-in-Class Mitogen-Activated Protein Kinase Kinase 1/2 Degrader
- (2019) Jieli Wei et al. JOURNAL OF MEDICINAL CHEMISTRY
- Multifaceted roles of TAK1 signaling in cancer
- (2019) Himadri Mukhopadhyay et al. ONCOGENE
- Host signaling and EGR1 transcriptional control of human cytomegalovirus replication and latency
- (2019) Jason Buehler et al. PLoS Pathogens
- A Comparative Analysis of Individual RAS Mutations in Cancer Biology
- (2019) Carmen Muñoz-Maldonado et al. Frontiers in Oncology
- The role of JNK in prostate cancer progression and therapeutic strategies
- (2019) Ruiyuan Xu et al. BIOMEDICINE & PHARMACOTHERAPY
- Design, Synthesis, and Biological Evaluation of MEK PROTACs
- (2019) Stefan Vollmer et al. JOURNAL OF MEDICINAL CHEMISTRY
- c-Raf in KRas Mutant Cancers: A Moving Target
- (2018) Frank McCormick CANCER CELL
- Targeting p38α Increases DNA Damage, Chromosome Instability, and the Anti-tumoral Response to Taxanes in Breast Cancer Cells
- (2018) Begoña Cánovas et al. CANCER CELL
- M1-linked ubiquitination by LUBEL is required for inflammatory responses to oral infection in Drosophila
- (2018) Anna L. Aalto et al. CELL DEATH AND DIFFERENTIATION
- Loss of USP28-mediated BRAF degradation drives resistance to RAF cancer therapies
- (2018) Azad Saei et al. JOURNAL OF EXPERIMENTAL MEDICINE
- The deubiquitinating enzyme cylindromatosis mitigates nonalcoholic steatohepatitis
- (2018) Yan-Xiao Ji et al. NATURE MEDICINE
- MEKK2 and MEKK3 suppress Hedgehog pathway-dependent medulloblastoma by inhibiting GLI1 function
- (2018) Jinqiu Lu et al. ONCOGENE
- K63 ubiquitylation triggers proteasomal degradation by seeding branched ubiquitin chains
- (2018) Fumiaki Ohtake et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The deubiquitinase USP21 stabilizes MEK2 to promote tumor growth
- (2018) Wenjuan Li et al. Cell Death & Disease
- TAK1 mediates microenvironment-triggered autocrine signals and promotes triple-negative breast cancer lung metastasis
- (2018) Oihana Iriondo et al. Nature Communications
- Allele-Specific Mechanisms of Activation of MEK1 Mutants Determine Their Properties
- (2018) Yijun Gao et al. Cancer Discovery
- Mutual Stabilization between TRIM9 Short Isoform and MKK6 Potentiates p38 Signaling to Synergistically Suppress Glioblastoma Progression
- (2018) Kunpeng Liu et al. Cell Reports
- BRAF inhibitors in metastatic non-small cell lung cancer
- (2018) Geòrgia Anguera et al. Journal of Thoracic Disease
- MEK5 promotes lung adenocarcinoma
- (2018) Adrián Sánchez-Fdez et al. EUROPEAN RESPIRATORY JOURNAL
- Hippo kinase NDR2 inhibits IL-17 signaling by promoting Smurf1-mediated MEKK2 ubiquitination and degradation
- (2018) Xianwei Ma et al. MOLECULAR IMMUNOLOGY
- The ERK and JNK pathways in the regulation of metabolic reprogramming
- (2018) Salvatore Papa et al. ONCOGENE
- XIAP inhibitor embelin induces autophagic and apoptotic cell death in human oral squamous cell carcinoma cells
- (2017) You-Jin Lee et al. ENVIRONMENTAL TOXICOLOGY
- 1,4-Naphthoquinones as inhibitors of Itch, a HECT domain-E3 ligase, and tumor growth suppressors in multiple myeloma
- (2017) Yi-Min Liu et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Post-Translational Modifications of the TAK1-TAB Complex
- (2017) Yusuke Hirata et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- P38 delta MAPK promotes breast cancer progression and lung metastasis by enhancing cell proliferation and cell detachment
- (2017) M Wada et al. ONCOGENE
- Role of JNK signaling in oral cancer: A mini review
- (2017) Ioannis Gkouveris et al. TUMOR BIOLOGY
- The APC/C E3 Ligase Complex Activator FZR1 Restricts BRAF Oncogenic Function
- (2017) Lixin Wan et al. Cancer Discovery
- Relaxation oscillations and hierarchy of feedbacks in MAPK signaling
- (2017) Marek Kochańczyk et al. Scientific Reports
- TRIM48 Promotes ASK1 Activation and Cell Death through Ubiquitination-Dependent Degradation of the ASK1-Negative Regulator PRMT1
