期刊
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
卷 15, 期 6, 页码 10296-10333出版社
MDPI
DOI: 10.3390/ijms150610296
关键词
erythropoietin; erythropoietin receptor; signal transduction; stress response; wound healing; endothelial; brain; cardiovascular; inflammation; metabolism; obesity
资金
- National Institute of Diabetes and Digestive and Kidney Diseases
Erythropoietin (EPO) regulation of red blood cell production and its induction at reduced oxygen tension provides for the important erythropoietic response to ischemic stress. The cloning and production of recombinant human EPO has led to its clinical use in patients with anemia for two and half decades and has facilitated studies of EPO action. Reports of animal and cell models of ischemic stress in vitro and injury suggest potential EPO benefit beyond red blood cell production including vascular endothelial response to increase nitric oxide production, which facilitates oxygen delivery to brain, heart and other non-hematopoietic tissues. This review discusses these and other reports of EPO action beyond red blood cell production, including EPO response affecting metabolism and obesity in animal models. Observations of EPO activity in cell and animal model systems, including mice with tissue specific deletion of EPO receptor (EpoR), suggest the potential for EPO response in metabolism and disease.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据