Structure, Assembly, and Function of Tripartite Efflux and Type 1 Secretion Systems in Gram-Negative Bacteria

The Multidrug Efflux System AcrABZ-TolC Is Essential for Infection of Salmonella Typhimurium by the Flagellum-Dependent Bacteriophage Chi

(2021) Nathaniel C. Esteves et al.   JOURNAL OF VIROLOGY

Metabolomics Reveal Potential Natural Substrates of AcrB in Escherichia coli and Salmonella enterica Serovar Typhimurium

(2021) Xuan Wang-Kan et al.   mBio

Quantitative real-time analysis of the efflux by the MacAB-TolC tripartite efflux pump clarifies the role of ATP hydrolysis within mechanotransmission mechanism

(2021) Hager Souabni et al.   Communications Biology

Role of ppGpp-regulated efflux genes in Acinetobacter baumannii

(2020) Hye-Won Jung et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Phylogenetic analysis reveals an ancient gene duplication as the origin of the MdtABC efflux pump

(2020) Kamil Górecki et al.   PLoS One

Substrate‐dependent transport mechanism in AcrB of multidrug resistant bacteria

(2020) Yead Jewel et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Emergence of a Plasmid-Encoded Resistance-Nodulation-Division Efflux Pump Conferring Resistance to Multiple Drugs, Including Tigecycline, in Klebsiella pneumoniae

(2020) Luchao Lv et al.   mBio

Structural basis for itraconazole-mediated NPC1 inhibition

(2020) Tao Long et al.   Nature Communications

Structural basis of substrate recognition by a polypeptide processing and secretion transporter

(2020) Virapat Kieuvongngam et al.   eLife

Be Cautious with Crystal Structures of Membrane Proteins or Complexes Prepared in Detergents

(2020) Youzhong Guo   Crystals

Linearized Siderophore Products Secreted via MacAB Efflux Pump Protect Salmonella enterica Serovar Typhimurium from Oxidative Stress

(2020) L. M. Bogomolnaya et al.   mBio

Cryo-EM Structures of a Gonococcal Multidrug Efflux Pump Illuminate a Mechanism of Drug Recognition and Resistance

(2020) Meinan Lyu et al.   mBio

Chlorpromazine and Amitriptyline Are Substrates and Inhibitors of the AcrB Multidrug Efflux Pump

(2020) Elizabeth M. Grimsey et al.   mBio

Cryo-EM structures provide insight into how E. coli F1Fo ATP synthase accommodates symmetry mismatch

(2020) Meghna Sobti et al.   Nature Communications

A single power stroke by ATP binding drives substrate translocation in a heterodimeric ABC transporter

(2020) Erich Stefan et al.   eLife

A Putative Efflux Transporter of the ABC Family, YbhFSR, in Escherichia coli Functions in Tetracycline Efflux and Na+(Li+)/H+ Transport

(2020) Zhenyue Feng et al.   Frontiers in Microbiology

Structural and Mechanistic Principles of ABC Transporters

(2020) Christoph Thomas et al.   Annual Review of Biochemistry

Discovery of multidrug efflux pump inhibitors with a novel chemical scaffold

(2020) Adam T. Green et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Structural Basis of Low-pH-Dependent Lysosomal Cholesterol Egress by NPC1 and NPC2

(2020) Hongwu Qian et al.   CELL

The impaired quorum sensing response of MexAB‐OprM efflux pump overexpressing mutants is not due to non‐physiological efflux of 3‐oxo‐C12‐HSL

(2020) Manuel Alcalde‐Rico et al.   ENVIRONMENTAL MICROBIOLOGY

Assembly and regulation of the chlorhexidine-specific efflux pump AceI

(2020) Jani Reddy Bolla et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Interactions of a Bacterial RND Transporter with a Transmembrane Small Protein in a Lipid Environment

(2020) Dijun Du et al.   STRUCTURE

New Multidrug Efflux Inhibitors for Gram-Negative Bacteria

(2020) Robert L. Marshall et al.   mBio

The role of RND-type efflux pumps in multidrug-resistant mutants of Klebsiella pneumoniae

(2020) Rui Ting Ni et al.   Scientific Reports

Surface Protein Dispersin of Enteroaggregative Escherichia coli Binds Plasminogen That Is Converted Into Active Plasmin

(2020) Claudia T. P. Moraes et al.   Frontiers in Microbiology

CexE Is a Coat Protein and Virulence Factor of Diarrheagenic Pathogens

(2020) Zachary P. Rivas et al.   Frontiers in Microbiology

Cryo-EM structures of NPC1L1 reveal mechanisms of cholesterol transport and ezetimibe inhibition

(2020) Ching-Shin Huang et al.   Science Advances

Cryo-EM Structure and Molecular Dynamics Analysis of the Fluoroquinolone Resistant Mutant of the AcrB Transporter from Salmonella

(2020) Rachel M. Johnson et al.   Microorganisms

Mutations in the TolC Periplasmic Domain Affect Substrate Specificity of the AcrAB-TolC Pump

(2020) Robert L. Marshall et al.   Frontiers in Molecular Biosciences

Structure of human Dispatched-1 provides insights into Hedgehog ligand biogenesis

(2020) Hongwen Chen et al.   Life Science Alliance

Peptide-Based Approach to Inhibition of the Multidrug Resistance Efflux Pump AcrB

(2020) Joshua A. Jesin et al.   BIOCHEMISTRY

Structural mechanism of phospholipids translocation by MlaFEDB complex

(2020) Ximin Chi et al.   CELL RESEARCH

Assembly and Maintenance of Lipids at the Bacterial Outer Membrane

(2020) Emily Lundstedt et al.   CHEMICAL REVIEWS

Coordinate overexpression of two RND efflux systems, ParXY and TtgABC , is responsible for multidrug resistance in Pseudomonas putida

(2020) Hélène Puja et al.   ENVIRONMENTAL MICROBIOLOGY

Tripartite transporters as mechanotransmitters in periplasmic alternating‐access mechanisms

(2020) Satoshi Murakami et al.   FEBS LETTERS

Structural and functional diversity calls for a new classification of ABC transporters

(2020) Christoph Thomas et al.   FEBS LETTERS

The Evolutionary Conservation of Escherichia coli Drug Efflux Pumps Supports Physiological Functions

(2020) Tanisha Teelucksingh et al.   JOURNAL OF BACTERIOLOGY

ATP-dependent interactions of a cargo protein with the transmembrane domain of a polypeptide processing and secretion ABC transporter

(2020) Suhaila Rahman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

MexXY RND pump of Pseudomonas aeruginosa PA7 effluxes bi-anionic β-lactams carbenicillin and sulbenicillin when it partners with the outer membrane factor OprA but not with OprM

(2020) Manu Singh et al.   MICROBIOLOGY-SGM

Insights into bacterial cell division from a structure of EnvC bound to the FtsX periplasmic domain

(2020) Jonathan Cook et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A “Drug Sweeping” State of the TriABC Triclosan Efflux Pump from Pseudomonas aeruginosa

(2020) Lucien Fabre et al.   STRUCTURE

Antibiotic export by MexB multidrug efflux transporter is allosterically controlled by a MexA-OprM chaperone-like complex

(2020) Marie Glavier et al.   Nature Communications

Genetic variation in the MacAB-TolC efflux pump influences pathogenesis of invasive Salmonella isolates from Africa

(2020) Jared D. Honeycutt et al.   PLoS Pathogens

Expression Profile of Multidrug Resistance Efflux Pumps During Intracellular Life of Adherent-Invasive Escherichia coli Strain LF82

(2020) Giulia Fanelli et al.   Frontiers in Microbiology

Efflux Pump-Driven Antibiotic and Biocide Cross-Resistance in Pseudomonas aeruginosa Isolated from Different Ecological Niches: A Case Study in the Development of Multidrug Resistance in Environmental Hotspots

(2020) Anteneh Amsalu et al.   Microorganisms

Structural characterization of the EmrAB-TolC efflux complex from E. coli

(2020) Narek Yousefian et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Biochemical characterization of an E. coli cell division factor FtsE shows ATPase cycles similar to the NBDs of ABC-transporters

(2020) Sunanda Mallick et al.   BIOSCIENCE REPORTS

Structural and Functional Diversity of Resistance–Nodulation–Cell Division Transporters

(2020) Philip A. Klenotic et al.   CHEMICAL REVIEWS

Structure and Function of Hepatobiliary ATP Binding Cassette Transporters

(2020) Tim Kroll et al.   CHEMICAL REVIEWS

Fake It ‘Till You Make It—The Pursuit of Suitable Membrane Mimetics for Membrane Protein Biophysics

(2020) Johannes Thoma et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Burkholderia collagen-like protein 8, Bucl8, is a unique outer membrane component of a putative tetrapartite efflux pump in Burkholderia pseudomallei and Burkholderia mallei

(2020) Megan E. Grund et al.   PLoS One

Characterization of RaeE-RaeF-RopN, a putative RND efflux pump system in Riemerella anatipestifer

(2020) Yanping Wang et al.   VETERINARY MICROBIOLOGY

Characterization of Posttranslationally Modified Multidrug Efflux Pumps Reveals an Unexpected Link between Glycosylation and Antimicrobial Resistance

(2020) Sherif Abouelhadid et al.   mBio

Structure of bacterial phospholipid transporter MlaFEDB with substrate bound

(2020) Nicolas Coudray et al.   eLife

RamA upregulates multidrug resistance efflux pumps AcrAB and OqxAB in Klebsiella pneumoniae

(2020) Qingqing Xu et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

The roles of efflux pumps from different superfamilies in the surface-associated motility and virulence of Acinetobacter baumannii ATCC 17978

(2019) María Pérez-Varela et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Learning the ABCs one at a time: structure and mechanism of ABC transporters

(2019) Robert C. Ford et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Identification of Binding Sites for Efflux Pump Inhibitors of the Escherichia coli AcrAB-TolC component AcrA

(2019) Zbigniew M. Darzynkiewicz et al.   BIOPHYSICAL JOURNAL

RTX Adhesins are Key Bacterial Surface Megaproteins in the Formation of Biofilms

(2019) Shuaiqi Guo et al.   TRENDS IN MICROBIOLOGY

Insights into AMS/PCAT transporters from biochemical and structural characterization of a double Glycine motif protease

(2019) Silvia C Bobeica et al.   eLife

The MFS efflux pump EmrKY contributes to the survival of Shigella within macrophages

(2019) Martina Pasqua et al.   Scientific Reports

A lipid gating mechanism for the channel-forming O antigen ABC transporter

(2019) Christopher A. Caffalette et al.   Nature Communications

Cryo-EM structure of the homohexameric T3SS ATPase-central stalk complex reveals rotary ATPase-like asymmetry

(2019) Dorothy D. Majewski et al.   Nature Communications

Identification of Novel Acinetobacter baumannii Host Fatty Acid Stress Adaptation Strategies

(2019) Jhih-Hang Jiang et al.   mBio

Structure of the Large Extracellular Loop of FtsX and Its Interaction with the Essential Peptidoglycan Hydrolase PcsB in Streptococcus pneumoniae

(2019) Britta E. Rued et al.   mBio

Structure of Outward-Facing PglK and Molecular Dynamics of Lipid-Linked Oligosaccharide Recognition and Translocation

(2019) Camilo Perez et al.   STRUCTURE

Structural insight into substrate and inhibitor discrimination by human P-glycoprotein

(2019) Amer Alam et al.   SCIENCE

Structural basis of lipopolysaccharide extraction by the LptB2FGC complex

(2019) Yanyan Li et al.   NATURE

Recent paradigm shift in the assembly of bacterial tripartite efflux pumps and the type I secretion system

(2019) Inseong Jo et al.   JOURNAL OF MICROBIOLOGY

Crystal Structures of Membrane Transporter MmpL3, an Anti-TB Drug Target

(2019) Bing Zhang et al.   CELL

Two Dev BCA ‐like ABC transporters are involved in the multidrug resistance of the cyanobacterium Anabaena sp. PCC 7120

(2019) Dmitry Shvarev et al.   FEBS LETTERS

Roles of DevBCA-like ABC transporters in the physiology of Anabaena sp. PCC 7120

(2019) Dmitry Shvarev et al.   INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY

MmpL3 is a lipid transporter that binds trehalose monomycolate and phosphatidylethanolamine

(2019) Chih-Chia Su et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Biosynthesis and secretion of the microbial sulfated peptide RaxX and binding to the rice XA21 immune receptor

(2019) Dee Dee Luu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Substrate-Activated Efflux Pump, DesABC, Confers Zeamine Resistance to Dickeya zeae

(2019) Zhibin Liang et al.   mBio

AcrAB-TolC Inhibition by Peptide-conjugated Phosphorodiamidate Morpholino Oligomers Restores Antibiotic Activity in vitro and in vivo

(2019) Carolyn R Sturge et al.   ACS Infectious Diseases

Efflux-mediated resistance to new oxazolidinones and pleuromutilin derivatives in Escherichia coli with class specificities in the RND-type drug transport pathways.

(2019) Sabine Schuster et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Non-traditional Antibacterial Therapeutic Options and Challenges

(2019) Ursula Theuretzbacher et al.   Cell Host & Microbe

Structural, biochemical and in vivo characterization of MtrR-mediated resistance to innate antimicrobials by the human pathogen Neisseria gonorrhoeae

(2019) Grace A. Beggs et al.   JOURNAL OF BACTERIOLOGY

Conformation space of a heterodimeric ABC exporter under turnover conditions

(2019) Susanne Hofmann et al.   NATURE

Cryo-Electron Microscopy Structure of an Acinetobacter baumannii Multidrug Efflux Pump

(2019) Chih-Chia Su et al.   mBio

Structures of the wild-type MexAB–OprM tripartite pump reveal its complex formation and drug efflux mechanism

(2019) Kenta Tsutsumi et al.   Nature Communications

In situ structure and assembly of the multidrug efflux pump AcrAB-TolC

(2019) Xiaodong Shi et al.   Nature Communications

The extracellular gate shapes the energy profile of an ABC exporter

(2019) Cedric A. J. Hutter et al.   Nature Communications

Membrane Permeabilization by Pore-Forming RTX Toxins: What Kind of Lesions Do These Toxins Form?

(2019) Helena Ostolaza et al.   Toxins

Relationship Between Quorum Sensing and Secretion Systems

(2019) Rocio Trastoy Pena et al.   Frontiers in Microbiology

Multidrug resistance regulators MarA, SoxS, Rob, and RamA repress flagellar gene expression and motility in Salmonella enterica serovar Typhimurium

(2019) Srinivas S. Thota et al.   JOURNAL OF BACTERIOLOGY

Exploring the role of the various methionine residues in the Escherichia coli CusB adapter protein

(2019) Aviv Meir et al.   PLoS One

Multifaceted ABC transporters associated to microcin and bacteriocin export

(2019) Konstantinos Beis et al.   RESEARCH IN MICROBIOLOGY

Genetics, Toxicity, and Distribution of Enterohemorrhagic Escherichia coli Hemolysin

(2019) Maike Schwidder et al.   Toxins

Conformational Dynamics of AcrA Govern Multidrug Efflux Pump Assembly

(2019) Anthony J. Hazel et al.   ACS Infectious Diseases

The Varied Role of Efflux Pumps of the MFS Family in the Interplay of Bacteria with Animal and Plant Cells

(2019) Pasqua et al.   Microorganisms

AcrB: a mean, keen, drug efflux machine

(2019) Jessica Kobylka et al.   Annals of the New York Academy of Sciences

TetR-family transcription factors in Gram-negative bacteria: conservation, variation and implications for efflux-mediated antimicrobial resistance

(2019) A. L. Colclough et al.   BMC GENOMICS

Mutations that increase expression of the EmrAB-TolC efflux pump confer increased resistance to nitroxoline in Escherichia coli

(2019) Fabiola Puértolas-Balint et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Multidrug Resistance in Neisseria gonorrhoeae: Identification of Functionally Important Residues in the MtrD Efflux Protein

(2019) Mohsen Chitsaz et al.   mBio

Cryo-EM structures of lipopolysaccharide transporter LptB2FGC in lipopolysaccharide or AMP-PNP-bound states reveal its transport mechanism

(2019) Xiaodi Tang et al.   Nature Communications

Native CRISPR-Cas-Mediated Genome Editing Enables Dissecting and Sensitizing Clinical Multidrug-Resistant P. aeruginosa

(2019) Zeling Xu et al.   Cell Reports

Structure–Function Relationships of the Repeat Domains of RTX Toxins

(2019) Ulrich Baumann   Toxins

Molecular characterization of the outer membrane of Pseudomonas aeruginosa

(2019) Cesar A. López et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Binding and Transport of Carboxylated Drugs by the Multidrug Transporter AcrB

(2019) Heng-Keat Tam et al.   JOURNAL OF MOLECULAR BIOLOGY

An efflux inhibitor of the MacAB pump in Salmonella enterica serovar Typhimurium

(2019) Ami Yamagishi et al.   MICROBIOLOGY AND IMMUNOLOGY

Identification of binding residues between periplasmic adapter protein (PAP) and RND efflux pumps explains PAP-pump promiscuity and roles in antimicrobial resistance

(2019) Helen E. McNeil et al.   PLoS Pathogens

Diversified transporters and pathways for bacteriocin secretion in gram-positive bacteria

(2018) Sen Zheng et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

MxiN Differentially Regulates Monomeric and Oligomeric Species of the Shigella Type Three Secretion System ATPase Spa47

(2018) Heather B. Case et al.   BIOCHEMISTRY

Kinetic analysis of the inhibition of the drug efflux protein AcrB using surface plasmon resonance

(2018) Rumana Mowla et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Water-mediated interactions enable smooth substrate transport in a bacterial efflux pump

(2018) Attilio Vittorio Vargiu et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

New insights into the structural and functional involvement of the gate loop in AcrB export activity

(2018) Abdessamad Ababou   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

RiPP antibiotics: biosynthesis and engineering potential

(2018) Graham A Hudson et al.   CURRENT OPINION IN MICROBIOLOGY

ATP-Binding Cassette Transporter VcaM from Vibrio cholerae is Dependent on the Outer Membrane Factor Family for Its Function

(2018) Wen-Jung Lu et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Role of bacterial efflux pumps in biofilm formation

(2018) Ilyas Alav et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

An N-Terminal Retention Module Anchors the Giant Adhesin LapA of Pseudomonas fluorescens at the Cell Surface: a Novel Subfamily of Type I Secretion Systems

(2018) T. Jarrod Smith et al.   JOURNAL OF BACTERIOLOGY

Type 1 Does The Two-Step: Type 1 Secretion Substrates With A Functional Periplasmic Intermediate

(2018) Timothy J. Smith et al.   JOURNAL OF BACTERIOLOGY

Coordinated Expression of acrAB-tolC and Eight Other Functional Efflux Pumps Through Activating ramA and marA in Salmonella enterica serovar Typhimurium

(2018) Chuan-Zhen Zhang et al.   Microbial Drug Resistance

MexEF-OprN multidrug efflux pump transporter negatively controls N-acyl-homoserine lactone accumulation in pseudomonas syringae pv. Tabaci 6605

(2018) Takahiro Sawada et al.   MOLECULAR GENETICS AND GENOMICS

RNA-binding proteins in bacteria

(2018) Erik Holmqvist et al.   NATURE REVIEWS MICROBIOLOGY

Multidrug efflux pumps: structure, function and regulation

(2018) Dijun Du et al.   NATURE REVIEWS MICROBIOLOGY

Insights into bacterial lipoprotein trafficking from a structure of LolA bound to the LolC periplasmic domain

(2018) Elise Kaplan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure and mechanism of bacterial tripartite efflux pumps

(2018) Arthur Neuberger et al.   RESEARCH IN MICROBIOLOGY

RND transporters in the living world

(2018) Hiroshi Nikaido   RESEARCH IN MICROBIOLOGY

Structural basis for the recognition of Sonic Hedgehog by human Patched1

(2018) Xin Gong et al.   SCIENCE

Remote Coupled Drastic β-Barrel to β-Sheet Transition of the Protein Translocation Motor

(2018) Arata Furukawa et al.   STRUCTURE

Structure of a MacAB-like efflux pump from Streptococcus pneumoniae

(2018) Hong-Bo Yang et al.   Nature Communications

Multiple entry pathways within the efflux transporter AcrB contribute to multidrug recognition

(2018) Martijn Zwama et al.   Nature Communications

Communication between the leaflets of asymmetric membranes revealed from coarse-grain molecular dynamics simulations

(2018) Jonathan Shearer et al.   Scientific Reports

Antibiotic interceptors: Creating safe spaces for bacteria

(2018) Akshay Sabnis et al.   PLoS Pathogens

CRISPR-Cas antimicrobials: Challenges and future prospects

(2018) Elizabeth Pursey et al.   PLoS Pathogens

Energetics and conformational pathways of functional rotation in the multidrug transporter AcrB

(2018) Yasuhiro Matsunaga et al.   eLife

Antibiotic Resistance Mediated by the MacB ABC Transporter Family: A Structural and Functional Perspective

(2018) Nicholas P. Greene et al.   Frontiers in Microbiology

Widely Used Benzalkonium Chloride Disinfectants Can Promote Antibiotic Resistance

(2018) Minjae Kim et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Conformational dynamics of the ABC transporter McjD seen by single‐molecule FRET

(2018) Florence Husada et al.   EMBO JOURNAL

Antidepressant fluoxetine induces multiple antibiotics resistance in Escherichia coli via ROS-mediated mutagenesis

(2018) Min Jin et al.   ENVIRONMENT INTERNATIONAL

Structures of human Patched and its complex with native palmitoylated sonic hedgehog

(2018) Xiaofeng Qi et al.   NATURE

Structure of the EmrE multidrug transporter and its use for inhibitor peptide design

(2018) Victor Ovchinnikov et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mosaic Drug Efflux Gene Sequences from Commensal Neisseria Can Lead to Low-Level Azithromycin Resistance Expressed by Neisseria gonorrhoeae Clinical Isolates

(2018) William M. Shafer   mBio

Outward open conformation of a Major Facilitator Superfamily multidrug/H+ antiporter provides insights into switching mechanism

(2018) Kumar Nagarathinam et al.   Nature Communications

Two Regulators, PA3898 and PA2100, Modulate the Pseudomonas aeruginosa Multidrug Resistance MexAB-OprM and EmrAB Efflux Pumps and Biofilm Formation

(2018) Yun Heacock-Kang et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Substrate polyspecificity and conformational relevance in ABC transporters: new insights from structural studies

(2018) Jack Wright et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Structural Basis for Cholesterol Transport-like Activity of the Hedgehog Receptor Patched

(2018) Yunxiao Zhang et al.   CELL

Triclosan at environmentally relevant concentrations promotes horizontal transfer of multidrug resistance genes within and across bacterial genera

(2018) Ji Lu et al.   ENVIRONMENT INTERNATIONAL

Structure and activity of lipid bilayer within a membrane-protein transporter

(2018) Weihua Qiu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Protein assemblies ejected directly from native membranes yield complexes for mass spectrometry

(2018) Dror S. Chorev et al.   SCIENCE

PvdRT-OpmQ and MdtABC-OpmB efflux systems are involved in pyoverdine secretion in Pseudomonas putida KT2440

(2018) Tania Henríquez et al.   Environmental Microbiology Reports

Role of the Multidrug Resistance Efflux Pump MexCD-OprJ in the Pseudomonas aeruginosa Quorum Sensing Response

(2018) Manuel Alcalde-Rico et al.   Frontiers in Microbiology

The MtrCDE Efflux Pump Contributes to Survival of Neisseria gonorrhoeae From Human Neutrophils and Their Antimicrobial Components

(2018) Jonathan W. Handing et al.   Frontiers in Microbiology

Computational modelling of efflux pumps and their inhibitors

(2017) Venkata Krishnan Ramaswamy et al.   Essays in Biochemistry

Macrolide resistance inLegionella pneumophila: the role of LpeAB efflux pump

(2017) Clémence Massip et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

The outer-membrane protein TolC ofVibrio choleraeserves as a second cell-surface receptor for the VP3 phage

(2017) Fenxia Fan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Constant pH Molecular Dynamics Reveals How Proton Release Drives the Conformational Transition of a Transmembrane Efflux Pump

(2017) Zhi Yue et al.   Journal of Chemical Theory and Computation

Identification and Structure–Activity Relationships of Novel Compounds that Potentiate the Activities of Antibiotics in Escherichia coli

(2017) Keith M. Haynes et al.   JOURNAL OF MEDICINAL CHEMISTRY

Switch Loop Flexibility Affects Substrate Transport of the AcrB Efflux Pump

(2017) Reinke T. Müller et al.   JOURNAL OF MOLECULAR BIOLOGY

It Is Complicated: Curvature, Diffusion, and Lipid Sorting within the Two Membranes of Escherichia coli

(2017) Pin-Chia Hsu et al.   Journal of Physical Chemistry Letters

New Roads Leading to Old Destinations: Efflux Pumps as Targets to Reverse Multidrug Resistance in Bacteria

(2017) Gabriella Spengler et al.   MOLECULES

Structure of the human multidrug transporter ABCG2

(2017) Nicholas M. I. Taylor et al.   NATURE

Structural basis of MsbA-mediated lipopolysaccharide transport

(2017) Wei Mi et al.   NATURE

Energy transduction and alternating access of the mammalian ABC transporter P-glycoprotein

(2017) Brandy Verhalen et al.   NATURE

Structural basis for lipopolysaccharide extraction by ABC transporter LptB2FG

(2017) Qingshan Luo et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

CsrA maximizes expression of the AcrAB multidrug resistance transporter

(2017) Vito Ricci et al.   NUCLEIC ACIDS RESEARCH

The MEROPS database of proteolytic enzymes, their substrates and inhibitors in 2017 and a comparison with peptidases in the PANTHER database

(2017) Neil D Rawlings et al.   NUCLEIC ACIDS RESEARCH

Crystal structures of theBurkholderia multivoranshopanoid transporter HpnN

(2017) Nitin Kumar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Adaptor protein mediates dynamic pump assembly for bacterial metal efflux

(2017) Ace George Santiago et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

3.3 Å structure of Niemann–Pick C1 protein reveals insights into the function of the C-terminal luminal domain in cholesterol transport

(2017) Xiaochun Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure and mechanotransmission mechanism of the MacB ABC transporter superfamily

(2017) Allister Crow et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Crystal structure and mechanistic basis of a functional homolog of the antigen transporter TAP

(2017) Anne Nöll et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Reconstitution of the activity of RND efflux pumps: a “bottom-up” approach

(2017) Dhenesh Puvanendran et al.   RESEARCH IN MICROBIOLOGY

Clamping down on drugs: the Escherichia coli multidrug efflux protein MdtM

(2017) Christopher J. Law et al.   RESEARCH IN MICROBIOLOGY

The hydrophobic trap—the Achilles heel of RND efflux pumps

(2017) Zachary Aron et al.   RESEARCH IN MICROBIOLOGY

The fascinating but mysterious mechanistic aspects of multidrug transport by MdfA from Escherichia coli

(2017) Eliane H. Yardeni et al.   RESEARCH IN MICROBIOLOGY

Structure of a Type-1 Secretion System ABC Transporter

(2017) Jacob L.W. Morgan et al.   STRUCTURE

The Vibrio cholerae VexGH RND Efflux System Maintains Cellular Homeostasis by Effluxing Vibriobactin

(2017) Dillon E. Kunkle et al.   mBio

Lack of AcrB Efflux Function Confers Loss of Virulence on Salmonella enterica Serovar Typhimurium

(2017) Xuan Wang-Kan et al.   mBio

The multiple antibiotic resistance operon of enteric bacteria controls DNA repair and outer membrane integrity

(2017) Prateek Sharma et al.   Nature Communications

Structures and transport dynamics of a Campylobacter jejuni multidrug efflux pump

(2017) Chih-Chia Su et al.   Nature Communications

Structural and functional insights into the lipopolysaccharide ABC transporter LptB2FG

(2017) Haohao Dong et al.   Nature Communications

Structural basis for xenobiotic extrusion by eukaryotic MATE transporter

(2017) Hirotake Miyauchi et al.   Nature Communications

Crystal structure of tripartite-type ABC transporter MacB from Acinetobacter baumannii

(2017) Ui Okada et al.   Nature Communications

Structural basis for lipopolysaccharide extraction by ABC transporter LptB2FG

(2017) Qingshan Luo et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Dynamics of Intact MexAB-OprM Efflux Pump: Focusing on the MexA-OprM Interface

(2017) Cesar A. López et al.   Scientific Reports

Tunnel Formation Inferred from the I -Form Structures of the Proton-Driven Protein Secretion Motor SecDF

(2017) Arata Furukawa et al.   Cell Reports

Hoisting-Loop in Bacterial Multidrug Exporter AcrB Is a Highly Flexible Hinge That Enables the Large Motion of the Subdomains

(2017) Martijn Zwama et al.   Frontiers in Microbiology

Contribution of RaeB, a Putative RND-Type Transporter to Aminoglycoside and Detergent Resistance in Riemerella anatipestifer

(2017) Xin Zhang et al.   Frontiers in Microbiology

Two-Component Signal Transduction Systems of Pathogenic Bacteria As Targets for Antimicrobial Therapy: An Overview

(2017) Sandeep Tiwari et al.   Frontiers in Microbiology

Structure of the MacAB–TolC ABC-type tripartite multidrug efflux pump

(2017) Anthony W. P. Fitzpatrick et al.   Nature Microbiology

Structure of a 1.5-MDa adhesin that binds its Antarctic bacterium to diatoms and ice

(2017) Shuaiqi Guo et al.   Science Advances

Xenon for tunnelling analysis of the efflux pump component OprN

(2017) Yvette Véronique Ntsogo Enguéné et al.   PLoS One

Structural basis of inhibition of lipid-linked oligosaccharide flippase PglK by a conformational nanobody

(2017) Camilo Perez et al.   Scientific Reports

Molecular Rationale behind the Differential Substrate Specificity of Bacterial RND Multi-Drug Transporters

(2017) Venkata Krishnan Ramaswamy et al.   Scientific Reports

Structural and Functional Investigation of the Ag+/Cu+ Binding Domains of the Periplasmic Adaptor Protein SilB from Cupriavidus metallidurans CH34

(2016) Patricia Urbina et al.   BIOCHEMISTRY

Coiled-coils: The long and short of it

(2016) Linda Truebestein et al.   BIOESSAYS

Dynamics and Interactions of OmpF and LPS: Influence on Pore Accessibility and Ion Permeability

(2016) Dhilon S. Patel et al.   BIOPHYSICAL JOURNAL

Structural Insights into the Niemann-Pick C1 (NPC1)-Mediated Cholesterol Transfer and Ebola Infection

(2016) Xin Gong et al.   CELL

Efflux Pump Inhibitors: A Novel Approach to Combat Efflux-Mediated Drug Resistance in Bacteria

(2016) Yinhu Wang et al.   CURRENT DRUG TARGETS

Plasmid-mediated colistin resistance: the final blow to colistin?

(2016) Jean-Marc Rolain et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Small RNA Regulation of TolC, the Outer Membrane Component of Bacterial Multidrug Transporters

(2016) Ashley Parker et al.   JOURNAL OF BACTERIOLOGY

Opening the Channel: the Two Functional Interfaces of Pseudomonas aeruginosa OpmH with the Triclosan Efflux Pump TriABC

(2016) Abigail T. Ntreh et al.   JOURNAL OF BACTERIOLOGY

Cellular Innate Immunity: An Old Game with New Players

(2016) Georg Gasteiger et al.   Journal of Innate Immunity

Molecular basis of polyspecificity of the Small Multidrug Resistance Efflux Pump AbeS from Acinetobacter baumannii

(2016) Iryna Lytvynenko et al.   JOURNAL OF MOLECULAR BIOLOGY

The Effect of Lipopolysaccharide Core Oligosaccharide Size on the Electrostatic Binding of Antimicrobial Proteins to Models of the Gram Negative Bacterial Outer Membrane

(2016) Luke. A. Clifton et al.   LANGMUIR

AdeR protein regulates adeABC expression by binding to a direct-repeat motif in the intercistronic spacer

(2016) Tein-Yao Chang et al.   MICROBIOLOGICAL RESEARCH

Transcription factor CecR (YbiH) regulates a set of genes affecting the sensitivity of Escherichia coli against cefoperazone and chloramphenicol

(2016) Yuki Yamanaka et al.   MICROBIOLOGY-SGM

A mechanism of viral immune evasion revealed by cryo-EM analysis of the TAP transporter

(2016) Michael L. Oldham et al.   NATURE

Crystal structure of the human sterol transporter ABCG5/ABCG8

(2016) Jyh-Yeuan Lee et al.   NATURE

Crystal structure of a substrate-engaged SecY protein-translocation channel

(2016) Long Li et al.   NATURE

Biofilms: an emergent form of bacterial life

(2016) Hans-Curt Flemming et al.   NATURE REVIEWS MICROBIOLOGY

Quorum sensing signal–response systems in Gram-negative bacteria

(2016) Kai Papenfort et al.   NATURE REVIEWS MICROBIOLOGY

Understanding transport by the major facilitator superfamily (MFS): structures pave the way

(2016) Esben M. Quistgaard et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Mechanistic diversity in ATP-binding cassette (ABC) transporters

(2016) Kaspar P Locher   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The target spectrum of SdsR small RNA inSalmonella

(2016) Kathrin S. Fröhlich et al.   NUCLEIC ACIDS RESEARCH

Gram-negative trimeric porins have specific LPS binding sites that are essential for porin biogenesis

(2016) Wanatchaporn Arunmanee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure of human Niemann–Pick C1 protein

(2016) Xiaochun Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular basis for inhibition of AcrB multidrug efflux pump by novel and powerful pyranopyridine derivatives

(2016) Hanno Sjuts et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Crystal structures of OprN and OprJ, outer membrane factors of multidrug tripartite efflux pumps ofPseudomonas aeruginosa

(2016) Ryo Yonehara et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Crystal Structure of a Soluble Fragment of the Membrane Fusion Protein HlyD in a Type I Secretion System of Gram-Negative Bacteria

(2016) Jin-Sik Kim et al.   STRUCTURE

Pseudoatomic Structure of the Tripartite Multidrug Efflux Pump AcrAB-TolC Reveals the Intermeshing Cogwheel-like Interaction between AcrA and TolC

(2016) Hyeongseop Jeong et al.   STRUCTURE

The Acinetobacter baumannii Two-Component System AdeRS Regulates Genes Required for Multidrug Efflux, Biofilm Formation, and Virulence in a Strain-Specific Manner

(2016) Grace E. Richmond et al.   mBio

How to Measure Export via Bacterial Multidrug Resistance Efflux Pumps

(2016) Jessica M. A. Blair et al.   mBio

Beyond Antimicrobial Resistance: Evidence for a Distinct Role of the AcrD Efflux Pump in Salmonella Biology

(2016) Michelle M. C. Buckner et al.   mBio

Transport of lipophilic carboxylates is mediated by transmembrane helix 2 in multidrug transporter AcrB

(2016) Christine Oswald et al.   Nature Communications

Tripartite assembly of RND multidrug efflux pumps

(2016) Laetitia Daury et al.   Nature Communications

Mechanistic diversity in ATP-binding cassette (ABC) transporters

(2016) Kaspar P Locher   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Sequence-Specific Targeting of Bacterial Resistance Genes Increases Antibiotic Efficacy

(2016) Dilay Hazal Ayhan et al.   PLOS BIOLOGY

Mechanisms of Antimicrobial Resistance in ESKAPE Pathogens

(2016) Sirijan Santajit et al.   Biomed Research International

Defining key roles for auxiliary proteins in an ABC transporter that maintains bacterial outer membrane lipid asymmetry

(2016) Shuhua Thong et al.   eLife

Biochemical characterization of essential cell division proteins FtsX and FtsE that mediate peptidoglycan hydrolysis by PcsB inStreptococcus pneumoniae

(2016) Ruchika Bajaj et al.   MicrobiologyOpen

Multiple roles for a novel RND-type efflux system inAcinetobacter baumanniiAB5075

(2016) Kyle A. Tipton et al.   MicrobiologyOpen

Reviving Antibiotics: Efflux Pump Inhibitors That Interact with AcrA, a Membrane Fusion Protein of the AcrAB-TolC Multidrug Efflux Pump

(2016) Narges Abdali et al.   ACS Infectious Diseases

Structure–Function Profile of MmpL3, the Essential Mycolic Acid Transporter from Mycobacterium tuberculosis

(2016) Juan Manuel Belardinelli et al.   ACS Infectious Diseases

Staphylococcus aureus inactivates daptomycin by releasing membrane phospholipids

(2016) Vera Pader et al.   Nature Microbiology

The Crystal Structure of the YknZ Extracellular Domain of ABC Transporter YknWXYZ from Bacillus amyloliquefaciens

(2016) Yongbin Xu et al.   PLoS One

Structures of Gate Loop Variants of the AcrB Drug Efflux Pump Bound by Erythromycin Substrate

(2016) Abdessamad Ababou et al.   PLoS One

The SmeYZ Efflux Pump of Stenotrophomonas maltophilia Contributes to Drug Resistance, Virulence-Related Characteristics, and Virulence in Mice

(2015) Yi-Tsung Lin et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

A Fluorescent Microplate Assay Quantifies Bacterial Efflux and Demonstrates Two Distinct Compound Binding Sites in AcrB

(2015) Ramkumar Iyer et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Moraxella catarrhalis AcrAB-OprM Efflux Pump Contributes to Antimicrobial Resistance and Is Enhanced during Cold Shock Response

(2015) Violeta Spaniol et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

The use of SMALPs as a novel membrane protein scaffold for structure study by negative stain electron microscopy

(2015) Vincent Postis et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

The assembly and disassembly of the AcrAB-TolC three-component multidrug efflux pump

(2015) Reinke Tobias Müller et al.   BIOLOGICAL CHEMISTRY

Substrate-bound structure of the E. coli multidrug resistance transporter MdfA

(2015) Jie Heng et al.   CELL RESEARCH

Structures of multidrug and toxic compound extrusion transporters and their mechanistic implications

(2015) Min Lu   Channels

The Structure and Interactions of Periplasmic Domains of Crucial MmpL Membrane Proteins from Mycobacterium tuberculosis

(2015) Nicholas Chim et al.   CHEMISTRY & BIOLOGY

A novel alanine to serine substitution mutation in SoxS induces overexpression of efflux pumps and contributes to multidrug resistance in clinicalEscherichia coliisolates

(2015) Sherine A. Aly et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Differential impact oframRAmutations on bothramAtranscription and decreased antimicrobial susceptibility inSalmonellaTyphimurium

(2015) Anna Fàbrega et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

AcrB-AcrA Fusion Proteins That Act as Multidrug Efflux Transporters

(2015) Katsuhiko Hayashi et al.   JOURNAL OF BACTERIOLOGY

Revisiting the Gram-Negative Lipoprotein Paradigm

(2015) Eric D. LoVullo et al.   JOURNAL OF BACTERIOLOGY

Non-equivalent roles of two periplasmic subunits in the function and assembly of triclosan pump TriABC fromPseudomonas aeruginosa

(2015) Jon W. Weeks et al.   MOLECULAR MICROBIOLOGY

The Giant Adhesin SiiE of Salmonella enterica

(2015) Britta Barlag et al.   MOLECULES

Structure of the Tripartite Multidrug Efflux Pump AcrAB-TolC Suggests an Alternative Assembly Mode

(2015) Jin-Sik Kim et al.   MOLECULES AND CELLS

Crystal structures of a polypeptide processing and secretion transporter

(2015) David Yin-wei Lin et al.   NATURE

Secretion systems in Gram-negative bacteria: structural and mechanistic insights

(2015) Tiago R. D. Costa et al.   NATURE REVIEWS MICROBIOLOGY

The Transporter Classification Database (TCDB): recent advances

(2015) Milton H. Saier et al.   NUCLEIC ACIDS RESEARCH

The Role of the Two-Component System BaeSR in Disposing Chemicals through Regulating Transporter Systems in Acinetobacter baumannii

(2015) Ming-Feng Lin et al.   PLoS One

A Unique Set of the Burkholderia Collagen-Like Proteins Provides Insight into Pathogenesis, Genome Evolution and Niche Adaptation, and Infection Detection

(2015) Beth A. Bachert et al.   PLoS One

AcrB drug-binding pocket substitution confers clinically relevant resistance and altered substrate specificity

(2015) Jessica M. A. Blair et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Energy coupling mechanisms of MFS transporters

(2015) Xuejun C. Zhang et al.   PROTEIN SCIENCE

Gating Topology of the Proton-Coupled Oligopeptide Symporters

(2015) Philip W. Fowler et al.   STRUCTURE

The bacterial flagellar motor and its structural diversity

(2015) Tohru Minamino et al.   TRENDS IN MICROBIOLOGY

Homologs of the Acinetobacter baumannii AceI Transporter Represent a New Family of Bacterial Multidrug Efflux Systems

(2015) Karl A. Hassan et al.   mBio

In vitro transport activity of the fully assembled MexAB-OprM efflux pump from Pseudomonas aeruginosa

(2015) Alice Verchère et al.   Nature Communications

Elucidation of the RamA Regulon in Klebsiella pneumoniae Reveals a Role in LPS Regulation

(2015) Shyamasree De Majumdar et al.   PLoS Pathogens

Architecture and roles of periplasmic adaptor proteins in tripartite efflux assemblies

(2015) Martyn F. Symmons et al.   Frontiers in Microbiology

Catch me if you can: a biotinylated proteoliposome affinity assay for the investigation of assembly of the MexA-MexB-OprM efflux pump from Pseudomonas aeruginosa

(2015) Véronique Yvette Ntsogo Enguéné et al.   Frontiers in Microbiology

Mechanism of coupling drug transport reactions located in two different membranes

(2015) Helen I. Zgurskaya et al.   Frontiers in Microbiology

New OprM structure highlighting the nature of the N-terminal anchor

(2015) Laura Monlezun et al.   Frontiers in Microbiology

Structural basis of RND-type multidrug exporters

(2015) Akihito Yamaguchi et al.   Frontiers in Microbiology

Substrate-Dependent Activation of the Vibrio cholerae vexAB RND Efflux System Requires vexR

(2015) Dawn L. Taylor et al.   PLoS One

SmeOP-TolCSmEfflux Pump Contributes to the Multidrug Resistance of Stenotrophomonas maltophilia

(2014) Cheng-Wen Lin et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Switch-Loop Flexibility Affects Transport of Large Drugs by the Promiscuous AcrB Multidrug Efflux Transporter

(2014) Hi-jea Cha et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Molecular Mechanism of MBX2319 Inhibition of Escherichia coli AcrB Multidrug Efflux Pump and Comparison with Other Inhibitors

(2014) Attilio V. Vargiu et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Importance of Multidrug Efflux Pumps in the Antimicrobial Resistance Property of Clinical Multidrug-Resistant Isolates of Neisseria gonorrhoeae

(2014) Daniel Golparian et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

AbuO, a TolC-Like Outer Membrane Protein of Acinetobacter baumannii, Is Involved in Antimicrobial and Oxidative Stress Resistance

(2014) Vijaya Bharathi Srinivasan et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Folding and stability of integral membrane proteins in amphipols

(2014) Jörg H. Kleinschmidt et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Correlation between AcrB Trimer Association Affinity and Efflux Activity

(2014) Cui Ye et al.   BIOCHEMISTRY

Characterization and regulation of the Resistance-Nodulation-Cell Division-type multidrug efflux pumps MdtABC and MdtUVW from the fire blight pathogen Erwinia amylovora

(2014) Daniel Pletzer et al.   BMC MICROBIOLOGY

Diversity in ABC transporters: Type I, II and III importers

(2014) Austin J. Rice et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

Structure of the periplasmic adaptor protein from a major facilitator superfamily (MFS) multidrug efflux pump

(2014) Philip Hinchliffe et al.   FEBS LETTERS

MacABCsm, an ABC-type tripartite efflux pump of Stenotrophomonas maltophilia involved in drug resistance, oxidative and envelope stress tolerances and biofilm formation

(2014) Y.-T. Lin et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Structural Features of the Pseudomonas fluorescens Biofilm Adhesin LapA Required for LapG-Dependent Cleavage, Biofilm Formation, and Cell Surface Localization

(2014) C. D. Boyd et al.   JOURNAL OF BACTERIOLOGY

Functional Type 1 Secretion System Involved in Legionella pneumophila Virulence

(2014) Fabien Fuche et al.   JOURNAL OF BACTERIOLOGY

Mechanism of ATPase-mediated Cu+Export and Delivery to Periplasmic Chaperones

(2014) Teresita Padilla-Benavides et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Sensory Complex Consisting of an ATP-binding Cassette Transporter and a Two-component Regulatory System Controls Bacitracin Resistance inBacillus subtilis

(2014) Sebastian Dintner et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

β-Lactam Selectivity of Multidrug Transporters AcrB and AcrD Resides in the Proximal Binding Pocket

(2014) Naoki Kobayashi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural diversity of ABC transporters

(2014) Josy ter Beek et al.   JOURNAL OF GENERAL PHYSIOLOGY

HrtBA and menaquinones control haem homeostasis inLactococcus lactis

(2014) Laetitia Joubert et al.   MOLECULAR MICROBIOLOGY

Genetic assessment of the role of AcrB β-hairpins in the assembly of the TolC-AcrAB multidrug efflux pump ofEscherichia coli

(2014) Jon W. Weeks et al.   MOLECULAR MICROBIOLOGY

Structure of the AcrAB–TolC multidrug efflux pump

(2014) Dijun Du et al.   NATURE

The ensemble nature of allostery

(2014) Hesam N. Motlagh et al.   NATURE

Molecular mechanisms of antibiotic resistance

(2014) Jessica M. A. Blair et al.   NATURE REVIEWS MICROBIOLOGY

Deciphering key features in protein structures with the new ENDscript server

(2014) Xavier Robert et al.   NUCLEIC ACIDS RESEARCH

Role of Novel Multidrug Efflux Pump Involved in Drug Resistance in Klebsiella pneumoniae

(2014) Vijaya Bharathi Srinivasan et al.   PLoS One

Interaction Mediated by the Putative Tip Regions of MdsA and MdsC in the Formation of a Salmonella-Specific Tripartite Efflux Pump

(2014) Saemee Song et al.   PLoS One

Crystal Structure of the Open State of the Neisseria gonorrhoeae MtrE Outer Membrane Channel

(2014) Hsiang-Ting Lei et al.   PLoS One

AcrB, AcrD, and MdtABC Multidrug Efflux Systems Are Involved in Enterobactin Export in Escherichia coli

(2014) Tsukasa Horiyama et al.   PLoS One

A Linkage between SmeIJK Efflux Pump, Cell Envelope Integrity, and σE-Mediated Envelope Stress Response in Stenotrophomonas maltophilia

(2014) Yi-Wei Huang et al.   PLoS One

Major Facilitator Superfamily (MFS) evolved without 3-transmembrane segment unit rearrangements: Table 1.

(2014) Åke Västermark et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tracking metal ions through a Cu/Ag efflux pump assigns the functional roles of the periplasmic proteins

(2014) K. N. Chacon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mycobacterium tuberculosis FtsX extracellular domain activates the peptidoglycan hydrolase, RipC

(2014) D. Mavrici et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure of an antibacterial peptide ATP-binding cassette transporter in a novel outward occluded state

(2014) H. G. Choudhury et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Crystal structure of theCampylobacter jejuniCmeC outer membrane channel

(2014) Chih-Chia Su et al.   PROTEIN SCIENCE

Multiple conformational states and gate opening of outer membrane protein TolC revealed by molecular dynamics simulations

(2014) Beibei Wang et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Export of a single drug molecule in two transport cycles by a multidrug efflux pump

(2014) Nir Fluman et al.   Nature Communications

Structural basis of PcsB-mediated cell separation in Streptococcus pneumoniae

(2014) Sergio G. Bartual et al.   Nature Communications

Sequence analysis on the information of folding initiation segments in ferredoxin-like fold proteins

(2014) Masanari Matsuoka et al.   BMC STRUCTURAL BIOLOGY

The bacterial flagellar protein export apparatus processively transports flagellar proteins even with extremely infrequent ATP hydrolysis

(2014) Tohru Minamino et al.   Scientific Reports

Coupling of remote alternating-access transport mechanisms for protons and substrates in the multidrug efflux pump AcrB

(2014) Thomas Eicher et al.   eLife

Conformational dynamics of the nucleotide binding domains and the power stroke of a heterodimeric ABC transporter

(2014) Smriti Mishra et al.   eLife

RND transporters protectCorynebacterium glutamicumfrom antibiotics by assembling the outer membrane

(2014) Liang Yang et al.   MicrobiologyOpen

Protoporphyrin (PPIX) efflux by the MacAB-TolC pump inEscherichia coli

(2014) Evelyne Turlin et al.   MicrobiologyOpen

RND-Type Efflux Pumps in Multidrug-Resistant Clinical Isolates of Acinetobacter baumannii: Major Role for AdeABC Overexpression and AdeRS Mutations

(2013) Eun-Jeong Yoon et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Characterization of a Novel Pyranopyridine Inhibitor of the AcrAB Efflux Pump of Escherichia coli

(2013) Timothy J. Opperman et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Functional Rotation Induced by Alternating Protonation States in the Multidrug Transporter AcrB: All-Atom Molecular Dynamics Simulations

(2013) Tsutomu Yamane et al.   BIOCHEMISTRY

Structure and Dynamics of the N-Terminal Domain of the Cu(I) Binding Protein CusB

(2013) Melek N. Ucisik et al.   BIOCHEMISTRY

Some Ligands Enhance the Efflux of Other Ligands by the Escherichia coli Multidrug Pump AcrB

(2013) Alfred D. Kinana et al.   BIOCHEMISTRY

The Type 1 secretion pathway — The hemolysin system and beyond

(2013) Sabrina Thomas et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Molecular insights into type I secretion systems

(2013) Michael H.H. Lenders et al.   BIOLOGICAL CHEMISTRY

Two RND proteins involved in heavy metal efflux in Caulobacter crescentus belong to separate clusters within proteobacteria

(2013) Estela Y Valencia et al.   BMC MICROBIOLOGY

Long-Term Exposure to Benzalkonium Chloride Disinfectants Results in Change of Microbial Community Structure and Increased Antimicrobial Resistance

(2013) Madan Tandukar et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

Structure of an atypical periplasmic adaptor from a multidrug efflux pump of the spirocheteBorrelia burgdorferi

(2013) Nicholas P. Greene et al.   FEBS LETTERS

Structure-function analysis of the ATP-driven glycolipid efflux pump DevBCA reveals complex organization with TolC/HgdD

(2013) Peter Staron et al.   FEBS LETTERS

Characterization of a major facilitator superfamily (MFS) tripartite efflux pump EmrCABsm from Stenotrophomonas maltophilia

(2013) Y.-W. Huang et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Redundancy in the periplasmic adaptor proteins AcrA and AcrE provides resilience and an ability to export substrates of multidrug efflux

(2013) Helen E. Smith et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Target optimization for peptide nucleic acid (PNA)-mediated antisense inhibition of the CmeABC multidrug efflux pump in Campylobacter jejuni

(2013) E. Oh et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Regulation of acrAB expression by cellular metabolites in Escherichia coli

(2013) C. Ruiz et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

MacA, a Periplasmic Membrane Fusion Protein of the Macrolide Transporter MacAB-TolC, Binds Lipopolysaccharide Core Specifically and with High Affinity

(2013) S. Lu et al.   JOURNAL OF BACTERIOLOGY

The α-barrel tip region of Escherichia coli TolC homologs of Vibrio vulnificus interacts with the MacA protein to form the functional macrolide-specific efflux pump MacAB-TolC

(2013) Minho Lee et al.   JOURNAL OF MICROBIOLOGY

Crystal Structures of CusC Review Conformational Changes Accompanying Folding and Transmembrane Channel Formation

(2013) Hsiang-Ting Lei et al.   JOURNAL OF MOLECULAR BIOLOGY

Evidence that the C-terminal region is involved in the stability and functionality of OprM in E. coli

(2013) Jiangping Bai et al.   MICROBIOLOGICAL RESEARCH

The TetR Family of Regulators

(2013) L. Cuthbertson et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

Tripartite efflux pumps: energy is required for dissociation, but not assembly or opening of the outer membrane channel of the pump

(2013) Thamarai K. Janganan et al.   MOLECULAR MICROBIOLOGY

On the role of TolC in multidrug efflux: the function and assembly of AcrAB-TolC tolerate significant depletion of intracellular TolC protein

(2013) Ganesh Krishnamoorthy et al.   MOLECULAR MICROBIOLOGY

Structural basis for the inhibition of bacterial multidrug exporters

(2013) Ryosuke Nakashima et al.   NATURE

Structural basis for the drug extrusion mechanism by a MATE multidrug transporter

(2013) Yoshiki Tanaka et al.   NATURE

Structural insights into H+-coupled multidrug extrusion by a MATE transporter

(2013) Min Lu et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

MEROPS: the database of proteolytic enzymes, their substrates and inhibitors

(2013) Neil D. Rawlings et al.   NUCLEIC ACIDS RESEARCH

Geometric principles in the assembly of  -helical bundles

(2013) J. V. Pratap et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY A-MATHEMATICAL PHYSICAL AND ENGINEERING SCIENCES

