Mechanisms and functions of p38 MAPK signalling

Macrophage Deletion of p38  Partially Impairs Lipopolysaccharide-Induced Cellular Activation

(2014) Y. J. Kang et al.   JOURNAL OF IMMUNOLOGY

Nuclear Localization of p38 MAPK in Response to DNA Damage

(2012) C. David Wood et al.   International Journal of Biological Sciences

Essential role of p18Hamlet/SRCAP-mediated histone H2A.Z chromatin incorporation in muscle differentiation

(2010) Ana Cuadrado et al.   EMBO JOURNAL

Direct Activation of TACE-Mediated Ectodomain Shedding by p38 MAP Kinase Regulates EGF Receptor-Dependent Cell Proliferation

(2010) Pinglong Xu et al.   MOLECULAR CELL

The three-dimensional structure of MAP kinase p38β: different features of the ATP-binding site in p38β compared with p38α

(2009) Sangita B. Patel et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Structural Bioinformatics-Based Prediction of Exceptional Selectivity of p38 MAP Kinase Inhibitor PH-797804

(2009) Li Xing et al.   BIOCHEMISTRY

p38α Is Active in Vitro and in Vivo When Monophosphorylated at Threonine 180†

(2009) Nadav Askari et al.   BIOCHEMISTRY

p38  Mitogen-Activated Protein Kinase Is Essential for Skin Tumor Development in Mice

(2009) E. M. Schindler et al.   CANCER RESEARCH

Computational Identification of a p38SAPK-Regulated Transcription Factor Network Required for Tumor Cell Quiescence

(2009) A. P. Adam et al.   CANCER RESEARCH

Induction of MAPK phosphatase-1 by hypothermia inhibits TNF- -induced endothelial barrier dysfunction and apoptosis

(2009) D. Yang et al.   CARDIOVASCULAR RESEARCH

Regulation of PKD by the MAPK p38δ in Insulin Secretion and Glucose Homeostasis

(2009) Grzegorz Sumara et al.   CELL

The Ste5 Scaffold Directs Mating Signaling by Catalytically Unlocking the Fus3 MAP Kinase for Activation

(2009) Matthew Good et al.   CELL

Chromatin Signatures in Multipotent Human Hematopoietic Stem Cells Indicate the Fate of Bivalent Genes during Differentiation

(2009) Kairong Cui et al.   Cell Stem Cell

Differential activation of p38MAPK isoforms by MKK6 and MKK3

(2009) Gaëlle Remy et al.   CELLULAR SIGNALLING

Peptides as Signaling Inhibitors for Mammalian MAP Kinase Cascades

(2009) Matthias Gaestel et al.   CURRENT PHARMACEUTICAL DESIGN

p38MAPK Controls Expression of Multiple Cell Cycle Inhibitors and Islet Proliferation with Advancing Age

(2009) Esther Sook Miin Wong et al.   DEVELOPMENTAL CELL

Coordinated regulation of autophagy by p38α MAPK through mAtg9 and p38IP

(2009) Jemma L Webber et al.   EMBO JOURNAL

Wip1 confers G2 checkpoint recovery competence by counteracting p53-dependent transcriptional repression

(2009) Arne Lindqvist et al.   EMBO JOURNAL

Multilayered control of gene expression by stress-activated protein kinases

(2009) Eulàlia de Nadal et al.   EMBO JOURNAL

A non-redundant role for MKP5 in limiting ROS production and preventing LPS-induced vascular injury

(2009) Feng Qian et al.   EMBO JOURNAL

Cdo promotes neuronal differentiation via activation of the p38 mitogen-activated protein kinase pathway

(2009) Ji-Eun Oh et al.   FASEB JOURNAL

Selectivity of Docking Sites in MAPK Kinases

(2009) A. Jane Bardwell et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

MKK4/SEK1 Is Negatively Regulated through a Feedback Loop Involving the E3 Ubiquitin Ligase Itch

(2009) Young-Ho Ahn et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Target Gene Specificity of USF-1 Is Directed via p38-mediated Phosphorylation-dependent Acetylation

(2009) Sébastien Corre et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

p38-γ–dependent gene silencing restricts entry into the myogenic differentiation program

(2009) Mark A. Gillespie et al.   JOURNAL OF CELL BIOLOGY

Glutamine Protects Mice from Lethal Endotoxic Shock via a Rapid Induction of MAPK Phosphatase-1

(2009) H.-M. Ko et al.   JOURNAL OF IMMUNOLOGY

p38α MAP Kinase C-Terminal Domain Binding Pocket Characterized by Crystallographic and Computational Analyses

(2009) J. Jefferson P. Perry et al.   JOURNAL OF MOLECULAR BIOLOGY

p38 Mitogen-Activated Protein Kinase- and HuR-Dependent Stabilization of p21Cip1 mRNA Mediates the G1/S Checkpoint

(2009) V. Lafarga et al.   MOLECULAR AND CELLULAR BIOLOGY

Cell Density-Dependent Inhibition of Epidermal Growth Factor Receptor Signaling by p38  Mitogen-Activated Protein Kinase via Sprouty2 Downregulation

(2009) A. Swat et al.   MOLECULAR AND CELLULAR BIOLOGY

WIP1 phosphatase is a negative regulator of NF-κB signalling

(2009) Joanne Chew et al.   NATURE CELL BIOLOGY

A TNF- and c-Cbl-dependent FLIPS-degradation pathway and its function in Mycobacterium tuberculosis–induced macrophage apoptosis

