期刊
FRONTIERS IN IMMUNOLOGY
卷 10, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fimmu.2019.01281
关键词
mucosal immunology; mesenchymal cells; fibroblasts; intestinal stem cells (ISCs); Peyer's patches
类别
资金
- Ministry of Education, Culture, Sports, Science, and Technology
- Japan Agency for Medical Research and Development (AMED) for PRIME
- Japan Society for the Promotion of Science
- Funds for the Promotion of Joint International Research [18KK0432, 17KK0196]
- Senri Life Science Foundation
- Mochida Memorial Foundation for Medical and Pharmaceutical Research
- Takeda Science Foundation
- Uehara Memorial Foundation
- Sumitomo Foundation
- Naito Foundation
- Kato Memorial Bio Science Foundation
- Yakult Bio-Science Foundation
- NipponHam Foundation
- Chiba University-UC San Diego Center for Mucosal Immunology, Allergy, and Vaccines [cMAV]
- Translational Research Network Program (at the University of Tokyo) Seed A
- Translational Research Network Program (at the University of Tokyo) Seed B
- Translational Research Network Program (at the University of Tokyo) Seed C
- LEADER (at Chiba University)
- [18H05280]
- [19H03450]
- [16H06243]
- [17K19550]
- [16K10039]
The epithelial layer creates a chemical and physical barrier at the forefront of intestinal mucosa, and immune cells beneath the surface epithelium are poised to react to extrinsic factors, to maintain tissue homeostasis. Importantly, the nexus of epithelial-immune responses at mucosal surfaces is dexterously modulated by intrinsic stromal-mesenchymal cells. First, organogenesis of lymphoid tissues, including Peyer's patches, requires dynamic interplay between lymphoid cells and stromal cells, which have become known as lymphoid organizers. Second, correct spatiotemporal interaction between these cell populations is essential to generate the infrastructure for gut immune responses. Moreover, immune cells at the intestinal barrier are functionally modulated by stromal cells; one such example is the stromal cell-mediated differentiation of innate immune cells, including innate lymphoid cells andmast cells. Ultimately, mucosal stromal cells orchestrate the destinations of epithelial and immune cells to maintain intestinal immune homeostasis.
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