Article
Medicine, General & Internal
Jie Guo, Abigail Dove, Jiao Wang, Erika J. Laukka, Ingrid Ekstrom, Michelle M. Dunk, David A. Bennett, Weili Xu
Summary: The pattern of olfactory identification change in the early phases of dementing disorders is unclear. This study assessed olfactory identification trajectories preceding incident mild cognitive impairment (MCI) and dementia and found that olfactory identification declined faster preceding dementia disorders, with Alzheimer's pathology potentially underlying these faster declines.
Article
Neurosciences
Jasmin E. Guevara, Natalie E. Kurniadi, Kevin Duff
Summary: This study quantifies cognitive change in patients with mild cognitive impairment (MCI) using standardized regression-based (SRB) z-scores. The findings show a significant decline in cognitive function over time, especially in learning and memory. Patients who progressed to dementia (MCI-Decline) showed more decline compared to those who remained stable (MCI-Stable). The study highlights the value of SRB in quantifying cognitive decline and identifying individuals at higher risk for MCI progression.
JOURNAL OF ALZHEIMERS DISEASE
(2023)
Review
Biochemistry & Molecular Biology
Kyoungjoo Cho
Summary: Cognitive impairment is a serious condition associated with aging and disruption of inflammation and innate immunity. Recent studies have shown that the innate immune system is prevalent in patients with Alzheimer's disease, and peripheral neutrophil markers can predict a decline in cognitive function in patients with mild cognitive impairment. Furthermore, altered levels of pro-inflammatory interleukins have been reported in patients with mild cognitive impairment, potentially playing a role in the progression from early cognitive impairment to dementia.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Neurosciences
Waleed Riaz, Zain Yar Khan, Ali Jawaid, Suleman Shahid
Summary: This study evaluated the usability of a long-term virtual reality-based environmental enrichment training program for older adults with MCI and mild dementia. The results showed that the VR training was well-tolerated, effective in stabilizing cognitive functioning, and potentially improving mental wellbeing.
Article
Geriatrics & Gerontology
Eva Y. L. Tan, Niels Janssen, Ron Handels, Inez H. G. B. Ramakers, Frans R. J. Verhey, Wiesje M. van der Flier, Rene J. F. Melis, Marcel G. M. Olde Rikkert, Jos M. G. A. Schols, Marjolein E. de Vugt
Summary: The objective of this study was to investigate the health-related quality of life (HRQol) of family caregivers of individuals with mild cognitive impairment (MCI), and to explore possible determinants and differences compared to caregivers of individuals with mild dementia. The study found no significant difference in HRQoL between family caregivers of individuals with MCI and mild dementia. However, caregiver characteristics, such as being a spouse and having a lower educational level, were associated with lower HRQoL.
AGING & MENTAL HEALTH
(2023)
Article
Clinical Neurology
Gowsaly Mahalingam, Suraj Samtani, Ben Chun Pan Lam, Darren M. Lipnicki, Maria Fernanda Lima-Costa, Sergio Luis Blay, Erico Castro-Costa, Shifu Xiao, Maelenn Guerchet, Pierre-Marie Preux, Antoine Gbessemehlan, Ingmar Skoog, Jenna Najar, Therese Rydberg Sterner, Nikolaos Scarmeas, Mary Yannakoulia, Themis Dardiotis, Ki-Woong Kim, Steffi Riedel-Heller, Susanne Roehr, Alexander Pabst, Suzana Shahar, Katya Numbers, Mary F. Ganguli, Tiffany Hughes, Chung-Chou H. Chang, Michael Crowe, Tze Pin Ng, Xinyi Gwee, Denise Qian Ling Chua, Joanna Rymaszewska, Karin Wolf-Ostermann, Anna-Karin Welmer, Jean Stafford, Rene Melis, Myrra Vernooij-Dassen, Yun-Hee Jeon, Perminder S. Sachdev, Henry Brodaty
Summary: Based on individual participant data from 13 longitudinal ageing studies, the study found that social connections are associated with lower risks of mild cognitive impairment, dementia, and mortality. Specifically, good social connection structure and quality are linked to lower risk of incident mild cognitive impairment, while social connection structure and function are related to lower risk of incident dementia and mortality. In Asian cohorts, being married/in a relationship is associated with reduced risk of dementia, and having a confidante is associated with reduced risk of dementia and mortality.
ALZHEIMERS & DEMENTIA
(2023)
Article
Geriatrics & Gerontology
Antonio Muscari, Fabio Clavarino, Vincenzo Allegri, Andrea Farolfi, Maria Macchiarulo, Lorenzo Maestri, Elisa Sessagesimi, Luca Spinardi, Maria Lia Lunardelli
Summary: This study proposed a two-step procedure to assess the risk of CAD in MCI patients, initially evaluating MMSE, MoCA, and MTA before deciding whether to perform FDG-PET. The results showed that patients with 2-3 points in the first step had a higher risk of CAD, and in the second step, FDG-PET had significant diagnostic value in identifying high-risk patients.
ARCHIVES OF GERONTOLOGY AND GERIATRICS
(2021)
Review
Medicine, General & Internal
Ingrid Arevalo-Rodriguez, Nadja Smailagic, Marta Roque-Figuls, Agustin Ciapponi, Erick Sanchez-Perez, Antri Giannakou, Olga L. Pedraza, Xavier Bonfill Cosp, Sarah Cullum
Summary: The review included studies focusing on the conversion from MCI to all-cause dementia, Alzheimer's disease dementia, and vascular dementia. Baseline MMSE scores had a range of accuracy in predicting dementia, but alone cannot determine the direction of progression for MCI patients.
COCHRANE DATABASE OF SYSTEMATIC REVIEWS
(2021)
Review
Clinical Neurology
Shellie-Anne Levy, Glenn Smith, Liselotte De Wit, Brittany DeFeis, Gelan Ying, Priscilla Amofa, Dona Locke, Anne Shandera-Ochsner, Courtney McAlister, Vaishali Phatak, Melanie Chandler
Summary: The comparative effectiveness of behavioral interventions for mitigating cognitive decline is not well understood. This study summarizes the findings from the HABIT (R) program, which includes various interventions for individuals with mild cognitive impairment (pwMCI) and their partners. The results suggest that knowledge-based interventions like wellness education benefit patient well-being, while skill-based interventions like yoga and memory compensation training aid in maintaining functional status. Future personalized interventions may involve different combinations of behavioral strategies to optimize patient outcomes prioritized by their values and preferences.
Article
Psychology, Clinical
Michael H. Connors, Armando Teixeira-Pinto, David Ames, Michael Woodward, Henry Brodaty
Summary: Apathy is a common symptom in patients with mild cognitive impairment (MCI) and may indicate progression to dementia. However, there is limited research on the longitudinal trajectory of apathy in MCI patients and its clinical correlates when controlled for depression, which can mimic apathy. This study aimed to address these issues.
INTERNATIONAL PSYCHOGERIATRICS
(2023)
Article
Clinical Neurology
Alan J. Thomas, Calum A. Hamilton, Amanda Heslegrave, Sally Barker, Rory Durcan, Sarah Lawley, Nicola Barnett, Debbie Lett, Michael Firbank, Gemma Roberts, John-Paul Taylor, Paul C. Donaghy, Henrik Zetterberg, John O'Brien
Summary: The study found that plasma pTau181 can serve as a blood-based biomarker for AD co-pathology and is associated with cognitive decline in patients with dementia with Lewy bodies and MCI with AD. pTau181 partially discriminated probable MCI-LB from controls and MCI-AD from controls, but was not useful in distinguishing probable MCI-LB from MCI-AD.
MOVEMENT DISORDERS
(2022)
Article
Clinical Neurology
Szu-Ying Lin, Po-Chen Lin, Yi-Cheng Lin, Yi-Jung Lee, Chen-Yu Wang, Shih-Wei Peng, Pei-Ning Wang
Summary: This study compared the prognosis and clinical course between early MCI (EMCI) and late MCI (LMCI). The results showed that during the follow-up period, more EMCI patients showed a reversion to normal cognitive status, while LMCI patients still had a risk of cognitive decline. The conversion rates to dementia were higher in the EMCI and LMCI groups compared to normal subjects, with LMCI patients showing a faster decline in cognitive function.
FRONTIERS IN NEUROLOGY
(2022)
Review
Clinical Neurology
Lei Zhuang, Yan Yang, Jianqun Gao
Summary: Mild cognitive impairment (MCI) is a clinical condition with a high risk of progressing to dementia. Early diagnosis and intervention at the MCI stage are considered critical strategies in disease management. Lack of consensus on guidelines for routine screening of MCI leads to a considerable number of undiagnosed patients in the community.
JOURNAL OF NEUROLOGY
(2021)
Article
Neurosciences
Eric Cao, Da Ma, Siddharth Nayak, Tim Q. Duong
Summary: This study presents a novel deep learning approach to predict the conversion from mild cognitive impairment (MCI) to Alzheimer's dementia (AD) using whole-brain FDG-PET and cognitive scores (CS). The results show that a combination of FDG-PET, age, and neurocognitive data yields the best model for predicting MCI conversion to AD.
NEUROBIOLOGY OF DISEASE
(2023)
Article
Medicine, General & Internal
Angie A. Diaz Baquero, Maria Perea Bartolome, Jose Miguel Toribio-Guzman, Fernando Martinez-Abad, Esther Parra Vidales, Yolanda Bueno Aguado, Henriette G. van der Roest, Manuel A. Franco-Martin
Summary: This study aimed to identify the determinants that predicted adherence to a computerized cognitive training program in people with mild cognitive impairment and mild dementia. The results showed that good executive functioning, attention, working memory, and language abilities predicted higher adherence.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Geriatrics & Gerontology
Serena Sabatini, Anthony Martyr, Laura D. Gamble, Ian R. Jones, Rachel Collins, Fiona E. Matthews, Christina R. Victor, Catherine Quinn, Claire Pentecost, Jeanette M. Thom, Linda Clare
Summary: This study explored the social, cultural, and economic capital of spousal carers of people with dementia, and the profiles of carers with different levels of capital. The results showed that carers with lower capital experienced less stress and reported more positive experiences in caring over time. However, compared to carers with better capital, those with poorer capital were more likely to be depressed over time.
AGING & MENTAL HEALTH
(2023)
Article
Geriatrics & Gerontology
Rotem Perach, Sanna Read, Ben Hicks, Peter R. Harris, Jennifer Rusted, Carol Brayne, Margaret Dangoor, Eleanor Miles, Josie Dixon, Louise Robinson, Alan Thomas, Sube Banerjee
Summary: This study aims to identify factors that predict loneliness for individuals with dementia and their caregivers during the COVID-19 pandemic. The study found that caregiver's loneliness was directly associated with caregiver type, anxiety levels, formal day activities, and cognitive impairment. For individuals with dementia, caregiver type, initial levels of social resources, wellbeing, and cognitive impairment predicted changes in loneliness through indirect effects on social contacts.
AGING & MENTAL HEALTH
(2023)
Article
Geriatrics & Gerontology
Connor D. Richardson, Hannah Roscoe, Emma Green, Racheal Brooks, Linda Barnes, Fiona E. Matthews, Carol Brayne
Summary: The prevalence of loneliness among older people has increased during the COVID-19 pandemic compared to before. Factors associated with prevalent loneliness include prior loneliness, living alone, being female, living in a deprived area, separation from family during the pandemic, and frequent pre-pandemic social contact at community groups. Weekly technology-mediated contact using telephone or video calls is associated with lower odds of loneliness.
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY
(2023)
Article
Multidisciplinary Sciences
Deborah L. O. King, Richard Henson, Rogier Kievit, Noham Wolpe, Carol Brayne, Lorraine K. Tyler, James B. A. Rowe, Kamen A. Tsvetanov, Cam-CAN
Summary: Cardiovascular ageing is associated with cognitive impairment, but the specific contributions of different cardiovascular factors to cognitive function are not clear.
SCIENTIFIC REPORTS
(2023)
Article
Public, Environmental & Occupational Health
Serena Sabatini, Anthony Martyr, Laura D. Gamble, Ian R. Jones, Rachel Collins, Fiona E. Matthews, Martin Knapp, Jeanette M. Thom, Catherine Henderson, Christina Victor, Claire Pentecost, Linda Clare, IDEAL Programme Team
Summary: This study describes the levels of social, cultural, and economic capital among people with dementia and examines the differences in personal characteristics and quality of life over time based on different combinations of capital. The results show that people with dementia have relatively lower levels of social, cultural, and economic capital, although they are not significantly lower compared to older adults in the UK. The study identifies four groups of people with dementia based on their capital levels and finds that higher levels of capital are associated with higher quality of life and well-being. Therefore, efforts from the government and society are needed to address the social, cultural, and economic disadvantages among people with dementia.
