Lipocalin 2 regulates iron homeostasis, neuroinflammation, and insulin resistance in the brains of patients with dementia: Evidence from the current literature
出版年份 2021 全文链接
标题
Lipocalin 2 regulates iron homeostasis, neuroinflammation, and insulin resistance in the brains of patients with dementia: Evidence from the current literature
作者
关键词
-
出版物
CNS Neuroscience & Therapeutics
Volume -, Issue -, Pages -
出版商
Wiley
发表日期
2021-05-05
DOI
10.1111/cns.13653
参考文献
相关参考文献
注意：仅列出部分参考文献，下载原文获取全部文献信息。- Chemotherapy and the Risk of Alzheimer's Disease in Colorectal Cancer Survivors: Evidence From the Medicare System
- (2021) Igor Akushevich et al. JCO Oncology Practice
- Association of anthropometry and weight change with risk of dementia and its major subtypes: A meta‐analysis consisting 2.8 million adults with 57 294 cases of dementia
- (2020) Crystal ManYing Lee et al. Obesity Reviews
- Cerebrospinal fluid lipocalin 2 as a novel biomarker for the differential diagnosis of vascular dementia
- (2020) Franc Llorens et al. Nature Communications
- Leaky memories: Impact of APOE4 on blood–brain barrier and dementia
- (2020) Wenlu Li et al. JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
- Lipocalin 2 induces neuroinflammation and blood-brain barrier dysfunction through liver-brain axis in murine model of nonalcoholic steatohepatitis
- (2020) Ayan Mondal et al. Journal of Neuroinflammation
- Neutralization of Lipocalin-2 Diminishes Stroke-Reperfusion Injury
- (2020) Guona Wang et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Iron accumulation in microglia triggers a cascade of events that leads to altered metabolism and compromised function in APP/PS1 mice
- (2019) Allison McIntosh et al. BRAIN PATHOLOGY
- Role of Hippocampal Lipocalin-2 in Experimental Diabetic Encephalopathy
- (2019) Anup Bhusal et al. Frontiers in Endocrinology
- Brain iron is associated with accelerated cognitive decline in people with Alzheimer pathology
- (2019) Scott Ayton et al. MOLECULAR PSYCHIATRY
- Targeted degradation of aberrant tau in frontotemporal dementia patient-derived neuronal cell models
- (2019) M Catarina Silva et al. eLife
- The Involvement of Peripheral and Brain Insulin Resistance in Late Onset Alzheimer’s Dementia
- (2019) Jaume Folch et al. Frontiers in Aging Neuroscience
- Brain perivascular macrophages: Recent advances and implications in health and diseases
- (2019) Tuo Yang et al. CNS Neuroscience & Therapeutics
- Diagnosis and Management of Dementia: Review
- (2019) Zoe Arvanitakis et al. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
- Progress toward standardized diagnosis of vascular cognitive impairment: Guidelines from the Vascular Impairment of Cognition Classification Consensus Study
- (2018) Olivia A. Skrobot et al. Alzheimers & Dementia
- NIA-AA Research Framework: Toward a biological definition of Alzheimer's disease
- (2018) Clifford R. Jack et al. Alzheimers & Dementia
- Why should neuroscientists worry about iron? The emerging role of ferroptosis in the pathophysiology of neuroprogressive diseases
- (2018) Gerwyn Morris et al. BEHAVIOURAL BRAIN RESEARCH
- Inflammatory microglia are glycolytic and iron retentive and typify the microglia in APP/PS1 mice
- (2018) R. Holland et al. BRAIN BEHAVIOR AND IMMUNITY
- Dihydromyricetin inhibits microglial activation and neuroinflammation by suppressing NLRP3 inflammasome activation in APP/PS1 transgenic mice
- (2018) Jie Feng et al. CNS Neuroscience & Therapeutics
- Iron and Alzheimer’s Disease: An Update on Emerging Mechanisms
- (2018) Darius J.R. Lane et al. JOURNAL OF ALZHEIMERS DISEASE
- Inflammation-induced iron transport and metabolism by brain microglia
- (2018) Ryan C. McCarthy et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Biomarkers identify the Binswanger type of vascular cognitive impairment
- (2018) Erik Barry Erhardt et al. JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
- Celastrol treatment protects against acute ischemic stroke-induced brain injury by promoting an IL-33/ST2 axis-mediated microglia/macrophage M2 polarization
- (2018) Mei Jiang et al. Journal of Neuroinflammation
- Brain insulin resistance in type 2 diabetes and Alzheimer disease: concepts and conundrums
- (2018) Steven E. Arnold et al. Nature Reviews Neurology
- Postmortem MRI and histology demonstrate differential iron accumulation and cortical myelin organization in early- and late-onset Alzheimer's disease
- (2018) Marjolein Bulk et al. NEUROBIOLOGY OF AGING
- Deciphering the Astrocyte Reaction in Alzheimer’s Disease
- (2018) Beatriz G. Perez-Nievas et al. Frontiers in Aging Neuroscience
- Brain-selective mild hypothermia promotes long-term white matter integrity after ischemic stroke in mice
- (2018) Li-Qiang Liu et al. CNS Neuroscience & Therapeutics
- Striking while the iron is hot: Iron metabolism and Ferroptosis in neurodegeneration
- (2018) Shashank Masaldan et al. FREE RADICAL BIOLOGY AND MEDICINE
- Perturbed Iron Distribution in Alzheimer's Disease Serum, Cerebrospinal Fluid, and Selected Brain Regions: A Systematic Review and Meta-Analysis
- (2018) Yunlong Tao et al. JOURNAL OF ALZHEIMERS DISEASE
- TSG-6 attenuates inflammation-induced brain injury via modulation of microglial polarization in SAH rats through the SOCS3/STAT3 pathway
- (2018) Ran Li et al. Journal of Neuroinflammation
- Lipocalin 2 contributes to brain iron dysregulation but does not affect cognition, plaque load, and glial activation in the J20 Alzheimer mouse model
- (2018) Doortje W. Dekens et al. Journal of Neuroinflammation
- Astrocyte-derived lipocalin-2 mediates hippocampal damage and cognitive deficits in experimental models of vascular dementia
- (2017) Jae-Hong Kim et al. GLIA
- Cortical Iron Reflects Severity of Alzheimer’s Disease
- (2017) Sara van Duijn et al. JOURNAL OF ALZHEIMERS DISEASE
- Microglia in Alzheimer’s disease
- (2017) Heela Sarlus et al. JOURNAL OF CLINICAL INVESTIGATION
- Binswanger's disease: biomarkers in the inflammatory form of vascular cognitive impairment and dementia
- (2017) Gary A. Rosenberg JOURNAL OF NEUROCHEMISTRY
- Lipocalin-2 regulates adult neurogenesis and contextual discriminative behaviours
- (2017) A C Ferreira et al. MOLECULAR PSYCHIATRY
- MC4R-dependent suppression of appetite by bone-derived lipocalin 2
- (2017) Ioanna Mosialou et al. NATURE
- Cerebrospinal Fluid Biomarkers of Alzheimer's Disease Show Different but Partially Overlapping Profile Compared to Vascular Dementia
- (2017) Franc Llorens et al. Frontiers in Aging Neuroscience
- T Lymphocytes and Inflammatory Mediators in the Interplay between Brain and Blood in Alzheimer’s Disease: Potential Pools of New Biomarkers
- (2017) Anna Mietelska-Porowska et al. Journal of Immunology Research
- Lipocalin 2 alleviates iron toxicity by facilitating hypoferremia of inflammation and limiting catalytic iron generation
- (2016) Xia Xiao et al. BIOMETALS
- Ginkgolide B Protects Against Ischemic Stroke Via Modulating Microglia Polarization in Mice
- (2016) Zhao-Ma Shu et al. CNS Neuroscience & Therapeutics
- Neutrophil Gelatinase-Associated Lipocalin and its Receptors in Alzheimer’s Disease (AD) Brain Regions: Differential Findings in AD with and without Depression
- (2016) Doortje W. Dekens et al. JOURNAL OF ALZHEIMERS DISEASE
- Patterns of Brain Iron Accumulation in Vascular Dementia and Alzheimer’s Dementia Using Quantitative Susceptibility Mapping Imaging
- (2016) Yeonsil Moon et al. JOURNAL OF ALZHEIMERS DISEASE
- Iron neurochemistry in Alzheimer's disease and Parkinson's disease: targets for therapeutics
- (2016) Abdel A. Belaidi et al. JOURNAL OF NEUROCHEMISTRY
- Pathogenic Upregulation of Glial Lipocalin-2 in the Parkinsonian Dopaminergic System
- (2016) B.-W. Kim et al. JOURNAL OF NEUROSCIENCE
- Serum lipocalin-2 levels are positively associated with not only total body fat but also visceral fat area in Chinese men
- (2016) Yuqi Luo et al. MEDICINE
- Cerebrospinal fluid lipocalin 2 in patients with clinically isolated syndromes and early multiple sclerosis
- (2016) M Khalil et al. Multiple Sclerosis Journal
- Magnetic susceptibility of brain iron is associated with childhood spatial IQ
- (2016) Kimberly L.H. Carpenter et al. NEUROIMAGE
- Functions and mechanisms of microglia/macrophages in neuroinflammation and neurogenesis after stroke
- (2016) Xiao-Yi Xiong et al. PROGRESS IN NEUROBIOLOGY
- Disposal of iron by a mutant form of lipocalin 2
- (2016) Jonathan Barasch et al. Nature Communications
- Cerebrospinal fluid lipocalin 2 in patients with clinically isolated syndromes and early multiple sclerosis
- (2016) M Khalil et al. Multiple Sclerosis Journal
- Lipocalin 2 (LCN2) Expression in Hepatic Malfunction and Therapy
- (2016) Anastasia Asimakopoulou et al. Frontiers in Physiology
- Lipocalin-2 released in response to cerebral ischaemia mediates reperfusion injury in mice
- (2015) Guona Wang et al. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
- Role of Lipocalin-2 in Brain Injury after Intracerebral Hemorrhage
- (2015) Wei Ni et al. JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
- Neuroinflammation in Alzheimer's disease
- (2015) Michael T Heneka et al. LANCET NEUROLOGY
- Evaluation and Management of the Elderly Patient Presenting with Cognitive Complaints
- (2015) Kerry L. Hildreth et al. MEDICAL CLINICS OF NORTH AMERICA
- Mitochondrial iron homeostasis and its dysfunctions in neurodegenerative disorders
- (2015) Natalia P. Mena et al. MITOCHONDRION
- Neurodegeneration with inflammation is accompanied by accumulation of iron and ferritin in microglia and neurons
- (2015) Maj Schneider Thomsen et al. NEUROBIOLOGY OF DISEASE
- Diverse functional roles of lipocalin-2 in the central nervous system
- (2015) Mithilesh Kumar Jha et al. NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
- From the periphery to the brain: Lipocalin-2, a friend or foe?
- (2015) Ana C. Ferreira et al. PROGRESS IN NEUROBIOLOGY
- Glucose regulation, cognition, and brain MRI in type 2 diabetes: a systematic review
- (2015) Stefan L C Geijselaers et al. Lancet Diabetes & Endocrinology
- The Ischemic Environment Drives Microglia and Macrophage Function
- (2015) Stefano Fumagalli et al. Frontiers in Neurology
- Lipocalin (LCN) 2 Mediates Pro-Atherosclerotic Processes and Is Elevated in Patients with Coronary Artery Disease
- (2015) Raghav Oberoi et al. PLoS One
- Improvement of functional recovery by chronic metformin treatment is associated with enhanced alternative activation of microglia/macrophages and increased angiogenesis and neurogenesis following experimental stroke
- (2014) Qin Jin et al. BRAIN BEHAVIOR AND IMMUNITY
- Lipocalin 2 modulates the cellular response to amyloid beta
- (2014) S D Mesquita et al. CELL DEATH AND DIFFERENTIATION
- Iron transport across the blood–brain barrier: development, neurovascular regulation and cerebral amyloid angiopathy
- (2014) Ryan C. McCarthy et al. CELLULAR AND MOLECULAR LIFE SCIENCES
- Lipocalin-2 Protein Deficiency Ameliorates Experimental Autoimmune Encephalomyelitis
- (2014) Youngpyo Nam et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Lipocalin-2 Deficiency Attenuates Neuroinflammation and Brain Injury after Transient Middle Cerebral Artery Occlusion in Mice
- (2014) Myungwon Jin et al. JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
- Serum lipocalin-2 as an insulin resistance marker in patients with polycystic ovary syndrome
- (2014) E. ©akal et al. JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
- Iron and mechanisms of emotional behavior
- (2014) Jonghan Kim et al. JOURNAL OF NUTRITIONAL BIOCHEMISTRY
- CSF Biomarkers and Neuropsychological Profiles in Patients with Cerebral Small-Vessel Disease
- (2014) Peter Hermann et al. PLoS One
- Neuronal Production of Lipocalin-2 as a Help-Me Signal for Glial Activation
- (2014) Changhong Xing et al. STROKE
- Lipocalin-2 is involved in emotional behaviors and cognitive function
- (2014) Ana Ferreira Frontiers in Cellular Neuroscience
- The FLS (Fatty liver Shionogi) mouse reveals local expressions of lipocalin-2, CXCL1 and CXCL9 in the liver with non-alcoholic steatohepatitis
- (2013) Toshihisa Semba et al. BMC GASTROENTEROLOGY
- Role of iron in brain lipocalin 2 upregulation after intracerebral hemorrhage in rats
- (2013) Ming Dong et al. BRAIN RESEARCH
- Iron and Copper in Mitochondrial Diseases
- (2013) Wenjing Xu et al. Cell Metabolism
- Mechanism and clinical evidence of lipocalin-2 and adipocyte fatty acid-binding protein linking obesity and atherosclerosis
- (2013) Guangyu Wu et al. DIABETES-METABOLISM RESEARCH AND REVIEWS
- Inflammation alters the expression of DMT1, FPN1 and hepcidin, and it causes iron accumulation in central nervous system cells
- (2013) Pamela Urrutia et al. JOURNAL OF NEUROCHEMISTRY
- Temporal Course of Changes in Gene Expression Suggests a Cytokine-Related Mechanism for Long-Term Hippocampal Alteration after Controlled Cortical Impact
- (2013) Camila P. Almeida-Suhett et al. JOURNAL OF NEUROTRAUMA
- The Bacteriostatic Protein Lipocalin 2 Is Induced in the Central Nervous System of Mice with West Nile Virus Encephalitis
- (2013) A. L. Nocon et al. JOURNAL OF VIROLOGY
- Iron metabolism in the CNS: implications for neurodegenerative diseases
- (2013) Tracey A. Rouault NATURE REVIEWS NEUROSCIENCE
- Glucose Levels and Risk of Dementia
- (2013) NEW ENGLAND JOURNAL OF MEDICINE
- Circulating Lipocalin-2 and Retinol-Binding Protein 4 Are Associated with Intima-Media Thickness and Subclinical Atherosclerosis in Patients with Type 2 Diabetes
