Lysosome-targeting chimaeras for degradation of extracellular proteins

Improved Precursor Characterization for Data-Dependent Mass Spectrometry

(2018) Alexander S. Hebert et al.   ANALYTICAL CHEMISTRY

The dTAG system for immediate and target-specific protein degradation

(2018) Behnam Nabet et al.   Nature Chemical Biology

CMTM6 maintains the expression of PD-L1 and regulates anti-tumour immunity

(2017) Marian L. Burr et al.   NATURE

Engineering of GlcNAc-1-Phosphotransferase for Production of Highly Phosphorylated Lysosomal Enzymes for Enzyme Replacement Therapy

(2017) Lin Liu et al.   Molecular Therapy-Methods & Clinical Development

A Biparatopic HER2-Targeting Antibody-Drug Conjugate Induces Tumor Regression in Primary Models Refractory to or Ineligible for HER2-Targeted Therapy

(2016) John Y. Li et al.   CANCER CELL

Apolipoprotein E as a Therapeutic Target in Alzheimer’s Disease: A Review of Basic Research and Clinical Evidence

(2016) Yu Yamazaki et al.   CNS DRUGS

Sweeping antibody as a novel therapeutic antibody modality capable of eliminating soluble antigens from circulation

(2016) Tomoyuki Igawa et al.   IMMUNOLOGICAL REVIEWS

The position of lysosomes within the cell determines their luminal pH

(2016) Danielle E. Johnson et al.   JOURNAL OF CELL BIOLOGY

The Perseus computational platform for comprehensive analysis of (prote)omics data

(2016) Stefka Tyanova et al.   NATURE METHODS

The MaxQuant computational platform for mass spectrometry-based shotgun proteomics

(2016) Stefka Tyanova et al.   Nature Protocols

EGFR oligomerization organizes kinase-active dimers into competent signalling platforms

(2016) Sarah R. Needham et al.   Nature Communications

Controlled Synthesis of End-Functionalized Mannose-6-phosphate Glycopolypeptides for Lysosome Targeting

(2016) Soumen Das et al.   ACS Macro Letters

Molecular basis for multimerization in the activation of the epidermal growth factor receptor

(2016) Yongjian Huang et al.   eLife

Compact and highly active next-generation libraries for CRISPR-mediated gene repression and activation

(2016) Max A Horlbeck et al.   eLife

Chemically tunable mucin chimeras assembled on living cells

(2015) Jessica R. Kramer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Phthalimide conjugation as a strategy for in vivo target protein degradation

(2015) G. E. Winter et al.   SCIENCE

Tissue-based map of the human proteome

(2015) M. Uhlen et al.   SCIENCE

Accurate Proteome-wide Label-free Quantification by Delayed Normalization and Maximal Peptide Ratio Extraction, Termed MaxLFQ

(2014) Jürgen Cox et al.   MOLECULAR & CELLULAR PROTEOMICS

Rapid and reversible knockdown of endogenous proteins by peptide-directed lysosomal degradation

(2014) Xuelai Fan et al.   NATURE NEUROSCIENCE

Functional genomics platform for pooled screening and generation of mammalian genetic interaction maps

(2014) Martin Kampmann et al.   Nature Protocols

The human secretome atlas initiative: Implications in health and disease conditions

(2013) Kristy J. Brown et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

The role of EGF-EGFR signalling pathway in hepatocellular carcinoma inflammatory microenvironment

(2013) Peixin Huang et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

A shortcut to the lysosome: The mannose-6-phosphate-independent pathway

(2012) Maria Francisca Coutinho et al.   MOLECULAR GENETICS AND METABOLISM

Exorcising the Exocyst Complex

(2012) Margaret R. Heider et al.   TRAFFIC

Andromeda: A Peptide Search Engine Integrated into the MaxQuant Environment

(2011) Jürgen Cox et al.   JOURNAL OF PROTEOME RESEARCH

Combination antibody treatment down-regulates epidermal growth factor receptor by inhibiting endosomal recycling

(2010) J. B. Spangler et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

GOrilla: a tool for discovery and visualization of enriched GO terms in ranked gene lists

(2009) Eran Eden et al.   BMC BIOINFORMATICS

Synthesis of new sulfonate and phosphonate derivatives for cation-independent mannose 6-phosphate receptor targeting

(2008) Audrey Jeanjean et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Activation of PI3K/Akt and MAPK pathways regulates Myc-mediated transcription by phosphorylating and promoting the degradation of Mad1

(2008) J. Zhu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA