Mutations in the TolC Periplasmic Domain Affect Substrate Specificity of the AcrAB-TolC Pump
出版年份 2020 全文链接
标题
Mutations in the TolC Periplasmic Domain Affect Substrate Specificity of the AcrAB-TolC Pump
作者
关键词
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出版物
Frontiers in Molecular Biosciences
Volume 7, Issue -, Pages -
出版商
Frontiers Media SA
发表日期
2020-07-21
DOI
10.3389/fmolb.2020.00166
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注意:仅列出部分参考文献,下载原文获取全部文献信息。- Structures of the wild-type MexAB–OprM tripartite pump reveal its complex formation and drug efflux mechanism
- (2019) Kenta Tsutsumi et al. Nature Communications
- In situ structure and assembly of the multidrug efflux pump AcrAB-TolC
- (2019) Xiaodong Shi et al. Nature Communications
- Identification of binding residues between periplasmic adapter protein (PAP) and RND efflux pumps explains PAP-pump promiscuity and roles in antimicrobial resistance
- (2019) Helen E. McNeil et al. PLoS Pathogens
- Type 1 Does The Two-Step: Type 1 Secretion Substrates With A Functional Periplasmic Intermediate
- (2018) Timothy J. Smith et al. JOURNAL OF BACTERIOLOGY
- Multidrug efflux pumps: structure, function and regulation
- (2018) Dijun Du et al. NATURE REVIEWS MICROBIOLOGY
- An allosteric transport mechanism for the AcrAB-TolC multidrug efflux pump
- (2017) Zhao Wang et al. eLife
- Bifurcation kinetics of drug uptake by Gram-negative bacteria
- (2017) David A. Westfall et al. PLoS One
- Emergence of a Potent Multidrug Efflux Pump Variant That Enhances Campylobacter Resistance to Multiple Antibiotics
- (2016) Hong Yao et al. mBio
- Tripartite assembly of RND multidrug efflux pumps
- (2016) Laetitia Daury et al. Nature Communications
- A Fluorescent Microplate Assay Quantifies Bacterial Efflux and Demonstrates Two Distinct Compound Binding Sites in AcrB
- (2015) Ramkumar Iyer et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- AcrB-AcrA Fusion Proteins That Act as Multidrug Efflux Transporters
- (2015) Katsuhiko Hayashi et al. JOURNAL OF BACTERIOLOGY
- Reversal of the Drug Binding Pocket Defects of the AcrB Multidrug Efflux Pump Protein of Escherichia coli
- (2015) Ketaki Soparkar et al. JOURNAL OF BACTERIOLOGY
- Structure of the Tripartite Multidrug Efflux Pump AcrAB-TolC Suggests an Alternative Assembly Mode
- (2015) Jin-Sik Kim et al. MOLECULES AND CELLS
- AcrB drug-binding pocket substitution confers clinically relevant resistance and altered substrate specificity
- (2015) Jessica M. A. Blair et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- In vitro transport activity of the fully assembled MexAB-OprM efflux pump from Pseudomonas aeruginosa
- (2015) Alice Verchère et al. Nature Communications
- Architecture and roles of periplasmic adaptor proteins in tripartite efflux assemblies
- (2015) Martyn F. Symmons et al. Frontiers in Microbiology
- New OprM structure highlighting the nature of the N-terminal anchor
- (2015) Laura Monlezun et al. Frontiers in Microbiology
- Structure of the AcrAB–TolC multidrug efflux pump
- (2014) Dijun Du et al. NATURE
- Tracking metal ions through a Cu/Ag efflux pump assigns the functional roles of the periplasmic proteins
- (2014) K. N. Chacon et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Coupling of remote alternating-access transport mechanisms for protons and substrates in the multidrug efflux pump AcrB
- (2014) Thomas Eicher et al. eLife
- Characterization of a Novel Pyranopyridine Inhibitor of the AcrAB Efflux Pump of Escherichia coli
- (2013) Timothy J. Opperman et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Redundancy in the periplasmic adaptor proteins AcrA and AcrE provides resilience and an ability to export substrates of multidrug efflux
- (2013) Helen E. Smith et al. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
- Regulation of acrAB expression by cellular metabolites in Escherichia coli
- (2013) C. Ruiz et al. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
- Evidence that the C-terminal region is involved in the stability and functionality of OprM in E. coli
- (2013) Jiangping Bai et al. MICROBIOLOGICAL RESEARCH
- Tripartite efflux pumps: energy is required for dissociation, but not assembly or opening of the outer membrane channel of the pump
- (2013) Thamarai K. Janganan et al. MOLECULAR MICROBIOLOGY
- On the role of TolC in multidrug efflux: the function and assembly of AcrAB-TolC tolerate significant depletion of intracellular TolC protein
- (2013) Ganesh Krishnamoorthy et al. MOLECULAR MICROBIOLOGY
- Structural basis for the inhibition of bacterial multidrug exporters
- (2013) Ryosuke Nakashima et al. NATURE
- Transport of drugs by the multidrug transporter AcrB involves an access and a deep binding pocket that are separated by a switch-loop
- (2012) T. Eicher et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Sequential Mechanism of Assembly of Multidrug Efflux Pump AcrAB-TolC
- (2011) Elena B. Tikhonova et al. CHEMISTRY & BIOLOGY
- Vestibules Are Part of the Substrate Path in the Multidrug Efflux Transporter AcrB of Escherichia coli
- (2011) F. Husain et al. JOURNAL OF BACTERIOLOGY
- Evidence for the Assembly of a Bacterial Tripartite Multidrug Pump with a Stoichiometry of 3:6:3
- (2011) Thamarai K. Janganan et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Funnel-like Hexameric Assembly of the Periplasmic Adapter Protein in the Tripartite Multidrug Efflux Pump in Gram-negative Bacteria
- (2011) Yongbin Xu et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Structures of the multidrug exporter AcrB reveal a proximal multisite drug-binding pocket
- (2011) Ryosuke Nakashima et al. NATURE
- Structures of sequential open states in a symmetrical opening transition of the TolC exit duct
- (2011) Xue-Yuan Pei et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Mechanism and Function of the Outer Membrane Channel TolC in Multidrug Resistance and Physiology of Enterobacteria
- (2011) Helen I. Zgurskaya et al. Frontiers in Microbiology
- Optimized Nile Red Efflux Assay of AcrAB-TolC Multidrug Efflux System Shows Competition between Substrates
- (2010) J. A. Bohnert et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Evidence that the C-terminus of OprM is involved in the assembly of the VceAB-OprM efflux pump
- (2010) Jiangping Bai et al. FEBS LETTERS
- Substrate path in the AcrB multidrug efflux pump of Escherichia coli
- (2010) Fasahath Husain et al. MOLECULAR MICROBIOLOGY
- Metal-induced conformational changes in ZneB suggest an active role of membrane fusion proteins in efflux resistance systems
- (2010) F. De Angelis et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Assembly and transport mechanism of tripartite drug efflux systems
- (2009) Rajeev Misra et al. BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS
- An Excretory Function for the Escherichia coli Outer Membrane Pore TolC: Upregulation of marA and soxS Transcription and Rob Activity Due to Metabolites Accumulated in tolC Mutants
- (2009) J. L. Rosner et al. JOURNAL OF BACTERIOLOGY
- The assembled structure of a complete tripartite bacterial multidrug efflux pump
- (2009) M. F. Symmons et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Direct Metal Transfer between Periplasmic Proteins Identifies a Bacterial Copper Chaperone†
- (2008) Ireena Bagai et al. BIOCHEMISTRY
- MacB ABC Transporter Is a Dimer Whose ATPase Activity and Macrolide-binding Capacity Are Regulated by the Membrane Fusion Protein MacA
- (2008) Hong Ting Lin et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Assembly and Channel Opening in a Bacterial Drug Efflux Machine
- (2008) Vassiliy N. Bavro et al. MOLECULAR CELL
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