Antibiotic Resistance Mediated by the MacB ABC Transporter Family: A Structural and Functional Perspective

A Novel Inhibitor of the LolCDE ABC Transporter Essential for Lipoprotein Trafficking in Gram-Negative Bacteria

(2018) Nicholas N. Nickerson et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

ATP Binding Enables Substrate Release from Multidrug Resistance Protein 1

(2018) Zachary Lee Johnson et al.   CELL

Structure of a MacAB-like efflux pump from Streptococcus pneumoniae

(2018) Hong-Bo Yang et al.   Nature Communications

Multiple entry pathways within the efflux transporter AcrB contribute to multidrug recognition

(2018) Martijn Zwama et al.   Nature Communications

Distribution of different efflux pump genes in clinical isolates of multidrug-resistant Acinetobacter baumannii and their correlation with antimicrobial resistance

(2017) Ming-Feng Lin et al.   JOURNAL OF MICROBIOLOGY IMMUNOLOGY AND INFECTION

Structural basis of MsbA-mediated lipopolysaccharide transport

(2017) Wei Mi et al.   NATURE

Structural basis for lipopolysaccharide extraction by ABC transporter LptB2FG

(2017) Qingshan Luo et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structure and mechanotransmission mechanism of the MacB ABC transporter superfamily

(2017) Allister Crow et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Crystal structure of tripartite-type ABC transporter MacB from Acinetobacter baumannii

(2017) Ui Okada et al.   Nature Communications

Structural basis for lipopolysaccharide extraction by ABC transporter LptB2FG

(2017) Qingshan Luo et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

An allosteric transport mechanism for the AcrAB-TolC multidrug efflux pump

(2017) Zhao Wang et al.   eLife

Structure of the MacAB–TolC ABC-type tripartite multidrug efflux pump

(2017) Anthony W. P. Fitzpatrick et al.   Nature Microbiology

The Vibrio cholerae var regulon encodes a metallo-β-lactamase and an antibiotic efflux pump, which are regulated by VarR, a LysR-type transcription factor

(2017) Hong-Ting Victor Lin et al.   PLoS One

A putative Vibrio cholerae two-component system controls a conserved periplasmic protein in response to the antimicrobial peptide polymyxin B

(2017) Jyl S. Matson et al.   PLoS One

VraH Is the Third Component of the Staphylococcus aureus VraDEH System Involved in Gallidermin and Daptomycin Resistance and Pathogenicity

(2016) Peter Popella et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Crystal structure of the human sterol transporter ABCG5/ABCG8

(2016) Jyh-Yeuan Lee et al.   NATURE

Understanding transport by the major facilitator superfamily (MFS): structures pave the way

(2016) Esben M. Quistgaard et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Mechanistic diversity in ATP-binding cassette (ABC) transporters

(2016) Kaspar P Locher   NATURE STRUCTURAL & MOLECULAR BIOLOGY

FtsEX acts on FtsA to regulate divisome assembly and activity

(2016) Shishen Du et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Crystal structures of OprN and OprJ, outer membrane factors of multidrug tripartite efflux pumps ofPseudomonas aeruginosa

(2016) Ryo Yonehara et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

ATP-dependent substrate transport by the ABC transporter MsbA is proton-coupled

(2016) Himansha Singh et al.   Nature Communications

Tripartite assembly of RND multidrug efflux pumps

(2016) Laetitia Daury et al.   Nature Communications

Mechanistic diversity in ATP-binding cassette (ABC) transporters

(2016) Kaspar P Locher   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The Crystal Structure of the YknZ Extracellular Domain of ABC Transporter YknWXYZ from Bacillus amyloliquefaciens

(2016) Yongbin Xu et al.   PLoS One

Small-Molecule Inhibitors of Gram-Negative Lipoprotein Trafficking Discovered by Phenotypic Screening

(2015) Sarah M. McLeod et al.   JOURNAL OF BACTERIOLOGY

Novel Antibacterial Targets and Compounds Revealed by a High-Throughput Cell Wall Reporter Assay

(2015) Asha S. Nayar et al.   JOURNAL OF BACTERIOLOGY

Lantibiotic Resistance

(2015) Lorraine A. Draper et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

Crystal structures of a polypeptide processing and secretion transporter

(2015) David Yin-wei Lin et al.   NATURE

Structure and mechanism of an active lipid-linked oligosaccharide flippase

(2015) Camilo Perez et al.   NATURE

Crystal structure of an antigenic outer-membrane protein from Salmonella Typhi suggests a potential antigenic loop and an efflux mechanism

(2015) Hong-Hsiang Guan et al.   Scientific Reports

Small Proteins Can No Longer Be Ignored

(2014) Gisela Storz et al.   Annual Review of Biochemistry

Structure of the periplasmic adaptor protein from a major facilitator superfamily (MFS) multidrug efflux pump

(2014) Philip Hinchliffe et al.   FEBS LETTERS

MacABCsm, an ABC-type tripartite efflux pump of Stenotrophomonas maltophilia involved in drug resistance, oxidative and envelope stress tolerances and biofilm formation

(2014) Y.-T. Lin et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

A Sensory Complex Consisting of an ATP-binding Cassette Transporter and a Two-component Regulatory System Controls Bacitracin Resistance inBacillus subtilis

(2014) Sebastian Dintner et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural diversity of ABC transporters

(2014) Josy ter Beek et al.   JOURNAL OF GENERAL PHYSIOLOGY

HrtBA and menaquinones control haem homeostasis inLactococcus lactis

(2014) Laetitia Joubert et al.   MOLECULAR MICROBIOLOGY

Accumulation of heptaprenyl diphosphate sensitizesBacillus subtilisto bacitracin: implications for the mechanism of resistance mediated by the BceAB transporter

(2014) Anthony W. Kingston et al.   MOLECULAR MICROBIOLOGY

Structure of the AcrAB–TolC multidrug efflux pump

(2014) Dijun Du et al.   NATURE

Mycobacterium tuberculosis FtsX extracellular domain activates the peptidoglycan hydrolase, RipC

(2014) D. Mavrici et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure of an antibacterial peptide ATP-binding cassette transporter in a novel outward occluded state

(2014) H. G. Choudhury et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Crystal structure of theCampylobacter jejuniCmeC outer membrane channel

(2014) Chih-Chia Su et al.   PROTEIN SCIENCE

Protoporphyrin (PPIX) efflux by the MacAB-TolC pump inEscherichia coli

(2014) Evelyne Turlin et al.   MicrobiologyOpen

Structure and Operation of Bacterial Tripartite Pumps

(2013) Philip Hinchliffe et al.   Annual Review of Microbiology

NSR from Streptococcus agalactiae confers resistance against nisin and is encoded by a conserved nsr operon

(2013) Sakshi Khosa et al.   BIOLOGICAL CHEMISTRY

Structure of an atypical periplasmic adaptor from a multidrug efflux pump of the spirocheteBorrelia burgdorferi

(2013) Nicholas P. Greene et al.   FEBS LETTERS

Structure-function analysis of the ATP-driven glycolipid efflux pump DevBCA reveals complex organization with TolC/HgdD

(2013) Peter Staron et al.   FEBS LETTERS

MacA, a Periplasmic Membrane Fusion Protein of the Macrolide Transporter MacAB-TolC, Binds Lipopolysaccharide Core Specifically and with High Affinity

(2013) S. Lu et al.   JOURNAL OF BACTERIOLOGY

Identification of Regions Important for Resistance and Signalling within the Antimicrobial Peptide Transporter BceAB of Bacillus subtilis

(2013) F. Kallenberg et al.   JOURNAL OF BACTERIOLOGY

Crystal structure of a folate energy-coupling factor transporter from Lactobacillus brevis

(2013) Ke Xu et al.   NATURE

The Antimicrobial Compound Xantholysin Defines a New Group of Pseudomonas Cyclic Lipopeptides

