Article
Endocrinology & Metabolism
Robert Haddad Tovolli, Joseane Morari, Roberta Barbizan, Vanessa C. Bobbo, Rodrigo S. Carraro, Carina Solon, Nathalia R. Dragano, Marcio A. Torsoni, Eliana P. Araujo, Licio A. Velloso
Summary: Maternal obesity is a significant risk factor for obesity, cardiovascular, and metabolic diseases in offspring. It leads to inflammation in the hypothalamus of the offspring, affecting the function of neurons that regulate food intake and energy expenditure. Maternal obesity-induced structural and functional damage to the offspring's hypothalamic BBB, but breastfeeding by lean mothers can partially reverse these effects.
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
(2023)
Article
Neurosciences
Ruksana Yesmin, Miho Watanabe, Adya Saran Sinha, Masaru Ishibashi, Tianying Wang, Atsuo Fukuda
Summary: Activated AgRP neurons in the arcuate nucleus directly project to CRH axon terminals in the median-eminence and modulate the hypothalamic-pituitary-adrenal (HPA) axis via NKCC1-dependent GABAergic excitation. These findings highlight the important role of AgRP neurons in HPA axis regulation.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2022)
Article
Medicine, Research & Experimental
Tori Lhomme, Jerome Clasadonte, Monica Imbernon, Daniela Fernandois, Florent Sauve, Emilie Caron, Natalia da Silva Lima, Violeta Heras, Ines Martinez-Corral, Helge Mueller-Fielitz, Sowmyalakshmi Rasika, Markus Schwaninger, Ruben Nogueiras, Vincent Prevot
Summary: Tanycytes in the hypothalamus convert brain glucose into lactate and transmit it to proopiomelanocortin neurons, driving their activity and metabolic response. This transmission relies on the formation of metabolic networks and plays a key role in regulating feeding behavior and energy metabolism.
JOURNAL OF CLINICAL INVESTIGATION
(2021)
Article
Endocrinology & Metabolism
Sophie Buller, Sara Kohnke, Robert Hansford, Takahiro Shimizu, William D. Richardson, Clemence Blouet
Summary: This study reveals the plasticity of myelination in the adult median eminence (ME) and its regulation by nutritional signals. It shows that oligodendrocyte generation and myelin production are continuously occurring in the adult ME, but myelin amounts remain stable due to turnover. Furthermore, it demonstrates that the plasticity of ME myelination is influenced by diet and plays a role in energy balance regulation.
MOLECULAR METABOLISM
(2023)
Article
Reproductive Biology
Rodrigo A. Carrasco, Jaswant Singh, Marcelo H. Ratto, Gregg P. Adams
Summary: The study characterized the anatomical framework and sites of action of the NGF-mediated ovulation-inducing system in llamas. Both TrkA and P75 receptors were highly expressed in specific regions of the llama hypothalamus, with tanycytes playing a close role between GnRH and kisspeptin.
BIOLOGY OF REPRODUCTION
(2021)
Review
Endocrinology & Metabolism
Alexander Jais, Jens C. Bruning
Summary: The central nervous system plays a crucial role in maintaining metabolic homeostasis and regulating various physiological functions through the ARC. Energy state-sensing neurons in the ARC are master regulators that control feeding, glucose homeostasis, and other physiological responses based on the organism's energy status.
Article
Endocrinology & Metabolism
Marilena Marraudino, Beatriz Carrillo, Brigitta Bonaldo, Ricardo Llorente, Elia Campioli, Iciar Garate, Helena Pinos, Luis Miguel Garcia-Segura, Paloma Collado, Daniela Grassi
Summary: The study evaluated the distribution of GPER in the rat hypothalamus, showing that GPER immunoreactivity is expressed in neurons, astrocytes, and oligodendrocytes, with differences observed in different sexes, regions, and stages of the estrous cycle in females.
NEUROENDOCRINOLOGY
(2021)
Article
Agriculture, Dairy & Animal Science
D. J. Innes, N. J. Hudson, S. T. Anderson, D. P. Poppi, S. P. Quigley
Summary: A reduction in voluntary feed intake is observed in ruminants consuming nutrient-deficient diets, such as those with a low CP or P content, and has been attributed to active metabolic regulation, rather than a physical constraint. The hypothalamus is the key integrator of feed intake regulation in mammals. The objectives of this experiment were to establish a model of metabolic feed intake regulation in ruminants consuming diets of variable CP and P content, and determine key biochemical pathways and influential points of regulation within the hypothalamus.
Review
Endocrinology & Metabolism
Sreekala Nampoothiri, Ruben Nogueiras, Markus Schwaninger, Vincent Prevot
Summary: This review discusses the key role glial cells play in regulating energy balance, emphasizing their relevance in the pathophysiology of metabolic diseases. Glial cells, located at the interface of blood vessels and neurons, participate in integrating and transmitting peripheral signals to neuronal networks in the brain for whole-body metabolism control. Metabolic diseases like obesity and type 2 diabetes can disrupt the communication mediated by glial cells between the brain and the periphery, highlighting the importance of these cell types in the pathophysiology of such complications.
Article
Biology
Wenyu Ding, Changjiang Zhang, Baisong Wang, Xin Zhou, Le Sun, Suijuan Zhong, Jing Liu, Junjing Zhang, Xiaoqun Wang, Qian Wu
Summary: The study reveals the crucial roles of the centrosomal protein Cenpj in neurogenesis, cerebral cortex development, and body weight regulation. Deletion of Cenpj leads to obesity in mice and affects hypothalamic cell proliferation, neuron number, and function, providing insights into the pathological mechanisms of related diseases.
SCIENCE CHINA-LIFE SCIENCES
(2021)
Article
Multidisciplinary Sciences
Aakansha Sharma, Subhajit Das, Sayantan Sur, Jyoti Tiwari, Khushboo Chaturvedi, Neha Agarwal, Shalie Malik, Sangeeta Rani, Vinod Kumar
Summary: Through investigating the time course of photoperiodically driven transcriptional responses in physiologically contrasting seasonal life-history states in migratory blackheaded buntings, it was found that there were differences in gene expression between the photosensitive and photorefractory states. The results demonstrate the important role of hypothalamic molecular pathways in life-history-dependent activation.
SCIENTIFIC REPORTS
(2021)
Article
Developmental Biology
Sharifuddin Rifat Ahmed, Elise Liu, Alissa Yip, Yuqi Lin, Evan Balaban, Maria Pompeiano
Summary: Mammalian TRPC5 channels are predominantly expressed in the brain, particularly in areas that play a role in neurotransmission. This study in chick embryos found a significant increase in TRPC5 expression in the brain between days 8 and 16 of incubation, suggesting a potential role in late embryonic brain development. The distribution and staining patterns of TRPC5 in the chick embryo brain provide new insights into its functions and possible contributions to brain development.
DEVELOPMENTAL NEUROBIOLOGY
(2022)
Article
Anatomy & Morphology
Maria G. Bilbao, Daniel Garrigos, Marta Martinez-Morga, Angel Toval, Yevheniy Kutsenko, Rosario Bautista, Alberto Barreda, Bruno Ribeiro Do-Couto, Luis Puelles, Jose Luis Ferran
Summary: In this study, a prosomeric immunohistochemical mapping of hypothalamic cells expressing tyrosine hydroxylase (TH) in rats was conducted. The results showed that TH-positive cells were predominantly located in the periventricular stratum of the paraventricular and subparaventricular alar domains, as well as in the acroterminal arcuate nucleus and the terminal periventricular stratum in the tuberal region. The prosomeric model proved useful for determining the precise location of TH-positive cells relative to morphogenetic signals and provided potential causal explanation for the specification of this hypothalamic cell type.
FRONTIERS IN NEUROANATOMY
(2022)
Article
Physiology
John Ciriello, Jason M. Moreau, Monica M. Caverson, Rebecca Moranis
Summary: This study found that long-term exposure to chronic intermittent hypoxia may be related to obesity and leptin resistance, leading to weight gain.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Nutrition & Dietetics
Eduardo Natan Muraro, Bruno Marques Sbardelotto, Zoe Maria Guareschi, Wellington de Almeida, Adriana Souza dos Santos, Sabrina Grassiolli, Ligia Aline Centenaro
Summary: In response to the increasing prevalence of obesity and metabolic syndrome in children and adolescents, this study proposed early and combined treatments to restore brain areas associated with satiety. The findings suggest that the combined use of vitamin D supplementation and aerobic exercise can effectively restore brain nuclei involved in the control of food intake, improving the treatment of obesity.
CLINICAL NUTRITION ESPEN
(2022)
Article
Psychology, Biological
Merel Rijnsburger, Evita Belegri, Leslie Eggels, Unga A. Unmehopa, Anita Boelen, Mireille J. Serlie, Susanne E. la Fleur
PHYSIOLOGY & BEHAVIOR
(2016)
Article
Biochemical Research Methods
M. Rijnsburger, L. Eggels, J. Castel, C. Cruciani-Guglielmacci, M. T. Ackermans, S. Luquet, S. E. la Fleur
JOURNAL OF NEUROSCIENCE METHODS
(2017)
Article
Neurosciences
C. Diepenbroek, M. Rijnsburger, L. Eggels, K. M. van Megen, M. T. Ackermans, E. Fliers, A. Kalsbeek, M. J. Serlie, S. E. la Fleur
NEUROSCIENCE LETTERS
(2017)
Article
Neurosciences
Evita Belegri, Merel Rijnsburger, Leslie Eggels, Unga Unmehopa, Wiep Scheper, Anita Boelen, Susanne E. la Fleur
FRONTIERS IN NEUROSCIENCE
(2017)
Article
Biochemistry & Molecular Biology
C. Cansell, J. Castel, R. G. P. Denis, C. Rouch, A-S Delbes, S. Martinez, D. Mestivier, B. Finan, J. G. Maldonado-Aviles, M. Rijnsburger, M. H. Tschoep, R. J. DiLeone, R. H. Eckel, S. E. la Fleur, C. Magnan, T. S. Hnasko, S. Luquet
MOLECULAR PSYCHIATRY
(2014)
Article
Neurosciences
Charlene Diepenbroek, Geoffrey van der Plasse, Leslie Eggels, Merel Rijnsburger, Matthijs G. P. Feenstra, Andries Kalsbeek, Damiaan Denys, Eric Fliers, Mireille J. Serlie, Susanne E. la Fleur
FRONTIERS IN NEUROSCIENCE
(2013)
Article
Immunology
Alwin Kamermans, Merel Rijnsburger, Ananya Chakraborty, Susanne van der Pol, Helga E. de Vries, Jack van Horssen
FRONTIERS IN IMMUNOLOGY
(2019)
Article
Immunology
Alwin Kamermans, Tom Verhoeven, Bert van het Hof, Jasper J. Koning, Lauri Borghuis, Maarten Witte, Jack van Horssen, Helga E. de Vries, Merel Rijnsburger
FRONTIERS IN IMMUNOLOGY
(2019)
Article
Neurosciences
Sabela Rodriguez-Lorenzo, David Miguel Ferreira Francisco, Ricardo Vos, Bert van het Hof, Merel Rijnsburger, Horst Schroten, Hiroshi Ishikawa, Wissam Beaino, Remy Bruggmann, Gijs Kooij, Helga E. de Vries
ACTA NEUROPATHOLOGICA COMMUNICATIONS
(2020)
Review
Biochemistry & Molecular Biology
Merel Rijnsburger, Niek Djuric, Inge A. Mulder, Helga E. de Vries
Summary: Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease of the central nervous system, with significant impact on patients and their proxies. Obesity is associated with an increased risk of developing MS. Adipokines play a crucial role in MS pathology and may have therapeutic potential in targeting neuroinflammation and neurodegeneration.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Endocrinology & Metabolism
Katy A. van Galen, Anouk Schrantee, Kasper W. ter Horst, Susanne E. la Fleur, Jan Booij, R. Todd Constable, Gary J. Schwartz, Ralph J. DiLeone, Mireille J. Serlie
Summary: This study found that intragastric glucose and lipid infusions can induce cerebral neuronal activity and striatal dopamine release in individuals with a healthy body weight, but these responses are severely impaired in individuals with obesity. Furthermore, the impaired neuronal responses are not restored after diet-induced weight loss.