Leptin signalling pathways in hypothalamic neurons

Protein tyrosine phosphatase-1B contributes to LPS-induced leptin resistance in male rats

(2015) Beatriz de Carvalho Borges et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Functional properties of Claramine: A novel PTP1B inhibitor and insulin-mimetic compound

(2015) Zhaohong Qin et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Diet-Induced Obese Mice Retain Endogenous Leptin Action

(2015) Nickki Ottaway et al.   Cell Metabolism

Leptin Keeps Working, Even in Obesity

(2015) Martin G. Myers   Cell Metabolism

Central Inhibition of IKKβ/NF-κB Signaling Attenuates High-Fat Diet–Induced Obesity and Glucose Intolerance

(2015) Jonas Benzler et al.   DIABETES

Brain Innate Immunity Regulates Hypothalamic Arcuate Neuronal Activity and Feeding Behavior

(2015) Wagner L. Reis et al.   ENDOCRINOLOGY

Hypothalamic ER stress: A bridge between leptin resistance and obesity

(2015) Sara Ramírez et al.   FEBS LETTERS

Leptin Elongates Hypothalamic Neuronal Cilia via Transcriptional Regulation and Actin Destabilization

(2015) Gil Myoung Kang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Leptin Promotes Wound Healing in the Skin

(2015) Susumu Tadokoro et al.   PLoS One

Hypomorphism for RPGRIP1L, a Ciliary Gene Vicinal to the FTO Locus, Causes Increased Adiposity in Mice

(2014) George Stratigopoulos et al.   Cell Metabolism

Xbp1s in Pomc Neurons Connects ER Stress with Energy Balance and Glucose Homeostasis

(2014) Kevin W. Williams et al.   Cell Metabolism

Hypothalamic Tanycytes Are an ERK-Gated Conduit for Leptin into the Brain

(2014) Eglantine Balland et al.   Cell Metabolism

IKK  Is Key to Induction of Insulin Resistance in the Hypothalamus, and Its Inhibition Reverses Obesity

(2014) L. Weissmann et al.   DIABETES

Clusterin/ApoJ enhances central leptin signaling through Lrp2-mediated endocytosis

(2014) K. Byun et al.   EMBO REPORTS

Leptin-promoted cilia assembly is critical for normal energy balance

(2014) Yu Mi Han et al.   JOURNAL OF CLINICAL INVESTIGATION

PPARγ ablation sensitizes proopiomelanocortin neurons to leptin during high-fat feeding

(2014) Lihong Long et al.   JOURNAL OF CLINICAL INVESTIGATION

Mild Lipid Stress Induces Profound Loss of MC4R Protein Abundance and Function

(2014) Faith K. Cragle et al.   MOLECULAR ENDOCRINOLOGY

Leptin signaling in astrocytes regulates hypothalamic neuronal circuits and feeding

(2014) Jae Geun Kim et al.   NATURE NEUROSCIENCE

Distinct Roles for JNK and IKK Activation in Agouti-Related Peptide Neurons in the Development of Obesity and Insulin Resistance

(2014) Eva Tsaousidou et al.   Cell Reports

Improved metabolic phenotype of hypothalamic PTP1B-deficiency is dependent upon the leptin receptor

(2014) Ryan C. Tsou et al.   Molecular Metabolism

Narrative Review: The Role of Leptin in Human Physiology: Emerging Clinical Applications

(2013) Theodore Kelesidis   ANNALS OF INTERNAL MEDICINE

Mitochondrial Dynamics Controlled by Mitofusins Regulate Agrp Neuronal Activity and Diet-Induced Obesity

(2013) Marcelo O. Dietrich et al.   CELL

Mitofusin 2 in POMC Neurons Connects ER Stress with Leptin Resistance and Energy Imbalance

(2013) Marc Schneeberger et al.   CELL

Hypothalamic mTORC1 Signaling Controls Sympathetic Nerve Activity and Arterial Pressure and Mediates Leptin Effects

(2013) Shannon M. Harlan et al.   Cell Metabolism

Nuclear factor κB (NF-κB) suppresses food intake and energy expenditure in mice by directly activating the Pomc promoter

(2013) X. Shi et al.   DIABETOLOGIA

Acute Inhibition of Central c-Jun N-terminal Kinase Restores Hypothalamic Insulin Signalling and Alleviates Glucose Intolerance in Diabetic Mice