(2013) Wen Li et al.   PLoS One

The ABC-Type Efflux Pump MacAB Protects Salmonella enterica serovar Typhimurium from Oxidative Stress

(2013) L. M. Bogomolnaya et al.   mBio

YknWXYZ Is an Unusual Four-Component Transporter with a Role in Protection against Sporulation-Delaying-Protein-Induced Killing of Bacillus subtilis

(2012) Y. Yamada et al.   JOURNAL OF BACTERIOLOGY

Assembly and Channel Opening of Outer Membrane Protein in Tripartite Drug Efflux Pumps of Gram-negative Bacteria

(2012) Yongbin Xu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The PseEF efflux system is a virulence factor of Pseudomonas syringae pv. syringae

(2012) Hyosun Cho et al.   JOURNAL OF MICROBIOLOGY

Menaquinone biosynthesis potentiates haem toxicity inStaphylococcus aureus

(2012) Catherine A. Wakeman et al.   MOLECULAR MICROBIOLOGY

Role of ATP binding and hydrolysis in assembly of MacAB-TolC macrolide transporter

(2012) Shuo Lu et al.   MOLECULAR MICROBIOLOGY

Structure of AMP-PNP-bound vitamin B12 transporter BtuCD–F

(2012) Vladimir M. Korkhov et al.   NATURE

Conserved small protein associates with the multidrug efflux pump AcrB and differentially affects antibiotic resistance

(2012) E. C. Hobbs et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Transport of drugs by the multidrug transporter AcrB involves an access and a deep binding pocket that are separated by a switch-loop

(2012) T. Eicher et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Colistin-Resistant, Lipopolysaccharide-Deficient Acinetobacter baumannii Responds to Lipopolysaccharide Loss through Increased Expression of Genes Involved in the Synthesis and Transport of Lipoproteins, Phospholipids, and Poly-β-1,6-N-Acetylglucosamine

(2011) Rebekah Henry et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Biosynthesis of the pyoverdine siderophore ofPseudomonas aeruginosainvolves precursors with a myristic or a myristoleic acid chain

(2011) Mélissa Hannauer et al.   FEBS LETTERS

Coevolution of ABC Transporters and Two-Component Regulatory Systems as Resistance Modules against Antimicrobial Peptides in Firmicutes Bacteria

(2011) S. Dintner et al.   JOURNAL OF BACTERIOLOGY

Novel ATP-driven Pathway of Glycolipid Export Involving TolC Protein

(2011) Peter Staron et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Functional Implications of an Intermeshing Cogwheel-like Interaction between TolC and MacA in the Action of Macrolide-specific Efflux Pump MacAB-TolC

(2011) Yongbin Xu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The periplasmic membrane proximal domain of MacA acts as a switch in stimulation of ATP hydrolysis by MacB transporter

(2011) Sita D. Modali et al.   MOLECULAR MICROBIOLOGY

Structures of the multidrug exporter AcrB reveal a proximal multisite drug-binding pocket

(2011) Ryosuke Nakashima et al.   NATURE

A New Highly Conserved Antibiotic Sensing/Resistance Pathway in Firmicutes Involves an ABC Transporter Interplaying with a Signal Transduction System

(2011) Stéphanie Coumes-Florens et al.   PLoS One

Crystal Structure of Escherichia coli CusC, the Outer Membrane Component of a Heavy Metal Efflux Pump

(2011) Rithika Kulathila et al.   PLoS One

Structures of sequential open states in a symmetrical opening transition of the TolC exit duct

(2011) Xue-Yuan Pei et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Essential PcsB putative peptidoglycan hydrolase interacts with the essential FtsXSpn cell division protein in Streptococcus pneumoniae D39

(2011) L.-T. Sham et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An ATP-binding cassette transporter-like complex governs cell-wall hydrolysis at the bacterial cytokinetic ring

(2011) D. C. Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The ABC Transporter AnrAB Contributes to the Innate Resistance of Listeria monocytogenes to Nisin, Bacitracin, and Various  -Lactam Antibiotics

(2010) B. Collins et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

The tip region of the MacA α-hairpin is important for the binding to TolC to the Escherichia coli MacAB–TolC pump