- (2017) Yusuke Hirata et al. Cell Reports
- Combined MEK and ERK inhibition overcomes therapy-mediated pathway reactivation in RAS mutant tumors
- (2017) Mark Merchant et al. PLoS One
- p38 MAPK α and β isoforms differentially regulate plasma membrane localization of MRP2
- (2016) Christopher M. Schonhoff et al. AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
- Bakuchiol sensitizes cancer cells to TRAIL through ROS- and JNK-mediated upregulation of death receptors and downregulation of survival proteins
- (2016) Mi Hee Park et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- BRAFV600E mutation in hairy cell leukemia: from bench to bedside
- (2016) Brunangelo Falini et al. BLOOD
- MEK5 overexpression is associated with the occurrence and development of colorectal cancer
- (2016) Dechang Diao et al. BMC CANCER
- Activation Mechanism of Oncogenic Deletion Mutations in BRAF, EGFR, and HER2
- (2016) Scott A. Foster et al. CANCER CELL
- Regulation of pluripotency and differentiation by deubiquitinating enzymes
- (2016) B Suresh et al. CELL DEATH AND DIFFERENTIATION
- The MEK5/ERK5 signalling pathway in cancer: a promising novel therapeutic target
- (2016) André E.S. Simões et al. DRUG DISCOVERY TODAY
- JNK Signaling: Regulation and Functions Based on Complex Protein-Protein Partnerships
- (2016) András Zeke et al. MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS
- Upregulation of MEK5 by Stat3 promotes breast cancer cell invasion and metastasis
- (2016) Fang Liu et al. ONCOLOGY REPORTS
- The Ras/Raf/MEK/ERK signaling pathway and its role in the occurrence and development of HCC
- (2016) Lei Li et al. Oncology Letters
- The ubiquitin E3 ligase TRAF6 exacerbates pathological cardiac hypertrophy via TAK1-dependent signalling
- (2016) Yan-Xiao Ji et al. Nature Communications
- RNF166 Determines Recruitment of Adaptor Proteins during Antibacterial Autophagy
- (2016) Robert J. Heath et al. Cell Reports
- Lys29-linkage of ASK1 by Skp1−Cullin 1−Fbxo21 ubiquitin ligase complex is required for antiviral innate response
- (2016) Zhou Yu et al. eLife
- MLK3 Signaling in Cancer Invasion
- (2016) Chotirat Rattanasinchai et al. Cancers
- Ras activation revisited: role of GEF and GAP systems
- (2015) Anne Hennig et al. BIOLOGICAL CHEMISTRY
- TAT-OSBP-1-MKK6(E), a novel TAT-fusion protein with high selectivity for human ovarian cancer, exhibits anti-tumor activity
- (2015) Jiali Zhong et al. MEDICAL ONCOLOGY
- K63 polyubiquitination is a new modulator of the oxidative stress response
- (2015) Gustavo M Silva et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Neddylation controls basal MKK7 kinase activity in breast cancer cells
- (2015) T Zhu et al. ONCOGENE
- K63 polyubiquitination is a new modulator of the oxidative stress response
- (2015) Gustavo M Silva et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- RNF168 Promotes Noncanonical K27 Ubiquitination to Signal DNA Damage
- (2015) Marco Gatti et al. Cell Reports
- HTLV-1 Tax Stimulates Ubiquitin E3 Ligase, Ring Finger Protein 8, to Assemble Lysine 63-Linked Polyubiquitin Chains for TAK1 and IKK Activation
- (2015) Yik-Khuan Ho et al. PLoS Pathogens
- Inactivation of Sag/Rbx2/Roc2 E3 Ubiquitin Ligase Triggers Senescence and Inhibits Kras-Induced Immortalization
- (2015) Mingjia Tan et al. NEOPLASIA
- Combination Therapies to Inhibit the RAF/MEK/ERK Pathway in Melanoma: We are not Done Yet
- (2015) Grant A. McArthur Frontiers in Oncology
- MEKK2 regulates focal adhesion stability and motility in invasive breast cancer cells
- (2014) Ahmed A. Mirza et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
- Activation of JNK1/2 and p38 MAPK signaling pathways promotes enterovirus 71 infection in immature dendritic cells
- (2014) Hongjun Peng et al. BMC MICROBIOLOGY
- MKK6 is Upregulated in Human Esophageal, Stomach, and Colon Cancers
- (2014) Arif Ali Parray et al. CANCER INVESTIGATION
- ERKs in Cancer: Friends or Foes?