(2009) Manikuntala Kundu et al.   NATURE IMMUNOLOGY

Akt2, but not Akt1, is required for cell survival by inhibiting activation of JNK and p38 after UV irradiation

(2009) M-A Kim et al.   ONCOGENE

Phosphorylation-Independent Regulation of Atf1-Promoted Meiotic Recombination by Stress-Activated, p38 Kinase Spc1 of Fission Yeast

(2009) Jun Gao et al.   PLoS One

RNF2 is the target for phosphorylation by the p38 MAPK and ERK signaling pathways

(2009) Prema S. Rao et al.   PROTEOMICS

Increased MKK4 Abundance with Replicative Senescence Is Linked to the Joint Reduction of Multiple MicroRNAs

(2009) B. S. Marasa et al.   Science Signaling

MSK2 Inhibits p53 Activity in the Absence of Stress

(2009) S. Llanos et al.   Science Signaling

p38 MAP Kinase Inhibits Neutrophil Development Through Phosphorylation of C/EBPα on Serine 21

(2009) Christian R. Geest et al.   STEM CELLS

The Structure of the MAP2K MEK6 Reveals an Autoinhibitory Dimer

(2009) Xiaoshan Min et al.   STRUCTURE

WIP1 phosphatase at the crossroads of cancer and aging

(2009) Xavier Le Guezennec et al.   TRENDS IN BIOCHEMICAL SCIENCES

p38MAPK: stress responses from molecular mechanisms to therapeutics

(2009) Lydia R. Coulthard et al.   TRENDS IN MOLECULAR MEDICINE

Suppression of GATA-3 Nuclear Import and Phosphorylation: A Novel Mechanism of Corticosteroid Action in Allergic Disease

(2009) Kittipong Maneechotesuwan et al.   PLOS MEDICINE

Phosphorylation of Argonaute 2 at serine-387 facilitates its localization to processing bodies

(2008) Yan Zeng et al.   BIOCHEMICAL JOURNAL

Genetic disruption of p38  Tyr323 phosphorylation prevents T-cell receptor-mediated p38  activation and impairs interferon-  production

(2008) L. Jirmanova et al.   BLOOD

Hepatocyte Necrosis Induced by Oxidative Stress and IL-1α Release Mediate Carcinogen-Induced Compensatory Proliferation and Liver Tumorigenesis

(2008) Toshiharu Sakurai et al.   CANCER CELL

Enzymatic Activity and Substrate Specificity of Mitogen-activated Protein Kinase p38α in Different Phosphorylation States

(2008) Yuan-Yuan Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The p38 Mitogen-activated Protein Kinase Augments Nucleotide Excision Repair by Mediating DDB2 Degradation and Chromatin Relaxation

(2008) Qun Zhao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

AMP-activated Protein Kinase and p38 MAPK ActivateO-GlcNAcylation of Neuronal Proteins during Glucose Deprivation

(2008) Win D. Cheung et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ATR-dependent Activation of p38 MAP Kinase Is Responsible for Apoptotic Cell Death in Cells Depleted of Cdc7

(2008) Jun-Sub Im et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Cdo–Bnip-2–Cdc42 signaling pathway regulates p38α/β MAPK activity and myogenic differentiation

(2008) Jong-Sun Kang et al.   JOURNAL OF CELL BIOLOGY

Acetylation of mitogen-activated protein kinase phosphatase-1 inhibits Toll-like receptor signaling

(2008) Wangsen Cao et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Phosphorylation of Fibroblast Growth Factor (FGF) Receptor 1 at Ser777 by p38 Mitogen-Activated Protein Kinase Regulates Translocation of Exogenous FGF1 to the Cytosol and Nucleus

(2008) V. Sorensen et al.   MOLECULAR AND CELLULAR BIOLOGY

Hematopoietic Protein Tyrosine Phosphatase Mediates  2-Adrenergic Receptor-Induced Regulation of p38 Mitogen-Activated Protein Kinase in B Lymphocytes

(2008) J. W. McAlees et al.   MOLECULAR AND CELLULAR BIOLOGY

TRAF6 Mediates Smad-Independent Activation of JNK and p38 by TGF-β

(2008) Motozo Yamashita et al.   MOLECULAR CELL

The type I TGF-β receptor engages TRAF6 to activate TAK1 in a receptor kinase-independent manner

(2008) Alessandro Sorrentino et al.   NATURE CELL BIOLOGY

The kinase p38α serves cell type–specific inflammatory functions in skin injury and coordinates pro- and anti-inflammatory gene expression

(2008) Chun Kim et al.   NATURE IMMUNOLOGY

Sustained release of a p38 inhibitor from non-inflammatory microspheres inhibits cardiac dysfunction

(2008) Jay C. Sy et al.   NATURE MATERIALS

Essential Cytoplasmic Translocation of a Cytokine Receptor-Assembled Signaling Complex

(2008) A. Matsuzawa et al.   SCIENCE

Phosphorylation by p38 MAPK as an Alternative Pathway for GSK3  Inactivation

(2008) T. M. Thornton et al.   SCIENCE

Phosphatase-mediated crosstalk between MAPK signaling pathways in the regulation of cell survival

(2007) Melissa R. Junttila et al.   FASEB JOURNAL