(2010) Yongbin Xu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

An efflux pump is involved in secretion of newly synthesized siderophore byPseudomonas aeruginosa

(2010) Mélissa Hannauer et al.   FEBS LETTERS

The ABC Transporter HrtAB Confers Resistance to Hemin Toxicity and Is Regulated in a Hemin-Dependent Manner by the ChrAS Two-Component System in Corynebacterium diphtheriae

(2010) L. A. Bibb et al.   JOURNAL OF BACTERIOLOGY

Asymmetric ATP Hydrolysis Cycle of the Heterodimeric Multidrug ABC Transport Complex TmrAB fromThermus thermophilus

(2010) Ariane Zutz et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Imaging mass spectrometry of intraspecies metabolic exchange revealed the cannibalistic factors of Bacillus subtilis

(2010) W.-T. Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Generic and Specific Adaptive Responses of Streptococcus pneumoniae to Challenge with Three Distinct Antimicrobial Peptides, Bacitracin, LL-37, and Nisin

(2009) J. A. Majchrzykiewicz et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

The multidrug resistance efflux complex, EmrAB from Escherichia coli forms a dimer in vitro

(2009) Mikio Tanabe et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Crystal Structure of the Periplasmic Region of MacB, a Noncanonic ABC Transporter,

(2009) Yongbin Xu et al.   BIOCHEMISTRY

Molecular cloning and characterization of SmrA, a novel ABC multidrug efflux pump from Stenotrophomonas maltophilia

(2009) A. Al-Hamad et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Flexible exportation mechanisms of arthrofactin inPseudomonassp. MIS38

(2009) S.P. Lim et al.   JOURNAL OF APPLIED MICROBIOLOGY

Membrane Porters of ATP-Binding Cassette Transport Systems Are Polyphyletic

(2009) Bin Wang et al.   JOURNAL OF MEMBRANE BIOLOGY

Crystal Structure of the Periplasmic Component of a Tripartite Macrolide-Specific Efflux Pump

(2009) Soohwan Yum et al.   JOURNAL OF MOLECULAR BIOLOGY

Mass spectrometry of membrane transporters reveals subunit stoichiometry and interactions

(2009) Nelson P Barrera et al.   NATURE METHODS

A coordinated network of transporters with overlapping specificities provides a robust survival strategy

(2009) N. Tal et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular basis of pyoverdine siderophore recycling in Pseudomonas aeruginosa

(2009) F. Imperi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure of P-Glycoprotein Reveals a Molecular Basis for Poly-Specific Drug Binding

(2009) S. G. Aller et al.   SCIENCE

Structural and functional diversity of bacterial membrane fusion proteins

(2008) Helen I. Zgurskaya et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Staphylococcus aureus HrtA Is an ATPase Required for Protection against Heme Toxicity and Prevention of a Transcriptional Heme Stress Response

(2008) D. L. Stauff et al.   JOURNAL OF BACTERIOLOGY

MacAB Is Involved in the Secretion of Escherichia coli Heat-Stable Enterotoxin II

(2008) H. Yamanaka et al.   JOURNAL OF BACTERIOLOGY

MacB ABC Transporter Is a Dimer Whose ATPase Activity and Macrolide-binding Capacity Are Regulated by the Membrane Fusion Protein MacA

(2008) Hong Ting Lin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Genetic and functional characterization of the gene cluster directing the biosynthesis of putisolvin I and II in Pseudomonas putida strain PCL1445

(2008) J.-F. Dubern et al.   MICROBIOLOGY-SGM

Assembly and Channel Opening in a Bacterial Drug Efflux Machine

(2008) Vassiliy N. Bavro et al.   MOLECULAR CELL

Bacitracin sensing in Bacillus subtilis

(2008) Eva Rietkötter et al.   MOLECULAR MICROBIOLOGY

The FtsEX ABC transporter directs cellular differentiation inBacillus subtilis

(2008) Sharon Garti-Levi et al.   MOLECULAR MICROBIOLOGY