标题
Toxicology and pharmacology of synthetic organoselenium compounds: an update
作者
关键词
-
出版物
ARCHIVES OF TOXICOLOGY
Volume 95, Issue 4, Pages 1179-1226
出版商
Springer Science and Business Media LLC
发表日期
2021-04-01
DOI
10.1007/s00204-021-03003-5
参考文献
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- Diphenyl diselenide protects neuronal cells against oxidative stress and mitochondrial dysfunction: Involvement of the glutathione-dependent antioxidant system
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- Toxicity of organochalcogens in human leukocytes is associated, but not directly related with reactive species production, apoptosis and changes in antioxidant gene expression
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- Role of thymoquinone and ebselen in the prevention of sodium arsenite–induced nephrotoxicity in female rats
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- Selenium Species: Current Status and Potentials in Cancer Prevention and Therapy
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- Synthetic approaches to organoselenium derivatives with antimicrobial and anti-biofilm activity
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- Comprehensive review of mechanisms of pathogenesis involved in Alzheimer’s disease and potential therapeutic strategies
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- Selenium and Type 2 Diabetes: Systematic Review
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- A multifunctional compound ebselen reverses memory impairment, apoptosis and oxidative stress in a mouse model of sporadic Alzheimer's disease
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- The antimetastatic effect and underlying mechanisms of thioredoxin reductase inhibitor ethaselen
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- Chronic Dietary Selenomethionine Exposure Induces Oxidative Stress, Dopaminergic Dysfunction, and Cognitive Impairment in Adult Zebrafish (Danio rerio)
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- p,p′-Methoxyl-diphenyl diselenide-loaded polymeric nanocapsules are chemically stable and do not induce toxicity in mice
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- Hypothalamic pathways regulate the anorectic action of p -chloro-diphenyl diselenide in rats
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- Involvement of BDNF/TrkB signaling in the effect of diphenyl diselenide on motor function in a Parkinson's disease rat model
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- Toxoplasmosis treatment with diphenyl diselenide in infected mice modulates the activity of purinergic enzymes and reduces inflammation in spleen
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- ( p -ClPhSe) 2 stimulates carbohydrate metabolism and reverses the metabolic alterations induced by high fructose load in rats
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- Induction of reactive oxygen species by diphenyl diselenide is preceded by changes in cell morphology and permeability in Saccharomyces cerevisiae
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- Synergistic effect of Ebselen and gamma radiation on breast cancer cells
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- Selenomethionine Attenuates the Amyloid-β Level by Both Inhibiting Amyloid-β Production and Modulating Autophagy in Neuron-2a/AβPPswe Cells
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- In vitro assessment of the growth and plasma membrane H+ -ATPase inhibitory activity of ebselen and structurally related selenium- and sulfur-containing compounds in Candida albicans
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- Ebselen ameliorates β-amyloid pathology, tau pathology, and cognitive impairment in triple-transgenic Alzheimer’s disease mice
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- A diphenyldiselenide derivative induces autophagy via JNK in HTB-54 lung cancer cells
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- Ebselen impairs cellular oxidative state and induces endoplasmic reticulum stress and activation of crucial mitogen-activated protein kinases in pancreatic tumour AR42J cells
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- Sulfhydryl-Based Inhibition of δ-ALA-D and Na+, K+-ATPase Activities Depends on the Organoselenium Group Bonded to the Isoquinoline
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- Diphenyl Diselenide Reduces Oxidative Stress and Toxicity Caused by HSV-2 Infection in Mice
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- (p -ClPhSe)2 Reduces Hepatotoxicity Induced by Monosodium Glutamate by Improving Mitochondrial Function in Rats
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- Selenomethionine Mitigates Cognitive Decline by Targeting Both Tau Hyperphosphorylation and Autophagic Clearance in an Alzheimer's Disease Mouse Model
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- Bis(phenylimidazoselenazolyl) diselenide elicits antinociceptive effect by modulating myeloperoxidase activity, NOx and NFkB levels in the collagen-induced arthritis mouse model
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- 4-phenylselenyl-7-chloroquinoline, a novel multitarget compound with anxiolytic activity: Contribution of the glutamatergic system
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- Opioid system contribution to the antidepressant-like action of m-trifluoromethyl-diphenyl diselenide in mice: A compound devoid of tolerance and withdrawal syndrome
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- Antidepressant-like effect of a new selenium-containing compound is accompanied by a reduction of neuroinflammation and oxidative stress in lipopolysaccharide-challenged mice
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- Preparation, physicochemical characterization and antioxidant activity of diphenyl diselenide-loaded poly(lactic acid) nanoparticles
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- A systematic review and meta-analysis of the circulatory, erythrocellular and CSF selenium levels in Alzheimer's disease: A metal meta-analysis (AMMA study-I)
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- Safety and efficacy of ebselen for the prevention of noise-induced hearing loss: a randomised, double-blind, placebo-controlled, phase 2 trial
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- Reversal of bioenergetics dysfunction by diphenyl diselenide is critical to protection against the acetaminophen-induced acute liver failure
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- Organoselenium compounds as mimics of selenoproteins and thiol modifier agents
