标题
Investigating the pharmacodynamic durability of GalNAc–siRNA conjugates
作者
关键词
-
出版物
NUCLEIC ACIDS RESEARCH
Volume -, Issue -, Pages -
出版商
Oxford University Press (OUP)
发表日期
2020-08-01
DOI
10.1093/nar/gkaa670
参考文献
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注意:仅列出部分参考文献,下载原文获取全部文献信息。- Two Phase 3 Trials of Inclisiran in Patients with Elevated LDL Cholesterol
- (2020) Kausik K. Ray et al. NEW ENGLAND JOURNAL OF MEDICINE
- RT-qPCR Methods to Support Pharmacokinetics and Drug Mechanism of Action to Advance Development of RNAi Therapeutics
- (2020) Elena Castellanos-Rizaldos et al. Nucleic Acid Therapeutics
- Phase 3 Trial of RNAi Therapeutic Givosiran for Acute Intermittent Porphyria
- (2020) Manisha Balwani et al. NEW ENGLAND JOURNAL OF MEDICINE
- The Onpattro story and the clinical translation of nanomedicines containing nucleic acid-based drugs
- (2019) Akin Akinc et al. Nature Nanotechnology
- Facile Synthesis, Geometry, and 2′-Substituent-Dependent in Vivo Activity of 5′-(E)- and 5′-(Z)-Vinylphosphonate-Modified siRNA Conjugates
- (2018) Rubina Giare Parmar et al. JOURNAL OF MEDICINAL CHEMISTRY
- Advanced siRNA Designs Further Improve In Vivo Performance of GalNAc-siRNA Conjugates
- (2018) Donald J. Foster et al. MOLECULAR THERAPY
- Intracellular Trafficking and Endosomal Release of Oligonucleotides: What We Know and What We Don’t
- (2018) R.L. Juliano Nucleic Acid Therapeutics
- GalNAc-siRNA Conjugates: Leading the Way for Delivery of RNAi Therapeutics
- (2018) Aaron D. Springer et al. Nucleic Acid Therapeutics
- RNA Therapeutics (Almost) Comes of Age: Targeting, Delivery and Endosomal Escape
- (2018) Steven F. Dowdy et al. Nucleic Acid Therapeutics
- Clinical Proof of Concept for a Novel Hepatocyte-Targeting GalNAc-siRNA Conjugate
- (2017) Tracy S. Zimmermann et al. MOLECULAR THERAPY
- Overcoming cellular barriers for RNA therapeutics
- (2017) Steven F Dowdy NATURE BIOTECHNOLOGY
- A Highly Durable RNAi Therapeutic Inhibitor of PCSK9
- (2017) Kevin Fitzgerald et al. NEW ENGLAND JOURNAL OF MEDICINE
- Inclisiran in Patients at High Cardiovascular Risk with Elevated LDL Cholesterol
- (2017) Kausik K. Ray et al. NEW ENGLAND JOURNAL OF MEDICINE
- Intra-endosomal trafficking mediated by lysobisphosphatidic acid contributes to intracellular release of phosphorothioate-modified antisense oligonucleotides
- (2017) Shiyu Wang et al. NUCLEIC ACIDS RESEARCH
- Impact of enhanced metabolic stability on pharmacokinetics and pharmacodynamics of GalNAc–siRNA conjugates
- (2017) Jayaprakash K. Nair et al. NUCLEIC ACIDS RESEARCH
- Chemistry, mechanism and clinical status of antisense oligonucleotides and duplex RNAs
- (2017) Xiulong Shen et al. NUCLEIC ACIDS RESEARCH
- siRNA carrying an (E)-vinylphosphonate moiety at the 5΄ end of the guide strand augments gene silencing by enhanced binding to human Argonaute-2
- (2016) Elad Elkayam et al. NUCLEIC ACIDS RESEARCH
- Visualization of self-delivering hydrophobically modified siRNA cellular internalization
- (2016) Socheata Ly et al. NUCLEIC ACIDS RESEARCH
- The delivery of therapeutic oligonucleotides
- (2016) Rudolph L. Juliano NUCLEIC ACIDS RESEARCH
- siRNA Conjugates Carrying Sequentially Assembled Trivalent N-Acetylgalactosamine Linked Through Nucleosides Elicit Robust Gene Silencing In Vivo in Hepatocytes
- (2015) Shigeo Matsuda et al. ACS Chemical Biology
- A role for peptides in overcoming endosomal entrapment in siRNA delivery — A focus on melittin
- (2015) Kirk K. Hou et al. BIOTECHNOLOGY ADVANCES
- Visualizing lipid-formulated siRNA release from endosomes and target gene knockdown
- (2015) Anders Wittrup et al. NATURE BIOTECHNOLOGY
- Biochemical isolation of Argonaute protein complexes by Ago-APP
- (2015) Judith Hauptmann et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Multivalent N-Acetylgalactosamine-Conjugated siRNA Localizes in Hepatocytes and Elicits Robust RNAi-Mediated Gene Silencing
- (2014) Jayaprakash K. Nair et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Identification of the endosomal sorting complex required for transport-I (ESCRT-I) as an important modulator of anti-miR uptake by cancer cells
- (2014) Timothy R. Wagenaar et al. NUCLEIC ACIDS RESEARCH
- The rough endoplasmatic reticulum is a central nucleation site of siRNA-mediated RNA silencing
- (2013) Lukas Stalder et al. EMBO JOURNAL
- Biodegradable Lipids Enabling Rapidly Eliminated Lipid Nanoparticles for Systemic Delivery of RNAi Therapeutics
- (2013) Martin A Maier et al. MOLECULAR THERAPY
- Image-based analysis of lipid nanoparticle–mediated siRNA delivery, intracellular trafficking and endosomal escape
- (2013) Jerome Gilleron et al. NATURE BIOTECHNOLOGY
- Efficiency of siRNA delivery by lipid nanoparticles is limited by endocytic recycling
- (2013) Gaurav Sahay et al. NATURE BIOTECHNOLOGY
- Safety and Efficacy of RNAi Therapy for Transthyretin Amyloidosis
- (2013) Teresa Coelho et al. NEW ENGLAND JOURNAL OF MEDICINE
- Maximizing the Potency of siRNA Lipid Nanoparticles for Hepatic Gene Silencing In Vivo
- (2012) Muthusamy Jayaraman et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Long-lived microRNA-Argonaute complexes in quiescent cells can be activated to regulate mitogenic responses
- (2012) S. H. Olejniczak et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- A rapid two-step method for isolation of functional primary mouse hepatocytes: cell characterization and asialoglycoprotein receptor based assay development
- (2011) Mariano Severgnini et al. CYTOTECHNOLOGY
- RNA-Induced Silencing Complex-Bound Small Interfering RNA Is a Determinant of RNA Interference-Mediated Gene Silencing in Mice
- (2011) J. Wei et al. MOLECULAR PHARMACOLOGY
- Analysis of microRNA turnover in mammalian cells following Dicer1 ablation
- (2011) Michael P. Gantier et al. NUCLEIC ACIDS RESEARCH
- Argonaute proteins regulate microRNA stability: Increased microRNA abundance by Argonaute proteins is due to microRNA stabilization
- (2011) Julia Winter et al. RNA Biology
- Endosomal escape pathways for delivery of biologicals
- (2010) Amir K. Varkouhi et al. JOURNAL OF CONTROLLED RELEASE
- Targeted Delivery of RNAi Therapeutics With Endogenous and Exogenous Ligand-Based Mechanisms
- (2010) Akin Akinc et al. MOLECULAR THERAPY
- Rational design of cationic lipids for siRNA delivery
- (2010) Sean C Semple et al. NATURE BIOTECHNOLOGY
- Quantitative evaluation of siRNA delivery in vivo
- (2010) Y. Pei et al. RNA
- RISC hitches onto endosome trafficking
- (2009) Haruhiko Siomi et al. NATURE CELL BIOLOGY
- Silencing by small RNAs is linked to endosomal trafficking
- (2009) Young Sik Lee et al. NATURE CELL BIOLOGY
- Multivesicular bodies associate with components of miRNA effector complexes and modulate miRNA activity
- (2009) Derrick J. Gibbings et al. NATURE CELL BIOLOGY
- Synthesis and characterization of 2′-modified-4′-thioRNA: a comprehensive comparison of nuclease stability
- (2009) Mayumi Takahashi et al. NUCLEIC ACIDS RESEARCH
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