Innovative developments and emerging technologies in RNA therapeutics

DNA Nanodevices with Selective Immune Cell Interaction and Function

(2021) Nishkantha Arulkumaran et al.   ACS Nano

Nanobody–siRNA Conjugates for Targeted Delivery of siRNA to Cancer Cells

(2021) Oleksandr Zavoiura et al.   MOLECULAR PHARMACEUTICS

A DNA origami-based aptamer nanoarray for potent and reversible anticoagulation in hemodialysis

(2021) Shuai Zhao et al.   Nature Communications

DNA Nanostructures: Current Challenges and Opportunities for Cellular Delivery

(2021) Aurélie Lacroix et al.   ACS Nano

Antisense Technology: A Review

(2021) Stanley T. Crooke et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Glucagon Like Peptide 1 Receptor Agonists for Targeted Delivery of Antisense Oligonucleotides to Pancreatic Beta Cell

(2021) Laurent Knerr et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Centyrin ligands for extrahepatic delivery of siRNA

(2021) Donna Klein et al.   MOLECULAR THERAPY

siRNAs containing 2′-fluorinated Northern-methanocarbacyclic (2′-F-NMC) nucleotides: in vitro and in vivo RNAi activity and inability of mitochondrial polymerases to incorporate 2′-F-NMC NTPs

(2021) Masaaki Akabane-Nakata et al.   NUCLEIC ACIDS RESEARCH

Catalytic asymmetric and stereodivergent oligonucleotide synthesis

(2021) Aaron L. Featherston et al.   SCIENCE

Nuclease resistance of DNA nanostructures

(2021) Arun Richard Chandrasekaran   Nature Reviews Chemistry

Determinants of Ligand-Functionalized DNA Nanostructure–Cell Interactions

(2021) Glenn A. O. Cremers et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Cholesterol-functionalized DNA/RNA heteroduplexes cross the blood–brain barrier and knock down genes in the rodent CNS

(2021) Tetsuya Nagata et al.   NATURE BIOTECHNOLOGY

Destruction of DNA‐Binding Proteins by Programmable Oligonucleotide PROTAC (O'PROTAC): Effective Targeting of LEF1 and ERG

(2021) Jingwei Shao et al.   Advanced Science

Challenges and Perspectives of DNA Nanostructures in Biomedicine

(2020) Adrian Keller et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Proteolysis-Targeting Chimeras as Therapeutics and Tools for Biological Discovery

(2020) George M. Burslem et al.   CELL

Understanding the effect of controlling phosphorothioate chirality in the DNA gap on the potency and safety of gapmer antisense oligonucleotides

(2020) Michael E Østergaard et al.   NUCLEIC ACIDS RESEARCH

The effector mechanism of siRNA spherical nucleic acids

(2020) Gokay Yamankurt et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Light-induced control of protein destruction by opto-PROTAC

(2020) Jing Liu et al.   Science Advances

PHOTACs enable optical control of protein degradation

(2020) Martin Reynders et al.   Science Advances

Antibody–PROTAC Conjugates Enable HER2-Dependent Targeted Protein Degradation of BRD4

(2020) Marı́a Maneiro et al.   ACS Chemical Biology

MTL-CEBPA, a small activating RNA therapeutic up-regulating C/EBP-α, in patients with advanced liver cancer: a first-in-human, multi-centre, open-label, phase I trial

(2020) Debashis Sarker et al.   CLINICAL CANCER RESEARCH

Origins of the Increased Affinity of Phosphorothioate-Modified Therapeutic Nucleic Acids for Proteins

(2020) Malwina Hyjek-Składanowska et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A Trisbenzimidazole Phosphoramidite Building Block Enables High-Yielding Syntheses of RNA-Cleaving Oligonucleotide Conjugates

(2020) Felix Zellmann et al.   MOLECULES

Dual miRNases for Triple Incision of miRNA Target: Design Concept and Catalytic Performance

(2020) Olga Patutina et al.   MOLECULES

Inclisiran for the Treatment of Heterozygous Familial Hypercholesterolemia

(2020) Frederick J. Raal et al.   NEW ENGLAND JOURNAL OF MEDICINE

Generation and validation of structurally defined antibody–siRNA conjugates

(2020) Alex R Nanna et al.   NUCLEIC ACIDS RESEARCH

Phosphorothioate modified oligonucleotide–protein interactions

(2020) Stanley T Crooke et al.   NUCLEIC ACIDS RESEARCH

Defining the Design Parameters for in Vivo Enzyme Delivery Through Protein Spherical Nucleic Acids

(2020) Caroline D. Kusmierz et al.   ACS Central Science

Opportunities, Barriers, and a Strategy for Overcoming Translational Challenges to Therapeutic Nucleic Acid Nanotechnology

(2020) Kirill A. Afonin et al.   ACS Nano

The Interaction of Phosphorothioate Containing RNA Targeted Drugs with Proteins is a Critical Determinant of The Therapeutic Effects of These Agents

(2020) Stanley Crooke et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Protein Spherical Nucleic Acids for Live-Cell Chemical Analysis

(2020) Devleena Samanta et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Delivery of Oligonucleotides to the Liver with GalNAc: From Research to Registered Therapeutic Drug

(2020) Alexandre J. Debacker et al.   MOLECULAR THERAPY

Lysosome-targeting chimaeras for degradation of extracellular proteins

(2020) Steven M. Banik et al.   NATURE

Role of nanoscale antigen organization on B-cell activation probed using DNA origami

(2020) Rémi Veneziano et al.   Nature Nanotechnology

Advances in oligonucleotide drug delivery

(2020) Thomas C. Roberts et al.   NATURE REVIEWS DRUG DISCOVERY

LB002ILLUMINATE-A, A PHASE 3 STUDY OF LUMASIRAN, AN INVESTIGATIONAL RNAI THERAPEUTIC, IN CHILDREN AND ADULTS WITH PRIMARY HYPEROXALURIA TYPE 1 (PH1)

(2020) Sander Garrelfs et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Phase 3 Trial of RNAi Therapeutic Givosiran for Acute Intermittent Porphyria

(2020) Manisha Balwani et al.   NEW ENGLAND JOURNAL OF MEDICINE

The chemical structure and phosphorothioate content of hydrophobically modified siRNAs impact extrahepatic distribution and efficacy

(2020) Annabelle Biscans et al.   NUCLEIC ACIDS RESEARCH

RNA Nanoparticles as Rubber for Compelling Vessel Extravasation to Enhance Tumor Targeting and for Fast Renal Excretion to Reduce Toxicity

(2020) Chiran Ghimire et al.   ACS Nano

Investigating the pharmacodynamic durability of GalNAc–siRNA conjugates

(2020) Christopher R Brown et al.   NUCLEIC ACIDS RESEARCH

Strict conformational demands of RNA cleavage in bulge-loops created by peptidyl-oligonucleotide conjugates

(2020) Yaroslav Staroseletz et al.   NUCLEIC ACIDS RESEARCH

Synthesis, chirality-dependent conformational and biological properties of siRNAs containing 5′-(R)- and 5′-(S)-C-methyl-guanosine

(2020) Atsushi Mikami et al.   NUCLEIC ACIDS RESEARCH

Sixteen Different Types of Lipid-Conjugated siRNAs Containing Saturated and Unsaturated Fatty Acids and Exhibiting Enhanced RNAi Potency

(2020) Takanori Kubo et al.   ACS Chemical Biology

RNA‐PROTACs: Degraders of RNA‐Binding Proteins

(2020) Alice Ghidini et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Docosanoic acid conjugation to siRNA enables functional and safe delivery to skeletal and cardiac muscles

(2020) Annabelle Biscans et al.   MOLECULAR THERAPY

High-resolution visualization and quantification of nucleic acid–based therapeutics in cells and tissues using Nanoscale secondary ion mass spectrometry (NanoSIMS)

(2020) Cuiwen He et al.   NUCLEIC ACIDS RESEARCH

Separation-related rapid nuclear transport of DNA/RNA heteroduplex oligonucleotide: Unveiling distinctive intracellular trafficking

(2020) Daisuke Ono et al.   Molecular Therapy-Nucleic Acids

Kidney-Targeted Cytosolic Delivery of siRNA Using a Small-Sized Mirror DNA Tetrahedron for Enhanced Potency

(2020) Hien Bao Dieu Thai et al.   ACS Central Science

Designer DNA nanostructures for therapeutics

(2020) Shuoxing Jiang et al.   Chem

Mechanisms involved in the activation of C/EBPα by small activating RNA in hepatocellular carcinoma