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- Reaction of bis[(2-chlorocarbonyl)phenyl] Diselenide with Phenols, Aminophenols, and Other Amines towards Diphenyl Diselenides with Antimicrobial and Antiviral Properties
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- p,p′-Methoxyl-diphenyl diselenide elicits an antidepressant-like effect in mice without discontinuation anxiety phenotype
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- Diphenyl diselenide modulates nucleotidases, reducing inflammatory responses in the liver of Toxoplasma gondii-infected mice
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- Synthesis and antioxidant properties of organosulfur and organoselenium compounds derived from 5-substituted-1,3,4-oxadiazole/thiadiazole-2-thiols
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- Preparation of bis(2-pyridyl) diselenide derivatives: Synthesis of selenazolo[5,4- b ]pyridines and unsymmetrical diorganyl selenides, and evaluation of antioxidant and anticholinesterasic activities
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- Cardiac and Metabolic Effects of Dietary Selenomethionine Exposure in Adult Zebrafish
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- Chalcogenozidovudine Derivatives With Antitumor Activity: Comparative Toxicities in Cultured Human Mononuclear Cells
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- Bisphenol A impairs the memory function and glutamatergic homeostasis in a sex-dependent manner in mice: Beneficial effects of diphenyl diselenide
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- Developing selective histone deacetylases (HDACs) inhibitors through ebselen and analogs
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- A selenium species in cerebrospinal fluid predicts conversion to Alzheimer’s dementia in persons with mild cognitive impairment
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- Exploring Covalent Allosteric Inhibition of Antigen 85C from Mycobacterium tuberculosis by Ebselen Derivatives
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- High dietary selenium intake is associated with less insulin resistance in the Newfoundland population
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- Alzheimer’s disease: experimental models and reality
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- Dose-biomarker-response modeling of the anticancer effect of ethaselen in a human non-small cell lung cancer xenograft mouse model
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- Ebselen does not improve oxidative stress and vascular function in patients with diabetes: a randomized, crossover trial
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- Ebselen, a Small-Molecule Capsid Inhibitor of HIV-1 Replication
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- Diphenyl diselenide elicits antidepressant-like activity in rats exposed to monosodium glutamate: A contribution of serotonin uptake and Na+, K+-ATPase activity
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- Ebselen and analogs as inhibitors of Bacillus anthracis thioredoxin reductase and bactericidal antibacterials targeting Bacillus species, Staphylococcus aureus and Mycobacterium tuberculosis
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- Cardioprotective Effect of Selenium Against Cyclophosphamide-Induced Cardiotoxicity in Rats
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- Cardioprotective Effect of Aloe vera Biomacromolecules Conjugated with Selenium Trace Element on Myocardial Ischemia-Reperfusion Injury in Rats
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- Sensitization of cancer cells to cyclophosphamide therapy by an organoselenium compound through ROS-mediated apoptosis
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- Selenium and mercury levels in rat liver slices co-treated with diphenyl diselenide and methylmercury
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- Diphenyl diselenide derivatives inhibit microbial biofilm formation involved in wound infection
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- The hypolipidemic action of a diet supplemented with p,p’-methoxyl-diphenyl diselenide is not directly related to its antioxidant property
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- Identification of Ebsulfur Analogues with Broad-Spectrum Antifungal Activity
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- Recent advances in the chemistry of selenium-containing heterocycles: Five-membered ring systems
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- Antioxidants selenomethionine and D-pantethine decrease the negative side effects of doxorubicin in NL/Ly lymphoma-bearing mice
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- 4-Phenylselenyl-7-chloroquinoline, a new quinoline derivative containing selenium, has potential antinociceptive and anti-inflammatory actions
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- Pain-depression dyad induced by reserpine is relieved by p , p' -methoxyl-diphenyl diselenide in rats
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- Toxoplasma gondii: Effects of diphenyl diselenide in experimental toxoplasmosis on biomarkers of cardiac function
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- Selenium Pretreatment for Mitigation of Ischemia/Reperfusion Injury in Cardiovascular Surgery: Influence on Acute Organ Damage and Inflammatory Response
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- Ebselen Is a Potential Anti-Osteoporosis Agent by Suppressing Receptor Activator of Nuclear Factor Kappa-B Ligand-Induced Osteoclast Differentiation In vitro and Lipopolysaccharide-Induced Inflammatory Bone Destruction In vivo
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- An Overview of Severe Acute Respiratory Syndrome–Coronavirus (SARS-CoV) 3CL Protease Inhibitors: Peptidomimetics and Small Molecule Chemotherapy
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- 1,2-Benzisoselenazol-3(2H)-one Derivatives As a New Class of Bacterial Urease Inhibitors
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- 4-Organoseleno-Isoquinolines Selectively and Reversibly Inhibit the Cerebral Monoamine Oxidase B Activity
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- Selenium Supplementation for Prevention of Late-Onset Sepsis in Very Low Birth Weight Preterm Neonates
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- Antifungal activities of diphenyl diselenide and ebselen alone and in combination with antifungal agents againstFusariumspp.
