The Role of the Gastrointestinal Mucus System in Intestinal Homeostasis: Implications for Neurological Disorders

Brain-Gut-Microbiota Axis in Alzheimer’s Disease

(2019) Karol Kowalski et al.   Journal of Neurogastroenterology and Motility

The Contribution of Gut Barrier Changes to Multiple Sclerosis Pathophysiology

(2019) Maria Chiara Buscarinu et al.   Frontiers in Immunology

The intestinal barrier in multiple sclerosis: implications for pathophysiology and therapeutics

(2018) Carlos R Camara-Lemarroy et al.   BRAIN

Human gut microbiome: hopes, threats and promises

(2018) Patrice D Cani   GUT

Gut Microbiota is Altered in Patients with Alzheimer’s Disease

(2018) Zhen-Qian Zhuang et al.   JOURNAL OF ALZHEIMERS DISEASE

Altered goblet cell function in Hirschsprung’s disease

(2018) Hiroki Nakamura et al.   PEDIATRIC SURGERY INTERNATIONAL

Wnt/β-catenin signaling stimulates the expression and synaptic clustering of the autism-associated Neuroligin 3 gene

(2018) Matías A. Medina et al.   Translational Psychiatry

Exploring the Wnt signaling pathway in schizophrenia and bipolar disorder

(2018) Eva Z. Hoseth et al.   Translational Psychiatry

SPDEF Induces Quiescence of Colorectal Cancer Cells by Changing the Transcriptional Targets of β-catenin

(2017) Yuan-Hung Lo et al.   GASTROENTEROLOGY

Analysis of the Duodenal Microbiome in Autistic Individuals

(2017) Rafail I. Kushak et al.   JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION

Gut biofilm forming bacteria in inflammatory bowel disease

(2017) Ankita Srivastava et al.   MICROBIAL PATHOGENESIS

The nasal and gut microbiome in Parkinson's disease and idiopathic rapid eye movement sleep behavior disorder

(2017) Anna Heintz-Buschart et al.   MOVEMENT DISORDERS

Association of brain amyloidosis with pro-inflammatory gut bacterial taxa and peripheral inflammation markers in cognitively impaired elderly

(2017) Annamaria Cattaneo et al.   NEUROBIOLOGY OF AGING

Spatial organization of a model 15-member human gut microbiota established in gnotobiotic mice

(2017) Jessica L. Mark Welch et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Gut bacteria from multiple sclerosis patients modulate human T cells and exacerbate symptoms in mouse models

(2017) Egle Cekanaviciute et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Gut microbiota from multiple sclerosis patients enables spontaneous autoimmune encephalomyelitis in mice

(2017) Kerstin Berer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mucus organisation is shaped by colonic content; a new view

(2017) J. B. J. Kamphuis et al.   Scientific Reports

Mucus Detachment by Host Metalloprotease Meprin β Requires Shedding of Its Inactive Pro-form, which Is Abrogated by the Pathogenic Protease RgpB

(2017) Rielana Wichert et al.   Cell Reports

Interactions of Intestinal Bacteria with Components of the Intestinal Mucus

(2017) Jean-Félix Sicard et al.   Frontiers in Cellular and Infection Microbiology

The Metalloprotease Meprin β Is an Alternative β-Secretase of APP

(2017) Christoph Becker-Pauly et al.   Frontiers in Molecular Neuroscience

MUNC18–1 gene abnormalities are involved in neurodevelopmental disorders through defective cortical architecture during brain development

(2017) Nanako Hamada et al.   Acta Neuropathologica Communications

Gut microbiome alterations in Alzheimer’s disease

(2017) Nicholas M. Vogt et al.   Scientific Reports

Defensins, lectins, mucins, and secretory immunoglobulin A: microbe-binding biomolecules that contribute to mucosal immunity in the human gut

(2016) Phoom Chairatana et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

Development of the intrinsic and extrinsic innervation of the gut

(2016) Toshihiro Uesaka et al.   DEVELOPMENTAL BIOLOGY

The Densely O-Glycosylated MUC2 Mucin Protects the Intestine and Provides Food for the Commensal Bacteria

(2016) Liisa Arike et al.   JOURNAL OF MOLECULAR BIOLOGY

Generation of aggregation prone N-terminally truncated amyloid β peptides by meprin β depends on the sequence specificity at the cleavage site

(2016) Caroline Schönherr et al.   Molecular Neurodegeneration

Alterations of the human gut microbiome in multiple sclerosis

(2016) Sushrut Jangi et al.   Nature Communications

Alterations in the distal colon innervation in Winnie mouse model of spontaneous chronic colitis

(2015) Ahmed A. Rahman et al.   CELL AND TISSUE RESEARCH

Biogeography of the Intestinal Mucosal and Lumenal Microbiome in the Rhesus Macaque

(2015) Koji Yasuda et al.   Cell Host & Microbe

The Vat-AIEC protease promotes crossing of the intestinal mucus layer by Crohn's disease-associatedEscherichia coli

(2015) Lucie Gibold et al.   CELLULAR MICROBIOLOGY

Hydrogen Sulfide Protects from Colitis and Restores Intestinal Microbiota Biofilm and Mucus Production

(2015) Jean-Paul Motta et al.   INFLAMMATORY BOWEL DISEASES

Gut Microbiota in Multiple Sclerosis

(2015) Brandi L. Cantarel et al.   JOURNAL OF INVESTIGATIVE MEDICINE

Mucus Barriers to Microparticles and Microbes are Altered in Hirschsprung's Disease

(2015) Hasan M. Yildiz et al.   MACROMOLECULAR BIOSCIENCE

Colonic bacterial composition in Parkinson's disease

(2015) Ali Keshavarzian et al.   MOVEMENT DISORDERS

New developments in goblet cell mucus secretion and function

(2015) G M H Birchenough et al.   Mucosal Immunology

Gut biogeography of the bacterial microbiota

(2015) Gregory P. Donaldson et al.   NATURE REVIEWS MICROBIOLOGY

The Role of Wnt/β-Catenin Signaling Pathway in Disrupted Hippocampal Neurogenesis of Temporal Lobe Epilepsy: A Potential Therapeutic Target?

(2015) Cheng Huang et al.   NEUROCHEMICAL RESEARCH

Vasoactive Intestinal Polypeptide Promotes Intestinal Barrier Homeostasis and Protection Against Colitis in Mice

(2015) Xiujuan Wu et al.   PLoS One

Opposing Activities of Notch and Wnt Signaling Regulate Intestinal Stem Cells and Gut Homeostasis

(2015) Hua Tian et al.   Cell Reports

Direct evidence of Parkinson pathology spread from the gastrointestinal tract to the brain in rats

(2014) Staffan Holmqvist et al.   ACTA NEUROPATHOLOGICA

Cystic fibrosis transmembrane conductance regulator dysfunction in VIP knockout mice

(2014) Nicole G. Alcolado et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

The Canonical Wnt Signaling Pathway in Autism

(2014) Yinghua Zhang et al.   CNS & Neurological Disorders-Drug Targets

Wnt/β-Catenin Signaling in Alzheimer’s Disease

(2014) Giancarlo Ferrari et al.   CNS & Neurological Disorders-Drug Targets

Gut microbiota are related to Parkinson's disease and clinical phenotype

(2014) Filip Scheperjans et al.   MOVEMENT DISORDERS

Gastrointestinal Symptoms in Autism Spectrum Disorder: A Meta-analysis

(2014) B. O. McElhanon et al.   PEDIATRICS

Altered Goblet Cell Differentiation and Surface Mucus Properties in Hirschsprung Disease

(2014) Jay R. Thiagarajah et al.   PLoS One

AGR2, an Endoplasmic Reticulum Protein, Is Secreted into the Gastrointestinal Mucus

(2014) Joakim H. Bergström et al.   PLoS One

Shp2/MAPK signaling controls goblet/paneth cell fate decisions in the intestine

(2014) Julian Heuberger et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Microbial-induced meprin   cleavage in MUC2 mucin and a functional CFTR channel are required to release anchored small intestinal mucus

(2014) A. Schutte et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

STX1A and Asperger syndrome: a replication study

(2014) Jaroslava Durdiaková et al.   Molecular Autism

Innate and Adaptive Immunity Interact to Quench Microbiome Flagellar Motility in the Gut

