NPY receptors as potential targets for anti-obesity drug development

Y2 and Y4 receptor signaling synergistically act on energy expenditure and physical activity

(2010) Lei Zhang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

The identification of a series of novel, soluble non-peptidic neuropeptide Y Y2 receptor antagonists

(2010) Gillian E. Lunniss et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Discovery and structure–activity relationship of a novel spirocarbamate series of NPY Y5 antagonists

(2010) Colin P. Leslie et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Design, synthesis and SAR of a novel series of benzimidazoles as potent NPY Y5 antagonists

(2010) Domenica Antonia Pizzi et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis and structure–activity relationship of N-(3-azabicyclo[3.1.0]hex-6-ylmethyl)-5-(2-pyridinyl)-1,3-thiazol-2-amines derivatives as NPY Y5 antagonists

(2010) Matteo Biagetti et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

PYY3-36 and Oxyntomodulin Can Be Additive in Their Effect on Food Intake in Overweight and Obese Humans

(2010) B. C. T. Field et al.   DIABETES

Therapeutic potential of neuropeptide Y (NPY) receptor ligands

(2010) Shaun P. Brothers et al.   EMBO Molecular Medicine

Mechanical signals as anabolic agents in bone

(2010) Engin Ozcivici et al.   Nature Reviews Rheumatology

Synthesis, characterization, and monkey positron emission tomography (PET) studies of [18F]Y1-973, a PET tracer for the neuropeptide Y Y1 receptor

(2010) Eric D. Hostetler et al.   NEUROIMAGE

Y4 receptors and pancreatic polypeptide regulate food intake via hypothalamic orexin and brain-derived neurotropic factor dependent pathways

(2010) Amanda Sainsbury et al.   NEUROPEPTIDES

Regulatory effects of Y4 receptor agonist (BVD-74D) on food intake

(2010) Jiang-Bo Li et al.   PEPTIDES

NPY Neuron-Specific Y2 Receptors Regulate Adipose Tissue and Trabecular Bone but Not Cortical Bone Homeostasis in Mice

(2010) Yan-Chuan Shi et al.   PLoS One

Discovery of trans-N-[1-(2-fluorophenyl)-3-pyrazolyl]-3-oxospiro[6-azaisobenzofuran-1(3H),1′-cyclohexane]-4′-carboxamide, a potent and orally active neuropeptide Y Y5 receptor antagonist

(2009) Yuji Haga et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Novel orally active NPY Y5 receptor antagonists: Synthesis and structure–activity relationship of spiroindoline class compounds

(2009) Toshihiro Sakamoto et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Aryl urea derivatives of spiropiperidines as NPY Y5 receptor antagonists

(2009) Toshiyuki Takahashi et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Identification of novel and orally active spiroindoline NPY Y5 receptor antagonists

(2009) Toshihiro Sakamoto et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Optimization of a series of 2,4-diaminopyridines as neuropeptide Y Y1 receptor antagonists with reduced hERG activity

(2009) Minoru Kameda et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis and evaluation of a series of 2,4-diaminopyridine derivatives as potential positron emission tomography tracers for neuropeptide Y Y1 receptors

(2009) Minoru Kameda et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synergistic interaction between neuropeptide Y1 and Y5 receptor pathways in regulation of energy homeostasis

(2009) Satoshi Mashiko et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Pancreatic polypeptide enhances colonic muscle contraction and fecal output through neuropeptide Y Y4 receptor in mice

(2009) Ryuichi Moriya et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Peripheral neuropeptide Y Y1 receptors regulate lipid oxidation and fat accretion

(2009) L Zhang et al.   INTERNATIONAL JOURNAL OF OBESITY

Kinetic Study of Neuropeptide Y (NPY) Proteolysis in Blood and Identification of NPY3–35

(2009) Karim Abid et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Discovery of Tetrasubstituted Imidazolines as Potent and Selective Neuropeptide Y Y5 Receptor Antagonists: Reduced Human Ether-a-go-go Related Gene Potassium Channel Binding Affinity and Potent Antiobesity Effect

(2009) Nagaaki Sato et al.   JOURNAL OF MEDICINAL CHEMISTRY

First selective agonist of the neuropeptide Y1-receptor with reduced size

(2009) Denise Zwanziger et al.   JOURNAL OF PEPTIDE SCIENCE

Tolerance to ethanol sedation and withdrawal hyper-excitability is mediated via neuropeptide Y Y1 and Y5 receptors

(2009) Snehal M. Bhisikar et al.   LIFE SCIENCES

Role of the arcuate nucleus of the hypothalamus in regulation of body weight during energy deficit

(2009) A. Sainsbury et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Comparison of independent and combined chronic anti-obese effects of NPY Y2 receptor agonist, PYY(3-36), and NPY Y5 receptor antagonist in diet-induced obese mice

(2009) Ryuichi Moriya et al.   PEPTIDES

Critical Role of Arcuate Y4 Receptors and the Melanocortin System in Pancreatic Polypeptide-Induced Reduction in Food Intake in Mice

(2009) Shu Lin et al.   PLoS One

PYY3-36 injection in mice produces an acute anorexigenic effect followed by a delayed orexigenic effect not observed with other anorexigenic gut hormones

(2008) James R. C. Parkinson et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Effects of different intermittent peptide YY (3-36) dosing strategies on food intake, body weight, and adiposity in diet-induced obese rats

(2008) Roger D. Reidelberger et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Agonist induced receptor internalization of neuropeptide Y receptor subtypes depends on third intracellular loop and C-terminus☆

(2008) Ilka Böhme et al.   CELLULAR SIGNALLING

Pharmacological characterization and appetite suppressive properties of BMS-193885, a novel and selective neuropeptide Y1 receptor antagonist

(2008) Ildiko Antal-Zimanyi et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Identification and characterization of pseudoirreversible nonpeptide antagonists of the neuropeptide Y Y5 receptor and development of a novel Y5-selective radioligand

(2008) Deborra Mullins et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Neuropeptide Y is produced in visceral adipose tissue and promotes proliferation of adipocyte precursor cells via the Y1 receptor

(2008) Kaiping Yang et al.   FASEB JOURNAL

(9S)-9-(2-Hydroxy-4,4-dimethyl-6-oxo-1-cyclohexen-1-yl)-3,3-dimethyl-2,3,4,9-tetrahydro-1H-xanthen-1-one, a Selective and Orally Active Neuropeptide Y Y5 Receptor Antagonist

(2008) Nagaaki Sato et al.   JOURNAL OF MEDICINAL CHEMISTRY

Unknown

(2008) M. W. Walker et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

PYY transgenic mice are protected against diet-induced and genetic obesity

(2008) Dana Boey et al.   NEUROPEPTIDES

Effects of a Novel Y5 Antagonist in Obese Mice: Combination With Food Restriction or Sibutramine

(2008) Satoshi Mashiko et al.   Obesity

Feeding behavior and gene expression of appetite-related neuropeptides in mice lacking for neuropeptide Y Y5 receptor subclass

(2008) Hiroshi Higuchi et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Supraphysiological doses of intravenous PYY3-36 cause nausea, but no additional reduction in food intake

(2008) Carel W le Roux et al.   ANNALS OF CLINICAL BIOCHEMISTRY

Discovery of novel orally active ureido NPY Y5 receptor antagonists

(2007) Guoqing Li et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS