Article
Hematology
Daniela Weber, Markus Weber, Elisabeth Meedt, Sakhila Ghimire, Daniel Wolff, Matthias Edinger, Hendrik Poeck, Andreas Hiergeist, Andre Gessner, Francis Ayuk, Wolf Roesler, Matthias Woel, Sabrina Kraus, Robert Zeiser, Hannah Bertrand, Peter Bader, Evelyn Ullrich, Matthias Eder, Sigrun Gleich, Rachel Young, Wolfgang Herr, John E. Levine, James L. M. Ferrara, Ernst Holler
Summary: Intestinal microbiome diversity is crucial in acute GI GVHD and ASCT outcomes. Reg3 alpha concentration on the day of ASCT correlates with clinical data and indicators of intestinal microbiome diversity. High Reg3 alpha concentration predicts higher 1-year TRM and is an independent prognostic factor. Evaluating Reg3 alpha levels can help assess the risk for TRM in ASCT recipients.
Review
Cell Biology
Erpeng Yang, Jun Shen
Summary: Paneth cells play critical roles in controlling gut microbiota and maintaining intestinal homeostasis by secreting alpha-defensins. Inflammatory bowel disease, including Crohn's disease, is closely related to Paneth cells, which are identified as the central element of the pathogenesis.
CELL PROLIFERATION
(2021)
Article
Cell Biology
Michaela Quintero, Siyang Liu, Yanhua Xia, Yonghong Huang, Yi Zou, Ge Li, Ling Hu, Nagendra Singh, Richard Blumberg, Yafei Cai, Hong Xu, Honglin Li
Summary: Cdk5rap3 plays a key role in the development and maintenance of Paneth cells in the intestine, with its deficiency leading to early embryonic lethality and increased susceptibility to colitis. The protein is highly expressed in mature Paneth cells and is crucial for the fate specification of these cells.
CELL DEATH & DISEASE
(2021)
Article
Immunology
Pradeep K. Shukla, Roshan G. Rao, Avtar S. Meena, Francesco Giorgianni, Sue Chin Lee, Preeti Raju, Nitesh Shashikanth, Chandra Shekhar, Sarka Beranova, Louisa Balazs, Gabor Tigyi, Ankush Gosain, Radhakrishna Rao
Summary: This study demonstrates that radiation induces dysfunction of Paneth cells in the intestine, and feeding HD5 prevents and mitigates radiation-induced intestinal mucosal injury, endotoxemia, and systemic inflammation.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Multidisciplinary Sciences
Ana Sofia Rocha, Alejandro Collado-Sole, Osvaldo Grana-Castro, Jaime Redondo-Pedraza, Gonzalo Soria-Alcaide, Alex Cordero, Patricia G. Santamaria, Eva Gonzalez-Suarez
Summary: The Rank signaling pathway plays a crucial role in mammary gland homeostasis and epithelial cell differentiation. Loss of luminal Rank leads to abnormal alveolar differentiation and lactation failure, which can be restored by activating bipotency in basal cells during subsequent pregnancies.
NATURE COMMUNICATIONS
(2023)
Article
Biochemistry & Molecular Biology
M. J. Watson, P. L. Berger, K. Banerjee, S. B. Frank, L. Tang, S. S. Ganguly, G. Hostetter, M. Winn, C. K. Miranti
Summary: The study found that CREB1 plays a key role in maintaining luminal cell survival and that oncogenesis changes the CREB1-induced transcriptome. ING4 and JFK were identified as transcriptional targets of CREB1 in luminal cells. Oncogenic suppression of PTEN results in constitutive activation of CREB1, blocking CREB1 suppresses tumor growth. This is the first study to define the molecular mechanism where loss of PTEN in cancer leads to aberrant CREB1 activation and suppression of ING4 expression impacting luminal cell differentiation.
Article
Medicine, General & Internal
Ulvi Kahraman Gursoy, Mervi Gursoy, Anna Liukkonen, Anna Liisa Suominen, Eija Kononen
Summary: The aim of this study was to examine the levels of human beta-defensin 1-3 and human neutrophil peptide 1 (HNP-1) in the saliva of elderly individuals, in order to establish the extent of periodontal disease and tooth loss. The results showed that salivary HNP-1 levels were significantly higher in individuals with periodontal disease. The association between salivary HNP-1 levels and the number of pocket teeth remained significant after adjusting for various factors.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Chemistry, Organic
Chao Hong, Shuling Yu, Zhanxiang Liu, Yuhong Zhang
Summary: A coupling reaction of acrylic acids/benzoic acids with alpha-diazocarbonyl compounds has been achieved using a combined catalytic system of rhodium catalyst and Zn(OAc)(2) additive. The presence of Zn(OAc)(2) facilitates the C(sp(2))-H activation and disrupts the formation of carboxylic ester via nucleophilic O-H insertion to metal carbenoid. This method offers mild reaction conditions and broad substrate scope, providing a convenient and direct approach for the synthesis of alpha-pyrones and isocoumarins without the need for carboxylic acid transformation to amides.