(2019) Xiaoyang Zhao et al.   ONCOGENE

Differential PROTAC substrate specificity dictated by orientation of recruited E3 ligase

(2019) Blake E. Smith et al.   Nature Communications

Towards Self-Transfecting Nucleic Acid Nanostructures for Gene Regulation

(2019) Saketh Gudipati et al.   TRENDS IN BIOTECHNOLOGY

The current state and future directions of RNAi-based therapeutics

(2019) Ryan L. Setten et al.   NATURE REVIEWS DRUG DISCOVERY

Site-Specific Cleavage of RNAs Derived from the PIM1 3′-UTR by a Metal-Free Artificial Ribonuclease

(2019) Felix Zellmann et al.   MOLECULES

Further Probing of Cu2+-Dependent PNAzymes Acting as Artificial RNA Restriction Enzymes

(2019) Olivia Luige et al.   MOLECULES

Minimalist Design of a Stimuli-Responsive Spherical Nucleic Acid for Conditional Delivery of Oligonucleotide Therapeutics

(2019) Hassan H. Fakih et al.   ACS Applied Materials & Interfaces

Exploration of the nanomedicine-design space with high-throughput screening and machine learning

(2019) Gokay Yamankurt et al.   Nature Biomedical Engineering

The valency of fatty acid conjugates impacts siRNA pharmacokinetics, distribution, and efficacy in vivo

(2019) Annabelle Biscans et al.   JOURNAL OF CONTROLLED RELEASE

Targeting Nuclear Receptors with PROTAC degraders

(2019) John J. Flanagan et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Chemical modification of PS-ASO therapeutics reduces cellular protein-binding and improves the therapeutic index

(2019) Wen Shen et al.   NATURE BIOTECHNOLOGY

Differential uptake, kinetics and mechanisms of intracellular trafficking of next-generation antisense oligonucleotides across human cancer cell lines

(2019) Emily Linnane et al.   NUCLEIC ACIDS RESEARCH

Rational vaccinology with spherical nucleic acids

(2019) Shuya Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Effect of Sugar 2′,4′-Modifications on Gene Silencing Activity of Small Interfering RNA Duplexes

(2019) Elise Malek-Adamian et al.   Nucleic Acid Therapeutics

PNA Length Restriction of Antibacterial Activity of Peptide-PNA Conjugates in Escherichia coli Through Effects of the Inner Membrane

(2019) Lise Goltermann et al.   Frontiers in Microbiology

Highly efficient silencing of microRNA by heteroduplex oligonucleotides

(2019) Kotaro Yoshioka et al.   NUCLEIC ACIDS RESEARCH

Catalytic Knockdown of miR-21 by Artificial Ribonuclease: Biological Performance in Tumor Model

(2019) Olga A. Patutina et al.   Frontiers in Pharmacology

Influence of different Cell-Penetrating Peptides on the antimicrobial efficiency of antisense Peptide Nucleic Acids in Streptococcus pyogenes

(2019) Gina Barkowsky et al.   Molecular Therapy-Nucleic Acids

Potential and Challenges of Aptamers as Specific Carriers of Therapeutic Oligonucleotides for Precision Medicine in Cancer

(2019) Silvia Nuzzo et al.   Cancers

Antibody-mediated delivery of chimeric protein degraders which target estrogen receptor alpha (ERα)

(2019) Peter S. Dragovich et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Evaluating the Catalytic Potential of a General RNA‐Cleaving FANA Enzyme

(2019) Yajun Wang et al.   CHEMBIOCHEM

Impact of Phosphorothioate Chirality on Double‐Stranded siRNAs: A Systematic Evaluation of Stereopure siRNA Designs

(2019) Sukumar Sakamuri et al.   CHEMBIOCHEM

Golgi-endosome transport mediated by M6PR facilitates release of antisense oligonucleotides from endosomes

(2019) Xue-hai Liang et al.   NUCLEIC ACIDS RESEARCH

Liver Activation of Hepatocellular Nuclear Factor-4α by Small Activating RNA Rescues Dyslipidemia and Improves Metabolic Profile

(2019) Kai-Wen Huang et al.   Molecular Therapy-Nucleic Acids

Spherical Nucleic Acids with Tailored and Active Protein Coronae

(2019) Wuliang Zhang et al.   ACS Central Science

Anti-inflammatory and Antioxidative Effects of Tetrahedral DNA Nanostructures via the Modulation of Macrophage Responses

(2018) Qi Zhang et al.   ACS Applied Materials & Interfaces

Spherical Nucleic Acid Nanoparticles: Therapeutic Potential

(2018) Chintan H. Kapadia et al.   BIODRUGS

RNA-Targeted Therapeutics

(2018) Stanley T. Crooke et al.   Cell Metabolism

DNA Nanotechnology-Enabled Drug Delivery Systems

(2018) Qinqin Hu et al.   CHEMICAL REVIEWS

Recent advances in DNA nanotechnology

(2018) Pongphak Chidchob et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Therapeutic Potential of Small Activating RNAs (saRNAs) in Human cancers

(2018) Sorah Yoon et al.   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

Morpholino oligomers tested in vitro, in biofilm and in vivo against multidrug-resistant Klebsiella pneumoniae

(2018) Bruce L Geller et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Advanced siRNA Designs Further Improve In Vivo Performance of GalNAc-siRNA Conjugates

(2018) Donald J. Foster et al.   MOLECULAR THERAPY

A DNA-Based Nanocarrier for Efficient Gene Delivery and Combined Cancer Therapy

(2018) Jianbing Liu et al.   NANO LETTERS

Advances in the delivery of antisense oligonucleotides for combating bacterial infectious diseases

(2018) Xiao-Yan Xue et al.   Nanomedicine-Nanotechnology Biology and Medicine

Acute hepatotoxicity of 2′ fluoro-modified 5–10–5 gapmer phosphorothioate oligonucleotides in mice correlates with intracellular protein binding and the loss of DBHS proteins

(2018) Wen Shen et al.   NUCLEIC ACIDS RESEARCH

Cellular uptake mediated by epidermal growth factor receptor facilitates the intracellular activity of phosphorothioate-modified antisense oligonucleotides

(2018) Shiyu Wang et al.   NUCLEIC ACIDS RESEARCH

Comparison of partially and fully chemically-modified siRNA in conjugate-mediated delivery in vivo

(2018) Matthew R Hassler et al.   NUCLEIC ACIDS RESEARCH

Selection of GalNAc-conjugated siRNAs with limited off-target-driven rat hepatotoxicity

(2018) Maja M. Janas et al.   Nature Communications

Intracellular Trafficking and Endosomal Release of Oligonucleotides: What We Know and What We Don’t

(2018) R.L. Juliano   Nucleic Acid Therapeutics

Improving siRNA Delivery In Vivo Through Lipid Conjugation

(2018) Maire F. Osborn et al.   Nucleic Acid Therapeutics

Modulation of blood-brain barrier function by a heteroduplex oligonucleotide in vivo

(2018) Hiroya Kuwahara et al.   Scientific Reports

Antibody-Antisense Oligonucleotide Conjugate Downregulates a Key Gene in Glioblastoma Stem Cells

(2018) Amy E. Arnold et al.   Molecular Therapy-Nucleic Acids

Antisense Inhibitors Retain Activity in Pulmonary Models of Burkholderia Infection

(2018) Seth M. Daly et al.   ACS Infectious Diseases

DNA Nanostructures at the Interface with Biology

(2018) Katherine E. Bujold et al.   Chem

DNA Nanostructure-Programmed Like-Charge Attraction at the Cell-Membrane Interface

(2018) Hongming Ding et al.   ACS Central Science

A DNA nanomachine chemically resolves lysosomes in live cells

(2018) KaHo Leung et al.   Nature Nanotechnology

Hydrophobicity drives the systemic distribution of lipid-conjugated siRNAs via lipid transport pathways

(2018) Maire F Osborn et al.   NUCLEIC ACIDS RESEARCH

Quantitative fluorescence imaging determines the absolute number of locked nucleic acid oligonucleotides needed for suppression of target gene expression

(2018) Annette Buntz et al.   NUCLEIC ACIDS RESEARCH

Diverse lipid conjugates for functional extra-hepatic siRNA delivery in vivo

(2018) Annabelle Biscans et al.   NUCLEIC ACIDS RESEARCH

Specific delivery of delta-5-desaturase siRNA via RNA nanoparticles supplemented with dihomo-γ-linolenic acid for colon cancer suppression

