Integrity of the Intestinal Barrier: The Involvement of Epithelial Cells and Microbiota—A Mutual Relationship

Tight Junctions as a Key for Pathogens Invasion in Intestinal Epithelial Cells

(2021) Tracy Paradis et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Emc3 maintains intestinal homeostasis by preserving secretory lineages

(2021) Meina Huang et al.   Mucosal Immunology

Human gut-associated lymphoid tissues (GALT); diversity, structure, and function

(2021) Urs M. Mörbe et al.   Mucosal Immunology

An intercrypt subpopulation of goblet cells is essential for colonic mucus barrier function

(2021) Elisabeth E. L. Nyström et al.   SCIENCE

Epithelial Toll-like receptors and their role in gut homeostasis and disease

(2020) Juan F. Burgueño et al.   Nature Reviews Gastroenterology & Hepatology

Gut stem cell aging is driven by mTORC1 via a p38 MAPK-p53 pathway

(2020) Dan He et al.   Nature Communications

Function of Akkermansia muciniphila in Obesity: Interactions With Lipid Metabolism, Immune Response and Gut Systems

(2020) Yu Xu et al.   Frontiers in Microbiology

Targeting desmosomal adhesion and signalling for intestinal barrier stabilization in inflammatory bowel diseases—Lessons from experimental models and patients

(2020) Nicolas Schlegel et al.   Acta Physiologica

The Role of the Gastrointestinal Mucus System in Intestinal Homeostasis: Implications for Neurological Disorders

(2020) Madushani Herath et al.   Frontiers in Cellular and Infection Microbiology

Metaplastic Paneth Cells in Extra-Intestinal Mucosal Niche Indicate a Link to Microbiome and Inflammation

(2020) Rajbir Singh et al.   Frontiers in Physiology

The Paneth Cell: The Curator and Defender of the Immature Small Intestine

(2020) Shiloh R. Lueschow et al.   Frontiers in Immunology

Plasticity of Paneth cells and their ability to regulate intestinal stem cells

(2020) Xianglin Mei et al.   Stem Cell Research & Therapy

Mucus barrier, mucins and gut microbiota: the expected slimy partners?

(2020) Paola Paone et al.   GUT

Mucins in Intestinal Mucosal Defense and Inflammation: Learning From Clinical and Experimental Studies

(2020) Jensine A. Grondin et al.   Frontiers in Immunology

Tight Junction Proteins and Signaling Pathways in Cancer and Inflammation: A Functional Crosstalk

(2019) Ajaz A. Bhat et al.   Frontiers in Physiology

Paneth cell granule dynamics on secretory responses to bacterial stimuli in enteroids

(2019) Yuki Yokoi et al.   Scientific Reports

Paneth cell α-defensins HD-5 and HD-6 display differential degradation into active antimicrobial fragments

(2019) D. Ehmann et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Transforming Growth Factor-β Signaling in Immunity and Cancer

(2019) Eduard Batlle et al.   IMMUNITY

Mucus and mucins in diseases of the intestinal and respiratory tracts

(2019) G. C. Hansson   JOURNAL OF INTERNAL MEDICINE

Notum produced by Paneth cells attenuates regeneration of aged intestinal epithelium

(2019) Nalle Pentinmikko et al.   NATURE

Intrinsic Control of Surface Immune and Epithelial Homeostasis by Tissue-Resident Gut Stromal Cells

(2019) Yosuke Kurashima et al.   Frontiers in Immunology

Claudin Family Participates in the Pathogenesis of Inflammatory Bowel Diseases and Colitis-Associated Colorectal Cancer

(2019) Liguo Zhu et al.   Frontiers in Immunology

M Cells: Intelligent Engineering of Mucosal Immune Surveillance

(2019) Andrea Dillon et al.   Frontiers in Immunology

Epithelial Cells as a Transmitter of Signals From Commensal Bacteria and Host Immune Cells

(2019) Yoshiyuki Goto   Frontiers in Immunology

Lypd8 inhibits attachment of pathogenic bacteria to colonic epithelia

(2019) Ryu Okumura et al.   Mucosal Immunology

The Roles of Peyer's Patches and Microfold Cells in the Gut Immune System: Relevance to Autoimmune Diseases

(2019) Nobuhide Kobayashi et al.   Frontiers in Immunology

Paneth Cell Multipotency Induced by Notch Activation following Injury

(2018) Shiyan Yu et al.   Cell Stem Cell

Interpreting heterogeneity in intestinal tuft cell structure and function

(2018) Amrita Banerjee et al.   JOURNAL OF CLINICAL INVESTIGATION

Innate Recognition of the Microbiota by TLR1 Promotes Epithelial Homeostasis and Prevents Chronic Inflammation

(2018) Karishma Kamdar et al.   JOURNAL OF IMMUNOLOGY

The Intestinal Epithelium: Central Coordinator of Mucosal Immunity

(2018) Joannie M. Allaire et al.   TRENDS IN IMMUNOLOGY

The Role of the Polymeric Immunoglobulin Receptor and Secretory Immunoglobulins during Mucosal Infection and Immunity

(2018) Holly Turula et al.   Viruses-Basel

Regulation of Intestinal Epithelial Cells Properties and Functions by Amino Acids

(2018) Shanshan Kong et al.   Biomed Research International

Calcium-activated Chloride Channel Regulator 1 (CLCA1) Controls Mucus Expansion in Colon by Proteolytic Activity

(2018) Elisabeth E.L. Nyström et al.   EBioMedicine

A Map of Toll-like Receptor Expression in the Intestinal Epithelium Reveals Distinct Spatial, Cell Type-Specific, and Temporal Patterns

(2018) April E. Price et al.   IMMUNITY

Desmoglein 2, but not desmocollin 2, protects intestinal epithelia from injury

(2018) Annika Gross et al.   Mucosal Immunology

Paneth Cells Respond to Inflammation and Contribute to Tissue Regeneration by Acquiring Stem-like Features through SCF/c-Kit Signaling

(2018) Mark Schmitt et al.   Cell Reports

Tight Junction in the Intestinal Epithelium: Its Association with Diseases and Regulation by Phytochemicals

(2018) Bonggi Lee et al.   Journal of Immunology Research

Fight them or feed them: how the intestinal mucus layer manages the gut microbiota

(2018) Bjoern O Schroeder   Gastroenterology Report

Surface Toll-like receptor 3 expression in metastatic intestinal epithelial cells induces inflammatory cytokine production and promotes invasiveness

(2017) Marit Bugge et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

R-Spondin1 expands Paneth cells and prevents dysbiosis induced by graft-versus-host disease

(2017) Eiko Hayase et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Interplay between metabolic identities in the intestinal crypt supports stem cell function

(2017) Maria J. Rodríguez-Colman et al.   NATURE

High-avidity IgA protects the intestine by enchaining growing bacteria

(2017) Kathrin Moor et al.   NATURE

Resistin-like molecule β is a bactericidal protein that promotes spatial segregation of the microbiota and the colonic epithelium

(2017) Daniel C. Propheter et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cell Biology of Tight Junction Barrier Regulation and Mucosal Disease

(2017) Aaron Buckley et al.   Cold Spring Harbor Perspectives in Biology

Role of TLR1, TLR2 and TLR6 in the modulation of intestinal inflammation and Candida albicans elimination

(2017) Laura Choteau et al.   Gut Pathogens

Canonical Wnt Signaling Ameliorates Aging of Intestinal Stem Cells

(2017) Kodandaramireddy Nalapareddy et al.   Cell Reports

Breathless in the Gut: Implications of Luminal O 2 for Microbial Pathogenicity

(2016) Caleb J. Kelly et al.   Cell Host & Microbe

Depletion of Butyrate-Producing Clostridia from the Gut Microbiota Drives an Aerobic Luminal Expansion of Salmonella

(2016) Fabian Rivera-Chávez et al.   Cell Host & Microbe

Lypd8 promotes the segregation of flagellated microbiota and colonic epithelia

(2016) Ryu Okumura et al.   NATURE

A purified membrane protein from Akkermansia muciniphila or the pasteurized bacterium improves metabolism in obese and diabetic mice

(2016) Hubert Plovier et al.   NATURE MEDICINE

Tight junctions: from simple barriers to multifunctional molecular gates

(2016) Ceniz Zihni et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Promotion of Intestinal Epithelial Cell Turnover by Commensal Bacteria: Role of Short-Chain Fatty Acids

(2016) Jung-ha Park et al.   PLoS One

Gram-positive bacteria are held at a distance in the colon mucus by the lectin-like protein ZG16

(2016) Joakim H. Bergström et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A sentinel goblet cell guards the colonic crypt by triggering Nlrp6-dependent Muc2 secretion

(2016) G. M. H. Birchenough et al.   SCIENCE

Tight junctions in inflammatory bowel diseases and inflammatory bowel disease associated colorectal cancer

(2016) Jonathan Landy et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Nod2: A Critical Regulator of Ileal Microbiota and Crohn’s Disease

(2016) Tabasum Sidiq et al.   Frontiers in Immunology

Sodium Butyrate Induces Endoplasmic Reticulum Stress and Autophagy in Colorectal Cells: Implications for Apoptosis

(2016) Jintao Zhang et al.   PLoS One

Normalization of Host Intestinal Mucus Layers Requires Long-Term Microbial Colonization

(2015) Malin E.V. Johansson et al.   Cell Host & Microbe

Intestinal E-cadherin Deficiency Aggravates Dextran Sodium Sulfate-Induced Colitis

(2015) Jessica I. Grill et al.   DIGESTIVE DISEASES AND SCIENCES

New developments in goblet cell mucus secretion and function

(2015) G M H Birchenough et al.   Mucosal Immunology

Notum deacylates Wnt proteins to suppress signalling activity

(2015) Satoshi Kakugawa et al.   NATURE

Global Profiling of Carbohydrate Active Enzymes in Human Gut Microbiome

(2015) Tanudeep Bhattacharya et al.   PLoS One

Paneth cells

(2014) Johan H. van Es et al.   CURRENT BIOLOGY

Intestinal Epithelial Cell Toll-like Receptor 5 Regulates the Intestinal Microbiota to Prevent Low-Grade Inflammation and Metabolic Syndrome in Mice

(2014) Benoit Chassaing et al.   GASTROENTEROLOGY

The mucus and mucins of the goblet cells and enterocytes provide the first defense line of the gastrointestinal tract and interact with the immune system

(2014) Thaher Pelaseyed et al.   IMMUNOLOGICAL REVIEWS

Paneth cell extrusion and release of antimicrobial products is directly controlled by immune cell–derived IFN-γ

(2014) Henner F. Farin et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Interleukin-13-Mediated Paneth Cell Degranulation and Antimicrobial Peptide Release

(2014) Silvia Stockinger et al.   Journal of Innate Immunity

Microbial-induced meprin   cleavage in MUC2 mucin and a functional CFTR channel are required to release anchored small intestinal mucus

(2014) A. Schutte et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tight junctions and the regulation of gene expression

(2014) Lorenza González-Mariscal et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

TLR-Dependent Human Mucosal Epithelial Cell Responses to Microbial Pathogens

(2014) Ryan McClure et al.   Frontiers in Immunology

CD4+T Cells Drive Goblet Cell Depletion during Citrobacter rodentium Infection

(2013) Justin M. Chan et al.   INFECTION AND IMMUNITY

Development of a primary mouse intestinal epithelial cell monolayer culture system to evaluate factors that modulate IgA transcytosis

(2013) C Moon et al.   Mucosal Immunology

Microfold (M) cells: important immunosurveillance posts in the intestinal epithelium

(2013) N A Mabbott et al.   Mucosal Immunology

The gastrointestinal mucus system in health and disease

(2013) Malin E. V. Johansson et al.   Nature Reviews Gastroenterology & Hepatology

The gut microbiota — masters of host development and physiology

(2013) Felix Sommer et al.   NATURE REVIEWS MICROBIOLOGY

Host-Derived Nitrate Boosts Growth of E. coli in the Inflamed Gut

(2013) S. E. Winter et al.   SCIENCE

Toll-like receptor signaling and regulation of intestinal immunity

(2013) Karishma Kamdar et al.   Virulence

Lamellar Structures of MUC2-Rich Mucin: A Potential Role in Governing the Barrier and Lubricating Functions of Intestinal Mucus

(2012) Andrew N. Round et al.   BIOMACROMOLECULES

Graft-versus-host disease disrupts intestinal microbial ecology by inhibiting Paneth cell production of  -defensins

(2012) Y. Eriguchi et al.   BLOOD

Transient Inability to Manage Proteobacteria Promotes Chronic Gut Inflammation in TLR5-Deficient Mice

(2012) Frederic A. Carvalho et al.   Cell Host & Microbe

Regulation of intestinal epithelial permeability by tight junctions

(2012) Takuya Suzuki   CELLULAR AND MOLECULAR LIFE SCIENCES

A comprehensive summary of LL-37, the factotum human cathelicidin peptide

(2012) Dieter Vandamme et al.   CELLULAR IMMUNOLOGY

Butyrate Enhances Intestinal Epithelial Barrier Function via Up-Regulation of Tight Junction Protein Claudin-1 Transcription

(2012) Hong-Bo Wang et al.   DIGESTIVE DISEASES AND SCIENCES

Alternative Luminal Activation Mechanisms for Paneth Cell α-Defensins

(2012) Jennifer R. Mastroianni et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Resident and pro-inflammatory macrophages in the colon represent alternative context-dependent fates of the same Ly6Chi monocyte precursors

(2012) C C Bain et al.   Mucosal Immunology

Goblet cells deliver luminal antigen to CD103+ dendritic cells in the small intestine

(2012) Jeremiah R. McDole et al.   NATURE

Parasite-induced TH1 cells and intestinal dysbiosis cooperate in IFN-γ-dependent elimination of Paneth cells

(2012) Megan Raetz et al.   NATURE IMMUNOLOGY

Calcium and pH-dependent packing and release of the gel-forming MUC2 mucin

(2012) D. Ambort et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Gut stem cells in tissue renewal and disease: methods, markers, and myths

(2012) Pamela Rizk et al.   Wiley Interdisciplinary Reviews-Systems Biology and Medicine

Mucosal Immune System and M Cell-targeting Strategies for Oral Mucosal Vaccination

(2012) Sae-Hae Kim et al.   Immune Network

Notch signaling modulates proliferation and differentiation of intestinal crypt base columnar stem cells

(2011) K. L. VanDussen et al.   DEVELOPMENT

Increasing Incidence and Prevalence of the Inflammatory Bowel Diseases With Time, Based on Systematic Review

(2011) Natalie A. Molodecky et al.   GASTROENTEROLOGY

Reduced Paneth cell antimicrobial protein levels correlate with activation of the unfolded protein response in the gut of obese individuals

(2011) Caroline M Hodin et al.   JOURNAL OF PATHOLOGY

Loss of desmocollin-2 confers a tumorigenic phenotype to colonic epithelial cells through activation of Akt/β-catenin signaling

(2011) Keli Kolegraff et al.   MOLECULAR BIOLOGY OF THE CELL

Regulation of the polymeric immunoglobulin receptor by the classical and alternative NF-κB pathways in intestinal epithelial cells

(2011) M E C Bruno et al.   Mucosal Immunology

Importance and regulation of the colonic mucus barrier in a mouse model of colitis

(2010) J. Petersson et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Caveolin-1–dependent occludin endocytosis is required for TNF-induced tight junction regulation in vivo

(2010) Amanda M. Marchiando et al.   JOURNAL OF CELL BIOLOGY

Paneth cells constitute the niche for Lgr5 stem cells in intestinal crypts

(2010) Toshiro Sato et al.   NATURE

A Key Role for E-cadherin in Intestinal Homeostasis and Paneth Cell Maturation

(2010) Marlon R. Schneider et al.   PLoS One

The two mucus layers of colon are organized by the MUC2 mucin, whereas the outer layer is a legislator of host-microbial interactions

(2010) M. E. V. Johansson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

SAM pointed domain ETS factor (SPDEF) regulates terminal differentiation and maturation of intestinal goblet cells

(2009) Taeko K. Noah et al.   EXPERIMENTAL CELL RESEARCH

The Ets-Domain Transcription Factor Spdef Promotes Maturation of Goblet and Paneth Cells in the Intestinal Epithelium

(2009) Alex Gregorieff et al.   GASTROENTEROLOGY

α-Defensins in Enteric Innate Immunity

(2009) Jennifer R. Mastroianni et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Uptake through glycoprotein 2 of FimH+ bacteria by M cells initiates mucosal immune response

(2009) Koji Hase et al.   NATURE

Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche

(2009) Toshiro Sato et al.   NATURE

Inflammatory Bowel Disease

(2009) Clara Abraham et al.   NEW ENGLAND JOURNAL OF MEDICINE

Genetic Variants of Wnt Transcription Factor TCF-4 (TCF7L2) Putative Promoter Region Are Associated with Small Intestinal Crohn's Disease

(2009) Maureen J. Koslowski et al.   PLoS One

Adherens Junction: Molecular Architecture and Regulation

(2009) W. Meng et al.   Cold Spring Harbor Perspectives in Biology

Barrier properties of mucus

(2008) Richard A. Cone   ADVANCED DRUG DELIVERY REVIEWS

Stem Cells, Self-Renewal, and Differentiation in the Intestinal Epithelium

(2008) Laurens G. van der Flier et al.   Annual Review of Physiology

Tight junctions and the regulation of gene expression

(2008) Maria S. Balda et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

XBP1 Links ER Stress to Intestinal Inflammation and Confers Genetic Risk for Human Inflammatory Bowel Disease

(2008) Arthur Kaser et al.   CELL

A key role for autophagy and the autophagy gene Atg16l1 in mouse and human intestinal Paneth cells

(2008) Ken Cadwell et al.   NATURE

Paneth cells directly sense gut commensals and maintain homeostasis at the intestinal host-microbial interface

(2008) S. Vaishnava et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The inner of the two Muc2 mucin-dependent mucus layers in colon is devoid of bacteria

(2008) M. E. V. Johansson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA