Review
Cell Biology
Johannes Westman, Sergio Grinstein
Summary: The ability of phagosomes to halt microbial growth is closely linked to their ability to acidify their luminal pH, but certain pathogens can survive and replicate inside phagosomes by targeting the pH-regulatory machinery of host cells to survive or escape.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Nanoscience & Nanotechnology
Xiaojun Zeng, Tianli Nie, Chao Zhao, Guozhen Zhu, Xiaozhen Zhang, Ronghai Yu, Galen D. Stucky, Renchao Che
Summary: The strong interaction between the matrix and the active centers plays a crucial role in the design of high-performance electromagnetic wave absorption materials. This study successfully designed a material with excellent electromagnetic wave absorption performance by constructing a strong interaction between CoAl-LDH matrix and CoFe-CoCx@NC centers. The experimental and theoretical results demonstrate the importance of material combination and structure in achieving high reflection loss and good matching performance.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Review
Biochemistry & Molecular Biology
Asahiro Morishita, Kyoko Oura, Tomoko Tadokoro, Koji Fujita, Joji Tani, Tsutomu Masaki
Summary: The liver is a non-immunological organ involved in metabolic activities, nutrient storage, and detoxification. Resident immune cells in the liver drive immunological reactions and certain microRNAs are associated with the immune response to pathogens, although the exact mechanism of miRNA interference in these interactions remains unclear.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Jian Luo, Jinzhi Xu, Chaolu Xie, Zuoming Zhao, Junrui Guo, Yuan Wen, Tian Li, Zeyang Zhou
Summary: This study reveals the mechanism by which microsporidia manipulate host mitochondrial fragmentation (HMF), thus providing references for understanding the interactions between microsporidia and host mitochondria.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biotechnology & Applied Microbiology
Leon Kemper, Andreas Hensel
Summary: Campylobacter jejuni, causing severe enteritis, has unique features and adapts effectively to environmental conditions. The review summarizes the strategies of C. jejuni for host-pathogen interaction, providing insights for future drug development.
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
(2023)
Article
Plant Sciences
Supratim Basu, Elena Sineva, Liza Nguyen, Narattam Sikdar, Jong Won Park, Mikhail Sinev, Madhurababu Kunta, Goutam Gupta
Summary: This article introduces a novel therapy for citrus Huanglongbing (HLB) and apple fire blight by enhancing the innate immunity of the host plants. The researchers constructed chimeras with observed or predicted antibacterial activity and demonstrated their effectiveness in clearing the causative bacteria and augmenting the host's immune response.
FRONTIERS IN PLANT SCIENCE
(2022)
Review
Microbiology
Krzysztof Grzymajlo
Summary: This review sheds light on the current understanding of the interactions between enteric pathogens, host gut microbiota, and the gastrointestinal tract. It discusses the strengths and limitations of in vitro and in vivo models used in studying Salmonella-host-microbiome interactions, and outlines future challenges and directions.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Microbiology
Liam Caven, Rey Carabeo
Summary: Infection of the female genital tract by Chlamydia trachomatis can lead to severe fibrotic sequelae, and it remains unclear if intrinsic properties of the upper genital tract exacerbate the fibrotic response. This study found that cervical epithelial cells have enhanced expression of fibrosis-associated signal factors and infection-mediated induction of fibrosis-related genes. The activation of YAP, a transcriptional cofactor, by chlamydial infection in cervical epithelial cells was identified as a potential driver of fibrotic gene expression. These findings provide new insights into the mechanism of Chlamydia-induced fibrosis and suggest YAP as a potential therapeutic target for preventing scarring of the female genital tract.
Article
Immunology
Camila Gachet-Castro, Felipe Freitas-Castro, Raul Alexander Gonzales-Cordova, Carol Kobori da Fonseca, Marcelo Damario Gomes, Hellen Cristina Ishikawa-Ankerhold, Munira Muhammad Abdel Baqui
Summary: This study reveals that the parasite Trypanosoma cruzi can modulate host transcription and splicing machinery during infection by appropriating the host cell nucleus, specifically targeting the U2AF35 auxiliary factor.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Immunology
Maguy Hamie, Rania Najm, Carine Deleuze-Masquefa, Pierre Antoine Bonnet, Jean-Francois Dubremetz, Marwan El Sabban, Hiba El Hajj
Summary: Imiquimod is an efficient immunomodulatory drug against acute and chronic toxoplasmosis, reducing the number of brain cysts and rendering the remaining cysts un-infectious in vivo. It upregulates the expression of Toll-like receptors to activate the MyD88 pathway and induce an immune response to control reactivated Toxoplasma foci.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Jordi Gomez Borrego, Marc Torrent Burgas
Summary: Adhesion and colonization of host cells by pathogenic bacteria rely on protein-protein interactions (PPIs). This study developed a filtering process to obtain a reliable list of domains and motifs participating in PPIs between bacteria and human cells. Structural analysis revealed that human proteins involved in these interactions are rich in alpha helix and disordered regions. The most significant domain-domain interactions were validated, but verifying domain-motif interactions was more challenging. Post-translational modifications, especially phosphorylation, also play a role in these interactions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Engineering, Chemical
Chengpeng Wei, Weisheng Yu, Xian Liang, Yang Zhang, Fan Zhang, Wanjie Song, Xiaolin Ge, Liang Wu, Tongwen Xu
Summary: Constructing ion conduction channels through supramolecular host-guest interaction enhances ion conductivity and improves the performance of anion exchange membranes (AEMs).
JOURNAL OF MEMBRANE SCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Javier Macho Rendon, Rocio Rebollido-Rios, Marc Torrent Burgas
Summary: Protein-protein interactions play important roles in cellular processes. To address the limited knowledge of host-pathogen interactomes, we developed HPIPred, a numerical encoding-based host-pathogen PPI prediction tool. Through screening the entire proteomes of Homo sapiens and Pseudomonas aeruginosa PAO1, we generated a highly connected network topology of host-pathogen interactome using HPIPred.
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
(2022)
Article
Engineering, Environmental
Weisheng Yu, Chengpeng Wei, Kaiyu Zhang, Jianjun Zhang, Zijuan Ge, Xian Liang, Michael D. Guiver, Xiaolin Ge, Liang Wu, Tongwen Xu
Summary: In this study, a 4-sulfocalix[4]arene (4-SCA)-modified graphene oxide (GO) membrane was successfully fabricated, which exhibited high ion permeability and selectivity, as well as pH-responsiveness. The membrane preferentially transported potassium ions over radionuclide cations and showed an order of magnitude higher ion selectivity than the unmodified GO membrane. The improved selectivity resulted from the specific recognition between 4-SCA and radionuclide cations, which was responsive to the protonation/deprotonation transformation of 4-SCA. This biomimetic permselective GO membrane has potential applications in efficient nuclear wastewater treatment and contributes to a deeper understanding of biomimetic ion transport mechanisms.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2023)
Article
Microbiology
Arunima Bhattacharjee, Odeta Qafoku, Jocelyn A. Richardson, Lindsey N. Anderson, Kaitlyn Schwarz, Lisa M. Bramer, Gerard X. Lomas, Daniel J. Orton, Zihua Zhu, Mark H. Engelhard, Mark E. Bowden, William C. Nelson, Ari Jumpponen, Janet K. Jansson, Kirsten S. Hofmockel, Christopher R. Anderton
Summary: Soil fungi play a crucial role in the translocation of inorganic nutrients from minerals to other microorganisms and plants in impoverished soils. However, the molecular mechanisms of fungal mineral weathering and nutrient transport through soil are still poorly understood. In this study, a mineral-doped soil micromodel platform was developed to investigate mineral weathering mechanisms. The study found that Fusarium sp. strain DS 682 exhibited a mechanosensory response in the presence of minerals, and could acquire and transport potassium from potassium-rich mineral interfaces. Specific membrane transport proteins were expressed in the fungus in the presence of minerals. This study establishes the significance of a spatial visualization platform for investigating microbial induced mineral weathering and demonstrates the importance of fungal biology and nutrient translocation in maintaining fungal growth under water and carbon limitations in a reduced-complexity soil-like microenvironment.