(2018) Yi Xu et al.   Redox Biology

Highly tumor-specific DNA nanostructures discovered by in vivo screening of a nucleic acid cage library and their applications in tumor-targeted drug delivery

(2018) Kyoung-Ran Kim et al.   BIOMATERIALS

The APPROACH Study: A Randomized, Double-Blind, Placebo-Controlled, Phase 3 Study of Volanesorsen Administered Subcutaneously to Patients with Familial Chylomicronemia Syndrome (FCS)

(2017) D. Gaudet et al.   Journal of Clinical Lipidology

Development of DNA Nanostructures for High-Affinity Binding to Human Serum Albumin

(2017) Aurélie Lacroix et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Clinical Proof of Concept for a Novel Hepatocyte-Targeting GalNAc-siRNA Conjugate

(2017) Tracy S. Zimmermann et al.   MOLECULAR THERAPY

Development and Mechanism of Small Activating RNA Targeting CEBPA, a Novel Therapeutic in Clinical Trials for Liver Cancer

(2017) Jon Voutila et al.   MOLECULAR THERAPY

Zinc Ion-Dependent Peptide Nucleic Acid-Based Artificial Enzyme that Cleaves RNA—Bulge Size and Sequence Dependence

(2017) Merita Murtola et al.   MOLECULES

Fractal assembly of micrometre-scale DNA origami arrays with arbitrary patterns

(2017) Grigory Tikhomirov et al.   NATURE

Control of phosphorothioate stereochemistry substantially increases the efficacy of antisense oligonucleotides

(2017) Naoki Iwamoto et al.   NATURE BIOTECHNOLOGY

Cellular uptake and trafficking of antisense oligonucleotides

(2017) Stanley T Crooke et al.   NATURE BIOTECHNOLOGY

Overcoming cellular barriers for RNA therapeutics

(2017) Steven F Dowdy   NATURE BIOTECHNOLOGY

Chemistry, mechanism and clinical status of antisense oligonucleotides and duplex RNAs

(2017) Xiulong Shen et al.   NUCLEIC ACIDS RESEARCH

Thermodynamic stabilities of three-way junction nanomotifs in prohead RNA

(2017) Alyssa C. Hill et al.   RNA

FolamiRs: Ligand-targeted, vehicle-free delivery of microRNAs for the treatment of cancer

(2017) Esteban A. Orellana et al.   Science Translational Medicine

DNA nanotechnology

(2017) Nadrian C. Seeman et al.   Nature Reviews Materials

Overcoming Tamoxifen Resistance of Human Breast Cancer by Targeted Gene Silencing Using Multifunctional pRNA Nanoparticles

(2016) Yijuan Zhang et al.   ACS Nano

Antibacterial Peptide Nucleic Acid–Antimicrobial Peptide (PNA–AMP) Conjugates: Antisense Targeting of Fatty Acid Biosynthesis

(2016) Anna Mette Hansen et al.   BIOCONJUGATE CHEMISTRY

saRNA-guided Ago2 targets the RITA complex to promoters to stimulate transcription

(2016) Victoria Portnoy et al.   CELL RESEARCH

Antisense antimicrobial therapeutics

(2016) Erin K Sully et al.   CURRENT OPINION IN MICROBIOLOGY

Development of antibody-siRNA conjugate targeted to cardiac and skeletal muscles

(2016) Tsukasa Sugo et al.   JOURNAL OF CONTROLLED RELEASE

Optimized DNA “Nanosuitcases” for Encapsulation and Conditional Release of siRNA

(2016) Katherine E. Bujold et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Novel Targeted Therapy for Precursor B-Cell Acute Lymphoblastic Leukemia: Anti-CD22 Antibody-MXD3 Antisense Oligonucleotide Conjugate

(2016) Noriko Satake et al.   MOLECULAR MEDICINE

Induced protein degradation: an emerging drug discovery paradigm

(2016) Ashton C. Lai et al.   NATURE REVIEWS DRUG DISCOVERY

Small activating RNA binds to the genomic target site in a seed-region-dependent manner

(2016) Xing Meng et al.   NUCLEIC ACIDS RESEARCH

Stabilin-1 and Stabilin-2 are specific receptors for the cellular internalization of phosphorothioate-modified antisense oligonucleotides (ASOs) in the liver