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- Selenomethionine reduces the deposition of beta-amyloid plaques by modulating β-secretase and enhancing selenoenzymatic activity in a mouse model of Alzheimer's disease
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- Synthetic Approaches to the Multifunctional Drug Ebselen and Analogs: Past and Present
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- Protection of rat liver against hepatic ischemia-reperfusion injury by a novel selenocysteine-containing 7-mer peptide
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- Diphenyl Diselenide Protects Against Mortality, Locomotor Deficits and Oxidative Stress in Drosophila melanogaster Model of Manganese-Induced Neurotoxicity
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- Diphenyl diselenide attenuates oxidative stress and inflammatory parameters in ulcerative colitis: A comparison with ebselen
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- p -Chloro-diphenyl diselenide reverses memory impairment-related to stress caused by corticosterone and modulates hippocampal [ 3 H]glutamate uptake in mice
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- Diphenyl diselenide ameliorates monosodium glutamate induced anxiety-like behavior in rats by modulating hippocampal BDNF-Akt pathway and uptake of GABA and serotonin neurotransmitters
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- Involvement of monoaminergic system in the antidepressant-like effect of (octylseleno)-xylofuranoside in the mouse tail suspension test
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- Effects of the potential lithium-mimetic, ebselen, on brain neurochemistry: a magnetic resonance spectroscopy study at 7 tesla
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- Effects of the potential lithium-mimetic, ebselen, on impulsivity and emotional processing
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- Effects of diphenyl diselenide on growth, oxidative damage, and antioxidant response in silver catfish
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- Ebselen alters cellular oxidative status and induces endoplasmic reticulum stress in rat hippocampal astrocytes
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- Significant Beneficial Association of High Dietary Selenium Intake with Reduced Body Fat in the CODING Study
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- Design, synthesis and evaluation of clioquinol–ebselen hybrids as multi-target-directed ligands against Alzheimer's disease
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- Effect of Sodium Selenite Administration and Procalcitonin-Guided Therapy on Mortality in Patients With Severe Sepsis or Septic Shock
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- Effect of dietary selenium source (organic vs. mineral) and muscle pH on meat quality characteristics of pigs
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- Effect of selenium supplementation on CD4+ T-cell recovery, viral suppression and morbidity of HIV-infected patients in Rwanda
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- Homeostatic effect of p-chloro-diphenyl diselenide on glucose metabolism and mitochondrial function alterations induced by monosodium glutamate administration to rats
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- Stereodivergent Synthesis of N-Heterocycles by Catalyst-Controlled, Activity-Directed Tandem Annulation of Diazo Compounds with Amino Alkynes
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- Small Organoselenium Compounds: More than just Glutathione Peroxidase Mimics
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- Regulation of Selenium Metabolism and Transport
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- Update on Selenoprotein Biosynthesis
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- Antioxidant Rescue of Selenomethionine-Induced Teratogenesis in Zebrafish Embryos
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- Low zinc and selenium concentrations in sepsis are associated with oxidative damage and inflammation
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- Bis(phenylimidazoselenazolyl) diselenide as an antioxidant compound: An in vitro and in vivo study
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- Unusually Short Chalcogen Bonds Involving Organoselenium: Insights into the Se-N Bond Cleavage Mechanism of the Antioxidant Ebselen and Analogues
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- Organoselenium Compounds as Potential Neuroprotective Therapeutic Agents
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- Organoselenium Small Molecules and Chromium(III) Complexes for Intervention in Chronic Low-grade Inflammation and Type 2 Diabetes
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- Swimming exercise and diphenyl diselenide-supplemented diet affect the serum levels of pro- and anti-inflammatory cytokines differently depending on the age of rats
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- Organoselenocyanates and symmetrical diselenides redox modulators: Design, synthesis and biological evaluation
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- Antinociceptive action of diphenyl diselenide in the nociception induced by neonatal administration of monosodium glutamate in rats
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- Modulatory effect of diphenyl diselenide in Carioca High- and Low-conditioned Freezing rats
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- Reaction kinetics and targeting to cellular glutathione S-transferase of the glutathione peroxidase mimetic PhSeZnCl and its d,l-polylactide microparticle formulation
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- Glutathione S-transferase pi expression regulates the Nrf2-dependent response to hormetic diselenides
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- Late-intervention study with ebselen in an experimental model of type 1 diabetic nephropathy
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- Sensitization of cisplatin therapy by a naphthalimide based organoselenium compound through modulation of antioxidant enzymes and p53 mediated apoptosis
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- Antiviral Action of Diphenyl Diselenide on Herpes Simplex Virus 2 Infection in Female BALB/c Mice
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- Selenium and Human Health: Witnessing a Copernican Revolution?
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- New Organochalcogen Multitarget Drug: Synthesis and Antioxidant and Antitumoral Activities of Chalcogenozidovudine Derivatives
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- Effect of a Bromo Substituent on the Glutathione Peroxidase Activity of a Pyridoxine-like Diselenide
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- Depressive-like behavior induced by tumor necrosis factor-α is attenuated by m-trifluoromethyl-diphenyl diselenide in mice
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- Comprehensive modeling of the antioxidant mechanism of ebselen
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- Effectiveness of (PhSe)2 in protect against the HgCl2 toxicity
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- Diphenyl diselenide (PhSe)2 inhibits biofilm formation by Candida albicans, increasing both ROS production and membrane permeability
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- Effect of the Putative Lithium Mimetic Ebselen on Brain Myo-Inositol, Sleep and Emotional Processing in Humans
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- Individual Differences in Impulsive Action Reflect Variation in the Cortical Serotonin 5-HT2A Receptor System
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- Synthesis, characterization and antioxidant activity of organoselenium and organotellurium compound derivatives of chrysin