- (2014) Xavier Deschênes-Simard et al. CANCER RESEARCH
- Enhanced Protein Degradation by Branched Ubiquitin Chains
- (2014) Hermann-Josef Meyer et al. CELL
- Ubiquitin-dependent regulation of MEKK2/3-MEK5-ERK5 signaling module by XIAP and cIAP1
- (2014) A.-N. Takeda et al. EMBO JOURNAL
- The E3 Ubiquitin Ligase AMFR and INSIG1 Bridge the Activation of TBK1 Kinase by Modifying the Adaptor STING
- (2014) Qiang Wang et al. IMMUNITY
- Identification of a Peptide Inhibitor of the RPM-1·FSN-1 Ubiquitin Ligase Complex
- (2014) Jaiprakash Sharma et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Functional Roles of p38 Mitogen-Activated Protein Kinase in Macrophage-Mediated Inflammatory Responses
- (2014) Yanyan Yang et al. MEDIATORS OF INFLAMMATION
- HUWE1 Is a Molecular Link Controlling RAF-1 Activity Supported by the Shoc2 Scaffold
- (2014) E. R. Jang et al. MOLECULAR AND CELLULAR BIOLOGY
- The E3 Ligase CHIP Mediates Ubiquitination and Degradation of Mixed-Lineage Kinase 3
- (2014) Natalya A. Blessing et al. MOLECULAR AND CELLULAR BIOLOGY
- K33-Linked Polyubiquitination of Coronin 7 by Cul3-KLHL20 Ubiquitin E3 Ligase Regulates Protein Trafficking
- (2014) Wei-Chien Yuan et al. MOLECULAR CELL
- Oncogenic KRAS signalling promotes the Wnt/β-catenin pathway through LRP6 in colorectal cancer
- (2014) E Lemieux et al. ONCOGENE
- Roquin-2 Promotes Ubiquitin-Mediated Degradation of ASK1 to Regulate Stress Responses
- (2014) T. Maruyama et al. Science Signaling
- Emerging roles of the p38 MAPK and PI3K/AKT/mTOR pathways in oncogene-induced senescence
- (2014) Yingxi Xu et al. TRENDS IN BIOCHEMICAL SCIENCES
- The E3 Ligase CHIP: Insights into Its Structure and Regulation
- (2014) Indranil Paul et al. Biomed Research International
- JNK signalling in cancer: in need of new, smarter therapeutic targets
- (2013) Concetta Bubici et al. BRITISH JOURNAL OF PHARMACOLOGY
- When ubiquitination meets phosphorylation: a systems biology perspective of EGFR/MAPK signalling
- (2013) Lan K Nguyen et al. Cell Communication and Signaling
- Molecular Pathways: Mitogen-Activated Protein Kinase Pathway Mutations and Drug Resistance
- (2013) A. L. Pritchard et al. CLINICAL CANCER RESEARCH
- USP18 inhibits NF-κB and NFAT activation during Th17 differentiation by deubiquitinating the TAK1–TAB1 complex
- (2013) Xikui Liu et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Amplification and over-expression ofMAP3K3gene in human breast cancer promotes formation and survival of breast cancer cells
- (2013) Yihui Fan et al. JOURNAL OF PATHOLOGY
- Oncogenic H-Ras Reprograms Madin-Darby Canine Kidney (MDCK) Cell-derived Exosomal Proteins Following Epithelial-Mesenchymal Transition
- (2013) Bow J. Tauro et al. MOLECULAR & CELLULAR PROTEOMICS
- Overexpression of MEKK2 is associated with colorectal carcinogenesis
- (2013) LI JIANG et al. Oncology Letters
- BRAF Mutation is associated with early stage disease and improved outcome in patients with low-grade serous ovarian cancer
- (2012) Rachel N. Grisham et al. CANCER
- Inactivation of the Deubiquitinase CYLD in Hepatocytes Causes Apoptosis, Inflammation, Fibrosis, and Cancer
- (2012) Kostas Nikolaou et al. CANCER CELL
- A Comprehensive Survey of Ras Mutations in Cancer
- (2012) I. A. Prior et al. CANCER RESEARCH
- ERK5: Structure, regulation and function
- (2012) Gopika N. Nithianandarajah-Jones et al. CELLULAR SIGNALLING
- Ring Finger Protein 149 Is an E3 Ubiquitin Ligase Active on Wild-type v-Raf Murine Sarcoma Viral Oncogene Homolog B1 (BRAF)
- (2012) Seung-Woo Hong et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Direct and Indirect Control of Mitogen-activated Protein Kinase Pathway-associated Components, BRAP/IMP E3 Ubiquitin Ligase and CRAF/RAF1 Kinase, by the Deubiquitylating Enzyme USP15
- (2012) Sebastian D. Hayes et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- MAP Kinase Pathways
- (2012) D. K. Morrison Cold Spring Harbor Perspectives in Biology
- Role of JNK in Mammary Gland Development and Breast Cancer
- (2011) C. Cellurale et al. CANCER RESEARCH
- USP4 targets TAK1 to downregulate TNFα-induced NF-κB activation
- (2011) Y-H Fan et al. CELL DEATH AND DIFFERENTIATION
- Stability of F-box Protein Atrogin-1 is Regulated by p38 Mitogen-activated Protein Kinase Pathway in Cardiac H9c2 Cells
- (2011) Jun-Jie Li et al. CELLULAR PHYSIOLOGY AND BIOCHEMISTRY
- The E3 ligase Itch and deubiquitinase Cyld act together to regulate Tak1 and inflammation
- (2011) Neesar Ahmed et al. NATURE IMMUNOLOGY
- Evolutionary History of the Vertebrate Mitogen Activated Protein Kinases Family
- (2011) Meng Li et al. PLoS One
- Tripartite motif 8 (TRIM8) modulates TNF - and IL-1 -triggered NF- B activation by targeting TAK1 for K63-linked polyubiquitination
- (2011) Q. Li et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Axon regeneration requires coordinate activation of p38 and JNK MAPK pathways
- (2011) P. Nix et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Mechanisms and functions of p38 MAPK signalling
- (2010) Ana Cuadrado et al. BIOCHEMICAL JOURNAL
- Pathological roles of MAPK signaling pathways in human diseases
- (2010) Eun Kyung Kim et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
- Targets of Raf in tumorigenesis
- (2010) T. S. Niault et al. CARCINOGENESIS
- K33-Linked Polyubiquitination of T Cell Receptor-ζ Regulates Proteolysis-Independent T Cell Signaling
- (2010) Haining Huang et al. IMMUNITY
- Flavokawain B, a kava chalcone, induces apoptosis via up-regulation of death-receptor 5 and Bim expression in androgen receptor negative, hormonal refractory prostate cancer cell lines and reduces tumor growth
- (2010) Yaxiong Tang et al. INTERNATIONAL JOURNAL OF CANCER
- Emerging role of Lys-63 ubiquitination in protein kinase and phosphatase activation and cancer development
- (2010) W-L Yang et al. ONCOGENE
- ASK1 and ASK2 differentially regulate the counteracting roles of apoptosis and inflammation in tumorigenesis
- (2009) Takayuki Iriyama et al. EMBO JOURNAL
- The p38 MAPK inhibitors for the treatment of inflammatory diseases and cancer
- (2009) Hae-Young Yong et al. EXPERT OPINION ON INVESTIGATIONAL DRUGS
- Lysine 63-linked Polyubiquitination of TAK1 at Lysine 158 Is Required for Tumor Necrosis Factor α- and Interleukin-1β-induced IKK/NF-κB and JNK/AP-1 Activation
- (2009) Yihui Fan et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- MKK4/SEK1 Is Negatively Regulated through a Feedback Loop Involving the E3 Ubiquitin Ligase Itch
- (2009) Young-Ho Ahn et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Depleting MEKK1 expression inhibits the ability of invasion and migration of human pancreatic cancer cells
- (2009) Fuqin Su et al. JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
- Ubiquitin-like Sequence in ASK1 Plays Critical Roles in the Recognition and Stabilization by USP9X and Oxidative Stress-Induced Cell Death
- (2009) Hiroaki Nagai et al. MOLECULAR CELL
- XIAP regulates bi-phasic NF-κB induction involving physical interaction and ubiquitination of MEKK2
- (2008) Gabriele Winsauer et al. CELLULAR SIGNALLING
- Proliferation of human HCC cells and chemically induced mouse liver cancers requires JNK1-dependent p21 downregulation
- (2008) Lijian Hui et al. JOURNAL OF CLINICAL INVESTIGATION
- X-linked and cellular IAPs modulate the stability of C-RAF kinase and cell motility
- (2008) Taner Dogan et al. NATURE CELL BIOLOGY
- JNK signaling in apoptosis
- (2008) D N Dhanasekaran et al. ONCOGENE
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