(2016) Colton M. Miller et al.   NUCLEIC ACIDS RESEARCH

Splice-switching antisense oligonucleotides as therapeutic drugs

(2016) Mallory A. Havens et al.   NUCLEIC ACIDS RESEARCH

Influence of conjugation and other structural changes on the activity of Cu2+ based PNAzymes

(2016) A. Ghidini et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Three-way junction conformation dictates self-association of phage packaging RNAs

(2016) Yumeng Hao et al.   RNA Biology

Structural and Molecular Basis for Coordination in a Viral DNA Packaging Motor

(2016) Huzhang Mao et al.   Cell Reports

Prohead RNA: a noncoding viral RNA of novel structure and function

(2016) Alyssa C. Hill et al.   Wiley Interdisciplinary Reviews-RNA

Studies on Tris(2-aminobenzimidazole)-PNA Based Artificial Nucleases: A Comparison of Two Analytical Techniques

(2015) Plamena Dogandzhiyski et al.   BIOCONJUGATE CHEMISTRY

Cell-Type Specific Penetrating Peptides: Therapeutic Promises and Challenges

(2015) Maliha Zahid et al.   MOLECULES

DNA rendering of polyhedral meshes at the nanoscale

(2015) Erik Benson et al.   NATURE

Functional correction in mouse models of muscular dystrophy using exon-skipping tricyclo-DNA oligomers

(2015) Aurélie Goyenvalle et al.   NATURE MEDICINE

High-throughput screening identifies small molecules that enhance the pharmacological effects of oligonucleotides

(2015) B. Yang et al.   NUCLEIC ACIDS RESEARCH

Identification and characterization of intracellular proteins that bind oligonucleotides with phosphorothioate linkages

(2015) Xue-hai Liang et al.   NUCLEIC ACIDS RESEARCH

DNA/RNA heteroduplex oligonucleotide for highly efficient gene silencing

(2015) Kazutaka Nishina et al.   Nature Communications

RNA nanoparticle as a vector for targeted siRNA delivery into glioblastoma mouse model

(2015) Tae Jin Lee et al.   Oncotarget

Regression of Gastric Cancer by Systemic Injection of RNA Nanoparticles Carrying both Ligand and siRNA

(2015) Daxiang Cui et al.   Scientific Reports

Efficient delivery of RNAi prodrugs containing reversible charge-neutralizing phosphotriester backbone modifications

(2014) Bryan R Meade et al.   NATURE BIOTECHNOLOGY

Diverse self-association properties within a family of phage packaging RNAs

(2014) Yumeng Hao et al.   RNA

The role of antisense long noncoding RNA in small RNA-triggered gene activation

(2014) Xizhe Zhang et al.   RNA

Utilizing the bioorthogonal base-pairing system ofl-DNA to design ideal DNA nanocarriers for enhanced delivery of nucleic acid cargos

(2014) Kyoung-Ran Kim et al.   Chemical Science

2′-OMe-phosphorodithioate-modified siRNAs show increased loading into the RISC complex and enhanced anti-tumour activity

(2014) Sherry Y. Wu et al.   Nature Communications

Phosphorothioates, Essential Components of Therapeutic Oligonucleotides

(2014) Fritz Eckstein   Nucleic Acid Therapeutics

Gene-Silencing Antisense Oligomers Inhibit Acinetobacter Growth In Vitro and In Vivo

(2013) B. L. Geller et al.   JOURNAL OF INFECTIOUS DISEASES

DNA “Nano-Claw”: Logic-Based Autonomous Cancer Targeting and Therapy

(2013) Mingxu You et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Image-based analysis of lipid nanoparticle–mediated siRNA delivery, intracellular trafficking and endosomal escape

(2013) Jerome Gilleron et al.   NATURE BIOTECHNOLOGY

The small molecule Retro-1 enhances the pharmacological actions of antisense and splice switching oligonucleotides

(2013) Xin Ming et al.   NUCLEIC ACIDS RESEARCH

Promoter RNA links transcriptional regulation of inflammatory pathway genes

(2013) Masayuki Matsui et al.   NUCLEIC ACIDS RESEARCH

Targeting RNA splicing for disease therapy

(2013) Mallory A. Havens et al.   Wiley Interdisciplinary Reviews-RNA

Role of SbmA in the Uptake of Peptide Nucleic Acid (PNA)-Peptide Conjugates in E. coli

