K29-linked ubiquitin signaling regulates proteotoxic stress response and cell cycle

Seesaw conformations of Npl4 in the human p97 complex and the inhibitory mechanism of a disulfiram derivative

(2021) Man Pan et al.   Nature Communications

Nonproteolytic K29-Linked Ubiquitination of the PB2 Replication Protein of Influenza A Viruses by Proviral Cullin 4-Based E3 Ligases

(2020) Marwah Karim et al.   mBio

Decoding without the cipher

(2019) Amit Kumar Singh Gautam et al.   Nature Chemical Biology

Structural Snapshots of 26S Proteasome Reveal Tetraubiquitin-Induced Conformations

(2019) Zhanyu Ding et al.   MOLECULAR CELL

Branching Out: Improved Signaling by Heterotypic Ubiquitin Chains

(2019) Diane L. Haakonsen et al.   TRENDS IN CELL BIOLOGY

Insights into ubiquitin chain architecture using Ub-clipping

(2019) Kirby N. Swatek et al.   NATURE

M1-linked ubiquitination by LUBEL is required for inflammatory responses to oral infection in Drosophila

(2018) Anna L. Aalto et al.   CELL DEATH AND DIFFERENTIATION

Engineered synthetic antibodies as probes to quantify the energetic contributions of ligand binding to conformational changes in proteins

(2018) Somnath Mukherjee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ub-ProT reveals global length and composition of protein ubiquitylation in cells

(2018) Hikaru Tsuchiya et al.   Nature Communications

A Highly Efficient Synthesis of Polyubiquitin Chains

(2018) Qian Qu et al.   Advanced Science

Cryo-EM structures and dynamics of substrate-engaged human 26S proteasome

(2018) Yuanchen Dong et al.   NATURE

Substrate-engaged 26S proteasome structures reveal mechanisms for ATP-hydrolysis–driven translocation

(2018) Andres H. de la Peña et al.   SCIENCE

Conducting Multiple Imaging Modes with One Fluorescence Microscope

(2018) Seongjin Park et al.   Jove-Journal of Visualized Experiments

Ubiquitin Linkage-Specific Affimers Reveal Insights into K6-Linked Ubiquitin Signaling

(2017) Martin A. Michel et al.   MOLECULAR CELL

Alcohol-abuse drug disulfiram targets cancer via p97 segregase adaptor NPL4

(2017) Zdenek Skrott et al.   NATURE

Ubiquitin biology: Unraveling the chain

(2017) Grant Miura   Nature Chemical Biology

Mechanism and regulation of the Lys6-selective deubiquitinase USP30

(2017) Malte Gersch et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Mechanism and regulation of the Lys6-selective deubiquitinase USP30

(2017) Malte Gersch et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Linear ubiquitination of cytosolic Salmonella Typhimurium activates NF-κB and restricts bacterial proliferation

(2017) Sjoerd J. L. van Wijk et al.   Nature Microbiology

Ubiquitin modifications

(2016) Kirby N Swatek et al.   CELL RESEARCH

Arginine Demethylation of G3BP1 Promotes Stress Granule Assembly

(2016) Wei-Chih Tsai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Quasi-Racemic X-ray Structures of K27-Linked Ubiquitin Chains Prepared by Total Chemical Synthesis

(2016) Man Pan et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The increasing complexity of the ubiquitin code

(2016) Richard Yau et al.   NATURE CELL BIOLOGY

Conformational Chaperones for Structural Studies of Membrane Proteins Using Antibody Phage Display with Nanodiscs

(2016) Pawel K. Dominik et al.   STRUCTURE

K29-Selective Ubiquitin Binding Domain Reveals Structural Basis of Specificity and Heterotypic Nature of K29 Polyubiquitin

(2015) Yosua Adi Kristariyanto et al.   MOLECULAR CELL

Assembly and Specific Recognition of K29- and K33-Linked Polyubiquitin

(2015) Martin A. Michel et al.   MOLECULAR CELL

USP30 and parkin homeostatically regulate atypical ubiquitin chains on mitochondria

(2015) Christian N. Cunningham et al.   NATURE CELL BIOLOGY

Determination of in vivo target search kinetics of regulatory noncoding RNA

(2015) J. Fei et al.   SCIENCE

Irreversible Site-Specific Hydrazinolysis of Proteins by Use of Sortase

(2014) Yi-Ming Li et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Enhanced Protein Degradation by Branched Ubiquitin Chains

(2014) Hermann-Josef Meyer et al.   CELL

Deciphering Functions of Branched Ubiquitin Chains

(2014) Jaime López-Mosqueda et al.   CELL

USP8 regulates mitophagy by removing K6-linked ubiquitin conjugates from parkin

(2014) T. M. Durcan et al.   EMBO JOURNAL

K33-Linked Polyubiquitination of Coronin 7 by Cul3-KLHL20 Ubiquitin E3 Ligase Regulates Protein Trafficking

(2014) Wei-Chien Yuan et al.   MOLECULAR CELL

Rhbdd3 controls autoimmunity by suppressing the production of IL-6 by dendritic cells via K27-linked ubiquitination of the regulator NEMO

(2014) Juan Liu et al.   NATURE IMMUNOLOGY

Likelihood-based molecular-replacement solution for a highly pathological crystal with tetartohedral twinning and sevenfold translational noncrystallographic symmetry

(2014) Joanna Sliwiak et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

OTULIN Antagonizes LUBAC Signaling by Specifically Hydrolyzing Met1-Linked Polyubiquitin

(2013) Kirstin Keusekotten et al.   CELL

The Ubiquitin Code

(2012) David Komander et al.   Annual Review of Biochemistry

Generating conformation-specific synthetic antibodies to trap proteins in selected functional states

(2012) Marcin Paduch et al.   METHODS

Emerging functions of the VCP/p97 AAA-ATPase in the ubiquitin system

(2012) Hemmo Meyer et al.   NATURE CELL BIOLOGY

Atypical ubiquitylation — the unexplored world of polyubiquitin beyond Lys48 and Lys63 linkages

(2012) Yogesh Kulathu et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

T Cell Receptor-Like Recognition of Tumor In Vivo by Synthetic Antibody Fragment

(2012) Keith R. Miller et al.   PLoS One

Engineering and Structural Characterization of a Linear Polyubiquitin-Specific Antibody

(2011) Marissa L. Matsumoto et al.   JOURNAL OF MOLECULAR BIOLOGY

An ankyrin-repeat ubiquitin-binding domain determines TRABID's specificity for atypical ubiquitin chains

(2011) Julien D F Licchesi et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

XDS

(2010) Wolfgang Kabsch   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

PHENIX: a comprehensive Python-based system for macromolecular structure solution

(2010) Paul D. Adams et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

K33-Linked Polyubiquitination of T Cell Receptor-ζ Regulates Proteolysis-Independent T Cell Signaling

(2010) Haining Huang et al.   IMMUNITY

K11-Linked Polyubiquitination in Cell Cycle Control Revealed by a K11 Linkage-Specific Antibody

(2010) Marissa L. Matsumoto et al.   MOLECULAR CELL

Quantitative Proteomics Reveals the Function of Unconventional Ubiquitin Chains in Proteasomal Degradation

(2009) Ping Xu et al.   CELL

Ubiquitin Chain Editing Revealed by Polyubiquitin Linkage-Specific Antibodies

(2008) Kim Newton et al.   CELL

Atypical ubiquitin chains: new molecular signals. ‘Protein Modifications: Beyond the Usual Suspects’ Review Series

(2008) Fumiyo Ikeda et al.   EMBO REPORTS