Article
Biochemistry & Molecular Biology
Agnes Stephanie Harahap, Imam Subekti, Sonar Soni Panigoro, Mutiah Asmarinah, Fajar Lamhot Lisnawati, Retno Asti Werdhani, Hasrayati Agustina, Dina Khoirunnisa, Mutiah Mutmainnah, Fajar Lamhot Gultom, Abdillah Hasbi Assadyk, Maria Francisca Ham
Summary: This retrospective study aimed to assess the clinicopathology and pERK1/2 expression variations between BRAF-like and RAS-like papillary thyroid carcinoma (PTC) and establish predictive models for BRAFV600E and RAS-mutated PTCs. The results showed variations in biological behavior between BRAF-like and RAS-like PTCs, primarily determined by driver gene mutations and pERK1/2 expression levels.
Review
Oncology
Manuel Felipe Fernandez, Jacob Choi, Jeffrey Sosman
Summary: Immune checkpoint inhibitors and BRAF/MEK inhibitors are the main treatments for melanoma, but resistance to these therapies emphasizes the need for new treatment options. Monoclonal antibodies and small molecules allow targeted therapy by focusing on specific mediators of cancer. Melanoma has several driver mutations, and targeting them could lead to novel therapies.
Article
Multidisciplinary Sciences
Hyoun Wook Lee, Boram Song, Kyungneun Kim
Summary: The presence of a residual adenoma component in colorectal cancer is associated with a high frequency of KRAS mutation and indolent clinicopathological features. The discordance in the incidence of KRAS mutation between the adenoma and carcinoma components emphasizes the need to document the adenoma component in the pathology report and avoid including it in molecular testing samples.
Article
Biochemistry & Molecular Biology
Soheila Rezaei Adariani, Neda S. Kazemein Jasemi, Farhad Bazgir, Christoph Wittich, Ehsan Amin, Claus A. M. Seidel, Radovan Dvorsky, Mohammad R. Ahmadian
Summary: This study identified RA and RB domains in different proteins through human proteome databases, and investigated the sequence-structure-function relationship between RAS family members and RASSFs as well as CRAF. The research discovered novel interactions and provided insights into the functional properties and potential biological roles that should be further explored in cellular context.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2021)
Article
Pharmacology & Pharmacy
Aoli Wang, Juan Liu, Xixiang Li, Fengming Zou, Ziping Qi, Shuang Qi, Qingwang Liu, Zuowei Wang, Jiangyan Cao, Zongru Jiang, Beilei Wang, Juan Ge, Li Wang, Wenchao Wang, Jing Liu, Qingsong Liu
Summary: In this study, a highly potent pan-RAF inhibitor, IHMT-RAF-128, was developed, which demonstrated strong anti-tumor efficacy against cancer cells harboring RAF or RAS mutations, especially the KRAS-G12C secondary mutations resistant to AMG510. IHMT-RAF-128 also exhibited excellent pharmacokinetic profile and dose-dependent anti-tumor efficacy in xenograft mouse tumor models without obvious toxicities. These findings support further investigation of IHMT-RAF-128 as a potential clinical drug candidate for cancer patients with RAF or RAS mutations.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Pathology
Thomas Denize, Pierre Alexandre Just, Mathilde Sibony, Helene Blons, Marc Olivier Timsit, Tom Drossart, Deborah Jakubowicz, Chloe Broudin, Aurelien Morini, Thierry Molina, Yann Vano, Marie Auvray-Kuentz, Stephane Richard, Arnaud Mejean, Anne Paule Gimenez Roqueplo, Nelly Burnichon, Virginie Verkarre
Summary: Our study provides additional evidence that biphasic squamoid alveolar papillary RCC is a morphological variant of type 1 papillary renal RCC. Our data strongly suggest that MET represents a major oncogenic driver gene in BSA-PRCC, harboring a higher frequency of MET mutation that encourages further exploration of the benefits of anti-MET targeted therapies for aggressive BSA-PRCC.
Article
Biochemistry & Molecular Biology
Siwei Chen, Yuan Liu, Yingying Zhang, Shayne D. Wierbowski, Steven M. Lipkin, Xiaomu Wei, Haiyuan Yu
Summary: The study presents a computational framework that characterizes the functional relevance of mutational hotspots in the context of a human 3D interactome network. The analysis shows that hotspots are located in network hub proteins and are enriched on protein interaction interfaces. The framework enables systematic identification of specific protein interactions affected by hotspot mutations and reveals genome-wide relationships among hotspots.
