Article
Biochemistry & Molecular Biology
Hyeong Seok An, Jung-Wan Yoo, Jong Hwan Jeong, Manbong Heo, Si Hwan Hwang, Hye Min Jang, Eun Ae Jeong, Jaewoong Lee, Hyun Joo Shin, Kyung Eun Kim, Meong Cheol Shin, Gu Seob Roh
Summary: Lipocalin-2 (LCN2) is an acute-phase protein that regulates inflammatory responses to bacteria or lipopolysaccharide (LPS). This study found that LCN2 plays a key role in inflammation and oxidative stress following acute lung injury and may be a potential therapeutic target for pneumonia or acute lung injury.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Eun Bee Choi, Jae Hun Jeong, Hye Min Jang, Yu Jeong Ahn, Kyu Hyeon Kim, Hyeong Seok An, Jong Youl Lee, Eun Ae Jeong, Jaewoong Lee, Hyun Joo Shin, Kyung Eun Kim, Gu Seob Roh
Summary: The study revealed that elevated levels of LCN2 in skeletal muscle of obese individuals are associated with inflammation and oxidative stress related to muscle atrophy.
Article
Biochemistry & Molecular Biology
Heeyoung Kang, Hyun Joo Shin, Hyeong Seok An, Zhen Jin, Jong Youl Lee, Jaewoong Lee, Kyung Eun Kim, Eun Ae Jeong, Kyu Yeong Choi, Catriona McLean, Kun Ho Lee, Soo Kyoung Kim, Hae Ryong Lee, Gu Seob Roh
Summary: The study revealed that LCN2 is involved in various amyloid toxicity mechanisms, particularly neuroinflammation and oxidative stress, in an AD mouse model.
Article
Biochemistry & Molecular Biology
Hyun Joo Shin, Eun Ae Jeong, Jong Youl Lee, Hyeong Seok An, Hye Min Jang, Yu Jeong Ahn, Jaewoong Lee, Kyung Eun Kim, Gu Seob Roh
Summary: The deficiency of LCN2 reduces neuronal cell death, BBB leakage, iron overload, and oxidative stress in KA-induced hippocampal cell death, and inhibits related neuroinflammatory responses, indicating a significant role of LCN2 in this process.
Review
Biochemistry & Molecular Biology
Qinjie Liu, Jie Wu, Xufei Zhang, Xiuwen Wu, Yun Zhao, Jianan Ren
Summary: Iron metabolism plays a crucial role in sepsis, impacting disease severity and cell damage. Understanding the mechanisms of iron in sepsis is essential for predicting and treating the disease effectively.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Robert Szabo, Cristina Petrisor, Constantin Bodolea, Robert Simon, Ioana Maries, Sebastian Tranca, Teodora Mocan
Summary: Inflammation in COVID-19 leads to intracellular iron overload and non-programmed cell death, increasing mortality and morbidity. This study aims to evaluate the predictive values of serologic iron and inflammatory parameters in critically ill COVID-19 patients. The results suggest that iron metabolism parameters and models consisting of multiple variables may predict outcomes. Larger studies are needed to validate these results, but this paper highlights a new research direction.
Article
Obstetrics & Gynecology
Suryapriya Rajendran, Zachariah Bobby, Syed Habeebullah, Sajini Elizabeth Jacob
Summary: Iron supplementation has beneficial effects on hematological parameters and inflammation in anemic pregnant women, but increases oxidative stress and inflammation in nonanemic pregnant women.
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Ye-Jin Cho, So-Hyun Park, Kwon-Yul Ryu
Summary: Astrocytes and microglia play crucial roles in maintaining brain homeostasis and the progression of neurological disorders. This study reveals that mild oxidative stress can downregulate the production of lipocalin-2 (LCN2) in glial cells, independently of the NF-kappa B signaling pathway. Additionally, Nrf2, another pathway involved in oxidative stress response, is not responsible for the downregulation of LCN2 in glial cells. These findings suggest that mild oxidative stress may be important in regulating LCN2 homeostasis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, Research & Experimental
Sung Yeon Ham, Ji Hae Jun, Hye-Bin Kim, Jae-Kwang Shim, Gisong Lee, Young-Lan Kwak
Summary: This study investigated the activities of key regulators affecting erythropoiesis in a rat model of iron deficiency anemia with inflammation. The results showed that IV iron therapy exacerbated inflammation and oxidative stress and did not resolve anemia.
Article
Biochemistry & Molecular Biology
Zhaojin Zeng, Haohua Huang, Jinming Zhang, Yuanyuan Liu, Wenshan Zhong, Weimou Chen, Ye Lu, Yujie Qiao, Haijin Zhao, Xiaojing Meng, Fei Zou, Shaoxi Cai, Hangming Dong
Summary: This study found that ferroptosis plays an important role in house dust mite-induced asthma models, and ferroptosis inhibitors can reduce airway inflammation. This research reveals that ferroptosis may be a potential treatment target for house dust mite-induced asthma.
Article
Biochemistry & Molecular Biology
Rosalba Siracusa, Ramona D'Amico, Marika Cordaro, Alessio Filippo Peritore, Tiziana Genovese, Enrico Gugliandolo, Rosalia Crupi, Daniela Impellizzeri, Salvatore Cuzzocrea, Roberta Fusco, Rosanna Di Paola
Summary: CDDO-Me demonstrated anti-fibrotic, anti-inflammatory, and anti-oxidative effects in the treatment of endometriosis, effectively suppressing the disease by modulating the Nrf2 and NF-κB pathways.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Medical Laboratory Technology
Juliana Alvarez-Argote, Theresa A. Dlugi, Teresa Sundararajan, Annie Kleynerman, Mary L. Faber, William M. McKillop, Jeffrey A. Medin
Summary: By evaluating the Townes mouse model, we found that HbS mice exhibited higher hemolysis markers and white blood cell counts, with more pronounced differences in older adults. After hypoxia, HbS mice showed significant decreases in hemoglobin, platelet counts, and white blood cell counts, while HbA mice remained stable. Kidney function worsened in HbS mice. These findings are correlated with clinical manifestations in SCD patients and provide insights for preclinical therapeutic studies.
TRANSLATIONAL RESEARCH
(2023)
Article
Clinical Neurology
Klaus Munkholm, Anne Sophie Jacoby, Maj Vinberg, Lars Vedel Kessing
Summary: This study investigated the relationship between plasma ferritin levels and bipolar disorder. The results showed that ferritin levels were higher in depressed patients with bipolar disorder and were associated with levels of inflammatory markers and markers of oxidative DNA and RNA damage. This suggests that iron metabolism may play a role in the pathophysiology of bipolar disorder.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Review
Biochemistry & Molecular Biology
Jolanta Artym, Michal Zimecki, Marian L. Kruzel
Summary: Pregnancy requires higher levels of nutrients, including iron, for the growth and maintenance of the fetus. Iron deficiency during pregnancy can lead to serious health issues, making iron supplementation essential for pregnant women. Studies suggest that lactoferrin can be an effective prophylaxis and treatment for iron deficiency anemia during pregnancy, offering various beneficial effects on iron homeostasis and overall health.
Review
Biochemistry & Molecular Biology
Zihang Liu, Panpan Deng, Shengnan Liu, Yiying Bian, Yuanyuan Xu, Qiang Zhang, Huihui Wang, Jingbo Pi
Summary: Cytokine storm refers to a state of the immune system characterized by excessive release of cytokines, leading to inflammation, organ failure, and disease outcomes. NRF2, a transcription factor involved in cellular redox homeostasis, has emerged as a potential therapeutic target in preventing and treating cytokine storms. This review summarizes the causes of cytokine storms and the rationale for targeting NRF2 as a therapeutic intervention.
Article
Gastroenterology & Hepatology
Xia Xiao, Som Dev, Susanna Canali, Abraham Bayer, Yang Xu, Aneesh Agarwal, Chia-Yu Wang, Jodie L. Babitt
Article
Hematology
Chia-Yu Wang, Yang Xu, Lisa Traeger, Deniz Y. Dogan, Xia Xiao, Andrea U. Steinbicker, Jodie L. Babitt
Review
Biochemistry & Molecular Biology
Rachel M. Golonka, Xia Xiao, Ahmed A. Abokor, Bina Joe, Matam Vijay-Kumar
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2020)
Review
Gastroenterology & Hepatology
Vishal Singh, Matam Vijay-Kumar
GASTROENTEROLOGY REPORT
(2020)
Article
Gastroenterology & Hepatology
Rachel M. Golonka, Beng San Yeoh, Yaqi Li, Piu Saha, Ahmed A. Abokor, Xi Cheng, Xia Xiao, Darshan Shimoga Chandrahekar, Sooryanarayana Varambally, David J. Gonzalez, A. Catharine Ross, Matam Vijay-Kumar
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
(2020)
Article
Nutrition & Dietetics
Yaqi Li, Cheng-Hsin Wei, Xia Xiao, Michael H. Green, A. Catharine Ross
JOURNAL OF NUTRITION
(2020)
Article
Gastroenterology & Hepatology
Vishal Singh, Beng San Yeoh, Ahmed A. Abokor, Rachel M. Golonka, Yuan Tian, Andrew D. Patterson, Bina Joe, Mathias Heikenwalder, Matam Vijay-Kumar
Article
Nutrition & Dietetics
Shaneice K. Nettleford, Luming Zhao, Fenghua Qian, Morgan Herold, Brooke Arner, Dhimant Desai, Shantu Amin, Na Xiong, Vishal Singh, Bradley A. Carlson, K. Sandeep Prabhu
FRONTIERS IN NUTRITION
(2020)
Review
Endocrinology & Metabolism
Xia Xiao, Victor M. Alfaro-Magallanes, Jodie L. Babitt
Article
Hematology
Allison L. Fisher, Chia-yu Wang, Yang Xu, Kole Joachinn, Xia Xiao, Sydney Phillips, Gillian A. Moschetta, Victor M. Alfaro-Magallanes, Jodie L. Babitt
Summary: This study investigates the role of endothelial cell transferrin receptor 1 (TFR1) in iron uptake, BMP6 regulation, and systemic iron homeostasis. The results show that TFR1 mediates iron uptake and Bmp6 expression in primary liver endothelial cell cultures. Knockout mice lacking endothelial Tfrc exhibit altered iron homeostasis under limited iron diet conditions, but not under iron-rich standard diet conditions. Additionally, ferritin and non-transferrin bound iron (NTBI) can induce Bmp6 expression via TFR1-independent mechanisms in primary LEC cultures.
AMERICAN JOURNAL OF HEMATOLOGY
(2022)
Article
Hematology
Xia Xiao, Gillian A. Moschetta, Yang Xu, Allison L. Fisher, Victor M. Alfaro-Magallanes, Som Dev, Chia-Yu Wang, Jodie L. Babitt
Summary: This study investigated the role of transferrin receptor 1 (TfR1) in cellular iron uptake and its interaction with the HFE protein to regulate hepcidin production. The results showed that hepatocyte TfR1 function depends on HFE and contributes to hepcidin suppression and iron overload in beta-thalassemia. The study also demonstrated the modulatory effect of serum iron on hepcidin regulation by hepatocyte TfR1.
Article
Gastroenterology & Hepatology
Beng San Yeoh, Piu Saha, Rachel M. Golonka, Jun Zou, Jessica L. Petrick, Ahmed A. Abokor, Xia Xiao, Venugopal R. Bovilla, Alexis C. A. Bretin, Jesus Rivera-Esteban, Dominick Parisi, Andrea A. Florio, Stephanie J. Weinstein, Demetrius Albanes, Gordon J. Freeman, Amira F. Gohara, Andreea Ciudin, Juan M. Pericas, Bina Joe, Robert F. Schwabe, Katherine A. McGlynn, Andrew T. Gewirtz, Matam Vijay-Kumar
Summary: This study reveals the association between portosystemic shunt (PSS) and the development of hepatocellular carcinoma (HCC). In mice, PSS combined with a fermentable fiber-enriched diet leads to increased serum bile acids (BA), causing liver injury and progression to cholestatic HCC. Human serum analysis also shows that elevated BA is associated with future development of HCC.
Review
Oncology
Rinda Devi Bachu, Mariam Abou-Dahech, Swapnaa Balaji, Sai H. S. Boddu, Samson Amos, Vishal Singh, R. Jayachandra Babu, Amit K. Tiwari
Summary: Biologics play an important role in cancer treatment, but their high costs limit accessibility for many patients. The development of biosimilars aims to lower costs and provide new cancer therapies, but lack of knowledge and potential immunogenicity create uncertainties for healthcare professionals and patients.
Article
Gastroenterology & Hepatology
Piu Saha, Beng San Yeoh, Xia Xiao, Rachel M. Golonka, Ahmed A. Abokor, Camilla F. Wenceslau, Yatrik M. Shah, Bina Joe, Matam Vijay-Kumar
Article
Physiology
Piu Saha, Xia Xiao, Yaqi Li, Rachel M. Golonka, Ahmed A. Abokor, Beng San Yeoh, Matam Vijay-Kumar
PHYSIOLOGICAL REPORTS
(2020)