- (2013) Yang Xiao et al. PLoS One
- Reactive astrocytes secrete lcn2 to promote neuron death
- (2013) F. Bi et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Definitions of dementia and predementia states in Alzheimer's disease and vascular cognitive impairment: consensus from the Canadian conference on diagnosis of dementia
- (2013) Howard Chertkow et al. Alzheimers Research & Therapy
- STAT1, NF-κB and ERKs play a role in the induction of lipocalin-2 expression in adipocytes
- (2013) Peng Zhao et al. Molecular Metabolism
- Vascular disease and dementias: Paradigm shifts to drive research in new directions
- (2012) Mitchel A. Kling et al. Alzheimers & Dementia
- Mammalian Iron Homeostasis in Health and Disease: Uptake, Storage, Transport, and Molecular Mechanisms of Action
- (2012) Alfons Lawen et al. ANTIOXIDANTS & REDOX SIGNALING
- The role of mitochondria in cellular iron–sulfur protein biogenesis and iron metabolism
- (2012) Roland Lill et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
- The multifaceted roles of neutrophil gelatinase associated lipocalin (NGAL) in inflammation and cancer
- (2012) Subhankar Chakraborty et al. BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
- Lipocalin 2: Novel component of proinflammatory signaling in Alzheimer's disease
- (2012) Petrus J. W. Naudé et al. FASEB JOURNAL
- Lipocalin 2 is a novel immune mediator of experimental autoimmune encephalomyelitis pathogenesis and is modulated in multiple sclerosis
- (2012) Jennifer L. Berard et al. GLIA
- Diabetes as a risk factor for dementia and mild cognitive impairment: a meta-analysis of longitudinal studies
- (2012) G. Cheng et al. INTERNAL MEDICINE JOURNAL
- Mammalian Siderophores, Siderophore-binding Lipocalins, and the Labile Iron Pool
- (2012) Colin Correnti et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Demonstrated brain insulin resistance in Alzheimer’s disease patients is associated with IGF-1 resistance, IRS-1 dysregulation, and cognitive decline
- (2012) Konrad Talbot et al. JOURNAL OF CLINICAL INVESTIGATION
- Macrophage plasticity and polarization: in vivo veritas
- (2012) Antonio Sica et al. JOURNAL OF CLINICAL INVESTIGATION
- Intranasal deferoxamine reverses iron-induced memory deficits and inhibits amyloidogenic APP processing in a transgenic mouse model of Alzheimer's disease
- (2012) Chuang Guo et al. NEUROBIOLOGY OF AGING
- Lipocalin2 Promotes Invasion, Tumorigenicity and Gemcitabine Resistance in Pancreatic Ductal Adenocarcinoma
- (2012) Lisa Leung et al. PLoS One
- Microglia/Macrophage Polarization Dynamics Reveal Novel Mechanism of Injury Expansion After Focal Cerebral Ischemia
- (2012) Xiaoming Hu et al. STROKE
- Posterior Cortical Atrophy
- (2011) Po-Heng Tsai et al. American Journal of Alzheimers Disease and Other Dementias
- Outcomes of Mild Cognitive Impairment by Definition
- (2011) Mary Ganguli et al. ARCHIVES OF NEUROLOGY
- Distinguishing Alzheimer’s disease from other major forms of dementia
- (2011) Stella Karantzoulis et al. Expert Review of Neurotherapeutics
- Lipocalin-2 Induces Cardiomyocyte Apoptosis by Increasing Intracellular Iron Accumulation
- (2011) Guoxiong Xu et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Regulation by lipocalin-2 of neuronal cell death, migration, and morphology
- (2011) Shinrye Lee et al. JOURNAL OF NEUROSCIENCE RESEARCH
- Increased plasma levels of lipocalin 2 in mild cognitive impairment
- (2011) Jihye Choi et al. JOURNAL OF THE NEUROLOGICAL SCIENCES
