Review
Oncology
Lu Zhang, Binyu Sun, Xi Zhou, QiongQiong Wei, Sicheng Liang, Gang Luo, Tao Li, Muhan Lu
Summary: This article briefly describes the etiology and clinical significance of intestinal metaplasia in Barrett's esophagus, as well as its impact on diagnosis, monitoring, and treatment according to different guidelines. The basis for endoscopic diagnosis and identification techniques of goblet cells in Barrett's esophagus are explored, along with current treatment methods related to the condition.
FRONTIERS IN ONCOLOGY
(2021)
Review
Medicine, General & Internal
Peter M. M. Stawinski, Karolina N. N. Dziadkowiec, Lily A. A. Kuo, Juan Echavarria, Shreyas Saligram
Summary: Barrett's esophagus (BE) is a premalignant mucosal transformation characterized by the replacement of esophageal squamous epithelium with metaplastic columnar epithelium. It is associated with an increased risk of esophageal adenocarcinoma and is often caused by gastroesophageal reflux disease. Screening for BE is selective based on risk factors and is not recommended for the general population. Diagnosis involves endoscopic recognition, targeted biopsies, and histologic confirmation of columnar metaplasia. This review provides a comprehensive overview of the epidemiology, pathogenesis, screening, and advanced techniques for detecting and eradicating Barrett's esophagus.
Article
Genetics & Heredity
Nandan P. Deshpande, Stephen M. Riordan, Claire J. Gorman, Shaun Nielsen, Tonia L. Russell, Carolina Correa-Ospina, Bentotage S. M. Fernando, Shafagh A. Waters, Natalia Castano-Rodriguez, Si Ming Man, Nicodemus Tedla, Marc R. Wilkins, Nadeem O. Kaakoush
Summary: This study comprehensively assessed the esophageal microenvironment in patients with gastro-esophageal reflux disease and metaplasia, identifying bacterial strain-specific signatures with high relevance to disease progression.
Article
Microbiology
Maria Naama, Shahar Telpaz, Aya Awad, Shira Ben-Simon, Sarina Harshuk-Shabso, Sonia Modilevsky, Elad Rubin, Jasmin Sawaed, Lilach Zelik, Mor Zigdon, Nofar Asulin, Sondra Turjeman, Michal Werbner, Supapit Wongkuna, Rachel Feeney, Bjoern O. Schroeder, Abraham Nyska, Meital Nuriel-Ohayon, Shai Bel
Summary: Colonic goblet cells secrete mucus to protect against bacterial invasion and inflammation. Activation of autophagy in mice via Beclin 1 reduces endoplasmic reticulum (ER) stress, leading to thicker and less penetrable mucus production. This ER-stress-mediated regulation of mucus secretion is dependent on the microbiota and the Nod2 gene, and it plays a critical role in maintaining intestinal homeostasis.
CELL HOST & MICROBE
(2023)
Review
Medicine, General & Internal
Maja Mejza, Ewa Malecka-Wojciesko
Summary: Barrett's esophagus is a precancerous condition of the esophagus, characterized by a salmon-colored lining and the presence of columnar epithelium with goblet cells. It is associated with esophageal adenocarcinoma, a tumor with poor survival rates and increasing incidence. The diagnosis and management of Barrett's esophagus remain a topic of ongoing debate. This article provides an overview of current recommendations and new discoveries in this field.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Gastroenterology & Hepatology
Harshabad Singh, Kyungsik Ha, Jason L. Hornick, Shariq Madha, Paloma Cejas, Kunal Jajoo, Pratik Singh, Paz Polak, Hwajin Lee, Ramesh A. Shivdasani
Summary: The study found that Barrett's esophagus has epigenome fingerprints of both stomach and intestinal characteristics, with individual cells expressing genes from both tissues. This reflects simultaneous chromatin access at enhancers, leading to tissue and subclonal heterogeneity in cell states.
Article
Gastroenterology & Hepatology
Christine N. Noto, Stella G. Hoft, Kevin A. Bockerstett, Nicholas M. Jackson, Eric L. Ford, Luke S. Vest, Richard J. DiPaolo
Summary: The study identified six unique subsets of IL13-producing immune cells in inflamed stomachs and found that IL13 can directly induce a metaplastic phenotype in gastric epithelial cells. Neutralization of IL13 can reduce the severity of metaplasia during chronic gastritis.
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Article
Gastroenterology & Hepatology
Qiuyang Zhang, Ajay Bansal, Kerry B. Dunbar, Yan Chang, Jianning Zhang, Uthra Balaji, Jinghua Gu, Xi Zhang, Eitan Podgaetz, Zui Pan, Stuart Jon Spechler, Rhonda F. Souza
Summary: Reflux-induced epithelial-mesenchymal plasticity (EMP) may play a role in the development of subsquamous intestinal metaplasia (SSIM) in Barrett's esophagus (BE), potentially allowing Barrett's cells to migrate underneath squamous epithelium. This phenomenon could contribute to the formation of Barrett's cancers that escape detection by endoscopic surveillance and recurrences of Barrett's metaplasia following endoscopic eradication therapy.
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
(2022)
Article
Environmental Sciences
Chenbin Cui, Xinru Wang, Yao Zheng, Lindeng Li, Fangke Wang, Hongkui Wei, Jian Peng
Summary: A study found that treatment with deoxynivalenol (DON) reduced the number of Paneth cells in mouse intestines. However, disrupting Paneth cells using dithizone worsened intestinal injury and affected intestinal stem cells and microbiota in DON-treated mice. Surprisingly, the number of goblet cells and proliferative cells increased after treatment with dithizone and DON.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Surgery
Colin P. Dunn, Justin C. Henning, Jason A. Sterris, Paul Won, Caitlin Houghton, Nikolai A. Bildzukewicz, John C. Lipham
Summary: This retrospective study evaluated the effectiveness of MSA for Barrett's esophagus patients, showing significant reduction in Barrett's length and prevention of progression to dysplasia or neoplasia. The results remained consistent after 2 years of follow-up.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2021)
Review
Biochemistry & Molecular Biology
Ksenia Maslenkina, Liudmila Mikhaleva, Maxim Naumenko, Rositsa Vandysheva, Michail Gushchin, Dmitri Atiakshin, Igor Buchwalow, Markus Tiemann
Summary: Barrett's esophagus (BE) is a premalignant lesion that can develop into esophageal adenocarcinoma (EAC). The development of BE is caused by biliary reflux and involves various stem cell origins. The concept of healing has been replaced by the cytokine storm and inflammatory microenvironment, leading to intestinal metaplasia. This review discusses the roles of molecular pathways in the pathogenesis of BE and EAC, including NOTCH, hedgehog, NF-?B, and IL6/STAT3.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell Biology
Michaela Quintero, Siyang Liu, Yanhua Xia, Yonghong Huang, Yi Zou, Ge Li, Ling Hu, Nagendra Singh, Richard Blumberg, Yafei Cai, Hong Xu, Honglin Li
Summary: Cdk5rap3 plays a key role in the development and maintenance of Paneth cells in the intestine, with its deficiency leading to early embryonic lethality and increased susceptibility to colitis. The protein is highly expressed in mature Paneth cells and is crucial for the fate specification of these cells.
CELL DEATH & DISEASE
(2021)
Article
Gastroenterology & Hepatology
Cary C. Cotton, Nicholas J. Shaheen, Aaron P. Thrift
Summary: Endoscopic surveillance after successful ablation of baseline high-grade dysplasia or intramucosal cancer is much more effective than surveillance after successful treatment of baseline low-grade dysplasia in preventing invasive adenocarcinoma.
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Immunology
Ikenna C. Okereke, Aaron L. Miller, Daniel C. Jupiter, Catherine F. Hamilton, Gabriel L. Reep, Timothy Krill, Clark R. Andersen, Richard B. Pyles
Summary: The microbial community structures differ between patients with and without Barrett's esophagus, with certain organisms less likely to be detected as the severity of Barrett's esophagus worsens.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Multidisciplinary Sciences
Georg A. Busslinger, Buys de Barbanson, Rurika Oka, Bas L. A. Weusten, Michiel de Maat, Richard van Hillegersberg, Lodewijk A. A. Brosens, Ruben van Boxtel, Alexander van Oudenaarden, Hans Clevers
Summary: Barrett's esophagus is categorized into different stages based on morphological appearance, which correlate with the risk of developing esophageal adenocarcinoma. Single-cell sequencing experiments revealed chromosomal instabilities in dysplastic BE cells, with stable cells predominantly found in nondysplastic BE biopsies. The datasets provide insight into the mutational landscape and gene expression patterns at different stages of BE development.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Medicine, Research & Experimental
Catherine H. Feng, Mary L. Disis, Chao Cheng, Lanjing Zhang
Summary: This study developed a multimetric feature-selection based multinomial logistic regression model that outperformed random forest models in classifying the four-category outcome of colorectal cancer. Adding microsatellite instability and oncogenic-driver data to clinical and transcriptomic data improved models' performances, with pathologic staging, HBS1L, TSPYL4, and TP53TG3B as important features. Interestingly, precision and recall of tuned algorithms change as the feature number changes, but accuracy does not.