SOCIAL SCIENCE & MEDICINE
(2023)
Article
Geriatrics & Gerontology
Asri Maharani, David R. Sinclair, Tarani Chandola, Peter Bower, Andrew Clegg, Barbara Hanratty, James Nazroo, Neil Pendleton, Gindo Tampubolon, Chris Todd, Raphael Wittenberg, Terence W. O'Neill, Fiona E. Matthews
Summary: This study investigated the relationship between household wealth and neighborhood deprivation with frailty status, and found that individuals with lower wealth and living in deprived neighborhoods are at a higher risk of frailty.
Article
Clinical Neurology
Sebastian Walsh, Ishtar Govia, Ruth Peters, Edo Richard, Blossom C. M. Stephan, Nikki-Anne Wilson, Lindsay Wallace, Kaarin J. Anstey, Carol Brayne
Summary: Dementia is a global public health challenge, and individual-level prevention strategies have limited potential. A population-level approach is needed to reduce the incidence of dementia and address global inequalities in risk. This approach can be highly cost-effective.
ALZHEIMERS & DEMENTIA
(2023)
Letter
Clinical Neurology
Sebastian Walsh, Carol Brayne
ALZHEIMERS & DEMENTIA
(2023)
Editorial Material
Clinical Neurology
Gladys Maestre, Maria Carrillo, Raj Kalaria, Daisy Acosta, Larry Adams, Thierry Adoukonou, Kazeem Akinwande, Joshua Akinyemi, Rufus Akinyemi, Onoja Akpa, Suvarna Alladi, Ricardo Allegri, Raul Arizaga, Faheem Arshad, Oyedunni Arulogun, David Ndetei, Olusegun Baiyewu, Thomas Issac, Tarek Bellaj, Judith Boshe, Carol Brayne, David Brodie-Mends, Richard Brown, Jennifer Cahn, Nkouonlack Cyrille, Albertino Damasceno, Ranil de Silva, Rohan de Silva, Mamuka Djibuti, Anna Jane Dreyer, Ratnavalli Ellajosyula, Temitope Farombi, Bernard Fongang, Stefania Forner, Rob Friedland, Noe Garza, Antoine Gbessemehlan, Eliza (Eleni-Zacharoula) Georgiou, Riadh Gouider, Ishtar Govia, Lea Grinberg, Maelenn Guerchet, Seid Gugssa, Joy Louise Gumikiriza-Onoria, Deborah Gustafson, Eef Hogervorst, Michael Hornberger, Agustin Ibanez, Masafumi Ihara, Ozama Ismail, Thomas Issac, Linus Joensson, Celestin Kaputu, Wambui Karanja, Jackline Karungi, Desire Tshala-Katumbay, Brian Kunkle, Joseph H. Lee, Iracema Leroi, Raphaella Lewis, Gill Livingston, Francisco Lopera, Kamada Lwere, Facundo Manes, Lingani Mbakile-Mahlanza, Pedro Mena, Bruce Miller, Athanase Millogo, Abdul Mohamed, Christine Musyimi, Victoria Mutiso, Noeline Nakasujja, David Ndetei, Sam Nightingale, Alfred K. Njamnshi, Gabriela Novotni, Primrose Nyamayaro, Solomon Nyame, Julius Ogeng'o, Adesola Ogunniyi, Maira Okada De Oliveira, Njideka Okubadejo, Martin Orrell, Akintunde Orunmuyi, Mayowa Owolabi, Stella Paddick, Margaret A. Pericak-Vance, Zvezdan Pirtosek, Felix Potocnik, Bill Preston, Rema Raman, Kirti Ranchod, Mie Rizig, Monica Rosselli, Roy Deepa, Upal Roy, Marufjon Salokhiddinov, Mary Sano, Fred Sarfo, Claudia L. Satizabal, Diego Sepulveda-Falla, Sudha Seshadri, Claire Sexton, Ingmar Skoog, Peter St George-Hyslop, Claudia Suemoto, Jeremy Tanner, Prekshya Thapa, Kamadore Toure, Valentine Ucheagwu, Chinedu Udeh-Momoh, Victor Valcour, Jeffery Vance, Mathew Varghese, Jaime Vera, Richard Walker, Wendy Weidner, Walsh Sebastian, Patrice Whitehead Gay, Henrik Zetterberg, Yared Zewde
ALZHEIMERS & DEMENTIA
(2023)
Article
Clinical Neurology
Alex Tsui, Natalie Yeo, Samuel D. Searle, Helen Bowden, Katrin Hoffmann, Joanne Hornby, Arley Goslett, Maryse Weston-Clarke, David Lanham, Patrick Hogan, Anna Seeley, Mark Rawle, Nish Chaturvedi, Elizabeth L. Sampson, Kenneth Rockwood, Colm Cunningham, E. Wesley Ely, Sarah J. Richardson, Carol Brayne, Graciela Muniz Terrera, Zoe Tieges, Alasdair M. J. MacLullich, Daniel Davis
Summary: This study examines the relationship between cognitive function and the severity of delirium in older adults. The authors find a U-shaped relationship, indicating that both lower and higher cognitive function are associated with more severe delirium symptoms. This highlights the importance of cognitive function in the prevention and treatment of delirium.
Article
Public, Environmental & Occupational Health
Michelle C. Odden, Adina Zhang, Neal Jawadekar, Annabel Tan, Andrew E. Moran, M. Maria Glymour, Carol Brayne, Adina Zeki Al Hazzouri, Sebastian Calonico
Summary: Regression discontinuity design (RDD) is a quasi-experimental method used for causal inference. This study aims to estimate the effect of statins on myocardial infarction (MI) using RDD and compare it with other methods. The findings suggest that RDD is superior in replicating the protective effect of statins with MI, although precision is poor.
EUROPEAN JOURNAL OF EPIDEMIOLOGY
(2023)
Article
Clinical Neurology
Zhirong Yang, Chang Wei, Xiaojuan Li, Jinqiu Yuan, Xuefeng Gao, Bingyu Li, Ziyi Zhao, Sengwee Toh, Xin Yu, Carol Brayne, Zuyao Yang, Feng Sha, Jinling Tang
Summary: This study found that the regular use of laxatives is associated with a higher risk of all-cause dementia, especially in individuals who use multiple types of laxatives or osmotic laxatives.
Article
Clinical Neurology
Mohammed D. Rajab, Emmanuel Jammeh, Teruka Taketa, Carol Brayne, Fiona E. Matthews, Li Su, Paul G. Ince, Stephen B. Wharton, Dennis Wang
Summary: This study applies machine learning approaches to identify critical features of Alzheimer-related pathologies associated with dementia. Results show that Braak neurofibrillary tangle stage, beta-amyloid, and cerebral amyloid angiopathy are the most important features for dementia classification. The best-performing dementia classifier achieved 79% sensitivity, 69% specificity, and 75% precision using the top eight neuropathological features.
ALZHEIMERS RESEARCH & THERAPY
(2023)
Article
Clinical Neurology
Anthony Martyr, Madhumathi Ravi, Laura D. Gamble, Robin G. Morris, Jennifer M. Rusted, Claire Pentecost, Fiona E. Matthews, Linda Clare, DEAL study team
Summary: This study compared the trajectories of cognition and instrumental activities of daily living (iADL) in people with dementia. The results showed that cognition and self-rated iADL declined at a similar rate, while informant-rated iADL declined at a significantly higher rate than cognition. This suggests that either cognition and self-rated iADL decline at different rates or informants overestimate iADL difficulties compared to both cognition and self-ratings.
ALZHEIMERS & DEMENTIA
(2023)
Article
Geriatrics & Gerontology
Emma Nichols, Richard Merrick, Simon Hay, Dibya Himali, Jayandra J. Himali, Sally Hunter, Hannah A. D. Keage, Caitlin S. Latimer, Matthew R. Scott, Jaimie Steinmetz, Jamie M. Walker, Stephen B. Wharton, Crystal Wiedner, Paul K. Crane, Dirk Keene, Lenore J. Launer, Fiona E. Matthews, Julie Schneider, Sudha Seshadri, Lon White, Carol Brayne, Theo Vos
Summary: This study aimed to harmonise neuropathology measures across multiple community-based autopsy cohorts and assess the prevalence, correlation, and co-occurrence of neuropathologies in the ageing population. The results showed that the co-occurrence of neuropathologies in older adults was strongly associated with dementia status, highlighting the complexity of underlying brain pathologies. Rating: 9 out of 10.
LANCET HEALTHY LONGEVITY
(2023)
