标题
Gut stem cell aging is driven by mTORC1 via a p38 MAPK-p53 pathway
作者
关键词
-
出版物
Nature Communications
Volume 11, Issue 1, Pages -
出版商
Springer Science and Business Media LLC
发表日期
2020-01-02
DOI
10.1038/s41467-019-13911-x
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- Fasting Activates Fatty Acid Oxidation to Enhance Intestinal Stem Cell Function during Homeostasis and Aging
- (2018) Maria M. Mihaylova et al. Cell Stem Cell
- Calorie Restriction Governs Intestinal Epithelial Regeneration through Cell-Autonomous Regulation of mTORC1 in Reserve Stem Cells
- (2018) Maryam Yousefi et al. Stem Cell Reports
- In Vivo Imaging Reveals Existence of Crypt Fission and Fusion in Adult Mouse Intestine
- (2017) Lotte Bruens et al. GASTROENTEROLOGY
- Key proteins and pathways that regulate lifespan
- (2017) Haihui Pan et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Interplay between metabolic identities in the intestinal crypt supports stem cell function
- (2017) Maria J. Rodríguez-Colman et al. NATURE
- Hierarchy and Plasticity in the Intestinal Stem Cell Compartment
- (2017) Maryam Yousefi et al. TRENDS IN CELL BIOLOGY
- Canonical Wnt Signaling Ameliorates Aging of Intestinal Stem Cells
- (2017) Kodandaramireddy Nalapareddy et al. Cell Reports
- mTORC1 and SIRT1 Cooperate to Foster Expansion of Gut Adult Stem Cells during Calorie Restriction
- (2016) Masaki Igarashi et al. CELL
- Intestinal Phospholipid Remodeling Is Required for Dietary-Lipid Uptake and Survival on a High-Fat Diet
- (2016) Bo Wang et al. Cell Metabolism
- The ageing gastrointestinal tract
- (2016) Stijn Soenen et al. CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE
- When stem cells grow old: phenotypes and mechanisms of stem cell aging
- (2016) Michael B. Schultz et al. DEVELOPMENT
- mTOR disruption causes intestinal epithelial cell defects and intestinal atrophy postinjury in mice
- (2016) Leesa L. Sampson et al. FASEB JOURNAL
- Slowing ageing by design: the rise of NAD+ and sirtuin-activating compounds
- (2016) Michael S. Bonkowski et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Systemic Problems: A perspective on stem cell aging and rejuvenation
- (2015) Irina M. Conboy et al. Aging-US
- Wnt activity and basal niche position sensitize intestinal stem and progenitor cells to DNA damage
- (2015) S. Tao et al. EMBO JOURNAL
- Repression of Mammalian Target of Rapamycin Complex 1 Inhibits Intestinal Regeneration in Acute Inflammatory Bowel Disease Models
- (2015) Yuting Guan et al. JOURNAL OF IMMUNOLOGY
- Dormant Intestinal Stem Cells Are Regulated by PTEN and Nutritional Status
- (2015) Camilla A. Richmond et al. Cell Reports
- p38 MAPK signaling underlies a cell-autonomous loss of stem cell self-renewal in skeletal muscle of aged mice
- (2014) Jennifer D Bernet et al. NATURE MEDICINE
- SnapShot: The Intestinal Crypt
- (2013) Hans Clevers et al. CELL
- mTOR is a key modulator of ageing and age-related disease
- (2013) Simon C. Johnson et al. NATURE
- Adult intestinal stem cells: critical drivers of epithelial homeostasis and regeneration
- (2013) Nick Barker NATURE REVIEWS MOLECULAR CELL BIOLOGY
- mTOR Signaling in Growth Control and Disease
- (2012) Mathieu Laplante et al. CELL
- Tissue-Specific Stem Cells: Lessons from the Skeletal Muscle Satellite Cell
- (2012) Andrew S. Brack et al. Cell Stem Cell
- Relief with Rapamycin: mTOR Inhibition Protects against Radiation-Induced Mucositis
- (2012) Toren Finkel Cell Stem Cell
- A unifying model for mTORC1-mediated regulation of mRNA translation
- (2012) Carson C. Thoreen et al. NATURE
- mTORC1 in the Paneth cell niche couples intestinal stem-cell function to calorie intake
- (2012) Ömer H. Yilmaz et al. NATURE
- c-Abl promotes osteoblast expansion by differentially regulating canonical and non-canonical BMP pathways and p16INK4a expression
- (2012) Hui-Yi Kua et al. NATURE CELL BIOLOGY
- Manifestations and mechanisms of stem cell aging
- (2011) Ling Liu et al. JOURNAL OF CELL BIOLOGY
- A reserve stem cell population in small intestine renders Lgr5-positive cells dispensable
- (2011) Hua Tian et al. NATURE
- Interconversion Between Intestinal Stem Cell Populations in Distinct Niches
- (2011) N. Takeda et al. SCIENCE
- Spatial Coupling of mTOR and Autophagy Augments Secretory Phenotypes
- (2011) M. Narita et al. SCIENCE
- Intestinal Crypt Homeostasis Results from Neutral Competition between Symmetrically Dividing Lgr5 Stem Cells
- (2010) Hugo J. Snippert et al. CELL
- Focal Adhesion Kinase Is Required for Intestinal Regeneration and Tumorigenesis Downstream of Wnt/c-Myc Signaling
- (2010) Gabrielle H. Ashton et al. DEVELOPMENTAL CELL
- Distinct Effects of p38α Deletion in Myeloid Lineage and Gut Epithelia in Mouse Models of Inflammatory Bowel Disease
- (2010) Motoyuki Otsuka et al. GASTROENTEROLOGY
- Loss of Claudin-15, but Not Claudin-2, Causes Na+ Deficiency and Glucose Malabsorption in Mouse Small Intestine
- (2010) Atsushi Tamura et al. GASTROENTEROLOGY
- Mouse telomerase reverse transcriptase (mTert) expression marks slowly cycling intestinal stem cells
- (2010) R. K. Montgomery et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Intestinal Stem Cell Replacement Follows a Pattern of Neutral Drift
- (2010) C. Lopez-Garcia et al. SCIENCE
- mTORC1-Mediated Cell Proliferation, But Not Cell Growth, Controlled by the 4E-BPs
- (2010) R. J. O. Dowling et al. SCIENCE
- p38MAPK Controls Expression of Multiple Cell Cycle Inhibitors and Islet Proliferation with Advancing Age
- (2009) Esther Sook Miin Wong et al. DEVELOPMENTAL CELL
- Rapamycin fed late in life extends lifespan in genetically heterogeneous mice
- (2009) David E. Harrison et al. NATURE
- TSC–mTOR maintains quiescence and function of hematopoietic stem cells by repressing mitochondrial biogenesis and reactive oxygen species
- (2008) Chong Chen et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Biphasic Response of Pancreatic -Cell Mass to Ablation of Tuberous Sclerosis Complex 2 in Mice
- (2008) Y. Shigeyama et al. MOLECULAR AND CELLULAR BIOLOGY
- Bmi1 is expressed in vivo in intestinal stem cells
- (2008) Eugenio Sangiorgi et al. NATURE GENETICS
Discover Peeref hubs
Discuss science. Find collaborators. Network.
Join a conversationAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started