The Efflux Inhibitor Phenylalanine-Arginine Beta-Naphthylamide (PAβN) Permeabilizes the Outer Membrane of Gram-Negative Bacteria

(2013) Ryan P. Lamers et al.   PLoS One

Interplay between Three RND Efflux Pumps in Doxycycline-Selected Strains of Burkholderia thailandensis

(2013) Fabrice Vincent Biot et al.   PLoS One

Structures of intermediate transport states of ZneA, a Zn(II)/proton antiporter

(2013) J. E. Pak et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structures of a Na+-coupled, substrate-bound MATE multidrug transporter

(2013) M. Lu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Insight into the assembly mechanism in the supramolecular rings of the sodium-driven Vibrio flagellar motor from the structure of FlgT

(2013) H. Terashima et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Transcriptomic and biochemical analyses identify a family of chlorhexidine efflux proteins

(2013) K. A. Hassan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure of the YajR transporter suggests a transport mechanism based on the conserved motif A

(2013) Daohua Jiang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Refined structures of mouse P-glycoprotein

(2013) Jingzhi Li et al.   PROTEIN SCIENCE

Type I secretion systems – a story of appendices

(2013) Kerstin Kanonenberg et al.   RESEARCH IN MICROBIOLOGY

Structural Insight into the Giant Ca2+-Binding Adhesin SiiE: Implications for the Adhesion of Salmonella enterica to Polarized Epithelial Cells

(2013) Martin H. Griessl et al.   STRUCTURE

Structural advances for the major facilitator superfamily (MFS) transporters

(2013) Nieng Yan   TRENDS IN BIOCHEMICAL SCIENCES

The ABC-Type Efflux Pump MacAB Protects Salmonella enterica serovar Typhimurium from Oxidative Stress

(2013) L. M. Bogomolnaya et al.   mBio

The crystal structure of multidrug-resistance regulator RamR with multiple drugs

(2013) Suguru Yamasaki et al.   Nature Communications

Characterization of all RND-type multidrug efflux transporters inVibrio parahaemolyticus

(2013) Taira Matsuo et al.   MicrobiologyOpen

MOLECULAR DYNAMICS COMPUTER SIMULATIONS OF MULTIDRUG RND EFFLUX PUMPS

(2013) Paolo Ruggerone et al.   Computational and Structural Biotechnology Journal

Second Messenger Regulation of Biofilm Formation: Breakthroughs in Understanding c-di-GMP Effector Systems

(2012) Chelsea D. Boyd et al.   Annual Review of Cell and Developmental Biology

Involvement of the AcrAB-TolC Efflux Pump in the Resistance, Fitness, and Virulence of Enterobacter cloacae

(2012) Astrid Pérez et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

N-Terminal Region of CusB Is Sufficient for Metal Binding and Metal Transfer with the Metallochaperone CusF

(2012) Tiffany D. Mealman et al.   BIOCHEMISTRY

Locked on One Side Only: Ground State Dynamics of the Outer Membrane Efflux Duct TolC

(2012) Martin Raunest et al.   BIOCHEMISTRY

Unilateral Access Regulation: Ground State Dynamics of the Pseudomonas aeruginosa Outer Membrane Efflux Duct OprM

(2012) Dennis C. Koch et al.   BIOCHEMISTRY

Different Functions of MdtB and MdtC Subunits in the Heterotrimeric Efflux Transporter MdtB2C Complex of Escherichia coli

(2012) Hong-Suk Kim et al.   BIOCHEMISTRY

Porter domain opening and closing motions in the multi-drug efflux transporter AcrB

(2012) Nadine Fischer et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

A retrospective: Use of Escherichia coli as a vehicle to study phospholipid synthesis and function

(2012) William Dowhan   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

RND type efflux pump system MexAB-OprM of pseudomonas aeruginosa selects bacterial languages, 3-oxo-acyl-homoserine lactones, for cell-to-cell communication

(2012) Shu Minagawa et al.   BMC MICROBIOLOGY

Dissecting the Maturation Steps of the Lasso Peptide Microcin J25 in vitro

(2012) Kok-Phen Yan et al.   CHEMBIOCHEM

The RTX pore-forming toxin α-hemolysin of uropathogenicEscherichia coli: progress and perspectives

(2012) Travis J Wiles et al.   Future Microbiology

Functional study of the novel multidrug efflux pump KexD from Klebsiella pneumoniae

(2012) Wakano Ogawa et al.   GENE

Loss of or inhibition of all multidrug resistance efflux pumps of Salmonella enterica serovar Typhimurium results in impaired ability to form a biofilm

(2012) S. Baugh et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Identification of Transport Proteins Involved in Free Fatty Acid Efflux in Escherichia coli

(2012) R. M. Lennen et al.   JOURNAL OF BACTERIOLOGY

YknWXYZ Is an Unusual Four-Component Transporter with a Role in Protection against Sporulation-Delaying-Protein-Induced Killing of Bacillus subtilis

(2012) Y. Yamada et al.   JOURNAL OF BACTERIOLOGY

Assembly and Channel Opening of Outer Membrane Protein in Tripartite Drug Efflux Pumps of Gram-negative Bacteria

(2012) Yongbin Xu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The PseEF efflux system is a virulence factor of Pseudomonas syringae pv. syringae

(2012) Hyosun Cho et al.   JOURNAL OF MICROBIOLOGY

Charged Amino Acids (R83, E567, D617, E625, R669, and K678) of CusA Are Required for Metal Ion Transport in the Cus Efflux System

(2012) Chih-Chia Su et al.   JOURNAL OF MOLECULAR BIOLOGY

Interdomain Flexibility and pH-Induced Conformational Changes of AcrA Revealed by Molecular Dynamics Simulations

(2012) Beibei Wang et al.   JOURNAL OF PHYSICAL CHEMISTRY B

All0809/8/7 is a DevBCA-like ABC-type efflux pump required for diazotrophic growth in Anabaena sp. PCC 7120

(2012) P. Staron et al.   MICROBIOLOGY-SGM

Dissection of Mechanistic Principles of a Secondary Multidrug Efflux Protein

(2012) Nir Fluman et al.   MOLECULAR CELL

Menaquinone biosynthesis potentiates haem toxicity inStaphylococcus aureus

(2012) Catherine A. Wakeman et al.   MOLECULAR MICROBIOLOGY

Role of ATP binding and hydrolysis in assembly of MacAB-TolC macrolide transporter

(2012) Shuo Lu et al.   MOLECULAR MICROBIOLOGY

ABC transporters of antimicrobial peptides in Firmicutes bacteria - phylogeny, function and regulation

(2012) Susanne Gebhard   MOLECULAR MICROBIOLOGY

Ribosomally synthesized and post-translationally modified peptide natural products: overview and recommendations for a universal nomenclature

(2012) Paul G. Arnison et al.   NATURAL PRODUCT REPORTS

Crystal structure of a heterodimeric ABC transporter in its inward-facing conformation

(2012) Michael Hohl et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structure and mechanism of the tripartite CusCBA heavy-metal efflux complex

(2012) F. Long et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Vibrio cholerae vexH Encodes a Multiple Drug Efflux Pump That Contributes to the Production of Cholera Toxin and the Toxin Co-Regulated Pilus

(2012) Dawn L. Taylor et al.   PLoS One

Membrane Fusion Proteins of Type I Secretion System and Tripartite Efflux Pumps Share a Binding Motif for TolC in Gram-Negative Bacteria

(2012) Minho Lee et al.   PLoS One

An Inducible Fusaric Acid Tripartite Efflux Pump Contributes to the Fusaric Acid Resistance in Stenotrophomonas maltophilia

(2012) Rouh-Mei Hu et al.   PLoS One

Multidrug binding properties of the AcrB efflux pump characterized by molecular dynamics simulations

(2012) A. V. Vargiu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Conserved small protein associates with the multidrug efflux pump AcrB and differentially affects antibiotic resistance

(2012) E. C. Hobbs et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Transport of drugs by the multidrug transporter AcrB involves an access and a deep binding pocket that are separated by a switch-loop

(2012) T. Eicher et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An RTX Transporter Tethers Its Unfolded Substrate during Secretion via a Unique N-Terminal Domain

(2012) Justin Lecher et al.   STRUCTURE

Undecided membrane proteins insert in random topologies. Up, down and sideways: it does not really matter

(2012) Shimon Schuldiner   TRENDS IN BIOCHEMICAL SCIENCES

The role of lipids in defining membrane protein interactions: insights from mass spectrometry

(2012) Nelson P. Barrera et al.   TRENDS IN CELL BIOLOGY

Photo-induced proton gradients for the in vitro investigation of bacterial efflux pumps

(2012) Alice Verchère et al.   Scientific Reports

Advances in the Mass Spectrometry of Membrane Proteins: From Individual Proteins to Intact Complexes

(2011) Nelson P. Barrera et al.   Annual Review of Biochemistry

Binding of the RamR Repressor to Wild-Type and Mutated Promoters of theramAGene Involved in Efflux-Mediated Multidrug Resistance in Salmonella enterica Serovar Typhimurium

(2011) Sylvie Baucheron et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Contribution of Resistance-Nodulation-Division Efflux Pump OperonsmeU1-V-W-U2-Xto Multidrug Resistance of Stenotrophomonas maltophilia

(2011) Chao-Hsien Chen et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Yersinia pestisacrAB-tolCin Antibiotic Resistance and Virulence

(2011) Ida M. Lister et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Involvement of the SmeAB Multidrug Efflux Pump in Resistance to Plant Antimicrobials and Contribution to Nodulation Competitiveness in Sinorhizobium meliloti

(2011) Shima Eda et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Structural and Biochemical Characterization of Linear Dinucleotide Analogues Bound to the c-di-GMP-I Aptamer

(2011) Kathryn D. Smith et al.   BIOCHEMISTRY

Analysis of AcrB and AcrB/DARPin ligand complexes by LILBID MS

(2011) Lorenz Brandstätter et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Roles of Multidrug Efflux Pumps on the Biofilm Formation of Escherichia coli K-12

(2011) KAYO MATSUMURA et al.   BIOCONTROL SCIENCE

An alternative physiological role for the EmhABC efflux pump in Pseudomonas fluorescens cLP6a

(2011) Abigail A Adebusuyi et al.   BMC MICROBIOLOGY

Sequential Mechanism of Assembly of Multidrug Efflux Pump AcrAB-TolC

(2011) Elena B. Tikhonova et al.   CHEMISTRY & BIOLOGY

The PvdRT-OpmQ efflux pump controls the metal selectivity of the iron uptake pathway mediated by the siderophore pyoverdine in Pseudomonas aeruginosa

(2011) Mélissa Hannauer et al.   ENVIRONMENTAL MICROBIOLOGY

Strategies for bypassing the membrane barrier in multidrug resistant Gram-negative bacteria

(2011) Jean-Michel Bolla et al.   FEBS LETTERS

AcrA dependency of the AcrD efflux pump in Salmonella enterica serovar Typhimurium

(2011) Seiji Yamasaki et al.   JOURNAL OF ANTIBIOTICS

Characterization of the Induction and Cellular Role of the BaeSR Two-Component Envelope Stress Response of Escherichia coli

(2011) S. K. D. Leblanc et al.   JOURNAL OF BACTERIOLOGY

Efflux mediated adaptive and cross resistance to ciprofloxacin and benzalkonium chloride in Pseudomonas aeruginosa of dairy origin

(2011) Ankita Pagedar et al.   JOURNAL OF BASIC MICROBIOLOGY

Lantibiotic Transporter Requires Cooperative Functioning of the Peptidase Domain and the ATP Binding Domain

(2011) Mami Nishie et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Evidence for the Assembly of a Bacterial Tripartite Multidrug Pump with a Stoichiometry of 3:6:3

(2011) Thamarai K. Janganan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Multidrug Efflux Pump MdtEF Protects against Nitrosative Damage during the Anaerobic Respiration inEscherichia coli

(2011) Yiliang Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Novel ATP-driven Pathway of Glycolipid Export Involving TolC Protein

(2011) Peter Staron et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Functional Implications of an Intermeshing Cogwheel-like Interaction between TolC and MacA in the Action of Macrolide-specific Efflux Pump MacAB-TolC

(2011) Yongbin Xu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Funnel-like Hexameric Assembly of the Periplasmic Adapter Protein in the Tripartite Multidrug Efflux Pump in Gram-negative Bacteria

(2011) Yongbin Xu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The periplasmic membrane proximal domain of MacA acts as a switch in stimulation of ATP hydrolysis by MacB transporter

(2011) Sita D. Modali et al.   MOLECULAR MICROBIOLOGY

Crystal structure of the CusBA heavy-metal efflux complex of Escherichia coli

(2011) Chih-Chia Su et al.   NATURE

Structure and function of a membrane component SecDF that enhances protein export

(2011) Tomoya Tsukazaki et al.   NATURE

Structures of the multidrug exporter AcrB reveal a proximal multisite drug-binding pocket

(2011) Ryosuke Nakashima et al.   NATURE

Antiparallel EmrE exports drugs by exchanging between asymmetric structures

(2011) Emma A. Morrison et al.   NATURE

Crystal Structure of Escherichia coli CusC, the Outer Membrane Component of a Heavy Metal Efflux Pump

(2011) Rithika Kulathila et al.   PLoS One

A Requirement of TolC and MDR Efflux Pumps for Acid Adaptation and GadAB Induction in Escherichia coli

(2011) Kari N. W. Deininger et al.   PLoS One

MexEF-OprN Efflux Pump Exports the Pseudomonas Quinolone Signal (PQS) Precursor HHQ (4-hydroxy-2-heptylquinoline)

(2011) Martin G. Lamarche et al.   PLoS One

AcrB Trimer Stability and Efflux Activity, Insight from Mutagenesis Studies

(2011) Linliang Yu et al.   PLoS One

Structures of sequential open states in a symmetrical opening transition of the TolC exit duct

(2011) Xue-Yuan Pei et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An ATP-binding cassette transporter-like complex governs cell-wall hydrolysis at the bacterial cytokinetic ring

(2011) D. C. Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Electrical Spiking in Escherichia coli Probed with a Fluorescent Voltage-Indicating Protein

(2011) Joel M. Kralj et al.   SCIENCE

A Sorting Platform Determines the Order of Protein Secretion in Bacterial Type III Systems

(2011) M. Lara-Tejero et al.   SCIENCE

Mechanism and Function of the Outer Membrane Channel TolC in Multidrug Resistance and Physiology of Enterobacteria

(2011) Helen I. Zgurskaya et al.   Frontiers in Microbiology

Structure and Function of MARTX Toxins and Other Large Repetitive RTX Proteins

(2010) Karla J.F. Satchell   Annual Review of Microbiology

Optimized Nile Red Efflux Assay of AcrAB-TolC Multidrug Efflux System Shows Competition between Substrates

(2010) J. A. Bohnert et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Kinetic Parameters of Efflux of Penicillins by the Multidrug Efflux Transporter AcrAB-TolC of Escherichia coli

(2010) S. P. Lim et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

ramR Mutations in Clinical Isolates of Klebsiella pneumoniae with Reduced Susceptibility to Tigecycline

(2010) M. Hentschke et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Overexpression of Resistance-Nodulation-Cell Division Pump AdeFGH Confers Multidrug Resistance in Acinetobacter baumannii

(2010) S. Coyne et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Differential Regulation of Six Heavy Metal Efflux Systems in the Response of Myxococcus xanthus to Copper

(2010) A. Moraleda-Munoz et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

The tip region of the MacA α-hairpin is important for the binding to TolC to the Escherichia coli MacAB–TolC pump

(2010) Yongbin Xu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Promiscuous partnering and independent activity of MexB, the multidrug transporter protein fromPseudomonas aeruginosa

(2010) Alexander Welch et al.   BIOCHEMICAL JOURNAL

Escherichia coli genes that reduce the lethal effects of stress

(2010) Xiulin Han et al.   BMC MICROBIOLOGY

Evidence that the C-terminus of OprM is involved in the assembly of the VceAB-OprM efflux pump

(2010) Jiangping Bai et al.   FEBS LETTERS

Differing ability to transport nonmetal substrates by two RND-type metal exporters

(2010) Otakuye Conroy et al.   FEMS MICROBIOLOGY LETTERS

Host-specific symbiotic requirement of BdeAB, a RegR-controlled RND-type efflux system in Bradyrhizobium japonicum

(2010) Andrea Lindemann et al.   FEMS MICROBIOLOGY LETTERS

Tigecycline resistance in Serratia marcescens associated with up-regulation of the SdeXY-HasF efflux system also active against ciprofloxacin and cefpirome

(2010) M. Hornsey et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Impact of the RNA chaperone Hfq on multidrug resistance in Escherichia coli

(2010) J. Yamada et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

TolC dependency of multidrug efflux systems in Salmonella enterica serovar Typhimurium

(2010) Tsukasa Horiyama et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Various penA mutations together with mtrR, porB and ponA mutations in Neisseria gonorrhoeae isolates with reduced susceptibility to cefixime or ceftriaxone

(2010) S.-G. Lee et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Multiple Signals Direct the Assembly and Function of a Type 1 Secretion System

(2010) M. Masi et al.   JOURNAL OF BACTERIOLOGY

Functional Relationships between the AcrA Hairpin Tip Region and the TolC Aperture Tip Region for the Formation of the Bacterial Tripartite Efflux Pump AcrAB-TolC

(2010) H.-M. Kim et al.   JOURNAL OF BACTERIOLOGY

The ABC Transporter HrtAB Confers Resistance to Hemin Toxicity and Is Regulated in a Hemin-Dependent Manner by the ChrAS Two-Component System in Corynebacterium diphtheriae

(2010) L. A. Bibb et al.   JOURNAL OF BACTERIOLOGY

Asymmetric ATP Hydrolysis Cycle of the Heterodimeric Multidrug ABC Transport Complex TmrAB fromThermus thermophilus

(2010) Ariane Zutz et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Opening of the Outer Membrane Protein Channel in Tripartite Efflux Pumps Is Induced by Interaction with the Membrane Fusion Partner

(2010) Thamarai K. Janganan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Rate of Folding Dictates Substrate Secretion by theEscherichia coliHemolysin Type 1 Secretion System

(2010) Patrick J. Bakkes et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Crystal Structure of the Peptidase Domain ofStreptococcusComA, a Bifunctional ATP-binding Cassette Transporter Involved in the Quorum-sensing Pathway

(2010) Seiji Ishii et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Characterization of an Asymmetric Occluded State of P-glycoprotein with Two Bound Nucleotides

(2010) Alena Siarheyeva et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Correlation of Overexpression of Efflux Pump Genes with Antibiotic Resistance in Escherichia coli Strains Clinically Isolated from Urinary Tract Infection Patients

(2010) T. Yasufuku et al.   JOURNAL OF CLINICAL MICROBIOLOGY

Dynamics and Structural Changes Induced by ATP Binding in SAV1866, a Bacterial ABC Exporter

(2010) Jean-Paul Becker et al.   JOURNAL OF PHYSICAL CHEMISTRY B

AcrA suppressor alterations reverse the drug hypersensitivity phenotype of a TolC mutant by inducing TolC aperture opening

(2010) Jon W. Weeks et al.   MOLECULAR MICROBIOLOGY

Structure of a cation-bound multidrug and toxic compound extrusion transporter

(2010) Xiao He et al.   NATURE

Crystal structures of the CusA efflux pump suggest methionine-mediated metal transport

(2010) Feng Long et al.   NATURE

Metal-induced conformational changes in ZneB suggest an active role of membrane fusion proteins in efflux resistance systems

(2010) F. De Angelis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Imaging mass spectrometry of intraspecies metabolic exchange revealed the cannibalistic factors of Bacillus subtilis

(2010) W.-T. Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural and Dynamical Insights into the Opening Mechanism of P. aeruginosa OprM Channel

(2010) Gilles Phan et al.   STRUCTURE

Biofilms

(2010) D. Lopez et al.   Cold Spring Harbor Perspectives in Biology

Bacterial Nanomachines: The Flagellum and Type III Injectisome

(2010) M. Erhardt et al.   Cold Spring Harbor Perspectives in Biology

The Bacterial Cell Envelope

(2010) T. J. Silhavy et al.   Cold Spring Harbor Perspectives in Biology

Drug export and allosteric coupling in a multidrug transporter revealed by molecular simulations

(2010) Xin-Qiu Yao et al.   Nature Communications

Autoproteolytic Activation of Bacterial Toxins

(2010) Aimee Shen   Toxins

Role of AbeS, a Novel Efflux Pump of the SMR Family of Transporters, in Resistance to Antimicrobial Agents in Acinetobacter baumannii

(2009) V. B. Srinivasan et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Klebsiella pneumoniae AcrAB Efflux Pump Contributes to Antimicrobial Resistance and Virulence

(2009) E. Padilla et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Generic and Specific Adaptive Responses of Streptococcus pneumoniae to Challenge with Three Distinct Antimicrobial Peptides, Bacitracin, LL-37, and Nisin

(2009) J. A. Majchrzykiewicz et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Association of Hemolytic Activity of Pseudomonas entomophila, a Versatile Soil Bacterium, with Cyclic Lipopeptide Production

(2009) I. Vallet-Gely et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Identification, cloning, and functional characterization of EmrD-3, a putative multidrug efflux pump of the major facilitator superfamily from Vibrio cholerae O395

(2009) Kenneth P. Smith et al.   ARCHIVES OF MICROBIOLOGY

The multidrug resistance efflux complex, EmrAB from Escherichia coli forms a dimer in vitro

(2009) Mikio Tanabe et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

ATP-induced FliI hexamerization facilitates bacterial flagellar protein export

(2009) Ken-ichi Kazetani et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Crystal Structure of the Periplasmic Region of MacB, a Noncanonic ABC Transporter,

(2009) Yongbin Xu et al.   BIOCHEMISTRY

Crucial Role of Asp408 in the Proton Translocation Pathway of Multidrug Transporter AcrB: Evidence from Site-Directed Mutagenesis and Carbodiimide Labeling

(2009) Markus A. Seeger et al.   BIOCHEMISTRY

Structural and Chemical Basis for Glucosamine 6-Phosphate Binding and Activation of theglmSRibozyme†‡

(2009) Jesse C. Cochrane et al.   BIOCHEMISTRY

Assembly and transport mechanism of tripartite drug efflux systems

(2009) Rajeev Misra et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Drug transport mechanism of the AcrB efflux pump

(2009) Klaas M. Pos   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

EmrE, a model for studying evolution and mechanism of ion-coupled transporters

(2009) Shimon Schuldiner   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Transitions between Closed and Open Conformations of TolC: The Effects of Ions in Simulations

(2009) Robert Schulz et al.   BIOPHYSICAL JOURNAL

Assessment of three Resistance-Nodulation-Cell Division drug efflux transporters of Burkholderia cenocepacia in intrinsic antibiotic resistance

(2009) Silvia Buroni et al.   BMC MICROBIOLOGY

The Structure and Biological Aspects of Peptide Antibiotic Microcin J25

(2009) Paula Vincent et al.   CURRENT MEDICINAL CHEMISTRY

Functional interaction sites of OprM with MexAB in thePseudomonas aeruginosamultidrug efflux pump

(2009) Eisaku Yoshihara et al.   FEMS MICROBIOLOGY LETTERS

The C-Terminal Domain of AcrA Is Essential for the Assembly and Function of the Multidrug Efflux Pump AcrAB-TolC

(2009) Q. Ge et al.   JOURNAL OF BACTERIOLOGY

Interplay between Two RND Systems Mediating Antimicrobial Resistance in Brucella suis

(2009) F. A. Martin et al.   JOURNAL OF BACTERIOLOGY

Tryptophan Cu(I)–π interaction fine-tunes the metal binding properties of the bacterial metallochaperone CusF

(2009) Isabell R. Loftin et al.   JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY

Membrane Porters of ATP-Binding Cassette Transport Systems Are Polyphyletic

(2009) Bin Wang et al.   JOURNAL OF MEMBRANE BIOLOGY

Identification of the Interactions Critical for Propeptide-Catalyzed Folding of Tk-Subtilisin

(2009) Shun-ichi Tanaka et al.   JOURNAL OF MOLECULAR BIOLOGY

Crystal Structure of the Multidrug Exporter MexB from Pseudomonas aeruginosa

(2009) Gaby Sennhauser et al.   JOURNAL OF MOLECULAR BIOLOGY

Crystal Structure of the Periplasmic Component of a Tripartite Macrolide-Specific Efflux Pump

(2009) Soohwan Yum et al.   JOURNAL OF MOLECULAR BIOLOGY

Crystal Structure of the Membrane Fusion Protein CusB from Escherichia coli

(2009) Chih-Chia Su et al.   JOURNAL OF MOLECULAR BIOLOGY

Different effects of transcriptional regulators MarA, SoxS and Rob on susceptibility of Escherichia coli to cationic antimicrobial peptides (CAMPs): Rob-dependent CAMP induction of the marRAB operon

(2009) D. M. Warner et al.   MICROBIOLOGY-SGM

Gene cloning and characteristics of the RND-type multidrug efflux pump MuxABC-OpmB possessing two RND components in Pseudomonas aeruginosa

(2009) T. Mima et al.   MICROBIOLOGY-SGM

Effect of subinhibitory concentrations of benzalkonium chloride on the competitiveness of Pseudomonas aeruginosa grown in continuous culture

(2009) P. H. Mc Cay et al.   MICROBIOLOGY-SGM

MzrA: a novel modulator of the EnvZ/OmpR two-component regulon

(2009) Henri Gerken et al.   MOLECULAR MICROBIOLOGY

Follow the leader: the use of leader peptides to guide natural product biosynthesis

(2009) Trent J Oman et al.   Nature Chemical Biology

Mass spectrometry of membrane transporters reveals subunit stoichiometry and interactions

(2009) Nelson P Barrera et al.   NATURE METHODS

Compartmentalized function through cell differentiation in filamentous cyanobacteria

(2009) Enrique Flores et al.   NATURE REVIEWS MICROBIOLOGY

ABC transporters: the power to change

(2009) Douglas C. Rees et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

A coordinated network of transporters with overlapping specificities provides a robust survival strategy

(2009) N. Tal et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular basis of pyoverdine siderophore recycling in Pseudomonas aeruginosa

(2009) F. Imperi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The assembled structure of a complete tripartite bacterial multidrug efflux pump

(2009) M. F. Symmons et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Kinetic control of TolC recruitment by multidrug efflux complexes

(2009) E. B. Tikhonova et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An ABC transport system that maintains lipid asymmetry in the Gram-negative outer membrane

(2009) J. C. Malinverni et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Kinetic behavior of the major multidrug efflux pump AcrB of Escherichia coli

(2009) K. Nagano et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure of P-Glycoprotein Reveals a Molecular Basis for Poly-Specific Drug Binding

(2009) S. G. Aller et al.   SCIENCE

There is a baby in the bath water: AcrB contamination is a major problem in membrane-protein crystallization

(2008) David Veesler et al.   Acta Crystallographica Section F-Structural Biology and Crystallization Communications

Ins and Outs of Major Facilitator Superfamily Antiporters

(2008) Christopher J. Law et al.   Annual Review of Microbiology

Role of the AheABC Efflux Pump in Aeromonas hydrophila Intrinsic Multidrug Resistance

(2008) M. Hernould et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

RamA Confers Multidrug Resistance in Salmonella enterica via Increased Expression of acrB, Which Is Inhibited by Chlorpromazine

(2008) A. M. Bailey et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Inactivation of Efflux Pumps Abolishes Bacterial Biofilm Formation

(2008) M. Kvist et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

In VitroReconstitution and Substrate Specificity of a Lantibiotic Protease†

(2008) L. A. Furgerson Ihnken et al.   BIOCHEMISTRY

ATP-binding cassette transporters in Escherichia coli

(2008) Anastassiia Moussatova et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Bacterial multidrug transport through the lens of the major facilitator superfamily

(2008) Nir Fluman et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Structural and functional diversity of bacterial membrane fusion proteins

(2008) Helen I. Zgurskaya et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Multidrug efflux transporters in the MATE family

(2008) Teruo Kuroda et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Mechanisms of RND multidrug efflux pumps

(2008) Hiroshi Nikaido et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Properties and Expression of a Multidrug Efflux Pump AcrAB-KocC from Klebsiella pneumoniae

(2008) Dai-Wei Li et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Gating at Both Ends and Breathing in the Middle: Conformational Dynamics of TolC

(2008) Loredana Vaccaro et al.   BIOPHYSICAL JOURNAL

The AcrAB RND efflux system from the live vaccine strain ofFrancisella tularensisis a multiple drug efflux system that is required for virulence in mice

(2008) Xiaowen R. Bina et al.   FEMS MICROBIOLOGY LETTERS

Vibrio cholerae RND Family Efflux Systems Are Required for Antimicrobial Resistance, Optimal Virulence Factor Production, and Colonization of the Infant Mouse Small Intestine

(2008) X. R. Bina et al.   INFECTION AND IMMUNITY

Covalently Linked Trimer of the AcrB Multidrug Efflux Pump Provides Support for the Functional Rotating Mechanism

(2008) Y. Takatsuka et al.   JOURNAL OF BACTERIOLOGY

Staphylococcus aureus HrtA Is an ATPase Required for Protection against Heme Toxicity and Prevention of a Transcriptional Heme Stress Response

(2008) D. L. Stauff et al.   JOURNAL OF BACTERIOLOGY

MacAB Is Involved in the Secretion of Escherichia coli Heat-Stable Enterotoxin II

(2008) H. Yamanaka et al.   JOURNAL OF BACTERIOLOGY

CmeR Functions as a Pleiotropic Regulator and Is Required for Optimal Colonization of Campylobacter jejuni In Vivo

(2008) B. Guo et al.   JOURNAL OF BACTERIOLOGY

MtrR Modulates rpoH Expression and Levels of Antimicrobial Resistance in Neisseria gonorrhoeae

(2008) J. P. Folster et al.   JOURNAL OF BACTERIOLOGY

MacB ABC Transporter Is a Dimer Whose ATPase Activity and Macrolide-binding Capacity Are Regulated by the Membrane Fusion Protein MacA

(2008) Hong Ting Lin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Molecular Events Involved in a Single Cycle of Ligand Transfer from an ATP Binding Cassette Transporter, LolCDE, to a Molecular Chaperone, LolA

(2008) Naohiro Taniguchi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Changes of Protein Folding Pathways by Circular Permutation

(2008) Ellinor Haglund et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Effect of putative efflux pump inhibitors and inducers on the antimicrobial susceptibility of Campylobacter jejuni and Campylobacter coli

(2008) Minna Hannula et al.   JOURNAL OF MEDICAL MICROBIOLOGY

Assembly and Channel Opening in a Bacterial Drug Efflux Machine

(2008) Vassiliy N. Bavro et al.   MOLECULAR CELL

The structure of the efflux pump AcrB in complex with bile acid

(2008) David Drew et al.   MOLECULAR MEMBRANE BIOLOGY

Engineered disulfide bonds support the functional rotation mechanism of multidrug efflux pump AcrB

(2008) Markus A Seeger et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Opening of the ADP-bound active site in the ABC transporter ATPase dimer: Evidence for a constant contact, alternating sites model for the catalytic cycle

(2008) Peter M. Jones et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Small Molecule-Induced Allosteric Activation of the Vibrio cholerae RTX Cysteine Protease Domain

(2008) P. J. Lupardus et al.   SCIENCE

The High-Affinity E. coli Methionine ABC Transporter: Structure and Allosteric Regulation

(2008) N. S. Kadaba et al.   SCIENCE

Efflux pump gene hefA of Helicobacter pylori plays an important role in multidrug resistance

(2008) Zhi-Qiang Liu et al.   WORLD JOURNAL OF GASTROENTEROLOGY

An RND-Type Efflux System in Borrelia burgdorferi Is Involved in Virulence and Resistance to Antimicrobial Compounds

(2008) Ignas Bunikis et al.   PLoS Pathogens

The complete genome, comparative and functional analysis of Stenotrophomonas maltophilia reveals an organism heavily shielded by drug resistance determinants

(2008) Lisa C Crossman et al.   GENOME BIOLOGY