Article
Medicine, Research & Experimental
Kathrin Liszt, Qiaoling Wang, Mona Farhadipour, Anneleen Segers, Theo Thijs, Linda Nys, Ellen Deleus, Bart van der Schueren, Christopher Gerner, Benjamin Neuditschko, Laurens J. Ceulemans, Matthias Lannoo, Jan Tack, Inge Depoortere
Summary: Taste 2 receptors (TAS2Rs) in the human gut play a key role in detecting potentially toxic food. The study found that human jejunal crypts, especially in individuals with obesity, respond to bitter substances by releasing antimicrobial peptides and regulating other immune factors that affect the growth of E. coli. The study also identified the role of TAS2R43 in the effects of aloin on E. coli growth and mucus glycoprotein release. Additionally, the study revealed the potential of TAS2Rs as a target for treating diseases related to the immune system and body weight control.
JOURNAL OF CLINICAL INVESTIGATION
(2022)
Article
Biochemistry & Molecular Biology
Jamal Elhasnaoui, Giulio Ferrero, Valentina Miano, Lorenzo Franchitti, Isabella Tarulli, Lucia Coscujuela Tarrero, Santina Cutrupi, Michele De Bortoli
Summary: This study found that ESRP1 is overexpressed in breast cancer patients, particularly in luminal BCs, and is correlated with estrogen receptor alpha levels. Analysis of genome-binding profiles revealed that ER alpha regulates the expression of ESRP1 and ESRP2 genes. Knocking down ESRP1/2 led to dysregulation of 754 genes, including alterations in alternative splicing events involved in cell signaling, metabolism, cell growth, and EMT. Functional network analysis identified RAC1 as the hub node affected by ESRP1/2 silencing in ER alpha+ BCs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Shuwen Wu, Yuan Zhang, Jingchang Ma, Yongming Liu, Wenpeng Li, Tingting Wang, Xuexue Xu, Yuling Wang, Kun Cheng, Ran Zhuang
Summary: This study reveals the important role of IL-6 in mucosal immune cells and its interaction with gut microbiota. IL-6 loss can alter the composition of gut microbiota and affect the maintenance of immune cells, triggering mucosal immune response.
Article
Multidisciplinary Sciences
Yalong Wang, Kaixin He, Baifa Sheng, Xuqiu Lei, Wanyin Tao, Xiaoliang Zhu, Zheng Wei, Rongjie Fu, Anlei Wang, Shengdan Bai, Zhao Zhang, Na Hong, Chao Ye, Ye Tian, Jun Wang, Mingsong Li, Kaiguang Zhang, Lin Li, Hua Yang, Hua-Bing Li, Richard A. Flavell, Shu Zhu
Summary: RNA helicases play important roles in immune responses and antimicrobial reactions, with in vivo studies demonstrating the involvement of Dhx15 in intestinal antibacterial responses and colitis. The findings help to identify the regulatory mechanisms of Dhx15 in intestinal inflammation and antimicrobial responses.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Medicine, Research & Experimental
Lingxiao Huang, Zhenni Xu, Xudan Lei, Yujun Huang, Siyu Tu, Lu Xu, Jieying Xia, Dengqun Liu
Summary: This study reveals the important role of inducible nitric oxide synthase (iNOS) in the intestinal crypts and its effects on intestinal stem cell (ISC) proliferation and differentiation. iNOS deficiency leads to morphological changes in the intestine and alters gluconeogenesis and the adaptive immune response. These findings highlight the potential of iNOS as a therapeutic target for intestinal disorders.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Iyshwarya Balasubramanian, Sheila Bandyopadhyay, Juan Flores, Jared Bianchi-Smak, Xiang Lin, Haoran Liu, Shengxiang Sun, Natasha B. Golovchenko, Yue Liu, Dahui Wang, Radha Patel, Ivor Joseph, Panan Suntornsaratoon, Justin Vargas, Peter H. R. Green, Govind Bhagat, Stephen M. Lagana, Wang Ying, Yi Zhang, Zhihan Wang, Wei Vivian Li, Sukhwinder Singh, Zhongren Zhou, George Kollias, Laura A. Farr, Shannon N. Moonah, Shiyan Yu, Zhi Wei, Edward M. Bonder, Lanjing Zhang, Pawel R. Kiela, Karen L. Edelblum, Ronaldo Ferraris, Ta-Chiang Liu, Nan Gao
Summary: Paneth cells play a crucial role in host responses to microbiome and environmental stresses. Infection can modify the composition of Paneth cells and affect inflammation and disease progression.
Article
Oncology
Qiao Qiao, Ruixia Bai, Wanying Song, Haining Gao, Minyu Zhang, Jingkun Lu, Mei Hong, Xuan Zhang, Peng Sun, Qian Zhang, Pengwei Zhao
Summary: DEFA5 expression is decreased in colon cancer, and its overexpression inhibits proliferation and metastasis of colon cancer cells, suggesting a potential tumor suppressor role.
