Determinants of Ligand-Functionalized DNA Nanostructure–Cell Interactions

Spatial Regulation of T-Cell Signaling by Programmed Death-Ligand 1 on Wireframe DNA Origami Flat Sheets

(2021) Trixy Fang et al.   ACS Nano

Engineering the Orientation, Density, and Flexibility of Single-Domain Antibodies on Nanoparticles To Improve Cell Targeting

(2020) Ken W. Yong et al.   ACS Applied Materials & Interfaces

Glutaraldehyde Cross-Linking of Oligolysines Coating DNA Origami Greatly Reduces Susceptibility to Nuclease Degradation

(2020) Frances M. Anastassacos et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

On the design of precision nanomedicines

(2020) Xiaohe Tian et al.   Science Advances

Proximity-induced caspase-9 activation on a DNA origami-based synthetic apoptosome

(2020) Bas J. H. M. Rosier et al.   Nature Catalysis

DNA origami protection and molecular interfacing through engineered sequence-defined peptoids

(2020) Shih-Ting Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Role of nanoscale antigen organization on B-cell activation probed using DNA origami

(2020) Rémi Veneziano et al.   Nature Nanotechnology

A DNA nanodevice-based vaccine for cancer immunotherapy

(2020) Shaoli Liu et al.   NATURE MATERIALS

Delivering DNA origami to cells

(2019) Dhanasekaran Balakrishnan et al.   Nanomedicine

Pointing in the Right Direction: Controlling the Orientation of Proteins on Nanoparticles Improves Targeting Efficiency

(2019) Ken W. Yong et al.   NANO LETTERS

Barcoded DNA nanostructures for the multiplexed profiling of subcellular protein distribution

(2019) Noah R. Sundah et al.   Nature Biomedical Engineering

Efficient Small-Scale Conjugation of DNA to Primary Antibodies for Multiplexed Cellular Targeting

(2019) Glenn A. O. Cremers et al.   BIOCONJUGATE CHEMISTRY

Designer DNA architecture offers precise and multivalent spatial pattern-recognition for viral sensing and inhibition

(2019) Paul S. Kwon et al.   Nature Chemistry

Orthogonal regulation of DNA nanostructure self-assembly and disassembly using antibodies

(2019) Simona Ranallo et al.   Nature Communications

Visualization of the Cellular Uptake and Trafficking of DNA Origami Nanostructures in Cancer Cells

(2018) Pengfei Wang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Modulation of the Cellular Uptake of DNA Origami through Control over Mass and Shape

(2018) Maartje M. C. Bastings et al.   NANO LETTERS

A DNA nanorobot functions as a cancer therapeutic in response to a molecular trigger in vivo

(2018) Suping Li et al.   NATURE BIOTECHNOLOGY

Focus on Fundamentals: Achieving Effective Nanoparticle Targeting

(2018) Gregory T. Tietjen et al.   TRENDS IN MOLECULAR MEDICINE

Quantifying absolute addressability in DNA origami with molecular resolution

(2018) Maximilian T. Strauss et al.   Nature Communications

Immunomodulating Nanomedicine for Cancer Therapy

(2018) Zhigang Liu et al.   NANO LETTERS

Sequence-programmable covalent bonding of designed DNA assemblies

(2018) Thomas Gerling et al.   Science Advances

Ligand Density and Nanoparticle Clustering Cooperate in the Multivalent Amplification of Epidermal Growth Factor Receptor Activation

(2018) Qianyun Zhang et al.   ACS Nano

Multivalent Ligand Binding to Cell Membrane Antigens: Defining the Interplay of Affinity, Valency, and Expression Density

(2018) Clifford M. Csizmar et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The glycocalyx regulates the uptake of nanoparticles by human endothelial cells in vitro

(2017) Leonhard Möckl et al.   Nanomedicine

Biotechnological mass production of DNA origami

(2017) Florian Praetorius et al.   NATURE

Multivalent bi-specific nanobioconjugate engager for targeted cancer immunotherapy

(2017) Hengfeng Yuan et al.   Nature Nanotechnology

T cell costimulatory receptor CD28 is a primary target for PD-1–mediated inhibition

(2017) Enfu Hui et al.   SCIENCE

In vivo imaging reveals a tumor-associated macrophage–mediated resistance pathway in anti–PD-1 therapy

(2017) Sean P. Arlauckas et al.   Science Translational Medicine

Oligolysine-based coating protects DNA nanostructures from low-salt denaturation and nuclease degradation

(2017) Nandhini Ponnuswamy et al.   Nature Communications

High resolution single particle refinement in EMAN2.1

(2016) James M. Bell et al.   METHODS

Tumour homing and therapeutic effect of colloidal nanoparticles depend on the number of attached antibodies

(2016) Miriam Colombo et al.   Nature Communications

Purification of Functionalized DNA Origami Nanostructures

(2015) Alan Shaw et al.   ACS Nano

Accelerating the Translation of Nanomaterials in Biomedicine

(2015) Samir Mitragotri et al.   ACS Nano

Efficient Production of Single-Stranded Phage DNA as Scaffolds for DNA Origami

(2015) Benjamin Kick et al.   NANO LETTERS

Influence of the glycocalyx and plasma membrane composition on amphiphilic gold nanoparticle association with erythrocytes

(2015) Prabhani U. Atukorale et al.   Nanoscale

DNA nanotechnology from the test tube to the cell

(2015) Yuan-Jyue Chen et al.   Nature Nanotechnology

DNA Origami as an In Vivo Drug Delivery Vehicle for Cancer Therapy

(2014) Qian Zhang et al.   ACS Nano

Addressing the Instability of DNA Nanostructures in Tissue Culture

(2014) Jaeseung Hahn et al.   ACS Nano

Facile and Scalable Preparation of Pure and Dense DNA Origami Solutions

(2014) Evi Stahl et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Shape and Orientation Matter for the Cellular Uptake of Nonspherical Particles

(2014) Sabyasachi Dasgupta et al.   NANO LETTERS

Spatial control of membrane receptor function using ligand nanocalipers

(2014) Alan Shaw et al.   NATURE METHODS

Colloidal nanoparticles as advanced biological sensors

(2014) P. D. Howes et al.   SCIENCE

Engineered nanoparticles interacting with cells: size matters

(2014) Li Shang et al.   JOURNAL OF NANOBIOTECHNOLOGY

Particle shape enhances specificity of antibody-displaying nanoparticles

(2013) Sutapa Barua et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Shape-Dependent Cellular Processing of Polyelectrolyte Capsules

(2012) Olga Shimoni et al.   ACS Nano

Targeting Cancer Cells: Controlling the Binding and Internalization of Antibody-Functionalized Capsules

(2012) Angus P. R. Johnston et al.   ACS Nano

DNA Origami Delivery System for Cancer Therapy with Tunable Release Properties

(2012) Yong-Xing Zhao et al.   ACS Nano

Programmed cell death 1 forms negative costimulatory microclusters that directly inhibit T cell receptor signaling by recruiting phosphatase SHP2

(2012) Tadashi Yokosuka et al.   JOURNAL OF EXPERIMENTAL MEDICINE

DNA Origami as a Carrier for Circumvention of Drug Resistance

(2012) Qiao Jiang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A Logic-Gated Nanorobot for Targeted Transport of Molecular Payloads

(2012) S. M. Douglas et al.   SCIENCE

Cancer immunotherapy comes of age

(2011) Ira Mellman et al.   NATURE

Recovery of intact DNA nanostructures after agarose gel–based separation

(2011) Gaëtan Bellot et al.   NATURE METHODS

Designing super selectivity in multivalent nano-particle binding

(2011) F. J. Martinez-Veracoechea et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

More Effective Nanomedicines through Particle Design

(2011) Jin Wang et al.   Small

Morphing Low-Affinity Ligands into High-Avidity Nanoparticles by Thermally Triggered Self-Assembly of a Genetically Encoded Polymer

(2010) Andrew J. Simnick et al.   ACS Nano

Designer Biomaterials for Nanomedicine

(2009) Nishit Doshi et al.   ADVANCED FUNCTIONAL MATERIALS

Self-assembly of DNA into nanoscale three-dimensional shapes

(2009) Shawn M. Douglas et al.   NATURE