AcrB drug-binding pocket substitution confers clinically relevant resistance and altered substrate specificity
出版年份 2015 全文链接
标题
AcrB drug-binding pocket substitution confers clinically relevant resistance and altered substrate specificity
作者
关键词
-
出版物
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Volume 112, Issue 11, Pages 3511-3516
出版商
Proceedings of the National Academy of Sciences
发表日期
2015-03-04
DOI
10.1073/pnas.1419939112
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- Improving olefin tolerance and production in E. coli using native and evolved AcrB
- (2015) Florence Mingardon et al. BIOTECHNOLOGY AND BIOENGINEERING
- Molecular Mechanism of MBX2319 Inhibition of Escherichia coli AcrB Multidrug Efflux Pump and Comparison with Other Inhibitors
- (2014) Attilio V. Vargiu et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Random Mutagenesis of the Multidrug Transporter AcrB from Escherichia coli for Identification of Putative Target Residues of Efflux Pump Inhibitors
- (2014) Sabine Schuster et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Multidrug efflux pumps in Gram-negative bacteria and their role in antibiotic resistance
- (2014) Jessica MA Blair et al. Future Microbiology
- Molecular mechanisms of antibiotic resistance
- (2014) Jessica M. A. Blair et al. NATURE REVIEWS MICROBIOLOGY
- Structure and Operation of Bacterial Tripartite Pumps
- (2013) Philip Hinchliffe et al. Annual Review of Microbiology
- Some Ligands Enhance the Efflux of Other Ligands by the Escherichia coli Multidrug Pump AcrB
- (2013) Alfred D. Kinana et al. BIOCHEMISTRY
- Directed evolution of an E. coli inner membrane transporter for improved efflux of biofuel molecules
- (2013) Jee Foo et al. Biotechnology for Biofuels
- RND Efflux Pumps: Structural Information Translated into Function and Inhibition Mechanisms
- (2013) Paolo Ruggerone et al. CURRENT TOPICS IN MEDICINAL CHEMISTRY
- Genetic inactivation of acrAB or inhibition of efflux induces expression of ramA
- (2013) A. J. Lawler et al. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
- Drug Uptake Pathways of Multidrug Transporter AcrB Studied by Molecular Simulations and Site-Directed Mutagenesis Experiments
- (2013) Xin-Qiu Yao et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Structural basis for the inhibition of bacterial multidrug exporters
- (2013) Ryosuke Nakashima et al. NATURE
- Enhancing Tolerance to Short-Chain Alcohols by Engineering the Escherichia coli AcrB Efflux Pump to Secrete the Non-native Substrate n-Butanol
- (2013) Michael A. Fisher et al. ACS Synthetic Biology
- Fast gapped-read alignment with Bowtie 2
- (2012) Ben Langmead et al. NATURE METHODS
- Exploring Binding Properties of Agonists Interacting with a δ-Opioid Receptor
- (2012) Francesca Collu et al. PLoS One
- Multidrug binding properties of the AcrB efflux pump characterized by molecular dynamics simulations
- (2012) A. V. Vargiu et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Transport of drugs by the multidrug transporter AcrB involves an access and a deep binding pocket that are separated by a switch-loop
- (2012) T. Eicher et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Vestibules Are Part of the Substrate Path in the Multidrug Efflux Transporter AcrB of Escherichia coli
- (2011) F. Husain et al. JOURNAL OF BACTERIOLOGY
- Effect of the F610A Mutation on Substrate Extrusion in the AcrB Transporter: Explanation and Rationale by Molecular Dynamics Simulations
- (2011) Attilio V. Vargiu et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Evolution combined with genomic study elucidates genetic bases of isobutanol tolerance in Escherichia coli
- (2011) Jeremy J Minty et al. Microbial Cell Factories
- Structures of the multidrug exporter AcrB reveal a proximal multisite drug-binding pocket
- (2011) Ryosuke Nakashima et al. NATURE
- BEDTools: a flexible suite of utilities for comparing genomic features
- (2010) Aaron R. Quinlan et al. BIOINFORMATICS
- Single Nucleotide Polymorphism Analysis of the Major Tripartite Multidrug Efflux Pump of Escherichia coli: Functional Conservation in Disparate Animal Reservoirs despite Exposure to Antimicrobial Chemotherapy
- (2009) C. A. Elkins et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- The Sequence Alignment/Map format and SAMtools
- (2009) H. Li et al. BIOINFORMATICS
- Ciprofloxacin selects for multidrug resistance in Salmonella enterica serovar Typhimurium mediated by at least two different pathways
- (2009) V. Ricci et al. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
- Site-Directed Mutagenesis Reveals Putative Substrate Binding Residues in the Escherichia coli RND Efflux Pump AcrB
- (2008) J. A. Bohnert et al. JOURNAL OF BACTERIOLOGY
- Clinically relevant mutations that cause derepression of theNeisseria gonorrhoeaeMtrC-MtrD-MtrE Efflux pump system confer different levels of antimicrobial resistance andin vivofitness
- (2008) Douglas M. Warner et al. MOLECULAR MICROBIOLOGY
Discover Peeref hubs
Discuss science. Find collaborators. Network.
Join a conversationAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started