期刊
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
卷 564, 期 -, 页码 327-343出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.abb.2014.10.013
关键词
Membrane protein; Folding; Amphipols; Kinetics; Thermodynamic stability; Outer membrane proteins; Bacteriorhodopsin; G protein-coupled receptors; A8-35
资金
- Deutsche Forschungsgemeinschaft
- University of Konstanz
- University of Kassel
- French Centre National de la Recherche Scientifique, University Paris-7 Denis Diderot
- Human Frontier Scientific Program Organization
- European Community
- Agence Nationale pour la Recherche
- US National Institutes of Health
Amphipols (APols) are a family of amphipathic polymers designed to keep transmembrane proteins (TMPs) soluble in aqueous solutions in the absence of detergent. APols have proven remarkably efficient at (i) stabilizing TMPs, as compared to detergent solutions, and (ii) folding them from a denatured state to a native, functional one. The underlying physical chemical mechanisms are discussed. (C) 2014 Elsevier Inc. All rights reserved.
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