MEKK2 and MEKK3 suppress Hedgehog pathway-dependent medulloblastoma by inhibiting GLI1 function

MEKK2 mediates an alternative β-catenin pathway that promotes bone formation

(2016) Matthew Blake Greenblatt et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Targeting GLI factors to inhibit the Hedgehog pathway

(2015) Paola Infante et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Mitogen activated protein kinase kinase kinase 3 (MAP3K3/MEKK3) overexpression is an early event in esophageal tumorigenesis and is a predictor of poor disease prognosis

(2014) Raghibul Hasan et al.   BMC CANCER

Roles for Hedgehog signaling in adult organ homeostasis and repair

(2014) R. Petrova et al.   DEVELOPMENT

Differential regulation of Gli proteins by Sufu in the lung affects PDGF signaling and myofibroblast development

(2014) Chuwen Lin et al.   DEVELOPMENTAL BIOLOGY

SMYD3 links lysine methylation of MAP3K2 to Ras-driven cancer

(2014) Pawel K. Mazur et al.   NATURE

The kinase ALK stimulates the kinase ERK5 to promote the expression of the oncogene MYCN in neuroblastoma

(2014) G. Umapathy et al.   Science Signaling

Context-dependent signal integration by the GLI code: The oncogenic load, pathways, modifiers and implications for cancer therapy

(2014) Fritz Aberger et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Amplification and over-expression ofMAP3K3gene in human breast cancer promotes formation and survival of breast cancer cells

(2013) Yihui Fan et al.   JOURNAL OF PATHOLOGY

The mechanisms of Hedgehog signalling and its roles in development and disease

(2013) James Briscoe et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Synergism between Hedgehog-GLI and EGFR Signaling in Hedgehog-Responsive Human Medulloblastoma Cells Induces Downregulation of Canonical Hedgehog-Target Genes and Stabilized Expression of GLI1

(2013) Frank Götschel et al.   PLoS One

Overexpression of MEKK2 is associated with colorectal carcinogenesis

(2013) LI JIANG et al.   Oncology Letters

MicroRNA-520b Inhibits Growth of Hepatoma Cells by Targeting MEKK2 and Cyclin D1

(2012) Weiying Zhang et al.   PLoS One

Gli Proteins in Development and Disease

(2011) Chi-chung Hui et al.   Annual Review of Cell and Developmental Biology

Mechanism and evolution of cytosolic Hedgehog signal transduction

(2010) C. W. Wilson et al.   DEVELOPMENT

Learning from Jekyll to control Hyde: Hedgehog signaling in development and cancer

(2010) Monique T. Barakat et al.   TRENDS IN MOLECULAR MEDICINE

Mechanisms of Hedgehog pathway activation in cancer and implications for therapy

(2009) Suzie J. Scales et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Hedgehog Signaling in Development and Cancer

(2008) Jin Jiang et al.   DEVELOPMENTAL CELL