标题
The current state and future directions of RNAi-based therapeutics
作者
关键词
-
出版物
NATURE REVIEWS DRUG DISCOVERY
Volume -, Issue -, Pages -
出版商
Springer Nature
发表日期
2019-03-07
DOI
10.1038/s41573-019-0017-4
参考文献
相关参考文献
注意：仅列出部分参考文献，下载原文获取全部文献信息。- On the Formation and Morphology of Lipid Nanoparticles Containing Ionizable Cationic Lipids and siRNA
- (2018) Jayesh A. Kulkarni et al. ACS Nano
- Injectable and protease-degradable hydrogel for siRNA sequestration and triggered delivery to the heart
- (2018) Leo L. Wang et al. JOURNAL OF CONTROLLED RELEASE
- Evaluation of GalNAc-siRNA Conjugate Activity in Pre-clinical Animal Models with Reduced Asialoglycoprotein Receptor Expression
- (2018) Jennifer L.S. Willoughby et al. MOLECULAR THERAPY
- Reversal of siRNA-mediated gene silencing in vivo
- (2018) Ivan Zlatev et al. NATURE BIOTECHNOLOGY
- A DNA nanorobot functions as a cancer therapeutic in response to a molecular trigger in vivo
- (2018) Suping Li et al. NATURE BIOTECHNOLOGY
- Patisiran, an RNAi Therapeutic, for Hereditary Transthyretin Amyloidosis
- (2018) David Adams et al. NEW ENGLAND JOURNAL OF MEDICINE
- Inotersen Treatment for Patients with Hereditary Transthyretin Amyloidosis
- (2018) Merrill D. Benson et al. NEW ENGLAND JOURNAL OF MEDICINE
- Comparison of partially and fully chemically-modified siRNA in conjugate-mediated delivery in vivo
- (2018) Matthew R Hassler et al. NUCLEIC ACIDS RESEARCH
- Gene activation of CEBPA using saRNA: preclinical studies of the first in human saRNA drug candidate for liver cancer
- (2018) Vikash Reebye et al. ONCOGENE
- Selection of GalNAc-conjugated siRNAs with limited off-target-driven rat hepatotoxicity
- (2018) Maja M. Janas et al. Nature Communications
- Progress and challenges towards targeted delivery of cancer therapeutics
- (2018) Daniel Rosenblum et al. Nature Communications
- GalNAc-siRNA Conjugates: Leading the Way for Delivery of RNAi Therapeutics
- (2018) Aaron D. Springer et al. Nucleic Acid Therapeutics
- RNA Therapeutics (Almost) Comes of Age: Targeting, Delivery and Endosomal Escape
- (2018) Steven F. Dowdy et al. Nucleic Acid Therapeutics
- Receptor-targeted aptamer-siRNA conjugate-directed transcriptional regulation of HIV-1
- (2018) Jiehua Zhou et al. Theranostics
- Solving the RNA design problem with reinforcement learning
- (2018) Peter Eastman et al. PLoS Computational Biology
- Oral delivery of siRNA lipid nanoparticles: Fate in the GI tract
- (2018) Rebecca L. Ball et al. Scientific Reports
- Development of MTL-CEBPA: Small Activating RNA Drug for Hepatocellular Carcinoma
- (2018) Ryan L. Setten et al. CURRENT PHARMACEUTICAL BIOTECHNOLOGY
- RNAi modulation of placental sFLT1 for the treatment of preeclampsia
- (2018) Anton A Turanov et al. NATURE BIOTECHNOLOGY
- Roadmap and strategy for overcoming infusion reactions to nanomedicines
- (2018) Janos Szebeni et al. Nature Nanotechnology
- Diverse lipid conjugates for functional extra-hepatic siRNA delivery in vivo
- (2018) Annabelle Biscans et al. NUCLEIC ACIDS RESEARCH
- Nucleic Acid Strand Displacement with Synthetic mRNA Inputs in Living Mammalian Cells
- (2018) Gourab Chatterjee et al. ACS Synthetic Biology
- Signal Transduction in Human Cell Lysate via Dynamic RNA Nanotechnology
- (2018) Lisa M. Hochrein et al. ACS Synthetic Biology
- Biodegradable lipid nanoparticles induce a prolonged RNA interference-mediated protein knockdown and show rapid hepatic clearance in mice and nonhuman primates
- (2017) Yuta Suzuki et al. INTERNATIONAL JOURNAL OF PHARMACEUTICS
- Chirality Dependent Potency Enhancement and Structural Impact of Glycol Nucleic Acid Modification on siRNA