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- Insights into the catalytic mechanism of synthetic glutathione peroxidase mimetics
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- m-Trifluoromethyl-diphenyl diselenide, a multi-target selenium compound, prevented mechanical allodynia and depressive-like behavior in a mouse comorbid pain and depression model
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- Methylselenocysteine preventing castration-resistant progression of prostate cancer
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- Effects of diphenyl and p-chloro-diphenyl diselenides on feeding behavior of rats
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- In vitro evaluation of glutathione peroxidase (GPx)-like activity and antioxidant properties of an organoselenium compound
- (2015) Mohammad Ibrahim et al. TOXICOLOGY IN VITRO
- Pharmacokinetics and Toxicity of Sodium Selenite in the Treatment of Patients with Carcinoma in a Phase I Clinical Trial: The SECAR Study
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- Ebselen inhibits QSOX1 enzymatic activity and suppresses invasion of pancreatic and renal cancer cell lines
- (2015) Paul D. Hanavan et al. Oncotarget
- Dietary Selenium in Adjuvant Therapy of Viral and Bacterial Infections
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- Effect of diselenide administration in thioacetamide-induced acute neurological and hepatic failure in mice
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- Repurposing Clinical Molecule Ebselen to Combat Drug Resistant Pathogens
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- Repurposing ebselen for treatment of multidrug-resistant staphylococcal infections
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- Ebselen Inhibits Hepatitis C Virus NS3 Helicase Binding to Nucleic Acid and Prevents Viral Replication
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- Diphenyl diselenide-supplemented diet and swimming exercise enhance novel object recognition memory in old rats
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- Dietary selenomethionine exposure alters swimming performance, metabolic capacity and energy homeostasis in juvenile fathead minnow
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- Effects of Administering Sodium Selenite, Methylseleninic Acid, and Seleno-L-methionine on Glucose Tolerance in a Streptozotocin/Nicotinamide-Induced Diabetic Mouse Model
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- Synthesis and biological evaluation of a new series of ebselen derivatives as glutathione peroxidase (GPx) mimics and cholinesterase inhibitors against Alzheimer’s disease
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- Se-methylselenocysteine offers selective protection against toxicity and potentiates the antitumour activity of anticancer drugs in preclinical animal models
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- Ebselen exhibits glycation-inhibiting properties and protects against osmotic fragility of human erythrocytes in vitro
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- Pyridoxine-Derived Organoselenium Compounds with Glutathione Peroxidase-Like and Chain-Breaking Antioxidant Activity
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- Specific antioxidant compounds differentially modulate cytotoxic activity of doxorubicin and cisplatin: in vitro and in vivo study
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- Inhibitory Effect of Ebselen on Cerebral Acetylcholinesterase Activity In Vitro: Kinetics and Reversibility of Inhibition
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- Multi-target approach for natural products in inflammation
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- Antioxidant and antidepressant-like activities of semi-synthetic α-phenylseleno citronellal
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- ERK1/2 phosphorylation is involved in the antidepressant-like action of 2,5-diphenyl-3-(4-fluorophenylseleno)-selenophene in mice
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- Contribution of dopaminergic and adenosinergic systems in the antinociceptive effect of p-chloro-selenosteroid
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- Caffeine and diphenyl diselenide improve long-term memory impaired in middle-aged rats
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- Ebselen pretreatment attenuates ischemia/reperfusion injury and prevents hyperglycemia by improving hepatic insulin signaling and β-cell survival in gerbils
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- Synthesis and Antioxidant Activities of Novel Chiral Ebselen Analogues
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- Multicenter, Phase III Trial Comparing Selenium Supplementation With Observation in Gynecologic Radiation Oncology
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- Effects of ebselen on ischemia/reperfusion injury in rat brain
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- Kynurenine Aminotransferase III and Glutamine Transaminase L Are Identical Enzymes that have CysteineS-Conjugate β-Lyase Activity and Can Transaminate l-Selenomethionine
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- Effects of diphenyl diselenide on behavioral and biochemical changes induced by amphetamine in mice
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- Dicholesteroyl diselenide: Cytotoxicity, genotoxicity and mutagenicity in the yeast Saccharomyces cerevisiae and in Chinese hamster lung fibroblasts
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- Depression-related behavior and mechanical allodynia are blocked by 3-(4-fluorophenylselenyl)-2,5-diphenylselenophene in a mouse model of neuropathic pain induced by partial sciatic nerve ligation
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- Diphenyl-diselenide suppresses amyloid-β peptide in Caenorhabditis elegans model of Alzheimer’s disease
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- Effects of Organoselenium Compounds on Early and Late Brain Biochemical Alterations in Sepsis-Survivor Rats
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- Neuroprotective Effect of Diphenyl Diselenide in a Experimental Stroke Model: Maintenance of Redox System in Mitochondria of Brain Regions
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- Diphenyl diselenide and sodium selenite associated with chemotherapy in experimental toxoplasmosis: influence on oxidant/antioxidant biomarkers and cytokine modulation
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- Antinociceptive and anti-hyperalgesic effects of bis(4-methylbenzoyl) diselenide in mice: Evidence for the mechanism of action
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- Serotonergic systems are implicated in antinociceptive effect of m -trifluoromethyl diphenyl diselenide in the mouse glutamate test
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- Evaluation of the pharmacological properties of salicylic acid-derivative organoselenium: 2-Hydroxy-5-selenocyanatobenzoic acid as an anti-inflammatory and antinociceptive compound
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- Selenoproteins: Molecular Pathways and Physiological Roles
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- The impact of a diphenyl diselenide-supplemented diet and aerobic exercise on memory of middle-aged rats
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- Apaf-1 Inhibitors Protect from Unwanted Cell Death in In Vivo Models of Kidney Ischemia and Chemotherapy Induced Ototoxicity
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- Anxiolytic effects of diphenyl diselenide on adult zebrafish in a novelty paradigm
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- Safety evaluation of Se-methylselenocysteine as nutritional selenium supplement: Acute toxicity, genotoxicity and subchronic toxicity
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- 1-(2-(2-(2-(1-Aminoethyl)phenyl)diselanyl)phenyl)ethanamine: An amino organoselenium compound with interesting antioxidant profile
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- Selenium and selenocysteine: roles in cancer, health, and development
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- Pre-Antiretroviral Therapy Serum Selenium Concentrations Predict WHO Stages 3, 4 or Death but not Virologic Failure Post-Antiretroviral Therapy
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- Differential genotoxicity of diphenyl diselenide (PhSe)2and diphenyl ditelluride (PhTe)2
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- Toward Understanding Success and Failures in the Use of Selenium for Cancer Prevention
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- Glutathione Peroxidase Mimic Ebselen Improves Glucose-Stimulated Insulin Secretion in Murine Islets
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- Physicochemical and Biochemical Profiling of Diphenyl Diselenide
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- p,p′-Methoxyl-diphenyl diselenide protects against amyloid-β induced cytotoxicity in vitro and improves memory deficits in vivo
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- Kinetic characterization of ebselen, chelerythrine and apomorphine as glutaminase inhibitors
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- The early research and development of ebselen
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- Diphenyl diselenide modulates oxLDL-induced cytotoxicity in macrophage by improving the redox signaling
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- Diphenyl Diselenide Reduces Mechanical and Thermal Nociceptive Behavioral Responses After Unilateral Intrastriatal Administration of 6-Hydroxydopamine in Rats
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- Effect of Selenomethionine Supplementation in Food on the Excretion and Toxicity of Arsenic Exposure in Female Mice
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- Novel tacrine–ebselen hybrids with improved cholinesterase inhibitory, hydrogen peroxide and peroxynitrite scavenging activity
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- Diphenyl diselenide supplementation reduces biochemical alterations associated with oxidative stress in rats fed with fructose and hydrochlorothiazide
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- Protective effects of diphenyl diselenide in a mouse model of brain toxicity
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- Neuroprotective effects of ebselen in traumatic brain injury model: involvement of nitric oxide and p38 mitogen-activated protein kinase signalling pathway
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- The Effect of Selenium Therapy on Mortality in Patients With Sepsis Syndrome
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- Molecular Effects of Diphenyl Diselenide on Cholesterol and Glucose Cell Metabolism
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- Ebselen Treatment Prevents Islet Apoptosis, Maintains Intranuclear Pdx-1 and MafA Levels, and Preserves -Cell Mass and Function in ZDF Rats
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- Reduction of Reactive Oxygen Species Ameliorates Metabolism-Secretion Coupling in Islets of Diabetic GK Rats by Suppressing Lactate Overproduction
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- Ebselen Alters Mitochondrial Physiology and Reduces Viability of Rat Hippocampal Astrocytes
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- Diphenyl diselenide prevents hepatic alterations induced by paraquat in rats
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- Comparative study on effects of dietary with diphenyl diselenide on oxidative stress in carp (Cyprinus carpio) and silver catfish (Rhamdia sp.) exposed to herbicide clomazone
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- Disubstituted diaryl diselenides as potential atheroprotective compounds: Involvement of TrxR and GPx-like systems
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- Evaluation of the effects induced by dietary diphenyl diselenide on common carp Cyprinus carpio
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- Selenium and diabetes—Evidence from animal studies
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- Epidemiology of selenium and type 2 diabetes: Can we make sense of it?
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- Organochalcogen peroxidase mimetics as potential drugs: a long story of a promise still unfulfilled
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- Post SELECT: selenium on trial
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- Methylselenol prodrug enhances MDV3100 efficacy for treatment of castration-resistant prostate cancer
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- Synthesis and Evaluation of Multi-Target-Directed Ligands against Alzheimer’s Disease Based on the Fusion of Donepezil and Ebselen
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- Diphenyl diselenide differently modulates cardiovascular redox responses in young adult and middle-aged low-density lipoprotein receptor knockout hypercholesterolemic mice
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- Involvement of the dopaminergic and serotonergic systems in the antidepressant-like effect caused by 4-phenyl-1-(phenylselanylmethyl)-1,2,3-triazole
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- 2,2′-Dithienyl diselenide pro-oxidant activity accounts for antibacterial and antifungal activities
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- Antifungal Activities of Diphenyl Diselenide alone and in Combination with Fluconazole or Amphotericin B against Candida glabrata
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- Selenium Compounds Prevent Amyloid β-Peptide Neurotoxicity in Rat Primary Hippocampal Neurons
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- Protective effect of diphenyl diselenide against peroxynitrite-mediated endothelial cell death: A comparison with ebselen
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- A novel chemopreventive mechanism of selenomethionine: Enhancement of APE1 enzyme activity via a Gadd45a, PCNA and APE1 protein complex that regulates p53-mediated base excision repair
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- Diphenyl diselenide supplemented diet reduces depressive-like behavior in hypothyroid female rats
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- The Modified Selenenyl Amide, M-hydroxy Ebselen, Attenuates Diabetic Nephropathy and Diabetes-Associated Atherosclerosis in ApoE/GPx1 Double Knockout Mice
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- New Therapeutic Approach: Diphenyl Diselenide Reduces Mitochondrial Dysfunction in Acetaminophen-Induced Acute Liver Failure
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- Combination effects of dietary soy and methylselenocysteine in a mouse model of prostate cancer
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- An organoselenium compound improves behavioral, endocrinal and neurochemical changes induced by corticosterone in mice
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- Neuroprotective effect of ebselen against intracerebroventricular streptozotocin-induced neuronal apoptosis and oxidative stress in rats
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- Mechanism of inhibition of Mycobacterium tuberculosis antigen 85 by ebselen
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- Selenium and Prostate Cancer Prevention: Insights from the Selenium and Vitamin E Cancer Prevention Trial (SELECT)
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- Selenium Supranutrition: Are the Potential Benefits of Chemoprevention Outweighed by the Promotion of Diabetes and Insulin Resistance?
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- Oxidants, antioxidants and the current incurability of metastatic cancers
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- Effects of Diphenyl Diselenide on Methylmercury Toxicity in Rats
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- Cytotoxicity and Genotoxicity Evaluation of Organochalcogens in Human Leucocytes: A Comparative Study between Ebselen, Diphenyl Diselenide, and Diphenyl Ditelluride
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- Bis(phenylimidazoselenazolyl) diselenide
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- Methylselenocysteine Treatment Leads to Diselenide Formation in Human Cancer Cells: Evidence from X-ray Absorption Spectroscopy Studies
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- Acute Treatment with Bis Selenide, an Organic Compound Containing the Trace Element Selenium, Prevents Memory Deficits Induced by Reserpine in Rats
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- Ethanol-Induced Oxidative Stress: The Role of Binaphthyl Diselenide as a Potent Antioxidant
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- An Organoselenium Drug with Antioxidant Activity and Free Radical Scavenging Capacity In Vitro
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- Diphenyl diselenide protects cultured MCF-7 cells against tamoxifen-induced oxidative DNA damage
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- Effects of organoselenium compound 2-(5-selenocyanato-pentyl)-benzo[de]isoquinoline 1,3-dione on cisplatin induced nephrotoxicity and genotoxicity: an investigation of the influence of the compound on oxidative stress and antioxidant enzyme system
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- The antioxidant paradox: less paradoxical now?
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- Acute administration of the organochalcogen 3-methyl-1-phenyl-2-(phenylseleno)oct-2-en-1-one induces biochemical and hematological disorders in male rats
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- Hepatoprotective effect ofbis(4-methylbenzoyl) diselenide against CCl4-induced oxidative damage in mice
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- Ebselen reduces hyperglycemia temporarily-induced by diazinon: A compound with insulin-mimetic properties
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- In vitro metabolism of diphenyl diselenide in rat liver fractions. Conjugation with GSH and binding to thiol groups
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- Ebselen and Congeners Inhibit NADPH Oxidase 2-Dependent Superoxide Generation by Interrupting the Binding of Regulatory Subunits
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- The effects of diphenyl diselenide on oxidative stress biomarkers in Cyprinus carpio exposed to herbicide quinclorac (Facet®)
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- Diphenyl diselenide attenuates hepatic and hematologic toxicity induced by chlorpyrifos acute exposure in rats
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- Diphenyl diselenide protects against metabolic disorders induced by acephate acute exposure in rats
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- Effects of 4,4′-dichloro-diphenyl diselenide (ClPhSe)2 on toxicity induced by mercuric chloride in mice: A comparative study with diphenyl diselenide (PhSe)2
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- The antidepressant-like action of a simple selenium-containing molecule, methyl phenyl selenide, in mice
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- Toxicological evaluation of chronic exposure to the organochalcogen 3-methyl-1-phenyl-2-(phenylseleno)oct-2-en-1-one in male rats
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- p-Methoxyl-diphenyl diselenide protects against cisplatin-induced renal toxicity in mice
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- Ebselen as a redox based therapeutic for triple negative breast cancer
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- Diphenyl diselenide reduces inflammation in the mouse model of pleurisy induced by carrageenan: reduction of pro-inflammatory markers and reactive species levels
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- Diphenyl diselenide-modulation of macrophage activation: Down-regulation of classical and alternative activation markers
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- Diphenyl diselenide diet intake improves spatial learning and memory deficits in hypothyroid female rats
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- Selenium Compounds, Apoptosis and Other Types of Cell Death: An Overview for Cancer Therapy
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- (E)-2-Benzylidene-4-phenyl-1,3-diselenole ameliorates signals of renal injury induced by cisplatin in rats
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- 2,2′-dithienyl diselenide, an organoselenium compound, elicits antioxidant action and inhibits monoamine oxidase activityin vitro
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- Therapeutic effect of organoselenium dietary supplementation in a sporadic dementia of Alzheimer's type model in rats
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- Synthesis, characterization, structures and antioxidant activity of nicotinoyl based organoselenium compounds
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- Molecular Docking Studies of Disubstituted Diaryl Diselenides as Mammalian δ-Aminolevulinic Acid Dehydratase Enzyme Inhibitors
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- Selenium and human health
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- Selenium/Tellurium-Containing Hyperbranched Polymers: Effect of Molecular Weight and Degree of Branching on Glutathione Peroxidase-Like Activity
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- 2,2′-Dipyridyl diselenide is a better antioxidant than other disubstituted diaryl diselenides
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- Interaction Profile of Diphenyl Diselenide with Pharmacologically Significant Thiols
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- Effect of Chronic Administration of the Vinyl Chalcogenide 3-Methyl-1-phenyl-2-(phenylseleno)oct-2-en-1-one on Oxidative Stress in Different Brain Areas of Rats
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- Protective Effect of Diphenyl Diselenide on Ischemia and Reperfusion-Induced Cerebral Injury: Involvement of Oxidative Stress and Pro-Inflammatory Cytokines
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- Ebselen inhibits iron-induced tau phosphorylation by attenuating DMT1 up-regulation and cellular iron uptake
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- Organochalcogens Inhibit Mitochondrial Complexes I and II in Rat Brain: Possible Implications for Neurotoxicity
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- Free radicals and antioxidants: updating a personal view
- (2012) Barry Halliwell NUTRITION REVIEWS
- In vitro antioxidant activity and in vivo antidepressant-like effect of α-(phenylselanyl) acetophenone in mice
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- Synthesis, Characterization, and X-Ray Structures of 2-(3,5-Dimethylpyrazol-1-Yl)Phenyl-Based Organoselenium Compounds and Their Glutathione Peroxidase (Gpx) Like Activity
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- Inverse Correlation between Serum Levels of Selenoprotein P and Adiponectin in Patients with Type 2 Diabetes
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- A Randomized Trial of Selenium Supplementation and Risk of Type-2 Diabetes, as Assessed by Plasma Adiponectin
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- Diphenyl diselenide ameliorates behavioral and oxidative parameters in an animal model of mania induced by ouabain
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- Effects of diphenyl diselenide on depressive-like behavior in ovariectomized mice submitted to subchronic stress: involvement of the serotonergic system
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- The Protective Effect of Ebselen on Radiocontrast-Induced Nephrotoxicity
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- Reduction of Acute Hepatic Damage Induced by Acetaminophen after Treatment with Diphenyl Diselenide in Mice
- (2012) Edovando J. F. da Rosa et al. TOXICOLOGIC PATHOLOGY
- Effects of ebselen on radiocontrast media–induced hepatotoxicity in rats
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- Aminolevulinate dehydratase (δ-ALA-D) as marker protein of intoxication with metals and other pro-oxidant situations
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- Selenium-containing thioredoxin reductase inhibitor ethaselen sensitizes non-small cell lung cancer to radiotherapy
- (2011) Lei Wang et al. ANTI-CANCER DRUGS
- Both Maximal Expression of Selenoproteins and Selenoprotein Deficiency Can Promote Development of Type 2 Diabetes-Like Phenotype in Mice
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- The Role of Selenium in Inflammation and Immunity: From Molecular Mechanisms to Therapeutic Opportunities
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- Toxicology and pharmacology of selenium: emphasis on synthetic organoselenium compounds
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- Diphenyl diselenide ameliorates cognitive deficits induced by a model of menopause in rats
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- p-Chloro-diphenyl diselenide, an organoselenium compound, with antidepressant-like and memory enhancer actions in aging male rats
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- The combination of organoselenium compounds and guanosine prevents glutamate-induced oxidative stress in different regions of rat brains
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- Protective effects of organoselenium compounds against methylmercury-induced oxidative stress in mouse brain mitochondrial-enriched fractions
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- Methylseleninic acid inhibits HDAC activity in diffuse large B-cell lymphoma cell lines
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- Neuroprotector effect of p,p'-methoxyl-diphenyl diselenide in a model of sporadic dementia of Alzheimer's type in mice: contribution of antioxidant mechanism
- (2011) Simone Pinton et al. CELL BIOCHEMISTRY AND FUNCTION
- Reduction of Cisplatin-Induced Nephrotoxicity in Vivo by Selenomethionine: The Effect on Cisplatin–DNA Adducts
- (2011) Daniel García Sar et al. CHEMICAL RESEARCH IN TOXICOLOGY
- Synthesis, Structure, and Glutathione Peroxidase-Like Activity of Amino Acid Containing Ebselen Analogues and Diaryl Diselenides
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- Biologically significant selenium-containing heterocycles
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- Synthesis and biological activity of novel organoselenium derivatives targeting multiple kinases and capable of inhibiting cancer progression to metastases
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- Antidepressant-like effect of m-trifluoromethyl-diphenyl diselenide in the mouse forced swimming test involves opioid and serotonergic systems
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- Methylselenocysteine – a promising antiangiogenic agent for overcoming drug delivery barriers in solid malignancies for therapeutic synergy with anticancer drugs
- (2011) Arup Bhattacharya Expert Opinion on Drug Delivery
- Ethaselen: a potent mammalian thioredoxin reductase 1 inhibitor and novel organoselenium anticancer agent
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- Vitamin E and the Risk of Prostate Cancer
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- Diphenyl diselenide potentiates nephrotoxicity induced by mercuric chloride in mice
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- High doses of 2,2′-dithienyl diselenide cause systemic toxicity in rats: anin vitroandin vivostudy
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- Diphenyl Diselenide Effectively Reduces Atherosclerotic Lesions in LDLr −/− Mice by Attenuation of Oxidative Stress and Inflammation
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- Dietary Selenomethionine Increases Exon-Specific DNA Methylation of the p53 Gene in Rat Liver and Colon Mucosa
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- Effects of diphenyl diselenide on lipid profile and hepatic oxidative stress parameters in ovariectomized female rats
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- Effect of diphenyl diselenide on the development of experimental autoimmune encephalomyelitis
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- Diphenyl diselenide induces anxiolytic-like and sedative effects on the chick social separation-stress behavior
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- Diphenyl diselenide and analogs are substrates of cerebral rat thioredoxin reductase: A pathway for their neuroprotective effects
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- Acute Brain Damage Induced by Acetaminophen in Mice: Effect of Diphenyl Diselenide on Oxidative Stress and Mitochondrial Dysfunction
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- Synthesis and antidepressant-like activity of selenophenes obtained viairon(iii)–PhSeSePh-mediated cyclization of Z-selenoenynes
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- Effects of diphenyl diselenide on oxidative stress induced by sepsis in rats
- (2011) Carlos A. Prauchner et al. PATHOLOGY RESEARCH AND PRACTICE
- Beneficial Effects ofN-Acetylcysteine and Ebselen on Renal Ischemia/Reperfusion Injury
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- Diphenyl diselenide in vitro and in vivo activity against the oomycete Pythium insidiosum
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- Functional Mimics of Glutathione Peroxidase: Bioinspired Synthetic Antioxidants
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- NOX2 Complex–Derived ROS as Immune Regulators
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- Diphenyl diselenide induces apoptotic cell death and modulates ERK1/2 phosphorylation in human neuroblastoma SH-SY5Y cells
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- Diphenyl diselenide improves scopolamine-induced memory impairment in mice
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- Comparison of Different Forms of Dietary Selenium Supplementation on Growth Performance, Meat Quality, Selenium Deposition, and Antioxidant Property in Broilers
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- Hepatoprotective, Immunomodulatory, and Anti-inflammatory Activities of Selenocystine in Experimental Liver Injury of Rats
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- 3-Alkynyl selenophene protects against carbon-tetrachloride-induced and 2-nitropropane-induced hepatic damage in rats
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- Inhibitory effect of ebselen on lactate dehydrogenase activity from mammals: a comparative study with diphenyl diselenide and diphenyl ditelluride
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- Involvement of catalase in the protective effect of binaphthyl diselenide against renal damage induced by glycerol
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- (E)-2-benzylidene-4-phenyl-1,3-diselenole has antioxidant and hepatoprotective properties against oxidative damage induced by 2-nitropropane in rats
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- Acute exposure of rabbits to diphenyl diselenide: a toxicological evaluation
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- Organoselenium improves memory decline in mice: Involvement of acetylcholinesterase activity
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- Role of different types of potassium channels and peroxisome proliferator-activated receptors γ in the antidepressant-like activity of bis selenide in the mouse tail suspension test
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- A Nutrient Approach to Prostate Cancer Prevention: The Selenium and Vitamin E Cancer Prevention Trial (SELECT)
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- Role of selenium in HIV infection
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- Methyl-Selenium Compounds Inhibit Prostate Carcinogenesis in the Transgenic Adenocarcinoma of Mouse Prostate Model with Survival Benefit
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- REDOX MODULATION AT THE PERIPHERAL SITE ALTERS NOCICEPTIVE TRANSMISSIONIN VIVO
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- Protective effect ofp-methoxyl-diphenyl diselenide in lethal acute liver failure induced by lipopolysaccharide and d-galactosamine in mice
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- Diphenyl diselenide protects against glycerol-induced renal damage in rats
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- Bis-(3-hydroxyphenyl) diselenide inhibits LPS-stimulated iNOS and COX-2 expression in RAW 264.7 macrophage cells through the NF-κB inactivation
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- Hypolipidaemic activity of orally administered diphenyl diselenide in Triton WR-1339-induced hyperlipidaemia in mice
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- Effects of N-Acetylcysteine/Deferoxamine, Taurine and RC-3095 on Respiratory Chain Complexes and Creatine Kinase Activities in Rat Brain After Sepsis
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- Antidepressant-like effect of diphenyl diselenide on rats exposed to malathion: Involvement of Na+K+ ATPase activity
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- Serum Selenium Levels and All-Cause, Cancer, and Cardiovascular Mortality Among US Adults
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- Diphenyl diselenide, a simple glutathione peroxidase mimetic, inhibits human LDL oxidation in vitro
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- Diphenyl diselenide confers neuroprotection against hydrogen peroxide toxicity in hippocampal slices
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- Diphenyl diselenide, a simple organoselenium compound, decreases methylmercury-induced cerebral, hepatic and renal oxidative stress and mercury deposition in adult mice
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- Superior in vivo inhibitory efficacy of methylseleninic acid against human prostate cancer over selenomethionine or selenite
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- Effect of oral administration of diphenyl diselenide on antioxidant status, and activity of delta aminolevulinic acid dehydratase and isoforms of lactate dehydrogenase, in streptozotocin-induced diabetic rats
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- Introduction of trifluoromethyl group into diphenyl diselenide molecule alters its toxicity and protective effect against damage induced by 2-nitropropane in rats
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- Diphenyl diselenide reverses gastric lesions in rats: Involvement of oxidative stress
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- NSAIDs, Risks, and Gastroprotective Strategies: Current Status and Future
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- Selenocystine induces caspase-independent apoptosis in MCF-7 human breast carcinoma cells with involvement of p53 phosphorylation and reactive oxygen species generation
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- Pre-treatment with ebselen and vitamin E modulate acetylcholinesterase activity: interaction with demyelinating agents
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- Effect of Selenium and Vitamin E on Risk of Prostate Cancer and Other Cancers
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- Oral administration of diphenyl diselenide potentiates hepatotoxicity induced by carbon tetrachloride in rats
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- Diphenyl diselenide protects against hematological and immunological alterations induced by mercury in mice
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- Caffeine and a selective adenosine A2B receptor antagonist but not imidazoline receptor antagonists modulate antinociception induced by diphenyl diselenide in mice
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- Thiol cofactors for selenoenzymes and their synthetic mimics
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- Further analysis of the antinociceptive action caused by p-methoxyl-diphenyl diselenide in mice
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- Diphenyl diselenide exerts anxiolytic-like effect in Wistar rats: Putative roles of GABAA and 5HT receptors
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- Selenium in food and the human body: A review
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- Oral administration of diphenyl diselenide protects against cadmium-induced liver damage in rats
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- Dietary diphenyl diselenide reduces the STZ-induced toxicity
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- Selenium as an anticancer nutrient: roles in cell proliferation and tumor cell invasion
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- Evidence for the involvement of glutamatergic and GABAergic systems and protein kinase A pathway in the antinociceptive effect caused by p-methoxy-diphenyl diselenide in mice
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- The glutamate story
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