LABORATORY INVESTIGATION
(2022)
Editorial Material
Medical Laboratory Technology
Lanjing Zhang
ARCHIVES OF PATHOLOGY & LABORATORY MEDICINE
(2022)
Article
Developmental Biology
Soumyashree Das, Qiang Feng, Iyshwarya Balasubramanian, Xiang Lin, Haoran Liu, Oscar Pellon-Cardenas, Shiyan Yu, Xiao Zhang, Yue Liu, Zhi Wei, Edward M. Bonder, Michael P. Verzi, Wei Hsu, Lanjing Zhang, Timothy C. Wang, Nan Gao
Summary: This study found that blocking epithelial Wnt affects the differentiation of colonic epithelial cells and impairs colonic epithelial regeneration. The majority of Wnt-producing cells in intestinal stroma were found in populations expressing transgelin and smooth muscle actin alpha 2. Blocking the release of Wnt from these stromal cells impairs colonic epithelial healing and increases morbidity and mortality.
Editorial Material
Gastroenterology & Hepatology
Lanjing Zhang, Grace L. Guo
Article
Cell Biology
Xuetian Yue, Jianming Wang, Chun-Yuan Chang, Juan Liu, Xue Yang, Fan Zhou, Xia Qiu, Vrushank Bhatt, Jessie Yanxiang Guo, Xiaoyang Su, Lanjing Zhang, Zhaohui Feng, Wenwei Hu
Summary: This study found that overexpression of LIF in breast cancer promotes tumorigenesis by increasing glucose uptake and driving glycolysis. It also identifies LIF and its downstream signaling as potential therapeutic targets for breast cancers with LIF overexpression.
CELL DEATH & DISEASE
(2022)
Review
Medicine, Research & Experimental
Miao Cui, Chao Cheng, Lanjing Zhang
Summary: Proteomics plays a vital role in biomedical research by providing new insights into complex biomedical problems. This mini-review summarizes existing and emerging high-throughput proteomics methodologies and discusses the importance of computational methods and statistical algorithms in maximizing the value of proteomic data. The advances in high-throughput proteomics not only enhance our understanding of disease mechanisms, but also offer potential applications in various fields such as basic research, oncology, precision medicine, and drug discovery.
LABORATORY INVESTIGATION
(2022)
Editorial Material
Medical Laboratory Technology
Puay Hoon Tan, Lanjing Zhang
ARCHIVES OF PATHOLOGY & LABORATORY MEDICINE
(2022)
Article
Pathology
Weidong Li, Hongqin Jia, Shuling Wang, Xiaojing Guo, Xinmin Zhang, Lanjing Zhang, Hannah Y. Wen, Li Fu
Summary: Some invasive breast carcinomas exhibit features similar to invasive micropapillary carcinoma (IMPC), but lack the thin strands of connective tissue and characteristic growth pattern. These tumors with retraction clefts are considered as a precursor stage of IMPC. A study of 2497 cases of invasive breast carcinomas found that the presence of retraction clefts is associated with lymphovascular invasion, lymph node metastasis, and worse prognosis.
ANNALS OF DIAGNOSTIC PATHOLOGY
(2022)
Article
Medicine, Research & Experimental
Zehuan Ding, Naomi McCauley, Yushu Qin, Lauren Lawless, Shaodong Guo, Lanjing Zhang, Ke K. Zhang, Linglin Xie
Summary: FoxO1 is an important transcriptional factor that regulates cell survival and metabolism. Its role in placental development during mid-late gestation is unclear. Placental FoxO1 expression is increased in gestational diabetes patients and pregnant mice with hyperglycemia. The study investigated the effects of FoxO1 haploinsufficiency on placental development under normal and hyperglycemic conditions. FoxO1 haploinsufficiency increased term placental weight under both conditions, with different mechanisms observed under normoglycemia and hyperglycemia.
