Article
Engineering, Environmental
Payam Arabkhani, Nahid Saeedi, Hossein Sadeghi, Sadegh Nouripour-Sisakht, Maral Gharaghani, Arash Asfaram
Summary: In this study, a novel biosynthesis method for the preparation of zinc oxide/carbon nanofiber nanocomposite (ZnO-CNFs) was proposed and their photocatalytic and antimicrobial properties were evaluated for wastewater treatment. The synthesized ZnO-CNFs showed high photodegradation efficiency of tetracycline antibiotic residues and superior antibacterial and antifungal activity compared to ZnO nanoparticles. These findings indicate that ZnO-CNFTD exhibits excellent photocatalytic and antimicrobial potential and can be a promising candidate for effective treatment of water contaminated with microorganisms and organic compounds.
JOURNAL OF WATER PROCESS ENGINEERING
(2023)
Article
Infectious Diseases
Luz D. Gutierrez-Castaneda, Carmen R. Acosta, Monica A. Bustos, Diana K. Garcia, Diana P. Bohada, Raul Rodriguez, Martha Inirida Guerrero
Summary: The SNVs and haplotypes in TLR genes, particularly rs5743810 in TLR6 and the CGG haplotype (rs5743618-rs5743708-rs5743810), are associated with leprosy susceptibility.
TROPICAL MEDICINE AND INFECTIOUS DISEASE
(2023)
Article
Cell Biology
Justyna Smialek-Bartyzel, Monika Bzowska, Renata Mezyk-Kopec, Marcin Kwissa, Pawel Mak
Summary: The objective of this study is to identify the receptor that mediates the activity of BacSp222 bacteriocin. Through fluorescent labeling and confocal microscopy, it was found that BacSp222 interacts directly with cells. The results show that BacSp222 binds to TLR2/TLR6 heterodimers and induces proinflammatory signaling through MyD88 and NF-kappa B pathways.
INFLAMMATION RESEARCH
(2023)
Article
Integrative & Complementary Medicine
Zhijun Han, Xiaofen Tan, Juan Sun, Tianming Wang, Guiming Yan, Changzhong Wang, Kelong Ma
Summary: This study established a murine model of UC with C. albicans colonization and comprehensively examined the major bioactive constituents and potential mechanism of SHD against UC with fungal dysbiosis using systems pharmacology and in vivo transcriptomics. The results indicated that SHD could be a candidate for the treatment of fungal dysbiosis-associated UC via TLR4-NF-kappa B and PI3K-Akt signaling pathways.
Article
Multidisciplinary Sciences
Robert Zarnowski, Andrea Noll, Marc G. Chevrette, Hiram Sanchez, Ryley Jones, Hanna Anhalt, Jen Fossen, Anna Jaromin, Cameron Currie, Jeniel E. Nett, Aaron Mitchell, David R. Andes
Summary: The fungal pathogen Candida albicans can form biofilms that protect it from drugs and the immune system by releasing extracellular vesicles (EVs) that promote extracellular matrix formation and resistance to antifungal drugs. The study identifies functions for numerous EV cargo proteins in biofilm matrix assembly, drug resistance, fungal cell adhesion, and dissemination. The findings suggest that EVs play a crucial role in coordinating biofilm development in C. albicans.
NATURE COMMUNICATIONS
(2021)
Article
Veterinary Sciences
Dorota Chrobak-Chmiel, Ewelina Kwiecien, Anna Golke, Beata Dolka, Krzysztof Adamczyk, Malgorzata J. Bieganska, Marina Spinu, Marian Binek, Magdalena Rzewuska
Summary: The study reveals that pigeons can carry multidrug-resistant pathogens, including antibiotic-resistant Staphylococcus aureus, Escherichia coli, and Candida albicans. Further data is needed to understand how pigeons acquire highly resistant strains.
FRONTIERS IN VETERINARY SCIENCE
(2021)
Article
Microbiology
Shintaro Eshima, Sanae Kurakado, Yasuhiko Matsumoto, Takayuki Kudo, Takashi Sugita
Summary: This study evaluated the impact of Candida albicans on the antibacterial tolerance of Escherichia coli and explored the underlying mechanisms. The results showed that the culture supernatant of Candida induced antibacterial tolerance in E. coli biofilms. Further investigation is needed to identify the specific mechanisms and molecules involved. These findings have implications for the development of treatments for dual-species biofilm infections.