(2013) J. Benzler et al.   JOURNAL OF NEUROENDOCRINOLOGY

The LIM Domain Only 4 Protein Is a Metabolic Responsive Inhibitor of Protein Tyrosine Phosphatase 1B That Controls Hypothalamic Leptin Signaling

(2013) N. R. Pandey et al.   JOURNAL OF NEUROSCIENCE

Involvement of Hypothalamic AMP-Activated Protein Kinase in Leptin-Induced Sympathetic Nerve Activation

(2013) Mamoru Tanida et al.   PLoS One

Leptin resistance is a secondary consequence of the obesity in ciliopathy mutant mice

(2013) N. F. Berbari et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Modulation of AgRP-neuronal function by SOCS3 as an initiating event in diet-induced hypothalamic leptin resistance

(2013) L. E. Olofsson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Clusterin and LRP2 are critical components of the hypothalamic feeding regulatory pathway

(2013) So Young Gil et al.   Nature Communications

Phenotypic effects of an induced mutation of the ObRa isoform of the leptin receptor

(2013) Zhiying Li et al.   Molecular Metabolism

Hunting for the functions of short leptin receptor isoforms

(2013) Julie Dam et al.   Molecular Metabolism

Challenges and Opportunities of Defining Clinical Leptin Resistance

(2012) Martin G. Myers et al.   Cell Metabolism

p70S6 Kinase Phosphorylates AMPK on Serine 491 to Mediate Leptin's Effect on Food Intake

(2012) Yossi Dagon et al.   Cell Metabolism

Modulation of Leptin Resistance by Protein Tyrosine Phosphatases

(2012) Julie St-Pierre et al.   Cell Metabolism

Inhibition of Hypothalamic Inflammation Reverses Diet-Induced Insulin Resistance in the Liver

(2012) M. Milanski et al.   DIABETES

Hypothalamic AgRP-neurons control peripheral substrate utilization and nutrient partitioning

(2012) Aurélie Joly-Amado et al.   EMBO JOURNAL

Leptin and insulin pathways in POMC and AgRP neurons that modulate energy balance and glucose homeostasis

(2012) Luis Varela et al.   EMBO REPORTS

Leptin and the hypothalamo-pituitary–adrenal stress axis

(2012) Eric W. Roubos et al.   GENERAL AND COMPARATIVE ENDOCRINOLOGY

Calcium/Calmodulin-dependent Protein Kinase Kinase 2: Roles in Signaling and Pathophysiology

(2012) Luigi Racioppi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Leptin regulates glutamate and glucose transporters in hypothalamic astrocytes

(2012) Esther Fuente-Martín et al.   JOURNAL OF CLINICAL INVESTIGATION

FOXO1 in the ventromedial hypothalamus regulates energy balance

(2012) Ki Woo Kim et al.   JOURNAL OF CLINICAL INVESTIGATION

Role of leptin in the pancreatic β-cell: effects and signaling pathways

(2012) Laura Marroquí et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

Distinct Roles for Specific Leptin Receptor Signals in the Development of Hypothalamic Feeding Circuits

(2012) S. G. Bouret et al.   JOURNAL OF NEUROSCIENCE

Leptin action through hypothalamic nitric oxide synthase-1–expressing neurons controls energy balance

(2012) Rebecca L Leshan et al.   NATURE MEDICINE

Rho-kinase regulates energy balance by targeting hypothalamic leptin receptor signaling

(2012) Hu Huang et al.   NATURE NEUROSCIENCE

AMPK: a nutrient and energy sensor that maintains energy homeostasis

(2012) D. Grahame Hardie et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Rapamycin Ameliorates Age-Dependent Obesity Associated with Increased mTOR Signaling in Hypothalamic POMC Neurons

(2012) Shi-Bing Yang et al.   NEURON

mTOR Signaling Fades POMC Neurons during Aging

(2012) Jae Geun Kim et al.   NEURON

Unsaturated Fatty Acids Revert Diet-Induced Hypothalamic Inflammation in Obesity

(2012) Dennys E. Cintra et al.   PLoS One

Leptin resistance and desensitization of hypophagia during prolonged inflammatory challenge

(2011) Beatriz C. Borges et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Induction of Leptin Resistance by Activation of cAMP-Epac Signaling

(2011) Makoto Fukuda et al.   Cell Metabolism

Protein Tyrosine Phosphatase Epsilon Affects Body Weight by Downregulating Leptin Signaling in a Phosphorylation-Dependent Manner