Article
Cardiac & Cardiovascular Systems
Wentao Fang, Pier Luigi Filosso, Anja C. Roden, Zhitao Gu, Yuan Liu, John Agzarian, Robert K. Shen, Enrico Ruffini
Summary: This study retrospectively analyzed the clinicopathological features, diagnosis, treatment, and outcomes of 146 patients with neuroendocrine thymic tumors. The majority of patients had advanced disease, and complete resection was associated with better survival. Specific diagnostic tools and novel therapeutic agents are needed to improve the management outcomes of this disease.
EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
(2021)
Article
Genetics & Heredity
Haoran Qian, Na Yan, Xiaotong Hu, Junchang Jiang, Zhengzheng Cao, Dan Shen
Summary: This study investigated the genetic characterization and clinicopathological features of gastrointestinal stromal tumors (GISTs) using targeted next-generation sequencing. The results revealed that KIT and PDGFRA mutations were the main molecular drivers in GISTs, and they were mutually exclusive. Additionally, the frequency of driver mutations varied among different anatomical sites of GISTs and had an impact on resistance to tyrosine kinase inhibitors (TKIs). The study demonstrated that targeted next-generation sequencing can efficiently detect GIST-related gene mutations and provide guidance for individualized diagnosis and treatment.
FRONTIERS IN GENETICS
(2022)
Article
Oncology
Martin Schuler, Lisa Zimmer, Kevin B. Kim, Jeffrey A. Sosman, Paolo A. Ascierto, Michael A. Postow, Filip Y. F. L. De Vos, Carla M. L. van Herpen, Matteo S. Carlino, Douglas B. Johnson, Carola Berking, Micaela B. Reddy, Allison S. Harney, Jordan D. Berlin, Rodabe N. Amaria
Summary: The combination of Ribociclib and binimetinib is clinically active and well tolerated in patients with NRAS-mutant melanoma, with a potential benefit for patients with co-mutations of cell-cycle genes.
CLINICAL CANCER RESEARCH
(2022)
Article
Oncology
Masaoki Ito, Yoshihiro Miyata, Shoko Hirano, Fumiko Irisuna, Kei Kushitani, Yuichiro Kai, Naoto Kishi, Yasuhiro Tsutani, Yukio Takeshima, Morihito Okada
Summary: Liquid biopsy using ddPCR detected lung cancer in 12.0% of pN0M0 EGFR-mutant lung adenocarcinoma patients, with 83.3% of ddPCR-positive patients exhibiting pure-solid appearance in HRCT. Detection ratio increased to 21.3% among patients with pure-solid appearance tumors, suggesting tumor appearance might be useful for better selection of liquid biopsy candidates.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2022)
Article
Cell Biology
Kavita Y. Sarin, John Kincaid, Brittney Sell, Jahanbanoo Shahryari, Matthew A. J. Duncton, Elaine Morefield, Wenchao Sun, Karol Prieto, Omar Chavez-Chiang, Carlos de Moran Segura, Jonathan Nguyen, Roderick T. Bronson, Scott R. Plotkin, Gerd G. Kochendoerfer, Peter Fenn, Michael A. Wootton, Christopher Powala, Mark P. de Souza, Kenneth Y. Tsai
Summary: This study developed a metabolically labile MEK inhibitor, NFX-179, which effectively suppresses the development of cSCC when applied topically, without observed toxicities. NFX-179 inhibits the growth of cSCC cells by blocking MAPK signaling.
SCIENCE TRANSLATIONAL MEDICINE
(2023)
Editorial Material
Oncology
Aphrothiti J. Hanrahan, David B. Solit
Summary: This paper reports the different distributions of BRAF mutations in melanoma and lung cancer, and discusses how biochemical differences among mutant alleles and lineage-specific differences among cancer types impact drug sensitivity. These studies provide important insights for new drug development and rational treatment strategies.
Review
Pharmacology & Pharmacy
Furong Li, Yanping Lin, Rong Li, Xin Shen, Mengying Xiang, Guangrui Xiong, Ke Zhang, Tingrong Xia, Jiangyan Guo, Zhonghui Miao, Yedan Liao, Xuan Zhang, Lin Xie
Summary: Colorectal cancer is the third leading cause of cancer-related deaths, primarily due to metastasis. Targeted therapy has become the preferred option for individualized and comprehensive treatment, but managing these patients remains a challenge. Advances in precision diagnosis and sequencing technology have led to the discovery of rare molecular targets, with new therapeutic drugs actively being investigated.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Dandan Wang, Kai Ma, Wei Deng, Jingyu Li, Shaohua Xiang, Yang Zhang, Ying Fu, Heng Dai, Bingding Huang
Summary: This study developed a custom-targeted NGS panel for accurately detecting various genomic alterations in cancer patients, providing strong support for guiding targeted therapy decisions.
ONCOTARGETS AND THERAPY
(2021)