Article
Biochemistry & Molecular Biology
Saumen Chakraborty, Michael J. Polen, Kelly N. Chacon, Tiffany D. Wilson, Yang Yu, Julian Reed, Mark J. Nilges, Ninian J. Backburn, Yi Lu
Article
Biochemistry & Molecular Biology
Cristina N. Butterfield, Lizhi Tao, Kelly N. Chacon, Thomas G. Spiro, Ninian J. Blackburn, William H. Casey, R. David Britt, Bradley M. Tebo
BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS
(2015)
Article
Radiology, Nuclear Medicine & Medical Imaging
Annah Farashishiko, Kelly N. Chacon, Ninian J. Blackburn, Mark Woods
CONTRAST MEDIA & MOLECULAR IMAGING
(2016)
Article
Multidisciplinary Sciences
Parisa Hosseinzadeh, Nicholas M. Marshall, Kelly N. Chacon, Yang Yu, Mark J. Nilges, Siu Yee New, Stoyan A. Tashkov, Ninian J. Blackburn, Yi Lu
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2016)
Article
Chemistry, Inorganic & Nuclear
Vlad Martin-Diaconescu, Kelly N. Chacon, Mario Ulises Delgado-Jaime, Dimosthenis Sokaras, Tsu-Chien Weng, Serena DeBeer, Ninian J. Blackburn
INORGANIC CHEMISTRY
(2016)
Article
Biochemistry & Molecular Biology
Yang Yu, Igor D. Petrik, Kelly N. Chacon, Parisa Hosseinzadeh, Honghui Chen, Ninian J. Blackburn, Yi Lu
Article
Biochemistry & Molecular Biology
Tiffany D. Mealman, Mowei Zhou, Trisiani Affandi, Kelly N. Chacon, Mariana E. Aranguren, Ninian J. Blackburn, Vicki H. Wysocki, Megan M. McEvoy
Article
Chemistry, Multidisciplinary
Kelly N. Chacon, Ninian J. Blackburn
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2012)
Article
Biochemistry & Molecular Biology
Aaron T. Smith, Richard O. Linkous, Nathan J. Max, Alexandrea E. Sestok, Veronika A. Szalai, Kelly N. Chacon
Article
Chemistry, Inorganic & Nuclear
Marcos N. Morgada, Florencia Emiliani, Kelly N. Chacon, Damian Alyarez-Paggi, Daniel H. Murgida, Ninian J. Blackburn, Luciano A. Abriata, Alejandro J. Vila
INORGANIC CHEMISTRY
(2019)
Article
Biochemistry & Molecular Biology
Roma Mukhopadhyay, Kelly N. Chacon, Jacqueline M. Jarvis, Marat R. Talipov, Erik T. Yukl
BIOCHEMICAL JOURNAL
(2020)
Article
Multidisciplinary Sciences
Verna Van, Janae B. Brown, Corin R. O'Shea, Hannah Rosenbach, Ijaz Mohamed, Nna-Emeka Ejimogu, Toan S. Bui, Veronika A. Szalai, Kelly N. Chacon, Ingrid Span, Fangliang Zhang, Aaron T. Smith
Summary: ATE1 is an enzyme that catalyzes post-translational modification in eukaryotes, regulating protein stability and half-life. This study reveals the presence of an [Fe-S] cluster in ATE1, which is linked to its enzymatic activity and yeast stress response. This finding provides new insights into the regulatory mechanism of ATE1.
NATURE COMMUNICATIONS
(2023)
Article
Biology
Kelly N. Chacon, Jonathan Perkins, Zachary Mathe, Katherine Alwan, Ethan N. Ho, Melek N. Ucisik, Kenneth M. Merz, Ninian J. Blackburn
COMMUNICATIONS BIOLOGY
(2018)
Article
Biology
Durga Prasad Neupane, Stephanie Hope Fullam, Kelly Natalia Chacon, Erik Thomas Yukl
COMMUNICATIONS BIOLOGY
(2019)