EXPERIMENTAL CELL RESEARCH
(2021)
Article
Biochemical Research Methods
Qunyuan Zhang, Haley Abel, Alan Wells, Petra Lenzini, Felicia Gomez, Michael A. Province, Alan A. Templeton, George M. Weinstock, Nita H. Salzman, Ingrid B. Borecki
Article
Cell Biology
Jennifer A. Bartlett, David K. Meyerholz, Christine L. Wohlford-Lenane, Paul W. Naumann, Nita H. Salzman, Paul B. McCray
DISEASE MODELS & MECHANISMS
(2015)
Article
Immunology
Avijit Ray, Sreemanti Basu, Raad Z. Gharaibeh, Lydia C. Cook, Ranjit Kumar, Elliot J. Lefkowitz, Catherine R. Walker, Casey D. Morrow, Craig L. Franklin, Terrence L. Geiger, Nita H. Salzman, Anthony Fodor, Bonnie N. Dittel
JOURNAL OF IMMUNOLOGY
(2015)
Article
Multidisciplinary Sciences
Sushma Kommineni, Daniel J. Bretl, Vy Lam, Rajrupa Chakraborty, Michael Hayward, Pippa Simpson, Yumei Cao, Pavlos Bousounis, Christopher J. Kristich, Nita H. Salzman
Article
Immunology
B. Gurram, N. H. Salzman, M. L. Kaldunski, S. Jia, B. U. K. Li, M. Stephens, M. R. Sood, M. J. Hessner
CLINICAL AND EXPERIMENTAL IMMUNOLOGY
(2016)
Article
Immunology
Dipica Haribhai, Jennifer Ziegelbauer, Shuang Jia, Kyle Upchurch, Ke Yan, Erica G. Schmitt, Nita H. Salzman, Pippa Simpson, Martin J. Hessner, Talal A. Chatila, Calvin B. Williams
JOURNAL OF IMMUNOLOGY
(2016)
Article
Gastroenterology & Hepatology
Bhaskar Gurram, Erin Hammelev, Grant Syverson, Dipica Haribhai, Key Yan, Pippa Simpson, Nita Salzman, James W. Verbsky
JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION
(2016)
Article
Oncology
Pan Pan, Vy Lam, Nita Salzman, Yi-Wen Huang, Jianhua Yu, Jianying Zhang, Li-Shu Wang
NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL
(2017)
Review
Allergy
Nita H. Salzman
ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY
(2014)
Article
Pediatrics
Nisreen Rumman, Mutaz Sultan, Khalil El-Chammas, Vi Goh, Nita Salzman, Diana Quintero, Steven Werlin
Review
Microbiology
Leou Ismael Banla, Nita H. Salzman, Christopher J. Kristich
CURRENT OPINION IN MICROBIOLOGY
(2019)
Article
Immunology
Leou Ismael Banla, Adam M. Pickrum, Michael Hayward, Christopher J. Kristich, Nita H. Salzman
INFECTION AND IMMUNITY
(2019)
Article
Immunology
Xiaopeng Wu, Achia Khatun, Moujtaba Y. Kasmani, Yao Chen, Shikan Zheng, Samantha Atkinson, Christine Nguyen, Robert Burns, Elizabeth J. Taparowsky, Nita H. Salzman, Timothy W. Hand, Weiguo Cui
Summary: This study reveals that BATF is a key factor in maintaining the stability of ILC3s in the gut and in coordinating ILC3-mediated control of intestinal homeostasis. Depletion of BATF in ILC3s leads to excessive interferon-gamma production, dysbiosis, aberrant T cell immune responses, and spontaneous inflammatory bowel disease.
JOURNAL OF EXPERIMENTAL MEDICINE
(2022)
Article
Medicine, Research & Experimental
Tatsuya Dokoshi, Jason S. Seidman, Kellen J. Cavagnero, Fengwu Li, Marc C. Liggins, Bryn C. Taylor, Jocelyn Olvera, Rob Knight, John T. Chang, Nita H. Salzman, Richard L. Gallo
Summary: This study revealed that intestinal inflammation can promote the differentiation of intestinal stromal fibroblasts into preadipocytes with innate antimicrobial activity, and this process may be exacerbated by skin inflammation in mice. The activation of hyaluronan catabolism during skin injury was found to alter colon fibroblast function and promote excessive reactive adipogenesis, linking skin and colon inflammation through the release of hyaluronan.
JOURNAL OF CLINICAL INVESTIGATION
(2021)
Article
Medicine, Research & Experimental
Jasmohan S. Bajaj, Nita Salzman, Chathur Acharya, Hajime Takei, Genta Kakiyama, Andrew Fagan, Melanie B. White, Edith A. Gavis, Mary L. Holtz, Michael Hayward, Hiroshi Nittono, Phillip B. Hylemon, I. Jane Cox, Roger Williams, Simon D. Taylor-Robinson, Richard K. Sterling, Scott C. Matherly, Michael Fuchs, Hannah Lee, Puneet Puri, R. Todd Stravitz, Arun J. Sanyal, Lola Ajayi, Adrien Le Guennec, R. Andrew Atkinson, Mohammad S. Siddiqui, Velimir Luketic, William M. Pandak, Masoumeh Sikaroodi, Patrick M. Gillevet
