Understanding MAPK Signaling Pathways in Apoptosis

Autophagy-induced senescence is regulated by p38α signaling

(2019) Konstantin Slobodnyuk et al.   Cell Death & Disease

Efficient apoptosis requires feedback amplification of upstream apoptotic signals by effector caspase-3 or -7

(2019) Scott McComb et al.   Science Advances

NSC 95397 Suppresses Proliferation and Induces Apoptosis in Colon Cancer Cells through MKP-1 and the ERK1/2 Pathway

(2018) Navneet Dubey et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

TRPV6 protects ER stress-induced apoptosis via ATF6α-TRPV6-JNK pathway in human embryonic stem cell-derived cardiomyocytes

(2018) Zhichao Li et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Mutant and wild-type p53 form complexes with p73 upon phosphorylation by the kinase JNK

(2018) Eric R. Wolf et al.   Science Signaling

Mutant and wild-type p53 form complexes with p73 upon phosphorylation by the kinase JNK

(2018) Eric R. Wolf et al.   Science Signaling

Life, death and autophagy

(2018) Johnna Doherty et al.   NATURE CELL BIOLOGY

Apoptosis propagates through the cytoplasm as trigger waves

(2018) Xianrui Cheng et al.   SCIENCE

Cell-to-Cell Heterogeneity in p38-Mediated Cross-Inhibition of JNK Causes Stochastic Cell Death

(2018) Haruko Miura et al.   Cell Reports

Autophagy-dependent cell death

(2018) Donna Denton et al.   CELL DEATH AND DIFFERENTIATION

A novel synthetic analogue of ω-3 17,18-epoxyeicosatetraenoic acid activates TNF receptor-1/ASK1/JNK signaling to promote apoptosis in human breast cancer cells

(2017) Herryawan Ryadi Eziwar Dyari et al.   FASEB JOURNAL

Annexin A2 contributes to cisplatin resistance by activation of JNK-p53 pathway in non-small cell lung cancer cells

(2017) Xiaomin Feng et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Celastrol ameliorates Cd-induced neuronal apoptosis by targeting NOX2-derived ROS-dependent PP5-JNK signaling pathway

(2017) Chong Xu et al.   JOURNAL OF NEUROCHEMISTRY

PP2A Cdc55 Phosphatase Imposes Ordered Cell-Cycle Phosphorylation by Opposing Threonine Phosphorylation

(2017) Molly Godfrey et al.   MOLECULAR CELL

The Temporal Ordering of Cell-Cycle Phosphorylation

(2017) Julia Kamenz et al.   MOLECULAR CELL

p38MAPK/MK2-dependent phosphorylation controls cytotoxic RIPK1 signalling in inflammation and infection

(2017) Manoj B. Menon et al.   NATURE CELL BIOLOGY

Endogenous AMPK acts as a detrimental factor in fulminant hepatitis via potentiating JNK-dependent hepatocyte apoptosis

(2017) Kai Hu et al.   Cell Death & Disease

BNIP3 upregulation via stimulation of ERK and JNK activity is required for the protection of keratinocytes from UVB-induced apoptosis

(2017) Mariko Moriyama et al.   Cell Death & Disease

Induction of oxidative metabolism by the p38α/MK2 pathway

(2017) Natalia Trempolec et al.   Scientific Reports

Nur77 inhibits oxLDL induced apoptosis of macrophages via the p38 MAPK signaling pathway

(2016) Qin Shao et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

CDK Substrate Phosphorylation and Ordering the Cell Cycle

(2016) Matthew P. Swaffer et al.   CELL

JNK does not regulate meiotic progression in Xenopus oocytes: The strange case of pJNK and pERK

(2016) Jicheng Yue et al.   DEVELOPMENTAL BIOLOGY

An initial phase of JNK activation inhibits cell death early in the endoplasmic reticulum stress response

(2016) Max Brown et al.   JOURNAL OF CELL SCIENCE

JNK Signaling: Regulation and Functions Based on Complex Protein-Protein Partnerships

(2016) András Zeke et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

Oxidative Stress Induces Mouse Follicular Granulosa Cells Apoptosis via JNK/FoxO1 Pathway

(2016) Qiannan Weng et al.   PLoS One

The Roles of p38 MAPK and ERK1/2 in Coplanar Polychlorinated Biphenyls-Induced Apoptosis of Human Extravillous Cytotrophoblast-Derived Transformed Cells

(2015) Zhu Liu et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Hyperosmotic Shock Engages Two Positive Feedback Loops through Caspase-3-dependent Proteolysis of JNK1-2 and Bid

(2015) Jicheng Yue et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Extracellular Regulated Kinase Phosphorylates Mitofusin 1 to Control Mitochondrial Morphology and Apoptosis

(2015) Aswin Pyakurel et al.   MOLECULAR CELL

Basic Properties of the p38 Signaling Pathway in Response to Hyperosmotic Shock

(2015) Nabil Ben Messaoud et al.   PLoS One

Cell Death Signaling

(2015) Douglas R. Green et al.   Cold Spring Harbor Perspectives in Biology

Isoliensinine induces apoptosis in triple-negative human breast cancer cells through ROS generation and p38 MAPK/JNK activation

(2015) Xiyu Zhang et al.   Scientific Reports

Osmostress-Induced Apoptosis in Xenopus Oocytes: Role of Stress Protein Kinases, Calpains and Smac/DIABLO

(2015) Nabil Ben Messaoud et al.   PLoS One

Induction of hepatoma carcinoma cell apoptosis through activation of the JNK–nicotinamide adenine dinucleotide phosphate (NADPH) oxidase–ROS self-driven death signal circuit

(2014) Ke-Wu Zeng et al.   CANCER LETTERS

Stress-induced ceramide generation and apoptosis via the phosphorylation and activation of nSMase1 by JNK signaling

(2014) T Yabu et al.   CELL DEATH AND DIFFERENTIATION

ROS-dependent activation of JNK converts p53 into an efficient inhibitor of oncogenes leading to robust apoptosis

(2014) Y Shi et al.   CELL DEATH AND DIFFERENTIATION

NMDA receptor-mediated ERK 1/2 pathway is involved in PFHxS-induced apoptosis of PC12 cells

(2014) Youn Ju Lee et al.   SCIENCE OF THE TOTAL ENVIRONMENT

Ultrasensitivity part I: Michaelian responses and zero-order ultrasensitivity

(2014) James E. Ferrell et al.   TRENDS IN BIOCHEMICAL SCIENCES

Ultrasensitivity part II: multisite phosphorylation, stoichiometric inhibitors, and positive feedback

(2014) James E. Ferrell et al.   TRENDS IN BIOCHEMICAL SCIENCES

Ultrasensitivity part III: cascades, bistable switches, and oscillators

(2014) James E. Ferrell et al.   TRENDS IN BIOCHEMICAL SCIENCES

JNK1/2 regulate Bid by direct phosphorylation at Thr59 in response to ALDH1L1

(2014) A Prakasam et al.   Cell Death & Disease

Feedback loops and reciprocal regulation: recurring motifs in the systems biology of the cell cycle

(2013) James E Ferrell   CURRENT OPINION IN CELL BIOLOGY

The phosphorylation of ARPP19 by Greatwall renders the auto-amplification of MPF independently of PKA in Xenopus oocytes

(2013) A. Dupre et al.   JOURNAL OF CELL SCIENCE

Role of p38 and JNK MAPK signaling pathways and tumor suppressor p53 on induction of apoptosis in response to Ad-eIF5A1 in A549 lung cancer cells

(2013) Catherine A Taylor et al.   Molecular Cancer

Interplay between MEK-ERK signaling, cyclin D1, and cyclin-dependent kinase 5 regulates cell cycle reentry and apoptosis of neurons

(2012) Prashant Kumar Modi et al.   MOLECULAR BIOLOGY OF THE CELL

The Xenopus oocyte: A model for studying the metabolic regulation of cancer cell death

(2012) Leta K. Nutt   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Sir2 histone deacetylase prevents programmed cell death caused by sustained activation of the Hog1 stress-activated protein kinase

(2011) Alexandre Vendrell et al.   EMBO REPORTS

Unfertilized Xenopus Eggs Die by Bad-Dependent Apoptosis under the Control of Cdk1 and JNK

(2011) David Du Pasquier et al.   PLoS One

Transient Activation of the HOG MAPK Pathway Regulates Bimodal Gene Expression

(2011) S. Pelet et al.   SCIENCE

Cross-talk between the p38α and JNK MAPK Pathways Mediated by MAP Kinase Phosphatase-1 Determines Cellular Sensitivity to UV Radiation

(2010) Christopher J. Staples et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Apoptosis signal-regulating kinase 1 and cyclin D1 compose a positive feedback loop contributing to tumor growth in gastric cancer

(2010) Y. Hayakawa et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mutant p53 Disrupts the Stress MAPK Activation Circuit Induced by ASK1-Dependent Stabilization of Daxx

(2009) T. Kitamura et al.   CANCER RESEARCH

Caspases and Kinases in a Death Grip

(2009) Manabu Kurokawa et al.   CELL

p38α- and DYRK1A-dependent phosphorylation of caspase-9 at an inhibitory site in response to hyperosmotic stress

(2009) Anne Seifert et al.   CELLULAR SIGNALLING

ERK and cell death: Mechanisms of ERK-induced cell death - apoptosis, autophagy and senescence

(2009) Sebastien Cagnol et al.   FEBS Journal

MAPK Pathway Activation Delays G2/M Progression by Destabilizing Cdc25B

(2009) Puji Astuti et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Generation of Digital Responses in Stress Sensors

(2009) Tània Martiáñez et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Non-genetic origins of cell-to-cell variability in TRAIL-induced apoptosis

(2009) Sabrina L. Spencer et al.   NATURE

Non-genetic heterogeneity — a mutation-independent driving force for the somatic evolution of tumours

(2009) Amy Brock et al.   NATURE REVIEWS GENETICS

Four-dimensional dynamics of MAPK information-processing systems

(2009) Boris N. Kholodenko et al.   Wiley Interdisciplinary Reviews-Systems Biology and Medicine

Redox control of cell fate by MAP kinase: physiological roles of ASK1-MAP kinase pathway in stress signaling

(2008) Atsushi Matsuzawa et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Ceramide induces p38 MAPK and JNK activation through a mechanism involving a thioredoxin-interacting protein-mediated pathway

(2008) C.-L. Chen et al.   BLOOD

Tumour cell survival signalling by the ERK1/2 pathway

(2008) K Balmanno et al.   CELL DEATH AND DIFFERENTIATION

JNK signaling in apoptosis

(2008) D N Dhanasekaran et al.   ONCOGENE

Feedback Loops Shape Cellular Signals in Space and Time

(2008) O. Brandman et al.   SCIENCE

Activation of c-Jun N-terminal kinase (JNK) by widely used specific p38 MAPK inhibitors SB202190 and SB203580: A MLK-3-MKK7-dependent mechanism

(2007) Harish Muniyappa et al.   CELLULAR SIGNALLING

The BCL-2 protein family: opposing activities that mediate cell death

(2007) Richard J. Youle et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY