期刊
RESEARCH IN MICROBIOLOGY
卷 169, 期 7-8, 页码 455-460出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.resmic.2017.09.004
关键词
Multidrug resistance; Multidrug efflux; Secondary transport; MdfA; Escherichia coli; Promiscuity
类别
资金
- German-Israeli Foundation for Scientific Research and Development (GIF) [I-1202-248.9/2012]
- Weizmann Institute Clore-Krenter-Katz Center
MdfA is an interesting member of a large group of secondary multidrug (Mdr) transporters. Through genetic, biochemical and biophysical studies of MdfA, many challenging aspects of the multidrug transport phenomenon have been addressed. This includes its ability to interact with chemically unrelated drugs and how it utilizes energy to drive efflux of compounds that are not only structurally, but also electrically, different. Admittedly, however, despite all efforts and a recent pioneering structural contribution, several important mechanistic issues of the promiscuous capabilities of MdfA still seek better molecular and dynamic understanding. (C) 2017 Institut Pasteur. Published by Elsevier Masson SAS. All rights reserved.
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