- New lexicon and criteria for the diagnosis of Alzheimer's disease
- (2011) Giorgio Giaccone et al. LANCET NEUROLOGY
- Expression and localization of the iron–siderophore binding protein lipocalin 2 in the normal rat brain and after kainate-induced excitotoxicity
- (2011) Wan-Jie Chia et al. NEUROCHEMISTRY INTERNATIONAL
- Lipocalin-2 controls neuronal excitability and anxiety by regulating dendritic spine formation and maturation
- (2011) M. Mucha et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Vascular Contributions to Cognitive Impairment and Dementia
- (2011) Philip B. Gorelick et al. STROKE
- Iron in neuronal function and dysfunction
- (2010) Gabriela A. Salvador BIOFACTORS
- Mechanisms Underlying Inflammation in Neurodegeneration
- (2010) Christopher K. Glass et al. CELL
- Lipocalin-2 Deficiency Attenuates Insulin Resistance Associated With Aging and Obesity
- (2010) I. K.M. Law et al. DIABETES
- From kidney to cardiovascular diseases: NGAL as a biomarker beyond the confines of nephrology
- (2010) D. Bolignano et al. EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
- Cognitive impairment of vascular origin: Neuropathology of cognitive impairment of vascular origin
- (2010) Isidre Ferrer JOURNAL OF THE NEUROLOGICAL SCIENCES
- Cholesterol 24-Hydroxylase: An Enzyme of Cholesterol Turnover in the Brain
- (2009) David W. Russell et al. Annual Review of Biochemistry
- Absence of functional Hfe protects mice from invasive Salmonella enterica Serovar Typhimurium infection via induction of lipocalin-2
- (2009) M. Nairz et al. BLOOD
- Proteomic identification of HNE-bound proteins in early Alzheimer disease: Insights into the role of lipid peroxidation in the progression of AD
- (2009) Tanea T. Reed et al. BRAIN RESEARCH
- Ferroportin 1 but not hephaestin contributes to iron accumulation in a cell model of Parkinson's disease
- (2009) Ning Song et al. FREE RADICAL BIOLOGY AND MEDICINE
- CSF Biomarkers and Incipient Alzheimer Disease in Patients With Mild Cognitive Impairment
- (2009) Niklas Mattsson JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
- Lipocalin-2 Is an Autocrine Mediator of Reactive Astrocytosis
- (2009) S. Lee et al. JOURNAL OF NEUROSCIENCE
- Structure and function of the blood–brain barrier
- (2009) N. Joan Abbott et al. NEUROBIOLOGY OF DISEASE
- Retinol-Binding Protein 4 and Lipocalin-2 in Childhood and Adolescent Obesity: When Children Are Not Just "Small Adults"
- (2008) C. Kanaka-Gantenbein et al. CLINICAL CHEMISTRY
- Ex Vivo and In Vivo Regulation of Lipocalin-2, a Novel Adipokine, by Insulin
- (2008) B. K. Tan et al. DIABETES CARE
- Astrocytes play a key role in activation of microglia by persistent Borna disease virus infection
- (2008) Mikhail V Ovanesov et al. Journal of Neuroinflammation
- Two-Year Progression from Mild Cognitive Impairment to Dementia: To What Extent Do Different Definitions Agree?
- (2008) Fiona E. Matthews et al. JOURNAL OF THE AMERICAN GERIATRICS SOCIETY
- The Role of Lipocalin 2 in the Regulation of Inflammation in Adipocytes and Macrophages
- (2008) Jinhui Zhang et al. MOLECULAR ENDOCRINOLOGY
- Targeted Activation of Astrocytes: A Potential Neuroprotective Strategy
- (2008) Carole Escartin et al. MOLECULAR NEUROBIOLOGY
- Glucose neurotoxicity
- (2007) David R. Tomlinson et al. NATURE REVIEWS NEUROSCIENCE
- Prediction and longitudinal study of CSF biomarkers in mild cognitive impairment
- (2007) Miroslaw Brys et al. NEUROBIOLOGY OF AGING
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExploreDiscover Peeref hubs
Discuss science. Find collaborators. Network.
Join a conversation