(2013) Tyler C. Cullender et al.   Cell Host & Microbe

Structural basis for adaptation of lactobacilli to gastrointestinal mucus

(2013) Sabrina Etzold et al.   ENVIRONMENTAL MICROBIOLOGY

Gut dysfunction in patients with multiple sclerosis and the role of spinal cord involvement in the disease

(2013) Giuseppe Preziosi et al.   EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY

Mucin-type O-glycans and their roles in intestinal homeostasis

(2013) K. S. B. Bergstrom et al.   GLYCOBIOLOGY

Microbiota-liberated host sugars facilitate post-antibiotic expansion of enteric pathogens

(2013) Katharine M. Ng et al.   NATURE

The gut as a sensory organ

(2013) John B. Furness et al.   Nature Reviews Gastroenterology & Hepatology

Mucus Properties and Goblet Cell Quantification in Mouse, Rat and Human Ileal Peyer's Patches

(2013) Anna Ermund et al.   PLoS One

Negative feedback by IRE1  optimizes mucin production in goblet cells

(2013) A. Tsuru et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Host-compound foraging by intestinal microbiota revealed by single-cell stable isotope probing

(2013) D. Berry et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Physiology of Epithelial Chloride and Fluid Secretion

(2013) R. A. Frizzell et al.   Cold Spring Harbor Perspectives in Medicine

The importance of Wnt signalling for neurodegeneration in Parkinson's disease

(2012) Daniel C. Berwick et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

The Wnt Pathway in Mood Disorders

(2012) Gabriele Sani et al.   Current Neuropharmacology

Butyrate-producing Clostridium cluster XIVa species specifically colonize mucins in an in vitro gut model

(2012) Pieter Van den Abbeele et al.   ISME Journal

Bicarbonate and functional CFTR channel are required for proper mucin secretion and link cystic fibrosis with its mucus phenotype

(2012) Jenny K. Gustafsson et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Downregulating the Canonical Wnt/β-catenin Signaling Pathway Attenuates the Susceptibility to Autism-like Phenotypes by Decreasing Oxidative Stress

(2012) Yinghua Zhang et al.   NEUROCHEMICAL RESEARCH

Intestinal aganglionosis is associated with early and sustained disruption of the colonic microbiome

(2012) N. L. Ward et al.   NEUROGASTROENTEROLOGY AND MOTILITY

The Co-Morbidity Burden of Children and Young Adults with Autism Spectrum Disorders

(2012) Isaac S. Kohane et al.   PLoS One

Calcium and pH-dependent packing and release of the gel-forming MUC2 mucin

(2012) D. Ambort et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Application of Novel PCR-Based Methods for Detection, Quantitation, and Phylogenetic Characterization of Sutterella Species in Intestinal Biopsy Samples from Children with Autism and Gastrointestinal Disturbances

(2012) B. L. Williams et al.   mBio

An ex vivo method for studying mucus formation, properties, and thickness in human colonic biopsies and mouse small and large intestinal explants

(2011) Jenny K. Gustafsson et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Low Relative Abundances of the Mucolytic Bacterium Akkermansia muciniphila and Bifidobacterium spp. in Feces of Children with Autism

(2011) Lv Wang et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Protein folding stress in neurodegenerative diseases: a glimpse into the ER

(2011) Soledad Matus et al.   CURRENT OPINION IN CELL BIOLOGY

Loss of intestinal core 1–derived O-glycans causes spontaneous colitis in mice

(2011) Jianxin Fu et al.   JOURNAL OF CLINICAL INVESTIGATION

Guidelines for the diagnosis and management of distal intestinal obstruction syndrome in cystic fibrosis patients

(2011) Carla Colombo et al.   Journal of Cystic Fibrosis

Notch post-translationally regulates β-catenin protein in stem and progenitor cells

(2011) Chulan Kwon et al.   NATURE CELL BIOLOGY

The intestinal microbiota and chronic disorders of the gut

(2011) Andrew W. DuPont et al.   Nature Reviews Gastroenterology & Hepatology

Paneth cells, antimicrobial peptides and maintenance of intestinal homeostasis

(2011) Charles L. Bevins et al.   NATURE REVIEWS MICROBIOLOGY

SNAP-25 single nucleotide polymorphisms are associated with hyperactivity in autism spectrum disorders

(2011) Franca R. Guerini et al.   PHARMACOLOGICAL RESEARCH

The Genome of Akkermansia muciniphila, a Dedicated Intestinal Mucin Degrader, and Its Use in Exploring Intestinal Metagenomes

(2011) Mark W. J. van Passel et al.   PLoS One

Intestinal Epithelial Stem/Progenitor Cells Are Controlled by Mucosal Afferent Nerves

(2011) Ove Lundgren et al.   PLoS One

Impaired Carbohydrate Digestion and Transport and Mucosal Dysbiosis in the Intestines of Children with Autism and Gastrointestinal Disturbances

(2011) Brent L. Williams et al.   PLoS One

The Antibacterial Lectin RegIII  Promotes the Spatial Segregation of Microbiota and Host in the Intestine

(2011) S. Vaishnava et al.   SCIENCE

Keeping Bacteria at a Distance

(2011) M. E. V. Johansson et al.   SCIENCE

Mucolytic Bacteria With Increased Prevalence in IBD Mucosa Augment In Vitro Utilization of Mucin by Other Bacteria

(2010) Chin Wen Png et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Importance and regulation of the colonic mucus barrier in a mouse model of colitis

(2010) J. Petersson et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Paneth cells and innate mucosal immunity

(2010) André J Ouellette   CURRENT OPINION IN GASTROENTEROLOGY

Spatial organization of intestinal microbiota in the mouse ascending colon

(2010) Gerardo M Nava et al.   ISME Journal

Evaluation, Diagnosis, and Treatment of Gastrointestinal Disorders in Individuals With ASDs: A Consensus Report

(2010) Timothy Buie et al.   PEDIATRICS

The two mucus layers of colon are organized by the MUC2 mucin, whereas the outer layer is a legislator of host-microbial interactions

(2010) M. E. V. Johansson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Differences in goblet cell differentiation between Crohn's disease and ulcerative colitis

(2009) Michael Gersemann et al.   DIFFERENTIATION

SAM pointed domain ETS factor (SPDEF) regulates terminal differentiation and maturation of intestinal goblet cells

(2009) Taeko K. Noah et al.   EXPERIMENTAL CELL RESEARCH

The Ets-Domain Transcription Factor Spdef Promotes Maturation of Goblet and Paneth Cells in the Intestinal Epithelium

(2009) Alex Gregorieff et al.   GASTROENTEROLOGY

Increased Expression of Endoplasmic Reticulum Stress-Related Signaling Pathway Molecules in Multiple Sclerosis Lesions

(2009) Aoife Ní Mháille et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Glycosyltransferase Function in Core 2-Type Protein O Glycosylation

(2009) E. L. Stone et al.   MOLECULAR AND CELLULAR BIOLOGY

Notch and Wnt signals cooperatively control cell proliferation and tumorigenesis in the intestine

(2009) S. Fre et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The protein disulfide isomerase AGR2 is essential for production of intestinal mucus

(2009) S.-W. Park et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Knockout mouse models for intestinal electrolyte transporters and regulatory PDZ adaptors: new insights into cystic fibrosis, secretory diarrhoea and fructose-induced hypertension

(2008) Ursula Seidler et al.   EXPERIMENTAL PHYSIOLOGY

Characterization of two different endo- -N-acetylgalactosaminidases from probiotic and pathogenic enterobacteria, Bifidobacterium longum and Clostridium perfringens

(2008) H. Ashida et al.   GLYCOBIOLOGY

Secreted enteric antimicrobial activity localises to the mucus surface layer

(2008) U Meyer-Hoffert et al.   GUT

The inner of the two Muc2 mucin-dependent mucus layers in colon is devoid of bacteria

(2008) M. E. V. Johansson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Munc18/SNARE proteins’ regulation of exocytosis in guinea pig duodenal Brunner’s gland acini

(2008) Laura I Cosen-Binker et al.   WORLD JOURNAL OF GASTROENTEROLOGY