LABORATORY INVESTIGATION
(2023)
Article
Oncology
Li Yang, Xiaomin Chen, Christy Lee, Jiejun Shi, Emily B. Lawrence, Lanjing Zhang, Yumei Li, Nan Gao, Sung Yun Jung, Chad J. Creighton, Jingyi Jessica Li, Ya Cui, Sumimasa Arimura, Yunping Lei, Wei Li, Lanlan Shen
Summary: This study found that p16 epimutation is associated with tumor development and immune cell infiltration in colorectal cancer. Colon tumors with p16 epimutation exhibit an activated interferon pathway, increased expression of programmed death-ligand 1 (Pdl1), and enhanced infiltration of immune cells. Combination therapy using a DNA methylation inhibitor and a PD-L1 immune checkpoint inhibitor is more effective for improving survival in tumor-bearing mice. These findings provide a mechanistic rationale for future targeted therapy in patients with p16 epimutation.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2023)
Article
Medicine, Research & Experimental
Juan Liu, Cen Zhang, Dandan Xu, Tianliang Zhang, Chun-Yuan Chang, Jianming Wang, Jie Liu, Lanjing Zhang, Bruce G. Haffty, Wei-Xing Zong, Wenwei Hu, Zhaohui Feng
Summary: The tumor suppressor gene TP53 is frequently mutated in human cancers, and mutant p53 (mutp53) proteins often accumulate to high levels to promote cancer progression. The study identified TRIM21 as a key E3 ubiquitin ligase that interacts with mutp53 and leads to its degradation, suppressing its gain-of-function in tumorigenesis. TRIM21 deficiency in cancer cells resulted in mutp53 accumulation and enhanced tumor progression. TRIM21 was downregulated in certain human cancers, and low expression was associated with poor prognosis in patients with mutp53-carrying cancers.
JOURNAL OF CLINICAL INVESTIGATION
(2023)
Article
Endocrinology & Metabolism
Juan Liu, Cen Zhang, Tianliang Zhang, Chun-Yuan Chang, Jianming Wang, Ludvinna Bazile, Lanjing Zhang, Bruce G. G. Haffty, Wenwei Hu, Zhaohui Feng
Summary: The glycolytic enzyme lactate dehydrogenase A (LDHA) activates small GTPase Rac1 to promote cancer independently of its glycolytic enzyme activity. LDHA interacts with the active form of Rac1, Rac1-GTP, to inhibit Rac1-GTP interaction with its negative regulator, GTPase-activating proteins, leading to Rac1 activation. LDHA overexpression in clinical breast cancer specimens is associated with higher Rac1 activity. Inhibition of Rac1 suppresses the oncogenic effect of LDHA. Combination inhibition of LDHA enzyme activity and Rac1 activity displays a synergistic inhibitory effect on breast cancers with LDHA overexpression.
Article
Medicine, Research & Experimental
Weiwei Dai, Jianliang Shen, Junrong Yan, Alex J. Bott, Sara Maimouni, Heineken Q. Daguplo, Yujue Wang, Khoosheh Khayati, Jessie Yanxiang Guo, Lanjing Zhang, Yongbo Wang, Alexander Valvezan, Wen-Xing Ding, Xin Chen, Xiaoyang Su, Shenglan Gao, Wei-Xing Zong
Summary: The text discusses the role of glutamine synthetase in liver function and cancer development. It shows that hepatic GS plays a critical role in tumor suppression through ammonia clearance and regulation of mTORC1 in the presence of beta-catenin mutations.
JOURNAL OF CLINICAL INVESTIGATION
(2022)
Article
Oncology
Emily Ryu, Harry H. Xia, Grace L. Guo, Lanjing Zhang
Summary: The study found that there is an upward trend in mortality from alcoholic liver disease (ALD) among U.S. adults, with no significant differences by sex, race, age or urbanization. Subtypes of ALD such as alcoholic fatty liver, alcoholic hepatitis, alcoholic cirrhosis, and non-alcoholic cirrhosis have upward mortality trends, while other subtypes and causes of death did not.
AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH
(2022)
Article
Oncology
Minhong Shen, Yong Wei, Hahn Kim, Liling Wan, Yi-Zhou Jiang, Xiang Hang, Michael Raba, Stacy Remiszewski, Michelle Rowicki, Cheng-Guo Wu, Songyang Wu, Lanjing Zhang, Xin Lu, Min Yuan, Heath A. Smith, Aiping Zheng, Joseph Bertino, John F. Jin, Yongna Xing, Zhi-Ming Shao, Yibin Kang
Summary: Targeting the MTDH-SND1 complex shows significant therapeutic potential for metastatic breast cancer. Specific compounds C26-A2 and C26-A6 inhibit tumor growth and metastasis, as well as enhancing chemotherapy sensitivity.