(2012) Anubrata Ghosal et al.   ACS Chemical Biology

Bacterial Resistance to Antisense Peptide Phosphorodiamidate Morpholino Oligomers

(2012) Susan E. Puckett et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Spherical Nucleic Acids

(2012) Joshua I. Cutler et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Molecularly self-assembled nucleic acid nanoparticles for targeted in vivo siRNA delivery

(2012) Hyukjin Lee et al.   Nature Nanotechnology

DNA Cage Delivery to Mammalian Cells

(2011) Anthony S. Walsh et al.   ACS Nano

Different Sequences Show Similar Quaternary Interaction Stabilities in Prohead Viral RNA Self-assembly

(2011) Xiaobo Gu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Pharmacological Characterization of Chemically Synthesized Monomeric phi29 pRNA Nanoparticles for Systemic Delivery

(2011) Sherine Abdelmawla et al.   MOLECULAR THERAPY

Thermodynamically stable RNA three-way junction for constructing multifunctional nanoparticles for delivery of therapeutics

(2011) Dan Shu et al.   Nature Nanotechnology

Activation of LDL Receptor Expression by Small RNAs Complementary to a Noncoding Transcript that Overlaps the LDLR Promoter

(2010) Masayuki Matsui et al.   CHEMISTRY & BIOLOGY

Defining Features and Exploring Chemical Modifications to Manipulate RNAa Activity

(2010) Robert F. Place et al.   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

Antisense Phosphorodiamidate Morpholino Oligomers Targeted to an Essential Gene InhibitBurkholderia cepaciaComplex

(2010) David E. Greenberg et al.   JOURNAL OF INFECTIOUS DISEASES

PNAzymes That Are Artificial RNA Restriction Enzymes

(2010) Merita Murtola et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Application of Phi29 Motor pRNA for Targeted Therapeutic Delivery of siRNA Silencing Metallothionein-IIA and Survivin in Ovarian Cancers

(2010) Pheruza Tarapore et al.   MOLECULAR THERAPY

Structural basis for 5′-nucleotide base-specific recognition of guide RNA by human AGO2

(2010) Filipp Frank et al.   NATURE

The emerging field of RNA nanotechnology

(2010) Peixuan Guo   Nature Nanotechnology

Aptamers as therapeutics

(2010) Anthony D. Keefe et al.   NATURE REVIEWS DRUG DISCOVERY

A screen of chemical modifications identifies position-specific modification by UNA to most potently reduce siRNA off-target effects

(2010) Jesper B. Bramsen et al.   NUCLEIC ACIDS RESEARCH

Involvement of argonaute proteins in gene silencing and activation by RNAs complementary to a non-coding transcript at the progesterone receptor promoter

(2010) Yongjun Chu et al.   NUCLEIC ACIDS RESEARCH

RNAa Is Conserved in Mammalian Cells

(2010) Vera Huang et al.   PLoS One

Targeted delivery of anti-coxsackievirus siRNAs using ligand-conjugated packaging RNAs

(2009) Huifang M. Zhang et al.   ANTIVIRAL RESEARCH

MicroRNAs: Target Recognition and Regulatory Functions

(2009) David P. Bartel   CELL

Efficient Regulation of VEGF Expression by Promoter-Targeted Lentiviral shRNAs Based on Epigenetic Mechanism

(2009) Mikko P. Turunen et al.   CIRCULATION RESEARCH

Antisense oligonucleotide pharmacokinetics and metabolism

(2009) Richard S Geary   Expert Opinion on Drug Metabolism & Toxicology

Efficient siRNA delivery into primary cells by a peptide transduction domain–dsRNA binding domain fusion protein

(2009) Akiko Eguchi et al.   NATURE BIOTECHNOLOGY

Coding sequence targeting by MicC RNA reveals bacterial mRNA silencing downstream of translational initiation

(2009) Verena Pfeiffer et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Efficient gene silencing by delivery of locked nucleic acid antisense oligonucleotides, unassisted by transfection reagents

(2009) C. A. Stein et al.   NUCLEIC ACIDS RESEARCH

DNA Origami Design of Dolphin-Shaped Structures with Flexible Tails

(2008) Ebbe S. Andersen et al.   ACS Nano

Mechanisms of RNA-mediated Disease

(2008) Jason R. O'Rourke et al.   JOURNAL OF BIOLOGICAL CHEMISTRY