Review
Biochemistry & Molecular Biology
Anita Woo, Amy Botta, Sammy S. W. Shi, Tomas Paus, Zdenka Pausova
Summary: Obesity is a major risk factor for Alzheimer's disease and related dementias. The link between obesity and the neurodegenerative processes of dementias is not fully understood, but recent research suggests that obesity-related inflammation may contribute to neuroinflammation. This review highlights the need to bridge the gap between animal microscopy and human MR imaging studies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Marina Ulanova, Lucy Gloag, Andre Bongers, Chul-Kyu Kim, Hong Thien Kim Duong, Ha Na Kim, John Justin Gooding, Richard D. Tilley, Joanna Biazik, Wei Wen, Perminder S. Sachdev, Nady Braidy, Alexander E. Kalyuzhny
Summary: Nanoparticle-based magnetic contrast agents have been developed for early non-invasive diagnosis of Alzheimer's disease (AD) using magnetic resonance imaging (MRI). This study developed a biocompatible magnetic nanoparticle targeted to amyloid beta (A beta) plaques to enhance the sensitivity of T2-weighted MRI for imaging of amyloid pathology in AD. The nanoparticles showed no significant cytotoxicity and were able to bind to amyloid species. The study provides promising preliminary results for the development of a targeted non-invasive method for early AD diagnosis using contrast-enhanced MRI.
Article
Medicine, General & Internal
Seung-Hyun Lim, Jiyoon Lee, Sumin Jung, Bokyung Kim, Hak Young Rhee, Se-Hong Oh, Soonchan Park, Ah Rang Cho, Chang-Woo Ryu, Geon-Ho Jahng
Summary: The purpose of this study was to investigate myelin loss in both AD and MCI patients using a new myelin water mapping technique. The study found that the AD group showed reduced myelin water compared to the CN and MCI groups, and the myelin water fraction in the corpus callosum can be used for group classification.
Review
Biochemistry & Molecular Biology
Petra Hnilicova, Ema Kantorova, Stanislav Sutovsky, Milan Grofik, Kamil Zelenak, Egon Kurca, Norbert Zilka, Petra Parvanovova, Martin Kolisek
Summary: Alzheimer's disease (AD) is an incurable neurodegenerative disease characterized by perturbed cerebral perfusion and metabolism, induced proinflammatory processes, and the aggregation of amyloid beta and hyperphosphorylated Tau proteins. Various imaging methods can detect subclinical AD changes, and new insights suggest a link between brain insulin resistance and AD pathogenesis. This article discusses the use of non-neuronal imaging modalities to assess AD-related structural changes in the liver and pancreas, which may be clinically important during the prodromal phase of the disease.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Neurosciences
Peiyu Huang, Minming Zhang
Summary: Neurodegenerative diseases pose a significant threat to an aging human society, and magnetic resonance imaging (MRI) is a non-invasive tool frequently used in studying these diseases.
NEUROSCIENCE BULLETIN
(2023)
Review
Biochemistry & Molecular Biology
Ruiqing Ni
Summary: Amyloid-beta (A beta) is crucial in the pathogenesis of Alzheimer's disease, with aberrant accumulation leading to neuroinflammation, cerebrovascular alterations, and cognitive impairments. High-field MRI technology has enabled non-invasive visualization of A beta-related alterations in animal models, offering translational value for clinical MRI applications.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biotechnology & Applied Microbiology
Yuting Ruan, Ying Xiong, Wenli Fang, Qun Yu, Yingren Mai, Zhiyu Cao, Kexi Wang, Ming Lei, Jiaxin Xu, Yan Liu, Xingcai Zhang, Wang Liao, Jun Liu
Summary: This study developed a nanotheranostics platform and demonstrated its effectiveness in reducing beta-amyloid plaque burden and improving memory deficits in APP/PS1 transgenic mice. The nanomaterial allowed noninvasive detection by magnetic resonance imaging and quantification of plaque volumes based on three-dimensional analysis.
JOURNAL OF NANOBIOTECHNOLOGY
(2022)
Article
Neurosciences
Luca Sacchi, Valeria Elisa Contarino, Silvia Siggillino, Tiziana Carandini, Giorgio Giulio Fumagalli, Anna Margherita Pietroboni, Marina Arcaro, Chiara Fenoglio, Eva Orunesu, Massimo Castellani, Silvia Casale, Giorgio Conte, Chunlei Liu, Fabio Triulzi, Daniela Galimberti, Elio Scarpini, Andrea Arighi
Summary: Increased QSM values in the left BANKSSTS may serve as an auxiliary imaging biomarker for AD diagnosis, as they are significantly associated with AD biomarkers. These findings suggest that QSM values in the left BANKSSTS have good accuracy in discriminating AD.
JOURNAL OF ALZHEIMERS DISEASE
(2023)
Article
Psychiatry
Sheng-Min Wang, Nak-Young Kim, Dong Woo Kang, Yoo Hyun Um, Hae-Ran Na, Young Sup Woo, Chang Uk Lee, Won-Myong Bahk, Hyun Kook Lim
Summary: The study found that rs-fMRI may reflect the impact of beta-amyloid pathology on brain activity in the early stages of AD, with functional connectivity maps showing the best classification performance.
FRONTIERS IN PSYCHIATRY
(2021)
Article
Clinical Neurology
Kevin A. Gonzalez, Wassim Tarraf, Ariana M. Stickel, Sonya Kaur, Christian Agudelo, Susan Redline, Linda C. Gallo, Carmen R. Isasi, Jianwen Cai, Martha L. Daviglus, Fernando D. Testai, Charles Decarli, Hector M. Gonzalez, Alberto R. Ramos
Summary: This study examined the association between sleep pattern and brain disease outcomes in diverse Hispanics/Latinos. The results showed that longer sleep duration was associated with smaller total brain and gray matter volume, highlighting the importance of sleep on brain aging in this population.
ALZHEIMERS & DEMENTIA
(2023)
Article
Nanoscience & Nanotechnology
Yongjie Xiong, Yi Qu, Zhe Min, Jun Wu, Suming Zhang, Zheng Xue
Summary: This study developed a novel MRI contrast agent by coupling ultrasmall superparamagnetic iron oxide nanoparticles with a functional protein. The contrast agent successfully penetrated biological membranes and bound to Aβ deposits, allowing for the visualization of Aβ deposits in Alzheimer's disease animal models by MRI.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2022)
Review
Clinical Neurology
Alessandro Galgani, Francesco Lombardo, Daniele Della Latta, Nicola Martini, Ubaldo Bonuccelli, Francesco Fornai, Filippo Sean Giorgi
Summary: LC-MRI studies have shown that LC signal is minimally affected during normal aging, but significantly reduced in patients with neurodegenerative diseases, making it a potential early biomarker.
CURRENT NEUROLOGY AND NEUROSCIENCE REPORTS
(2021)
Article
Pharmacology & Pharmacy
Ander Egimendia, Susana Carregal-Romero, Inaki Osorio-Querejeta, Daniel Padro, Jesus Ruiz-Cabello, David Otaegui, Pedro Ramos-Cabrer
Summary: Ex vivo models using multimodal imaging and myelin-targeting liposomes show potential for quantifying myelin content in organotypic cultures. MRI can successfully image brain tissue sections with good contrast, while myelin-targeting liposomes allow for semiquantitative detection by fluorescence. Fine tuning of the probe is necessary to improve specificity when using lipid-based systems.
Article
Chemistry, Multidisciplinary
Soyeon Kim, Hee-Kyung Kim, Ah Rum Baek, Bokyung Sung, Byeong Woo Yang, Yeoun-Hee Kim, Jung-jin Lee, Ji-ung Yang, Chang-Hoon Shin, Hoesu Jung, Minsup Kim, Art E. Cho, Taekwan Lee, Yongmin Chang
Summary: The study developed a new multimodal gadolinium contrast agent targeting VGLUTs as a potential new diagnostic tool for AD. The Gd-DO3A-RB showed high affinity to VGLUT1 and demonstrated imaging capabilities in the AD animal model, suggesting its potential for clinical use in diagnosing AD.
JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY
(2021)
Article
Neurosciences
Agnes Perez-Millan, Jose Contador, Jordi Junca-Parella, Beatriz Bosch, Laia Borrell, Adria Tort-Merino, Neus Falgas, Sergi Borrego-Ecija, Nuria Bargallo, Lorena Rami, Mircea Balasa, Albert Llado, Raquel Sanchez-Valle, Roser Sala-Llonch
Summary: Alzheimer's disease (AD) and frontotemporal dementia (FTD) are common causes of dementia with overlapping symptoms and brain signatures. This study used brain magnetic resonance imaging (MRI) and machine learning to accurately diagnose and classify AD and FTD. The algorithm achieved good accuracy in cross-sectional and longitudinal data.
HUMAN BRAIN MAPPING
(2023)
Article
Transplantation
Roel Bijkerk, Marije H. Kallenberg, Laurien E. Zijlstra, Bernard M. van den Berg, Jeroen de Bresser, Sebastiaan Hammer, Esther E. Bron, Hakim Achterberg, Mark A. van Buchem, Noeleen C. Berkhout-Byrne, Willem Jan W. Bos, Diana van Heemst, Ton J. Rabelink, Anton Jan van Zonneveld, Marjolijn van Buren, Simon Mooijaart
Summary: This study focused on the association between levels of angiopoietin and cognitive impairment in ESRD patients, revealing an unfavorable angiogenic profile in these patients and identifying certain miRNAs associated with different cognitive domains. These novel angiogenic markers may help to identify cognitive decline in older ESRD patients.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2022)
Article
Clinical Neurology
S. Voigt, P. C. de Kruijff, E. A. Koemans, I Rasing, E. S. van Etten, G. M. Terwindt, M. J. P. van Osch, M. A. van Buchem, M. A. A. van Walderveen, M. J. H. Wermer
Summary: Superficially located asymptomatic cerebellar macrobleeds and microbleeds are common in Dutch-type hereditary CAA. Cerebellar microbleeds are already present in the presymptomatic stage and are predominantly superficially located. Despite the high frequency of cerebellar micro and macrobleeds, CAA pathology did not result in symptomatic cerebellar ICH in patients with D-CAA.
INTERNATIONAL JOURNAL OF STROKE
(2022)
Letter
Clinical Neurology
Steven M. Greenberg, Charlotte Cordonnier, Julie A. Schneider, Eric E. Smith, Mark A. Van Buchem, Susanne J. Van Veluw, Marcel M. Verbeek, Anand Viswanathan, David J. Werring
Article
Clinical Neurology
Emma A. Koemans, Sabine Voigt, Ingeborg Rasing, Thijs W. van Harten, Wilmar M. T. Jolink, Floris H. B. M. Schreuder, Erik W. van Zwet, Mark A. van Buchem, Matthias J. P. van Osch, Gisela M. Terwindt, Catharina J. M. Klijn, Marianne A. A. van Walderveen, Marieke J. H. Wermer
Summary: This study investigated the frequency of cerebellar superficial siderosis and its relation to hemorrhagic magnetic resonance imaging markers in patients with cerebral amyloid angiopathy (CAA). The study found that cerebellar superficial siderosis may be a novel marker for CAA.
Article
Clinical Neurology
Sabine Voigt, Siham Amlal, Emma A. Koemans, Ingeborg Rasing, Ellis S. van Etten, Erik W. van Zwet, Mark A. van Buchem, Gisela M. Terwindt, Marianne A. A. van Walderveen, Marieke J. H. Wermer
Summary: The study investigated the topographical and temporal patterns of index and recurrent intracerebral hemorrhages in Dutch-type hereditary Cerebral Amyloid Angiopathy (D-CAA). Results showed a preference for occipital lobe in both index and recurrent ICHs, with no acceleration in time nor gradual increase of hematoma volume between subsequent ICHs.
INTERNATIONAL JOURNAL OF STROKE
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Lucia Bossoni, Ingrid Hegeman-Kleinn, Sjoerd G. van Duinen, Marjolein Bulk, Lena H. P. Vroegindeweij, Janneke G. Langendonk, Lydiane Hirschler, Andrew Webb, Louise Van der Weerd
Summary: The off-resonance saturation method was effective in detecting iron in gray matter structures in postmortem brain tissue, with iron concentrations obtained via this method shown to be in agreement with existing literature. This method can be used to study diseases characterized by brain iron accumulation and complement other iron-sensitive parametric methods.
MAGNETIC RESONANCE IN MEDICINE
(2022)
Article
Rheumatology
Francesca Inglese, Myriam G. Jaarsma-Coes, Gerda M. Steup-Beekman, Rory Monahan, Tom Huizinga, Mark A. van Buchem, Itamar Ronen, Jeroen de Bresser
Summary: Patients with neuropsychiatric manifestations of systemic lupus erythematosus (NPSLE) showed higher white matter hyperintensity (WMH) volume and more complex WMH shape compared to non-NPSLE patients, with the inflammatory phenotype exhibiting more significant findings.
Article
Clinical Neurology
Sigurdur Sigurdsson, Thor Aspelund, Olafur Kjartansson, Elias Gudmundsson, Palmi Jonsson, Mark A. van Buchem, Vilmundur Gudnason, Lenore J. Launer
Summary: This study found that the risk factors for different types of brain infarcts vary depending on the location in the brain. Small vessel disease risk factors such as hypertension and diabetes were associated with subcortical infarcts, while atherosclerotic/coronary processes were associated with cortical infarcts, and a mixed profile of factors was associated with cerebellar infarcts. Assessing risk factors based on the location of asymptomatic infarcts detected on magnetic resonance imaging may help improve preventive therapeutic approaches for stroke.
Article
Neurosciences
Francesca Inglese, Minseon Kim, Gerda M. Steup-Beekman, Tom W. J. Huizinga, Mark A. van Buchem, Jeroen de Bresser, Dae-Shik Kim, Itamar Ronen
Summary: Self-supervised contrastive learning algorithms can be used to distinguish between NPSLE and non-NPSLE patients in SLE. This study found that common brain changes in NPSLE patients include tissue loss, local atrophy, and periventricular white matter lesions.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Clinical Neurology
Suzanne E. van Dijk, Jeroen van der Grond, Jessie Lak, Annette van den Berg-Huysmans, Gerda Labadie, Gisela M. Terwindt, Marieke J. H. Wermer, M. Edip Gurol, Mark A. van Buchem, Steven M. Greenberg, Sanneke van Rooden
Summary: This study found that cerebrovascular reactivity worsens progressively in the presymptomatic phase of Dutch-type hereditary cerebral amyloid angiopathy (D-CAA). Recurrent intracerebral hemorrhage appears to be the most salient marker of progression in the symptomatic phase of the disease.
Article
Clinical Neurology
Andreas Charidimou, Gregoire Boulouis, Matthew P. Frosch, Jean-Claude Baron, Marco Pasi, Jean Francois Albucher, Gargi Banerjee, Carmen Barbato, Fabrice Bonneville, Sebastian Brandner, Lionel Calviere, Francois Caparros, Barbara Casolla, Charlotte Cordonnier, Marie-Bernadette Delisle, Vincent Deramecourt, Martin Dichgans, Elif Gokcal, Jochen Herms, Mar Hernandez-Guillamon, Hans Rolf Jager, Zane Jaunmuktane, Jennifer Linn, Sergi Martinez-Ramirez, Elena Martinez-Saez, Christian Mawrin, Joan Montaner, Solene Moulin, Jean-Marc Olivot, Fabrizio Piazza, Laurent Puy, Nicolas Raposo, Mark A. Rodrigues, Sigrun Roeber, Jose Rafael Romero, Neshika Samarasekera, Julie A. Schneider, Stefanie Schreiber, Frank Schreiber, Corentin Schwall, Colin Smith, Levente Szalardy, Pascale Varlet, Alain Viguier, Joanna M. Wardlaw, Andrew Warren, Frank A. Wollenweber, Marialuisa Zedde, Mark A. van Buchem, M. Edip Gurol, Anand Viswanathan, Rustam Al-Shahi Salman, Eric E. Smith, David J. Werring, Steven M. Greenberg
Summary: This study aimed to update and validate the Boston criteria for the diagnosis of cerebral amyloid angiopathy (CAA). The results showed that the Boston criteria version 2.0 had superior accuracy in terms of sensitivity and specificity, and incorporated new MRI markers.
Article
Neurosciences
Thijs W. van Harten, Anne Heijmans, Sanneke van Rooden, Marieke J. H. Wermer, Matthias J. P. van Osch, Hugo J. Kuijf, Susanne J. van Veluw, Steven M. Greenberg, Mark A. van Buchem, Jeroen van der Grond, Marianne A. A. van Walderveen
Summary: This study found no differences in DMV parameters between Dutch-type hereditary CAA mutation carriers and controls, and no associations between DMV parameters and MRI markers associated with D-CAA. Therefore, DMVs may not play a role in the pathogenesis of MRI markers associated with CAA.
JOURNAL OF ALZHEIMERS DISEASE
(2022)
Article
Clinical Neurology
Jasmin Annica Keller, Sigurdur Sigurdsson, Kelly Klaassen, Lydiane Hirschler, Mark A. A. van Buchem, Lenore J. J. Launer, Matthias J. P. van Osch, Vilmundur Gudnason, Jeroen H. J. M. de Bresser
Summary: This study aimed to investigate the association between the shape and volume of white matter hyperintensity (WMH) and the long-term risk of dementia in community-dwelling older adults. The results showed that an irregular shape of periventricular/confluent WMH, higher WMH volume, and higher deep WMH volume were associated with an increased risk of dementia.
ALZHEIMERS & DEMENTIA
(2023)
Article
Neuroimaging
Jasmin A. Keller, Ilse M. J. Kant, Arjen J. C. Slooter, Simone J. T. van Montfort, Mark A. van Buchem, Matthias J. P. van Osch, Jeroen Hendrikse, Jeroen de Bresser
Summary: This study investigated the association between cardiovascular risk factors and WMH markers in non-demented older adults. The results showed that hypertension was associated with irregular WMH shape, while diabetes was associated with WMH volume. Different cardiovascular risk factors may lead to different WMH MRI phenotypes.
NEUROIMAGE-CLINICAL
(2022)
Meeting Abstract
Clinical Neurology
R. Van Dort, I. Rasing, E. Koemans, S. Voigt, K. Kaushik, R. Van der Zwet, M. Schipper, T. Van Harten, E. Van Etten, M. Verbeek, M. Van Buchem, S. Van Rooden, J. Van der Grond, E. Van Zwet, M. Van Walderveen, M. Van Osch, G. Terwindt, M. Wermer
INTERNATIONAL JOURNAL OF STROKE
(2022)