Hypothalamic SIRT1 prevents age-associated weight gain by improving leptin sensitivity in mice

Sirt1 Extends Life Span and Delays Aging in Mice through the Regulation of Nk2 Homeobox 1 in the DMH and LH

(2013) Akiko Satoh et al.   Cell Metabolism

Neuronal Sirt1 Deficiency Increases Insulin Sensitivity in Both Brain and Peripheral Tissues

(2013) Min Lu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Beige Adipocytes Are a Distinct Type of Thermogenic Fat Cell in Mouse and Human

(2012) Jun Wu et al.   CELL

2-Arachidonoylglycerol Signaling in Forebrain Regulates Systemic Energy Metabolism

(2012) Kwang-Mook Jung et al.   Cell Metabolism

The NAD+ Precursor Nicotinamide Riboside Enhances Oxidative Metabolism and Protects against High-Fat Diet-Induced Obesity

(2012) Carles Cantó et al.   Cell Metabolism

Modulation of Leptin Resistance by Protein Tyrosine Phosphatases

(2012) Julie St-Pierre et al.   Cell Metabolism

Direct leptin action on POMC neurons regulates glucose homeostasis and hepatic insulin sensitivity in mice

(2012) Eric D. Berglund et al.   JOURNAL OF CLINICAL INVESTIGATION

Nicotinamide Phosphoribosyltransferase May Be Involved in Age-Related Brain Diseases

(2012) Li-Ying Liu et al.   PLoS One

SIRT1 Deacetylase in SF1 Neurons Protects against Metabolic Imbalance

(2011) Giorgio Ramadori et al.   Cell Metabolism

Digging deeper into obesity

(2011) Rexford S. Ahima   JOURNAL OF CLINICAL INVESTIGATION

Nutrient-Sensing Hypothalamic TXNIP Links Nutrient Excess to Energy Imbalance in Mice

(2011) C. Blouet et al.   JOURNAL OF NEUROSCIENCE

National, regional, and global trends in body-mass index since 1980: systematic analysis of health examination surveys and epidemiological studies with 960 country-years and 9·1 million participants

(2011) Mariel M Finucane et al.   LANCET

A guide to analysis of mouse energy metabolism

(2011) Matthias H Tschöp et al.   NATURE METHODS

Age standardization in mapping adult overweight and obesity trends in the WHO European Region

(2011) C. M. Doak et al.   Obesity Reviews

Age Related Changes in NAD+ Metabolism Oxidative Stress and Sirt1 Activity in Wistar Rats

(2011) Nady Braidy et al.   PLoS One

SIRT1 Deacetylase in POMC Neurons Is Required for Homeostatic Defenses against Diet-Induced Obesity

(2010) Giorgio Ramadori et al.   Cell Metabolism

Roles of FoxO1 and Sirt1 in the central regulation of food intake

(2010) Tsutomu Sasaki et al.   ENDOCRINE JOURNAL

Induction of Hypothalamic Sirt1 Leads to Cessation of Feeding via Agouti-Related Peptide

(2010) Tsutomu Sasaki et al.   ENDOCRINOLOGY

A Treasure Trove of Hypothalamic Neurocircuitries Governing Body Weight Homeostasis

(2010) Claudia R. Vianna et al.   ENDOCRINOLOGY

Agrp Neurons Mediate Sirt1's Action on the Melanocortin System and Energy Balance: Roles for Sirt1 in Neuronal Firing and Synaptic Plasticity

(2010) M. O. Dietrich et al.   JOURNAL OF NEUROSCIENCE

SIRT1 Promotes the Central Adaptive Response to Diet Restriction through Activation of the Dorsomedial and Lateral Nuclei of the Hypothalamus

(2010) A. Satoh et al.   JOURNAL OF NEUROSCIENCE

Effects of age and gender on Sirt 1 mRNA expressions in the hypothalamus of the mouse

(2010) Mathieu Lafontaine-Lacasse et al.   NEUROSCIENCE LETTERS

The roles of leptin receptors on POMC neurons in the regulation of sex-specific energy homeostasis

(2010) Haifei Shi et al.   PHYSIOLOGY & BEHAVIOR

SIRT1 Genetic Variation Is Related to BMI and Risk of Obesity

(2009) M.Carola Zillikens et al.   DIABETES

Genetic variations in regulatory pathways of fatty acid and glucose metabolism are associated with obesity phenotypes: a population-based cohort study

(2009) S W van den Berg et al.   INTERNATIONAL JOURNAL OF OBESITY

Hypothalamic Sirt1 Regulates Food Intake in a Rodent Model System

(2009) Işin Çakir et al.   PLoS One

Caloric Restriction Delays Disease Onset and Mortality in Rhesus Monkeys

(2009) R. J. Colman et al.   SCIENCE

Neuron-specific recombination by Cre recombinase inserted into the murine tau locus

(2008) Kazuhiro Muramatsu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Lessons from Extreme Human Obesity: Monogenic Disorders

(2008) Sayali A. Ranadive et al.   ENDOCRINOLOGY AND METABOLISM CLINICS OF NORTH AMERICA

Association of SIRT1 gene variation with visceral obesity

(2008) Armand V. Peeters et al.   HUMAN GENETICS

Global burden of obesity in 2005 and projections to 2030

(2008) T Kelly et al.   INTERNATIONAL JOURNAL OF OBESITY

Noradrenergic parenchymal nerve fiber branching after cold acclimatisation correlates with brown adipocyte density in mouse adipose organ

(2008) I. Murano et al.   JOURNAL OF ANATOMY