(2011) Liat Rousso-Noori et al.   Cell Metabolism

Elevated Hypothalamic TCPTP in Obesity Contributes to Cellular Leptin Resistance

(2011) Kim Loh et al.   Cell Metabolism

Ablation of LMO4 in glutamatergic neurons impairs leptin control of fat metabolism

(2011) Xun Zhou et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Defective Hypothalamic Autophagy Directs the Central Pathogenesis of Obesity via the IκB Kinase β (IKKβ)/NF-κB Pathway

(2011) Qingyuan Meng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Obesity is associated with hypothalamic injury in rodents and humans

(2011) Joshua P. Thaler et al.   JOURNAL OF CLINICAL INVESTIGATION

The AMPK signalling pathway coordinates cell growth, autophagy and metabolism

(2011) Maria M. Mihaylova et al.   NATURE CELL BIOLOGY

A role for central nervous system PPAR-γ in the regulation of energy balance

(2011) Karen K Ryan et al.   NATURE MEDICINE

Peroxisome proliferation–associated control of reactive oxygen species sets melanocortin tone and feeding in diet-induced obesity

(2011) Sabrina Diano et al.   NATURE MEDICINE

Leptin Action on GABAergic Neurons Prevents Obesity and Reduces Inhibitory Tone to POMC Neurons

(2011) Linh Vong et al.   NEURON

Steroidogenic factor 1 directs programs regulating diet-induced thermogenesis and leptin action in the ventral medial hypothalamic nucleus

(2011) K. W. Kim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neural dysregulation of peripheral insulin action and blood pressure by brain endoplasmic reticulum stress

(2011) S. Purkayastha et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lipoprotein Receptor LRP1 Regulates Leptin Signaling and Energy Homeostasis in the Adult Central Nervous System

(2011) Qiang Liu et al.   PLOS BIOLOGY

Central administration of interleukin-4 exacerbates hypothalamic inflammation and weight gain during high-fat feeding

(2010) Shinsuke Oh-I et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Disruption of Hepatic Leptin Signaling Protects Mice From Age- and Diet-Related Glucose Intolerance

(2010) F. K. Huynh et al.   DIABETES

Functional Role of Suppressor of Cytokine Signaling 3 Upregulation in Hypothalamic Leptin Resistance and Long-Term Energy Homeostasis

(2010) A. S. Reed et al.   DIABETES

Functional analysis of melanocortin-4-receptor mutants identified in severely obese subjects living in Southern Italy

(2010) Andreina Alfieri et al.   GENE

NF-κB Activation in Hypothalamic Pro-opiomelanocortin Neurons Is Essential in Illness- and Leptin-induced Anorexia

(2010) Pil-Geum Jang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cut-like Homeobox 1 (CUX1) Regulates Expression of the Fat Mass and Obesity-associated and Retinitis Pigmentosa GTPase Regulator-interacting Protein-1-like (RPGRIP1L) Genes and Coordinates Leptin Receptor Signaling

(2010) George Stratigopoulos et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Obesity-Linked Variants of Melanocortin-4 Receptor Are Misfolded in the Endoplasmic Reticulum and Can Be Rescued to the Cell Surface by a Chemical Chaperone

(2010) Susana Granell et al.   MOLECULAR ENDOCRINOLOGY

Leptin, Leptin Receptors, and the Control of Body Weight

(2010) Jeffrey M. Friedman   NUTRITION REVIEWS

Inhibition of PTP1B by Trodusquemine (MSI-1436) Causes Fat-specific Weight Loss in Diet-induced Obese Mice

(2010) Kristen A. Lantz et al.   Obesity

Hypothalamic and pituitary c-Jun N-terminal kinase 1 signaling coordinately regulates glucose metabolism

(2010) B. F. Belgardt et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IL-6 and IL-10 Anti-Inflammatory Activity Links Exercise to Hypothalamic Insulin and Leptin Sensitivity through IKKβ and ER Stress Inhibition

(2010) Eduardo R. Ropelle et al.   PLOS BIOLOGY

PET Imaging of Leptin Biodistribution and Metabolism in Rodents and Primates

(2009) Giovanni Ceccarini et al.   Cell Metabolism

Critical Role for Hypothalamic mTOR Activity in Energy Balance

(2009) Hiroyuki Mori et al.   Cell Metabolism

MyD88 Signaling in the CNS Is Required for Development of Fatty Acid-Induced Leptin Resistance and Diet-Induced Obesity

(2009) André Kleinridders et al.   Cell Metabolism

Endoplasmic Reticulum Stress Plays a Central Role in Development of Leptin Resistance

(2009) Lale Ozcan et al.   Cell Metabolism

PKA phosphorylates and inactivates AMPKα to promote efficient lipolysis

(2009) Nabil Djouder et al.   EMBO JOURNAL

Requirement of Bardet-Biedl syndrome proteins for leptin receptor signaling

(2009) Seongjin Seo et al.   HUMAN MOLECULAR GENETICS

Deletion of Tumor Necrosis Factor-α Receptor 1 (TNFR1) Protects against Diet-induced Obesity by Means of Increased Thermogenesis

(2009) Talita Romanatto et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Palmitic acid mediates hypothalamic insulin resistance by altering PKC-θ subcellular localization in rodents

(2009) Stephen C. Benoit et al.   JOURNAL OF CLINICAL INVESTIGATION

Saturated Fatty Acids Produce an Inflammatory Response Predominantly through the Activation of TLR4 Signaling in Hypothalamus: Implications for the Pathogenesis of Obesity

(2009) M. Milanski et al.   JOURNAL OF NEUROSCIENCE

Neuronal Protein Tyrosine Phosphatase 1B Deficiency Results in Inhibition of Hypothalamic AMPK and Isoform-Specific Activation of AMPK in Peripheral Tissues

(2009) B. Xue et al.   MOLECULAR AND CELLULAR BIOLOGY

Genome-wide association study for early-onset and morbid adult obesity identifies three new risk loci in European populations

(2009) David Meyre et al.   NATURE GENETICS

The obesity susceptibility gene Cpe links FoxO1 signaling in hypothalamic pro-opiomelanocortin neurons with regulation of food intake

(2009) Leona Plum et al.   NATURE MEDICINE

Central Administration of an Endoplasmic Reticulum Stress Inducer Inhibits the Anorexigenic Effects of Leptin and Insulin

(2009) Jong Chul Won et al.   Obesity

Adult Type 3 Adenylyl Cyclase–Deficient Mice Are Obese

(2009) Zhenshan Wang et al.   PLoS One

HF diets increase hypothalamic PTP1B and induce leptin resistance through both leptin-dependent and -independent mechanisms

(2008) Christy L. White et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Hypothalamic proinflammatory lipid accumulation, inflammation, and insulin resistance in rats fed a high-fat diet

(2008) Kelly A. Posey et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Leptin resistance: a prediposing factor for diet-induced obesity

(2008) Philip J. Scarpace et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Hypothalamic IKKβ/NF-κB and ER Stress Link Overnutrition to Energy Imbalance and Obesity

(2008) Xiaoqing Zhang et al.   CELL

Mediobasal Hypothalamic p70 S6 Kinase 1 Modulates the Control of Energy Homeostasis

(2008) Clémence Blouet et al.   Cell Metabolism

Hypothalamic ERK Mediates the Anorectic and Thermogenic Sympathetic Effects of Leptin

(2008) K. Rahmouni et al.   DIABETES

Reduction of Hypothalamic Protein Tyrosine Phosphatase Improves Insulin and Leptin Resistance in Diet-Induced Obese Rats

(2008) Paty Karoll Picardi et al.   ENDOCRINOLOGY

FoxO1 Inhibits Leptin Regulation of Pro-opiomelanocortin Promoter Activity by Blocking STAT3 Interaction with Specificity Protein 1

(2008) Guoqing Yang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Protein-tyrosine Phosphatase 1B Expression Is Induced by Inflammationin Vivo

(2008) Janice M. Zabolotny et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Acute effects of leptin require PI3K signaling in hypothalamic proopiomelanocortin neurons in mice

(2008) Jennifer W. Hill et al.   JOURNAL OF CLINICAL INVESTIGATION

The Role of Hypothalamic Mammalian Target of Rapamycin Complex 1 Signaling in Diet-Induced Obesity

(2008) D. Cota et al.   JOURNAL OF NEUROSCIENCE

Megalin mediates the transport of leptin across the blood-CSF barrier

(2007) Marcelo O. Dietrich et al.   NEUROBIOLOGY OF AGING