Article
Multidisciplinary Sciences
Fan Li, Hui Wang, Yan-Qi Li, Yebo Gu, Xin-Ming Jia
Summary: The study reveals that CLEC2D can form homodimers or heterodimers with TLR2, negatively regulating antifungal immunity by suppressing IRF5-mediated IL-12 production.
NATURE COMMUNICATIONS
(2023)
Article
Biotechnology & Applied Microbiology
Betul Yilmaz Ozturk, Bukay Yenice Gursu, Ilknur Dag
Summary: This study investigated the effects of farnesol on biofilms of Candida albicans and Escherichia coli, showing that farnesol significantly reduced metabolic activity and preformed biofilm formation. It also had a stronger effect on dual-species biofilms compared to commonly used antifungal and antibacterial drugs.
Article
Infectious Diseases
Nashwa Mohamed Reda, Reem Mostafa Hassan, Sherifa Tarek Salem, Reham Hamed A. Yousef
Summary: Candidemia remains a significant problem in healthcare settings, with a changing distribution of Candida species. C. albicans is still the most prevalent species, but non-albicans species are increasing, particularly in pediatric patients. The emergence of uncommon Candida species is concerning and requires prompt management.
Article
Immunology
Alireza Mansouri, Mohamed Samy Yousef, Rasoul Kowsar, Nonoka Usui, Ihshan Akthar, Akio Miyamoto
Summary: This study aimed to identify the active TLR2 heterodimer (TLR2/1 or TLR2/6) involved in sperm-uterine immune crosstalk in bovine. The results revealed that sperm triggered the expression of TLR1 and TLR2 through TLR2/1 heterodimer, and TLR2/6 heterodimer induced a stronger inflammatory response. The findings suggest that sperm utilize TLR2/1 heterodimerization to trigger a weak inflammatory response in the bovine uterus, providing an ideal uterine environment for early embryo reception and implantation.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Infectious Diseases
Yuzhu Ge, Min Pan, Chuanfeng Zhang, Changzhong Wang, Kelong Ma, Guiming Yan, Tianming Wang, Daqiang Wu, Jing Shao
Summary: The study demonstrates that supplementing C. albicans exacerbates UC, while Paeonol (PAE) can relieve its adverse effects on colitis. PAE may act through the Dectin-1/NF-kappa B pathway in collaboration with TLR2 and TLR4 to treat fungal dysbiosis-associated UC.
Review
Microbiology
Dallas L. Mould, Deborah A. Hogan
Summary: Microbial interactions play a crucial role in microbial physiology, with quorum sensing and metabolite exchange being key elements. Loss-of-function mutations in quorum-sensing components are common across different species, and quorum sensing is modulated by small molecules and environmental conditions. Recent evidence suggests that strain heterogeneity can impact microbial interactions and act as selective pressures on the emergence of common mutations in quorum sensing genes.
CURRENT OPINION IN MICROBIOLOGY
(2021)
Article
Infectious Diseases
Jie Hou, Jin Deng, Ya Liu, Weili Zhang, Siying Wu, Quanfeng Liao, Ying Ma, Mei Kang
Summary: The aim of this study was to investigate the current status of candidemia and evaluate the clinical characteristics, risk factors, and outcomes among different species. The study found variations in the prevalence of Candida albicans and non-albicans Candida and differences in the susceptibility to antifungal agents among different species. Risk factors associated with Candida albicans and non-albicans Candida were identified, and no significant differences in mortality were observed between the two species.
Article
Microbiology
Jian Miao, Jessica Regan, Chun Cai, Glen E. Palmer, David L. Williams, Michael D. Kruppa, Brian M. Peters
Summary: This study characterizes the glycogen metabolism pathways in Candida albicans and shows that glycogen metabolism is important for the long-term survival and virulence of the fungus.
Article
Infectious Diseases
Victor Mercier, Valerie Letscher-Bru, Marie-Elisabeth Bougnoux, Laurence Delhaes, Francoise Botterel, Daniele Maubon, Frederic Dalle, Alexandre Alanio, Sandrine Houze, Eric Dannaoui, Carole Cassagne, Sophie Cassaing, Marie-Fleur Durieux, Arnaud Fekkar, Jean-Philippe Bouchara, Jean-Pierre Gangneux, Julie Bonhomme, Damien Dupont, Damien Costa, Boualem Sendid, Taieb Chouaki, Nathalie Bourgeois, Antoine Huguenin, Sophie Brun, Caroline Mahinc, Lilia Hasseine, Solene Le Gal, Anne-Pauline Bellanger, Eric Bailly, Florent Morio, Celine Nourrisson, Nicole Desbois-Nogard, Estelle Perraud-Cateau, Anne Debourgogne, Helene Yera, Laurence Lachaud, Milene Sasso
Summary: The study aimed to determine the epidemiological cut-off values (ECVs) of ten antifungal agents in a wide range of yeasts and Aspergillus spp. using gradient concentration strips. Retrospective collection of minimum inhibitory concentrations for various antifungal agents was done from 35 French microbiology laboratories between 2002 and 2020. The calculated ECVs can aid in interpreting minimum inhibitory concentrations and identifying non-wild type isolates.