- (2017) Mark K. Schlegel et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Safety, tolerability, and antiviral effect of RG-101 in patients with chronic hepatitis C: a phase 1B, double-blind, randomised controlled trial
- (2017) Meike H van der Ree et al. LANCET
- RNA interference efficiently targets human leukemia driven by a fusion oncogene in vivo
- (2017) N Jyotsana et al. LEUKEMIA
- In Situ Gelling Liquid Crystalline System as Local siRNA Delivery System
- (2017) Livia N. Borgheti-Cardoso et al. MOLECULAR PHARMACEUTICS
- Immunoprotein-Mediated siRNA Delivery
- (2017) Nicole Bäumer et al. MOLECULAR PHARMACEUTICS
- Clinical Proof of Concept for a Novel Hepatocyte-Targeting GalNAc-siRNA Conjugate
- (2017) Tracy S. Zimmermann et al. MOLECULAR THERAPY
- Development and Mechanism of Small Activating RNA Targeting CEBPA, a Novel Therapeutic in Clinical Trials for Liver Cancer
- (2017) Jon Voutila et al. MOLECULAR THERAPY
- RNA Nanoparticle-Based Targeted Therapy for Glioblastoma through Inhibition of Oncogenic miR-21
- (2017) Tae Jin Lee et al. MOLECULAR THERAPY
- Exosomes facilitate therapeutic targeting of oncogenic KRAS in pancreatic cancer
- (2017) Sushrut Kamerkar et al. NATURE
- The chemical evolution of oligonucleotide therapies of clinical utility
- (2017) Anastasia Khvorova et al. NATURE BIOTECHNOLOGY
- Control of phosphorothioate stereochemistry substantially increases the efficacy of antisense oligonucleotides
- (2017) Naoki Iwamoto et al. NATURE BIOTECHNOLOGY
- Overcoming cellular barriers for RNA therapeutics
- (2017) Steven F Dowdy NATURE BIOTECHNOLOGY
- Nanoparticle orientation to control RNA loading and ligand display on extracellular vesicles for cancer regression
- (2017) Fengmei Pi et al. Nature Nanotechnology
- MicroRNA therapeutics: towards a new era for the management of cancer and other diseases
- (2017) Rajesha Rupaimoole et al. NATURE REVIEWS DRUG DISCOVERY
- Strategies and challenges for the next generation of antibody–drug conjugates
- (2017) Alain Beck et al. NATURE REVIEWS DRUG DISCOVERY
- Antisense oligonucleotides: the next frontier for treatment of neurological disorders
- (2017) Carlo Rinaldi et al. Nature Reviews Neurology
- Inclisiran in Patients at High Cardiovascular Risk with Elevated LDL Cholesterol
- (2017) Kausik K. Ray et al. NEW ENGLAND JOURNAL OF MEDICINE
- Impact of enhanced metabolic stability on pharmacokinetics and pharmacodynamics of GalNAc–siRNA conjugates
- (2017) Jayaprakash K. Nair et al. NUCLEIC ACIDS RESEARCH
- RNAi-based treatment of chronically infected patients and chimpanzees reveals that integrated hepatitis B virus DNA is a source of HBsAg
- (2017) Christine I. Wooddell et al. Science Translational Medicine
- The druggable genome and support for target identification and validation in drug development
- (2017) Chris Finan et al. Science Translational Medicine
- Disease Modeling in Stem Cell-Derived 3D Organoid Systems
- (2017) Devanjali Dutta et al. TRENDS IN MOLECULAR MEDICINE
- Cell-Penetrating Peptides: From Basic Research to Clinics
- (2017) Giulia Guidotti et al. TRENDS IN PHARMACOLOGICAL SCIENCES
- Nuclear-targeted siRNA delivery for long-term gene silencing
- (2017) Na Li et al. Chemical Science
- Cellular microRNA networks regulate host dependency of hepatitis C virus infection
- (2017) Qisheng Li et al. Nature Communications
- Oligolysine-based coating protects DNA nanostructures from low-salt denaturation and nuclease degradation
- (2017) Nandhini Ponnuswamy et al. Nature Communications
- Personalized In Vitro and In Vivo Cancer Models to Guide Precision Medicine
- (2017) Chantal Pauli et al. Cancer Discovery
- Chemodrug delivery using integrin-targeted PLGA-Chitosan nanoparticle for lung cancer therapy
- (2017) Anish Babu et al. Scientific Reports
- Human GW182 Paralogs Are the Central Organizers for RNA-Mediated Control of Transcription
- (2017) Jessica A. Hicks et al. Cell Reports
- Sustained miRNA delivery from an injectable hydrogel promotes cardiomyocyte proliferation and functional regeneration after ischaemic injury
- (2017) Leo L. Wang et al. Nature Biomedical Engineering
- Fabrication of RNA 3D Nanoprisms for Loading and Protection of Small RNAs and Model Drugs
- (2016) Emil F. Khisamutdinov et al. ADVANCED MATERIALS
- Preclinical evaluation of RNAi as a treatment for transthyretin-mediated amyloidosis
- (2016) James S. Butler et al. AMYLOID-JOURNAL OF PROTEIN FOLDING DISORDERS
- Second-Generation Tunable pH-Sensitive Phosphoramidate-Based Linkers for Controlled Release
- (2016) Cindy J. Choy et al. BIOCONJUGATE CHEMISTRY
- Tunable pH-Sensitive Linker for Controlled Release
- (2016) Cindy J. Choy et al. BIOCONJUGATE CHEMISTRY
- Nanolayered siRNA delivery platforms for local silencing of CTGF reduce cutaneous scar contraction in third-degree burns
- (2016) Steven A. Castleberry et al. BIOMATERIALS
- Precise and efficient siRNA design: a key point in competent gene silencing
- (2016) E Fakhr et al. CANCER GENE THERAPY
- saRNA-guided Ago2 targets the RITA complex to promoters to stimulate transcription
- (2016) Victoria Portnoy et al. CELL RESEARCH
- 5′-(E)-Vinylphosphonate: A Stable Phosphate Mimic Can Improve the RNAi Activity of siRNA-GalNAc Conjugates
- (2016) Rubina Parmar et al. CHEMBIOCHEM
- Development of antibody-siRNA conjugate targeted to cardiac and skeletal muscles
- (2016) Tsukasa Sugo et al. JOURNAL OF CONTROLLED RELEASE
- Functional exosome-mimic for delivery of siRNA to cancer: in vitro and in vivo evaluation
- (2016) Zhaogang Yang et al. JOURNAL OF CONTROLLED RELEASE
- Exosomes as therapeutics: The implications of molecular composition and exosomal heterogeneity
- (2016) Scott W. Ferguson et al. JOURNAL OF CONTROLLED RELEASE
- ALN-RSV01 for prevention of bronchiolitis obliterans syndrome after respiratory syncytial virus infection in lung transplant recipients
- (2016) Jens Gottlieb et al. JOURNAL OF HEART AND LUNG TRANSPLANTATION
- Optimized DNA “Nanosuitcases” for Encapsulation and Conditional Release of siRNA
- (2016) Katherine E. Bujold et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Structural Analysis of Human Argonaute-2 Bound to a Modified siRNA Guide
- (2016) Nicole T. Schirle et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Multistrand Structure Prediction of Nucleic Acid Assemblies and Design of RNA Switches
- (2016) Eckart Bindewald et al. NANO LETTERS
- Alnylam terminates revusiran program, stock plunges
- (2016) Ken Garber NATURE BIOTECHNOLOGY
- Aptamers as targeted therapeutics: current potential and challenges
- (2016) Jiehua Zhou et al. NATURE REVIEWS DRUG DISCOVERY
- A network-biology perspective of microRNA function and dysfunction in cancer
- (2016) Cameron P. Bracken et al. NATURE REVIEWS GENETICS
- Visualization of self-delivering hydrophobically modified siRNA cellular internalization
- (2016) Socheata Ly et al. NUCLEIC ACIDS RESEARCH
- Transcriptional gene silencing in humans
- (2016) Marc S. Weinberg et al. NUCLEIC ACIDS RESEARCH
- The delivery of therapeutic oligonucleotides
- (2016) Rudolph L. Juliano NUCLEIC ACIDS RESEARCH
- Targeted fibrillar nanocarbon RNAi treatment of acute kidney injury
- (2016) Simone Alidori et al. Science Translational Medicine
- DNA Nanotechnology for Precise Control over Drug Delivery and Gene Therapy
- (2016) Chava Angell et al. Small
- Shiga Toxins as Multi-Functional Proteins: Induction of Host Cellular Stress Responses, Role in Pathogenesis and Therapeutic Applications
