Catalytic asymmetric and stereodivergent oligonucleotide synthesis

Enantiodivergent Formation of C–P Bonds: Synthesis of P-Chiral Phosphines and Methyl-phosphonate Oligonucleotides

(2020) Dongmin Xu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Novel Applications of Biocatalysis to Stereochemistry Determination of 2′3′-cGAMP Bisphosphorothioate (2′3′-cGSASMP)

(2020) Jongwon Lim et al.   ACS Omega

Asymmetric Catalysis Mediated by Synthetic Peptides, Version 2.0: Expansion of Scope and Mechanisms

(2020) Anthony J. Metrano et al.   CHEMICAL REVIEWS

Disparate Catalytic Scaffolds for Atroposelective Cyclodehydration

(2019) Yongseok Kwon et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Stereocontrolled Synthesis of Boranophosphate DNA by an Oxazaphospholidine Approach and Evaluation of Its Properties

(2019) Rintaro Iwata Hara et al.   JOURNAL OF ORGANIC CHEMISTRY

Site-Selective Acylation of Natural Products with BINOL-Derived Phosphoric Acids

(2019) Junqi Li et al.   ACS Catalysis

Targeting Stimulator of Interferon Genes (STING): A Medicinal Chemistry Perspective

(2019) Han Zhang et al.   JOURNAL OF MEDICINAL CHEMISTRY

Disulfide-Bridged Peptides That Mediate Enantioselective Cycloadditions through Thiyl Radical Catalysis

(2018) Jonathan M. Ryss et al.   ORGANIC LETTERS

Unlocking P(V): Reagents for chiral phosphorothioate synthesis

(2018) Kyle W. Knouse et al.   SCIENCE

Phosphothreonine (pThr)-Based Multifunctional Peptide Catalysis for Asymmetric Baeyer–Villiger Oxidations of Cyclobutanones

(2018) Aaron L. Featherston et al.   ACS Catalysis

Stereodivergence in Asymmetric Catalysis

(2017) Simon Krautwald et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Control of phosphorothioate stereochemistry substantially increases the efficacy of antisense oligonucleotides

(2017) Naoki Iwamoto et al.   NATURE BIOTECHNOLOGY

Synthesis and antibacterial activity of 5′-tetrachlorophthalimido and 5′-azido 5′-deoxyribonucleosides

(2017) Robert Van Ostrand et al.   NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS

A multifunctional catalyst that stereoselectively assembles prodrugs

(2017) Daniel A. DiRocco et al.   SCIENCE

Recent Trends in Nucleotide Synthesis

(2016) Béatrice Roy et al.   CHEMICAL REVIEWS

Applications and stereoselective syntheses of P-chirogenic phosphorus compounds

(2016) Mathieu Dutartre et al.   CHEMICAL SOCIETY REVIEWS

Design, Synthesis, and Biological Evaluation of Novel Cyclic Adenosine–Inosine Monophosphate (cAIMP) Analogs That Activate Stimulator of Interferon Genes (STING)

(2016) Thierry Lioux et al.   JOURNAL OF MEDICINAL CHEMISTRY

Phosphorothioate anti-sense oligonucleotides: the kinetics and mechanism of the generation of the sulfurising agent from phenylacetyl disulfide (PADS)

(2016) James L. Scotson et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Phosphothreonine as a Catalytic Residue in Peptide-Mediated Asymmetric Transfer Hydrogenations of 8-Aminoquinolines

(2015) Christopher R. Shugrue et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Enantioselective Halogenative Semi-Pinacol Rearrangement: Extension of Substrate Scope and Mechanistic Investigations

(2015) Fedor Romanov-Michailidis et al.   CHEMISTRY-A EUROPEAN JOURNAL

Complete Field Guide to Asymmetric BINOL-Phosphate Derived Brønsted Acid and Metal Catalysis: History and Classification by Mode of Activation; Brønsted Acidity, Hydrogen Bonding, Ion Pairing, and Metal Phosphates

(2014) Dixit Parmar et al.   CHEMICAL REVIEWS

Hydrolysis of 2′3′-cGAMP by ENPP1 and design of nonhydrolyzable analogs

(2014) Lingyin Li et al.   Nature Chemical Biology

(3′-5′)-Cyclic Dinucleotides: Synthetic Strategies and Biological Potential

(2013) Pascale Clivio et al.   CHEMICAL REVIEWS

Advances in the development of nucleoside and nucleotide analogues for cancer and viral diseases

(2013) Lars Petter Jordheim et al.   NATURE REVIEWS DRUG DISCOVERY

Enantioselective Organocatalytic Iodination-Initiated Wagner–Meerwein Rearrangement

(2013) Fedor Romanov-Michailidis et al.   ORGANIC LETTERS

An Approach to the Site-Selective Deoxygenation of Hydroxy Groups Based on Catalytic Phosphoramidite Transfer

(2012) Peter A. Jordan et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Reactive intermediates in the H-phosphonate synthesis of oligonucleotides

(2012) Nicholas Powles et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

A General Preparation of Protected Phosphoamino Acids

(2012) Daniel E. Petrillo et al.   ORGANIC LETTERS

Cyclic GMP-AMP Synthase Is a Cytosolic DNA Sensor That Activates the Type I Interferon Pathway

(2012) L. Sun et al.   SCIENCE

A convenient synthesis of the cytidyl 3′-terminal monomer for solid-phase synthesis of RNG oligonucleotides

(2012) Ahmed M. Awad et al.   TETRAHEDRON LETTERS

Peptide Coupling Reagents, More than a Letter Soup

(2011) Ayman El-Faham et al.   CHEMICAL REVIEWS

Enantioselective Synthesis of Highly Substituted Furans by a Copper(II)-Catalyzed Cycloisomerization–Indole Addition Reaction

(2011) Vivek Rauniyar et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

STING is a direct innate immune sensor of cyclic di-GMP

(2011) Dara L. Burdette et al.   NATURE

A New Biarylphosphine Ligand for the Pd-Catalyzed Synthesis of Diaryl Ethers under Mild Conditions

(2011) Luca Salvi et al.   ORGANIC LETTERS

One-Flask Syntheses of c-di-GMP and the [Rp,Rp] and [Rp,Sp] Thiophosphate Analogues

(2010) Barbara L. Gaffney et al.   ORGANIC LETTERS

NMR Chemical Shifts of Trace Impurities: Common Laboratory Solvents, Organics, and Gases in Deuterated Solvents Relevant to the Organometallic Chemist

(2010) Gregory R. Fulmer et al.   ORGANOMETALLICS

Asymmetric phosphorylation through catalytic P(III) phosphoramidite transfer: Enantioselective synthesis of D-myo-inositol-6-phosphate

(2010) P. A. Jordan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Asymmetric Syntheses of l,l-and l,d-Di-myo-inositol-1,1′-phosphate and their Behavior as Stabilizers of Enzyme Activity at Extreme Temperatures

(2009) Christina M. Longo et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

De-racemization of Enantiomers versus De-epimerization of Diastereomers-Classification of Dynamic Kinetic Asymmetric Transformations (DYKAT)

(2008) Johannes Steinreiber et al.   CHEMISTRY-A EUROPEAN JOURNAL

STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling

(2008) Hiroki Ishikawa et al.   NATURE

The mechanism of the phosphoramidite synthesis of polynucleotides

(2008) Mark A. Russell et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Efficient catalyst turnover in the phosphitylation of alcohols with phosphoramidites

(2008) Patrick B. Brady et al.   TETRAHEDRON LETTERS