CLINICAL MICROBIOLOGY AND INFECTION
(2023)
Article
Pharmacology & Pharmacy
S. Moutaharrik, A. Maroni, C. Neut, C. Dubuquoy, L. Dubuquoy, A. Foppoli, M. Cerea, L. Palugan, F. Siepmann, J. Siepmann, A. Gazzaniga
Summary: A novel drug delivery system based on multiple drug release triggers was developed and evaluated for oral colon delivery, with a specific focus on inflammatory bowel disease (IBD) therapy. The system demonstrated pulsatile drug release in different release media and faster drug release in simulated colonic fluid with fecal bacteria from IBD patients. Promising results were observed in a preliminary rat study, indicating potential therapeutic effects on colitis progression and microbiota alteration.
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
(2023)
Article
Gastroenterology & Hepatology
Catherine Robbe Masselot, Camille Cordier, Benjamin Marsac, Maria Nachury, Renaud Leonard, Boualem Sendid
Summary: This study used mass spectrometry to analyze the fecal mucins of Crohn's disease patients and found a significant decrease in sialylated glycans compared to the control group. This may propose a new noninvasive tool for screening intestinal diseases.
INFLAMMATORY BOWEL DISEASES
(2023)
Correction
Immunology
Natalie Katzmarski, Jorge Dominguez-Andres, Branko Cirovic, Georgios Renieris, Eleonora Ciarlo, Didier Le Roy, Konstantin Lepikhov, Kathrin Kattler, Gilles Gasparoni, Kristian Haendler, Heidi Theis, Marc Beyer, Jos W. M. van der Meer, Leo A. B. Joosten, Joern Walter, Joachim L. Schultze, Thierry Roger, Evangelos J. Giamarellos-Bourboulis, Andreas Schlitzer, Mihai G. Netea
Article
Oncology
Marc Pfefferle, Irina L. Dubach, Raphael M. Buzzi, Elena Duerst, Nadja Schulthess-Lutz, Livio Baselgia, Kerstin Hansen, Larissa Imhof, Sandra Koernig, Didier Le Roy, Thierry Roger, Rok Humar, Dominik J. Schaer, Florence Vallelian
Summary: The study revealed that CD40 signaling in Clec4f(+) Kupffer cells triggers anti-CD40 antibody-induced liver toxicity. However, controlled erythrophagocytosis and the linked anti-inflammatory signaling by the endogenous metabolite heme can be exploited to reprogram liver macrophages and prevent necroinflammatory liver disease caused by high-dose administration of anti-CD40 antibodies.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2023)
Review
Immunology
Jeanne Bigot, Jordan Leroy, Taieb Chouaki, Laurence Cholley, Naike Bige, Marie-Dominique Tabone, Eolia Brissot, Sophie Thorez, Julien Maizel, Herve Dupont, Boualem Sendid, Christophe Hennequin, Juliette Guitard
Summary: This study assessed the value of beta 1,3-D-glucan (BDG) detection in the cerebrospinal fluid (CSF) of non-neonatal non-cryptococcosis patients. The results showed that the sensitivity of BDG assay in diagnosing proven/highly probable/probable FI-CNS ranged from 72.7% to 100%, and the specificity was found to be 81.8%. Despite its sub-optimal performance, BDG assay should be added to the diagnostic armamentarium for FI-CNS.
CLINICAL INFECTIOUS DISEASES
(2023)
Article
Infectious Diseases
Mickael Hirabidian, Saelens Thierry, Deleplancque Anne-Sophie, Benoit Bergues, Severine Loridant, Marjorie Cornu, Boualem Sendid, Jordan Leroy
Summary: This article describes a case of pleural fluid accumulation caused by Toxocara infection in a 72-year-old patient. The patient presented with symptoms such as dyspnea, fatigue, and diarrhea. Serological testing of both serum and pleural fluid confirmed the presence of anti-Toxocara antibodies. The symptoms were relieved after pleural drainage and treatment with anti-parasitic medication.
EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES
(2023)
Article
Public, Environmental & Occupational Health
N. Henoun Loukili, A. Loquet, A. Perrin, O. Gaillot, A. Bruandet, B. Sendid, J. R. Zahar, S. Nseir
Summary: This study aimed to evaluate the time to spontaneous CPE-IC and identify its potential associated risk factors. The median time to CPE-IC was 698 days. Female sex, multiple CPE-species, and E. coli or Klebsiella spp. infections were significantly associated with the time to CPE-IC. The presence of E. coli carbapenemase-producing or ESBL genes in index culture extended the median time to CPE-IC.
JOURNAL OF HOSPITAL INFECTION
(2023)
Editorial Material
Immunology
Lokesh Sharma, Shaon Sengupta, Thierry Roger
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Microbiology
Samir Jawhara
Summary: Western diets, high in fat and sugar and low in vegetable fiber, are causing an increase in obesity and diseases of civilization. These diets lead to gut dysbiosis and overgrowth of Candida albicans, a major cause of fungal infection worldwide. Factors such as smoking, excessive alcohol consumption, lack of physical activity, prolonged use of antibiotics, and chronic psychological stress also contribute to disease development and gut dysbiosis. A diversified diet containing vegetable fiber, omega-3 polyunsaturated fatty acids, vitamins D and E, and probiotic or prebiotic supplements can improve the biodiversity of the microbiota and reduce the abundance of fungal species in the gut. Traditional medicine offers various foods and plants effective against fungal overgrowth and gut dysbiosis. Overall, healthy diets and lifestyle factors positively impact the gut microbiota and the brain.
Editorial Material
Microbiology
Samir Jawhara
Review
Microbiology
Francois Danion, Anne Coste, Coralie Le Hyaric, Clea Melenotte, Frederic Lamoth, Thierry Calandra, Dea Garcia-Hermoso, Vishukumar Aimanianda, Fanny Lanternier, Olivier Lortholary
Summary: Mucormycosis is a rare and life-threatening fungal infection caused by molds of the order Mucorales. It mainly affects the lungs, following the rhino-orbito-cerebral (ROC) areas and the skin. Risk factors for pulmonary mucormycosis (PM) include hematological malignancies and solid organ transplantation, while ROC infections are commonly associated with diabetes mellitus. The diagnosis of PM relies on CT scans, cultures, PCR tests, and histology, and treatment involves liposomal amphotericin B as the first-line therapy.
Article
Biochemistry & Molecular Biology
Julie Dubois-Chevalier, Celine Gheeraert, Alexandre Berthier, Clemence Boulet, Vanessa Dubois, Loic Guille, Marie Fourcot, Guillemette Marot, Karine Gauthier, Laurent Dubuquoy, Bart Staels, Philippe Lefebvre, Jerome Eeckhoute
Summary: Cell identity is controlled by a core transcriptional regulatory circuitry (CoRC) consisting of cell-specific transcription factors (TFs). However, our study reveals that the transcriptional regulatory network regulating hepatocyte identity is more complex than initially thought. We identified a set of TFs, which we call hepatocyte identity (Hep-ID)(CONNECT) TFs, that not only control hepatocyte identity effector genes, but also interact with TFs of the CoRC. Furthermore, we found that Hep-IDCONNECT TFs play a role in fine-tuning CoRC TF expression and can reset CoRC TF expression in dedifferentiated hepatocytes.
Article
Chemistry, Medicinal
Morgane Rivoal, Laurent Dubuquoy, Regis Millet, Natascha Leleu-Chavain
Summary: RIPK2 is an essential downstream signaling molecule that activates various immune receptors, playing a crucial role in the release of pro-inflammatory cytokines. It has emerged as a potential therapeutic target for inflammatory diseases and cancer. This Perspective provides an overview of RIPK2 function, its role in diseases, available inhibitors, therapeutic strategies, and current challenges and outlook.
JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Infectious Diseases
Louis Camaioni, Bastien Ustyanowski, Mathys Buisine, Dylan Lambert, Boualem Sendid, Muriel Billamboz, Samir Jawhara
Summary: Candida albicans is a pathogenic yeast with increasing resistance to antifungal drugs. This study identified hinokitiol, a natural compound extracted from cypress wood, as showing excellent antifungal activity against C. albicans. Hi not only inhibited candida growth and biofilm formation, but also displayed anti-inflammatory effects against lipopolysaccharide-induced cytokine expression in macrophages.