- (2016) Moo-Seung Lee et al. Toxins
- Enhancing Endosomal Escape for Intracellular Delivery of Macromolecular Biologic Therapeutics
- (2016) Peter Lönn et al. Scientific Reports
- Self-Assembled Wound Dressings Silence MMP-9 and Improve Diabetic Wound Healing In Vivo
- (2015) Steven A. Castleberry et al. ADVANCED MATERIALS
- Miravirsen dosing in chronic hepatitis C patients results in decreased microRNA-122 levels without affecting other microRNAs in plasma
- (2015) M. H. van der Ree et al. ALIMENTARY PHARMACOLOGY & THERAPEUTICS
- Engineered In Vitro Disease Models
- (2015) Kambez H. Benam et al. Annual Review of Pathology-Mechanisms of Disease
- Folate Receptor Targeted Delivery of siRNA and Paclitaxel to Ovarian Cancer Cells via Folate Conjugated Triblock Copolymer to Overcome TLR4 Driven Chemotherapy Resistance
- (2015) Steven K. Jones et al. BIOMACROMOLECULES
- A role for peptides in overcoming endosomal entrapment in siRNA delivery — A focus on melittin
- (2015) Kirk K. Hou et al. BIOTECHNOLOGY ADVANCES
- Single-Molecule Imaging Reveals that Argonaute Reshapes the Binding Properties of Its Nucleic Acid Guides
- (2015) William E. Salomon et al. CELL
- A Dynamic Search Process Underlies MicroRNA Targeting
- (2015) Stanley D. Chandradoss et al. CELL
- Cell-Specific RNA Aptamer against Human CCR5 Specifically Targets HIV-1 Susceptible Cells and Inhibits HIV-1 Infectivity
- (2015) Jiehua Zhou et al. CHEMISTRY & BIOLOGY
- Ledipasvir/Sofosbuvir: A Review of Its Use in Chronic Hepatitis C
- (2015) Gillian M. Keating DRUGS
- Asialoglycoprotein receptor mediated hepatocyte targeting — Strategies and applications
- (2015) Anisha A. D'Souza et al. JOURNAL OF CONTROLLED RELEASE
- Gene Knockdown by EpCAM Aptamer-siRNA Chimeras Suppresses Epithelial Breast Cancers and Their Tumor-Initiating Cells
- (2015) A. Gilboa-Geffen et al. MOLECULAR CANCER THERAPEUTICS
- Reductively Responsive Hydrogel Nanoparticles with Uniform Size, Shape, and Tunable Composition for Systemic siRNA Delivery in Vivo
- (2015) Da Ma et al. MOLECULAR PHARMACEUTICS
- Lipid nanoparticle siRNA treatment of Ebola-virus-Makona-infected nonhuman primates
- (2015) Emily P. Thi et al. NATURE
- Visualizing lipid-formulated siRNA release from endosomes and target gene knockdown
- (2015) Anders Wittrup et al. NATURE BIOTECHNOLOGY
- Computing in mammalian cells with nucleic acid strand exchange
- (2015) Benjamin Groves et al. Nature Nanotechnology
- Designing DNA nanodevices for compatibility with the immune system of higher organisms
- (2015) Sunaina Surana et al. Nature Nanotechnology
- DNA nanotechnology from the test tube to the cell
- (2015) Yuan-Jyue Chen et al. Nature Nanotechnology
- Clinical experiences with systemically administered siRNA-based therapeutics in cancer
- (2015) Jonathan E. Zuckerman et al. NATURE REVIEWS DRUG DISCOVERY
- High-throughput screening identifies small molecules that enhance the pharmacological effects of oligonucleotides
- (2015) B. Yang et al. NUCLEIC ACIDS RESEARCH
- Cellular localization of long non-coding RNAs affects silencing by RNAi more than by antisense oligonucleotides
- (2015) Kim A. Lennox et al. NUCLEIC ACIDS RESEARCH
- Phase 2, open-label extension (OLE) study of revusiran, an investigational RNAi therapeutic for the treatment of patients with transthyretin cardiac amyloidosis
- (2015) Julian D Gillmore et al. Orphanet Journal of Rare Diseases
- Highly compacted biodegradable DNA nanoparticles capable of overcoming the mucus barrier for inhaled lung gene therapy
- (2015) Panagiotis Mastorakos et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Virus-Inspired Membrane Encapsulation of DNA Nanostructures To Achieve In Vivo Stability
- (2014) Steven D. Perrault et al. ACS Nano
- Adaptive Amphiphilic Dendrimer-Based Nanoassemblies as Robust and Versatile siRNA Delivery Systems
- (2014) Xiaoxuan Liu et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Recent Advances in Nanoparticle-Mediated siRNA Delivery
- (2014) John-Michael Williford et al. Annual Review of Biomedical Engineering
- Cardiac RNAi therapy using RAGE siRNA/deoxycholic acid-modified polyethylenimine complexes for myocardial infarction
- (2014) Jueun Hong et al. BIOMATERIALS
- Organs-on-a-chip: a new tool for drug discovery
- (2014) Alessandro Polini et al. Expert Opinion on Drug Discovery
- Current issues of RNAi therapeutics delivery and development
- (2014) D. Haussecker JOURNAL OF CONTROLLED RELEASE
- Development of lipid nanoparticle formulations of siRNA for hepatocyte gene silencing following subcutaneous administration
- (2014) Sam Chen et al. JOURNAL OF CONTROLLED RELEASE
- Gold Nanoparticles for Nucleic Acid Delivery
- (2014) Ya Ding et al. MOLECULAR THERAPY
- Efficient delivery of RNAi prodrugs containing reversible charge-neutralizing phosphotriester backbone modifications
- (2014) Bryan R Meade et al. NATURE BIOTECHNOLOGY
- In vivo endothelial siRNA delivery using polymeric nanoparticles with low molecular weight
- (2014) James E. Dahlman et al. Nature Nanotechnology
- Non-viral vectors for gene-based therapy
- (2014) Hao Yin et al. NATURE REVIEWS GENETICS
- Regulation of microRNA biogenesis
- (2014) Minju Ha et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Systematic evaluation of antibody-mediated siRNA delivery using an industrial platform of THIOMAB–siRNA conjugates
- (2014) Trinna L. Cuellar et al. NUCLEIC ACIDS RESEARCH
- Organogenesis in a dish: Modeling development and disease using organoid technologies
- (2014) M. A. Lancaster et al. SCIENCE
- RNAi Therapies: Drugging the Undruggable
- (2014) S. Y. Wu et al. Science Translational Medicine
- Retromer: A Master Conductor of Endosome Sorting
- (2014) C. Burd et al. Cold Spring Harbor Perspectives in Biology
- Cellular Uptake and Intracellular Trafficking of Oligonucleotides: Implications for Oligonucleotide Pharmacology
- (2014) R.L. Juliano et al. Nucleic Acid Therapeutics
- Stable RNA nanoparticles as potential new generation drugs for cancer therapy
- (2013) Yi Shu et al. ADVANCED DRUG DELIVERY REVIEWS
- TLR9-mediated siRNA delivery for targeting of normal and malignant human hematopoietic cells in vivo
- (2013) Q. Zhang et al. BLOOD
- Leukemia cell-targeted STAT3 silencing and TLR9 triggering generate systemic antitumor immunity
- (2013) D. M. S. Hossain et al. BLOOD
- The let-7/LIN-41 Pathway Regulates Reprogramming to Human Induced Pluripotent Stem Cells by Controlling Expression of Prodifferentiation Genes
- (2013) Kathleen A. Worringer et al. Cell Stem Cell
- Inhibition of Myc family proteins eradicates KRas-driven lung cancer in mice
- (2013) L. Soucek et al. GENES & DEVELOPMENT
- The mTOR pathway in hepatic malignancies
- (2013) Mamatha Bhat et al. HEPATOLOGY
- Novel RNA oligonucleotide improves liver function and inhibits liver carcinogenesisin vivo
- (2013) Vikash Reebye et al. HEPATOLOGY
- Long-term suppression of HIV-1C virus production in human peripheral blood mononuclear cells by LTR heterochromatization with a short double-stranded RNA
- (2013) A. Singh et al. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
- Conditional Dicer Substrate Formation via Shape and Sequence Transduction with Small Conditional RNAs
- (2013) Lisa M. Hochrein et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Hepatocyte-targeted RNAi Therapeutics for the Treatment of Chronic Hepatitis B Virus Infection
- (2013) Christine I Wooddell et al. MOLECULAR THERAPY
- High efficacy gold-KDEL peptide-siRNA nanoconstruct-mediated transfection in C2C12 myoblasts and myotubes
- (2013) Suresh Acharya et al. Nanomedicine-Nanotechnology Biology and Medicine
- Safety and Efficacy of RNAi Therapy for Transthyretin Amyloidosis
- (2013) Teresa Coelho et al. NEW ENGLAND JOURNAL OF MEDICINE
- Treatment of HCV Infection by Targeting MicroRNA
- (2013) Harry L.A. Janssen et al. NEW ENGLAND JOURNAL OF MEDICINE
- Differential roles of human Dicer-binding proteins TRBP and PACT in small RNA processing
- (2013) Ho Young Lee et al. NUCLEIC ACIDS RESEARCH
- Molecular basis for improved gene silencing by Dicer substrate interfering RNA compared with other siRNA variants
- (2013) Nicholas M. Snead et al. NUCLEIC ACIDS RESEARCH
- Promoter RNA links transcriptional regulation of inflammatory pathway genes
- (2013) Masayuki Matsui et al. NUCLEIC ACIDS RESEARCH
- Spherical Nucleic Acid Nanoparticle Conjugates as an RNAi-Based Therapy for Glioblastoma
- (2013) S. A. Jensen et al. Science Translational Medicine
- Retrograde Traffic from the Golgi to the Endoplasmic Reticulum
- (2013) A. Spang Cold Spring Harbor Perspectives in Biology
- Optimized siRNA-PEG Conjugates for Extended Blood Circulation and Reduced Urine Excretion in Mice
- (2013) Frank Iversen et al. Theranostics
- 5′ Unlocked Nucleic Acid Modification Improves siRNA Targeting
- (2013) Nicholas M Snead et al. Molecular Therapy-Nucleic Acids
- Promoter Targeting shRNA Suppresses HIV-1 Infection In vivo Through Transcriptional Gene Silencing
- (2013) Kazuo Suzuki et al. Molecular Therapy-Nucleic Acids
- Influence of Polyethylene Glycol Lipid Desorption Rates on Pharmacokinetics and Pharmacodynamics of siRNA Lipid Nanoparticles
- (2013) Barbara L Mui et al. Molecular Therapy-Nucleic Acids
- Functionalized, biodegradable hydrogels for control over sustained and localized siRNA delivery to incorporated and surrounding cells
- (2012) Khanh Nguyen et al. Acta Biomaterialia
- Exosomes for targeted siRNA delivery across biological barriers
- (2012) Samir EL Andaloussi et al. ADVANCED DRUG DELIVERY REVIEWS
- Maximizing the Potency of siRNA Lipid Nanoparticles for Hepatic Gene Silencing In Vivo
- (2012) Muthusamy Jayaraman et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Promoter-associated small double-stranded RNA interacts with heterogeneous nuclear ribonucleoprotein A2/B1 to induce transcriptional activation
- (2012) Jia Hu et al. BIOCHEMICAL JOURNAL
- Single-Stranded siRNAs Activate RNAi in Animals
- (2012) Walt F. Lima et al. CELL
- MicroRNA dysregulation in cancer: diagnostics, monitoring and therapeutics. A comprehensive review
- (2012) Marilena V. Iorio et al. EMBO Molecular Medicine
- Spherical Nucleic Acids
- (2012) Joshua I. Cutler et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- KDEL peptide gold nanoconstructs: promising nanoplatforms for drug delivery
- (2012) Guankui Wang et al. Nanomedicine-Nanotechnology Biology and Medicine
- Weathering a storm
- (2012) Douglas Fambrough NATURE BIOTECHNOLOGY
- Molecularly self-assembled nucleic acid nanoparticles for targeted in vivo siRNA delivery
- (2012) Hyukjin Lee et al. Nature Nanotechnology
- Biomolecular computing systems: principles, progress and potential
- (2012) Yaakov Benenson NATURE REVIEWS GENETICS
- Regulation of human Dicer by the resident ER membrane protein CLIMP-63
- (2012) Geneviève Pépin et al. NUCLEIC ACIDS RESEARCH
- Stabilization of hepatitis C virus RNA by an Ago2-miR-122 complex
- (2012) T. Shimakami et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Topical delivery of siRNA-based spherical nucleic acid nanoparticle conjugates for gene regulation
- (2012) Dan Zheng et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Polycation-siRNA nanoparticles can disassemble at the kidney glomerular basement membrane
- (2012) J. E. Zuckerman et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Liver-specific microRNA-122: Biogenesis and function
- (2012) Catherine Jopling RNA Biology
- A Logic-Gated Nanorobot for Targeted Transport of Molecular Payloads
- (2012) S. M. Douglas et al. SCIENCE
- Mucus-Penetrating Nanoparticles for Vaginal Drug Delivery Protect Against Herpes Simplex Virus
- (2012) L. M. Ensign et al. Science Translational Medicine
- An RNA Alternative to Human Transferrin: A New Tool for Targeting Human Cells
- (2012) Samantha E Wilner et al. Molecular Therapy-Nucleic Acids
- The Business of RNAi Therapeutics in 2012
- (2012) Dirk Haussecker Molecular Therapy-Nucleic Acids
- Chemical modification and design of anti-miRNA oligonucleotides
- (2011) K A Lennox et al. GENE THERAPY
- Characterization of an HIV-Targeted Transcriptional Gene-Silencing RNA in Primary Cells
- (2011) Anne-Marie W. Turner et al. HUMAN GENE THERAPY
- Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes
- (2011) Lydia Alvarez-Erviti et al. NATURE BIOTECHNOLOGY
- Dynamic DNA nanotechnology using strand-displacement reactions
- (2011) David Yu Zhang et al. Nature Chemistry
- Non-coding RNAs in human disease
- (2011) Manel Esteller NATURE REVIEWS GENETICS
- Masking the 5' terminal nucleotides of the hepatitis C virus genome by an unconventional microRNA-target RNA complex
- (2011) E. S. Machlin et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- An Aptamer-siRNA Chimera Suppresses HIV-1 Viral Loads and Protects from Helper CD4+ T Cell Decline in Humanized Mice
- (2011) C. P. Neff et al. Science Translational Medicine
- Engineered Design of Mesoporous Silica Nanoparticles to Deliver Doxorubicin and P-Glycoprotein siRNA to Overcome Drug Resistance in a Cancer Cell Line
- (2010) Huan Meng et al. ACS Nano
- Effects of particle size and surface charge on cellular uptake and biodistribution of polymeric nanoparticles
- (2010) Chunbai He et al. BIOMATERIALS
- Sustained Small Interfering RNA Delivery by Mesoporous Silicon Particles
- (2010) Takemi Tanaka et al. CANCER RESEARCH
- NUPACK: Analysis and design of nucleic acid systems
- (2010) Joseph N. Zadeh et al. JOURNAL OF COMPUTATIONAL CHEMISTRY
- RNA interference in vitro and in vivo using an arginine peptide/siRNA complex system
- (2010) Sung Wook Kim et al. JOURNAL OF CONTROLLED RELEASE
- Targeted Delivery of RNAi Therapeutics With Endogenous and Exogenous Ligand-Based Mechanisms
- (2010) Akin Akinc et al. MOLECULAR THERAPY
- Molecular Evolution of Functional Nucleic Acids with Chemical Modifications
- (2010) Masayasu Kuwahara et al. MOLECULES
- A dicer-independent miRNA biogenesis pathway that requires Ago catalysis
- (2010) Sihem Cheloufi et al. NATURE
- Evidence of RNAi in humans from systemically administered siRNA via targeted nanoparticles
- (2010) Mark E. Davis et al. NATURE
- Rational design of cationic lipids for siRNA delivery
- (2010) Sean C Semple et al. NATURE BIOTECHNOLOGY
- Transcriptional regulation by small RNAs at sequences downstream from 3′ gene termini
- (2010) Xuan Yue et al. Nature Chemical Biology
- Involvement of argonaute proteins in gene silencing and activation by RNAs complementary to a non-coding transcript at the progesterone receptor promoter
- (2010) Yongjun Chu et al. NUCLEIC ACIDS RESEARCH
- A randomized, double-blind, placebo-controlled study of an RNAi-based therapy directed against respiratory syncytial virus
- (2010) J. DeVincenzo et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- A Novel miRNA Processing Pathway Independent of Dicer Requires Argonaute2 Catalytic Activity
- (2010) D. Cifuentes et al. SCIENCE
- UNA (unlocked nucleic acid): A flexible RNA mimic that allows engineering of nucleic acid duplex stability
- (2009) Niels Langkjær et al. BIOORGANIC & MEDICINAL CHEMISTRY
- BLAST+: architecture and applications
- (2009) Christiam Camacho et al. BMC BIOINFORMATICS
- Exploring Chemical Modifications for siRNA Therapeutics: A Structural and Functional Outlook
- (2009) Siddharth Shukla et al. ChemMedChem
- Enhanced gene expression by a novel stearylated INF7 peptide derivative through fusion independent endosomal escape
- (2009) Ayman El-Sayed et al. JOURNAL OF CONTROLLED RELEASE
- Multivesicular bodies associate with components of miRNA effector complexes and modulate miRNA activity
- (2009) Derrick J. Gibbings et al. NATURE CELL BIOLOGY
- Selection, characterization and application of new RNA HIV gp 120 aptamers for facile delivery of Dicer substrate siRNAs into HIV infected cells
- (2009) Jiehua Zhou et al. NUCLEIC ACIDS RESEARCH
- Efficient gene silencing by delivery of locked nucleic acid antisense oligonucleotides, unassisted by transfection reagents
- (2009) C. A. Stein et al. NUCLEIC ACIDS RESEARCH
- A large-scale chemical modification screen identifies design rules to generate siRNAs with high activity, high stability and low toxicity
- (2009) Jesper B. Bramsen et al. NUCLEIC ACIDS RESEARCH
- Effects of chemical modification on the potency, serum stability, and immunostimulatory properties of short shRNAs
- (2009) Q. Ge et al. RNA
- Increased RNAi is related to intracellular release of siRNA via a covalently attached signal peptide
- (2009) A. Detzer et al. RNA
- Therapeutic Silencing of MicroRNA-122 in Primates with Chronic Hepatitis C Virus Infection
- (2009) R. E. Lanford et al. SCIENCE
- Mucus-penetrating nanoparticles for drug and gene delivery to mucosal tissues
- (2008) Samuel K. Lai et al. ADVANCED DRUG DELIVERY REVIEWS
- Trivalent, Gal/GalNAc-containing ligands designed for the asialoglycoprotein receptor
- (2008) Oleg Khorev et al. BIOORGANIC & MEDICINAL CHEMISTRY
- T Cell-Specific siRNA Delivery Suppresses HIV-1 Infection in Humanized Mice
- (2008) Priti Kumar et al. CELL
- Sequence- and target-independent angiogenesis suppression by siRNA via TLR3
- (2008) Mark E. Kleinman et al. NATURE
- Antisense transcripts are targets for activating small RNAs
- (2008) Jacob C Schwartz et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Effect of asymmetric terminal structures of short RNA duplexes on the RNA interference activity and strand selection
- (2008) Masayuki Sano et al. NUCLEIC ACIDS RESEARCH
- Chemical Modification of siRNAs for In Vivo Use
- (2008) Mark A. Behlke OLIGONUCLEOTIDES
- Chemical Modification Patterns Compatible with High Potency Dicer-Substrate Small Interfering RNAs
- (2008) Michael A. Collingwood et al. OLIGONUCLEOTIDES
- MicroRNA-directed transcriptional gene silencing in mammalian cells
- (2008) D. H. Kim et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Divergent Transcription from Active Promoters
- (2008) Amy C. Seila et al. SCIENCE
- Systemic Leukocyte-Directed siRNA Delivery Revealing Cyclin D1 as an Anti-Inflammatory Target
- (2008) D. Peer et al. SCIENCE
- Nascent RNA Sequencing Reveals Widespread Pausing and Divergent Initiation at Human Promoters
- (2008) Leighton J. Core et al. SCIENCE
Discover Peeref hubs
Discuss science. Find collaborators. Network.
Join a conversationBecome a Peeref-certified reviewer
The Peeref Institute provides free reviewer training that teaches the core competencies of the academic peer review process.
Get Started