Article
Pharmacology & Pharmacy
Chunting Zhang, Hongyong Wang, Weiwei Liang, Yueqing Yang, Chaohua Cong, Ying Wang, Shuyu Wang, Xudong Wang, Di Wang, Di Huo, Honglin Feng
Summary: The study demonstrates that DPDS provides neuroprotection by inhibiting microglia-mediated neuroinflammatory injury. DPDS attenuates neuroinflammation by inhibiting the I kappa B/NF-kappa B pathway and NLRP3 inflammasome activation. This finding was further validated in both in vitro and in vivo experiments.
PHARMACOLOGICAL RESEARCH
(2021)
Article
Pharmacology & Pharmacy
Sebastian Gnat, Dominik Lagowski, Mariusz Dylag, Grzegorz Jozwiak, Aleksandra Troscianczyk, Aneta Nowakiewicz
Summary: This study evaluated the antifungal activity of ebselen and diphenyl diselenide against Trichophyton mentagrophytes clinical isolates and found that they exhibit high antifungal activity. However, the observed synergistic effects in combination therapy with antifungal drugs were weak.
Article
Biochemistry & Molecular Biology
Xing Wang, Yi Huan, Shuainan Liu, Caina Li, Hui Cao, Lei Lei, Quan Liu, Wenming Ji, Sujuan Sun, Kaixun Huang, Jun Zhou, Zhufang Shen
Summary: DPDS improves t-BHP-induced oxidative stress by activating the Nrf2/Keap1 pathway, and also improves LPS-induced inflammation via inhibition of the NF kappa B/MAPK pathways.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Yomade Ayodeji Jimoh, Akeem Olalekan Lawal, Ige Joseph Kade, Damilola Moses Olatunde, Oluwafunso Oluwayomi
Summary: The study found that diphenyl diselenide (DPDSe) can reduce the effects of diesel exhaust particle (DEP)-induced neurotoxicity in rats by decreasing oxidative stress and inflammation. DPDSe not only reduced the production of oxidative reaction products, but also increased the activity of antioxidant enzymes and improved the abnormal expression of related genes. These findings suggest that DPDSe may be a promising therapeutic candidate for DEP-induced neurotoxicity.
CHEMICO-BIOLOGICAL INTERACTIONS
(2022)
Article
Psychology, Biological
Cassio M. Resmim, Joao V. Borba, Camilla W. Pretzel, Laura W. Santos, Maribel A. Rubin, Denis B. Rosemberg
Summary: This study compared the exploratory behaviors of two zebrafish populations with distinct baselines of anxiety in two consecutive open field test (OFT) sessions. The results showed that anxiety levels influence exploration patterns, and the two populations exhibited different behaviors in the second OFT session.
BEHAVIOURAL PROCESSES
(2023)
Article
Biochemistry & Molecular Biology
Xing Wang, Caina Li, Yi Huan, Hui Cao, Sujuan Sun, Lei Lei, Quan Liu, Shuainan Liu, Wenming Ji, Kaixun Huang, Zhufang Shen, Jun Zhou
Summary: DPDS supplementation improved hyperglycemia, glucose intolerance, dyslipidemia, and renal pathological abnormalities in STZ-induced DN rats. It also promoted antioxidant enzyme activities, reduced pro-inflammatory factors levels, and activated the renal Nrf2/Keap1 signaling pathway while attenuating NF kappa B/MAPK signaling pathways, suggesting DPDS as a potential therapeutic approach for DN.
CHEMICO-BIOLOGICAL INTERACTIONS
(2021)
Review
Infectious Diseases
Jessica Louise Benelli, Vanice Rodrigues Poester, Livia Silveira Munhoz, Aryse Martins Melo, Mariana Rodrigues Trapaga, David A. Stevens, Melissa Orzechowski Xavier
Summary: This study conducted a systematic review of the in vitro antifungal activity of organoselenium compounds Eb and [(PhSe)(2)]. The compounds showed broad spectrum inhibitory antifungal activity against various pathogenic fungi, indicating their potential as future antifungal drugs. Further in vivo testing is needed to determine their compatibility with efficacious therapy.
Article
Environmental Sciences
Johan Gustafsson, Jessica Legradi, Marja H. Lamoree, Lillemor Asplund, Pim E. G. Leonards
Summary: This study is the first to focus on the effects of OH-PBDEs at the metabolite level in vivo and uses metabolomics to investigate the metabolic effects of exposure to OH-PBDEs. The results suggest that OH-PBDEs may disrupt energy metabolism, neurotoxicity, and potential immunotoxicity, and different compounds have different metabolic effects.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Immunology
Guilherme Wildner, Amanda Resende Tucci, Alessandro de Souza Prestes, Talise Muller, Alice dos Santos Rosa, Nathalia Roberto R. Borba, Vivian Neuza Ferreira, Joao Batista Teixeira Rocha, Milene Dias Miranda, Nilda Vargas Barbosa
Summary: The novel coronavirus SARS-CoV-2, responsible for the COVID-19 pandemic, has limited FDA-approved antiviral treatments. Ebselen and (PhSe)2 exhibited significant anti-SARS-CoV-2 activity in human pneumocytes cells while remaining non-toxic to human PBMCs. These findings suggest that Ebselen and (PhSe)2 could be potential candidates for future trials against SARS-CoV-2 infection.
Article
Fisheries
Qiuping Wang, Yizheng Li, Yurou Chen, Liyan Tian, Dandan Gao, Hongping Liao, Chunmiao Kong, Xikun Chen, Muhammad Junaid, Jun Wang
Summary: This study demonstrates that co-exposure to nanoplastics (NPs) and polybrominated diphenyl ethers (PBDEs) exacerbates developmental and thyroid toxicity in zebrafish. NPs rapidly aggregate in the fish and cause various morphological deformities. Additionally, the combined exposure results in greater damage to the fish's organs and tissues. The findings highlight the significant toxicological effects mediated by complex chemical interactions in freshwater environments.
FISH & SHELLFISH IMMUNOLOGY
(2022)
Article
Pharmacology & Pharmacy
Luiza S. Marques, Vanessa A. Zborowski, Suelen O. Heck, Bruna C. W. Fulco, Cristina W. Nogueira
Summary: The study showed that (p-ClPhSe)(2) can alleviate oxidative stress in the liver of diabetic mice and restore certain antioxidant enzyme activities. However, in the kidney, although (p-ClPhSe)(2) reduced reactive species levels, it did not restore catalase activity. While there was no evidence of oxidative damage in the skeletal muscle of STZ-treated mice, there was an increase in catalase activity and a decrease in non-protein thiol levels.
CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY
(2021)
Article
Electrochemistry
Geumyong Park, Hyeonghun Park, WooJun Seol, Seokho Suh, Jihun Kim, Ji Young Jo, Hyeong-Jin Kim
Summary: Developing a novel electrolyte additive is crucial to enhance the stability of the electrolyte/electrode interface for high-nickel cathode materials. In this study, diphenyl diselenide (DPDS) was used as a bifunctional electrolyte additive for high-voltage LiNi0.8Mn0.1Co0.1O2 (NMC811)/graphite batteries. DPDS forms protective layers on electrode surfaces to prevent parasitic reactions, maintain electrode structural stability, and reduce active lithium loss, resulting in improved capacity retention.
ELECTROCHIMICA ACTA
(2022)
Article
Behavioral Sciences
Joao V. Borba, Eduarda Biasuz, Giovana R. Sabadin, Ana C. Savicki, Julia Canzian, Ana C. Luchiari, Isaac A. Adedara, Denis B. Rosemberg
Summary: This study aimed to explore the exploratory activity of adult zebrafish in an open field test. The results showed significant differences in behavior between different stress protocols, with the UCS group of zebrafish exhibiting more immobility and periodic bursts of swimming in the homebase. Additionally, the physiological stress response marker cortisol was confirmed.
BEHAVIOURAL BRAIN RESEARCH
(2022)
Article
Chemistry, Physical
Kunal Pawar, Radha Jayaram, Sunil S. Bhagwat
Summary: The solubilization of DPDS was investigated in CTAB, OPE-10, and SDS surfactant solutions. The solubility of DPDS increased with the concentration of surfactants, and it was found to be higher in OPE-10 and CTAB compared to SDS solutions.
JOURNAL OF DISPERSION SCIENCE AND TECHNOLOGY
(2023)
Article
Cell Biology
Chang Liu, Rui Li, Young Li, Xiumei Lin, Kaichen Zhao, Qun Liu, Shuowen Wang, Xueqian Yang, Xuyang Shi, Yuting Ma, Chenyu Pei, Hui Wang, Wendai Bao, Junhou Hui, Tao Yang, Zhicheng Xu, Tingting Lai, Michael Arman Berberoglu, Sunil Kumar Sahu, Miguel A. Esteban, Kailong Ma, Guangyi Fan, Yuxiang Li, Shiping Liu, Ao Chen, Xun Xu, Zhiqiang Dong, Longqi Liu
Summary: This study used Stereo-seq and scRNA-seq data to analyze the spatially resolved developmental trajectories of cell-fate transitions and molecular changes during zebrafish embryogenesis. Important interactions were identified, providing a fundamental reference for further studies on vertebrate development.
DEVELOPMENTAL CELL
(2022)
Article
Biochemistry & Molecular Biology
Opeyemi Babatunde Ogunsuyi, Folorunsho Bright Omage, Olawande Chinedu Olagoke, Ganiyu Oboh, Joao Batista Teixeria Rocha
Summary: This study tested the inhibitory effects of African eggplant and black nightshade leaf extracts on human erythrocyte AChE and investigated their potential molecular mechanisms using molecular docking and MD simulation. The findings suggest that certain compounds with dual-binding properties may serve as potential inhibitors of human AChE.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Article
Neurosciences
Adriana L. Silva, Joana L. Oliveira, Ravena P. do Nascimento, Leticia O. Santos, Fillipe M. de Aranjo, Balbino L. dos Santos, Rejane C. Santana, Eduardo Luiz T. Moreira, Maria Jose M. Batatinha, Iura M. Alves, Eudes S. Velozo, Mauricio M. Victor, Adriano M. Assis, Roberto F. Almeida, Diogo O. G. de Souza, Victor Diogenes A. Silva, Silvia L. Costa
Summary: The ingestion of MCT induces cerebrovascular lesions and toxicity to neurons in rats, accompanied by astroglial cell response and neuroinflammation in the cortex and hippocampus.
Article
Biochemistry & Molecular Biology
Pedro Pauletto, Marco Bortoli, Folorunsho Omage Bright, Cassia Pereira Delgado, Pablo Andrei Nogara, Laura Orian, Joao Batista Teixeira da Rocha
Summary: Acid Sphingomyelinase (ASM), involved in plasma membrane cell repair, is activated during SARS-CoV-2 infection. In silico analysis suggests that drugs like fluoxetine might inhibit ASM by breaking its interactions and disrupting its structure.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Review
Pharmacology & Pharmacy
Stela Karine Braun, Daiane Wagner Jorge, Geovani Bortolanza, Joao Batista Teixeira da Rocha
Summary: This systematic review and meta-analysis found that the use of statins before lower-limb arterial angioplasty was associated with improved patency and overall survival, as well as decreased limb loss.
INTERNATIONAL JOURNAL OF CLINICAL PHARMACY
(2023)
Article
Chemistry, Physical
Caroline Gross Jacoby, Jorge Hugo Sbardelotto, Tales da Silva Daitx, Bianca Thais Dalberto, Raquel Santos Mauler, Paulo Henrique Schneider
Summary: This study investigates the application of organocatalysts in polyesters, which are rarely used for this purpose. The proposal is to use the hydroxyl groups in chosen chiral compounds to promote the polymerization of epsilon-caprolactone, generating a support and anchoring the organocatalyst in a single step. A simple acid catalysis method was employed, which showed versatility in generating supported catalysts with different structures and functional groups. The materials were applied as organocatalysts in an aldol addition test reaction, yielding excellent product yields and good stereoselectivity. However, a recycling process seems to be necessary for their reuse.
Article
Information Science & Library Science
Carolina Bittencourt Gomes, Luciana Calabro, Suzana Rachel de Oliveira, Leo Anderson Meira Martins, Diogo Onofre Souza, Ediane Maria Gheno
Summary: This article evaluated the characteristics of grantees in the Health Sciences area of the National Council for Scientific and Technological Development. Various indicators were used to assess 1,634 researchers with current grants in 2021. The study found differences in the distribution of articles among Committees and the influence of article numbers on the level of grants. It provides important insights for public policies in Science and Technology and contributes to the field by evaluating the Health Sciences area using diverse indicators.
Review
Biochemistry & Molecular Biology
Pedro Jose Tronco Pauletto, Cassia Pereira Delgado, Joao Batista Teixeira da Rocha
Summary: In the past two years, various drugs have been identified as potential inhibitors of SARS-CoV-2 in laboratory studies. Among them, drugs known as functional inhibitors of acid sphingomyelinase (FIASMAs) have been shown to effectively inhibit the replication of SARS-CoV-2 in different types of cells. These drugs have similar chemical structures, with examples including fluoxetine, escitalopram, and fluvoxamine. They are already used as therapeutic agents for other diseases and can be considered as candidates for drug repositioning. This review summarizes two proposed mechanisms by which FIASMAs inhibit the replication of SARS-CoV-2 by targeting acid sphingomyelinase (ASM).
CELL BIOCHEMISTRY AND FUNCTION
(2023)
Article
Chemistry, Medicinal
Folorunsho Bright Omage, Andrea Madabeni, Amanda Resende Tucci, Pablo Andrei Nogara, Marco Bortoli, Alice dos Santos Rosa, Vivian Neuza dos Santos Ferreira, Joao Batista Teixeira Rocha, Milene Dias Miranda, Laura Orian
Summary: This study investigates the mechanism of SARS-CoV-2 inhibition by (PhSe)2 and reveals its potential as a therapeutic agent. The results show that (PhSe)2 effectively inhibits viral replication in a cell culture model and provides insights into the non-covalent and covalent inhibition modes of the viral proteases.
JOURNAL OF CHEMICAL INFORMATION AND MODELING
(2023)
Article
Psychiatry
Paula Michele da Silva Schmidt, Jessica Puchalski Trettim, Aline Longoni, Mateus Grings, Mariana Bonati de Matos, Luciana de Avila Quevedo, Ana Paula Ardais, Fernanda Nedel, Gabriele Ghisleni, Guilhian Leipnitz, Ricardo Tavares Pinheiro, Adriano Martimbianco de Assis
Summary: This study evaluates the serum levels of oxidative stress biomarkers in women at risk of suicide 18 months after postpartum. The findings suggest that low levels of glutathione may be a potential biomarker or etiologic factor in women at moderate to high risk of suicide.
FRONTIERS IN PSYCHIATRY
(2023)
Review
Environmental Sciences
Isaac A. Adedara, Oluwadarasimi E. Atanda, Camila Sant'Anna Monteiro, Denis B. Rosemberg, Michael Aschner, Ebenezer O. Farombi, Joao B. T. Rocha, Ana Flavia Furian, Tatiana Emanuelli
Summary: This review discusses the neurotoxicity of Aflatoxin B1 (AFB1) and its impact on the nervous system. Mechanisms of AFB1-induced neuronal dysregulation and neurotoxic effects are uncovered through studies using brain homogenates, neuroblastoma cell line IMR-32, human brain microvascular endothelial cells, microglial cells, and astrocytes, as well as mammalian and non-mammalian models. Furthermore, naturally occurring bioactive compounds with therapeutic effects on AFB1-induced neurotoxicity are reviewed.
ENVIRONMENTAL RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Blessing A. Obafemi, Isaac A. Adedara, Ana L. A. Segatto, Diogo O. Souza, Joao B. T. da Rocha, Olawande C. Olagoke
Summary: In this study, the mechanism of inflammatory response to organometallic cation methylmercury, common cooking seasoning (NaCl and MSG), and their crosstalk with redox signaling were investigated using the lobster cockroach as a model. The activation of Nox/Duox NADPH oxidases, along with JNK and Rel signaling pathways, was found to play crucial roles during methylmercury and MSG exposure.
JOURNAL OF FOOD BIOCHEMISTRY
(2023)
Article
Chemistry, Organic
Gul Badshah, Carla M. B. Gomes, Sher Ali, Eduardo Q. Luz, Gabriel L. Silverio, Francielli S. Santana, Diego Seckler, Douglas B. Paixao, Paulo H. Schneider, Daniel S. Rampon
Summary: The direct and selective conversion of a C-H bond into a C-Se bond is a significant challenge. In this study, we successfully achieved the selective selanylation of substrates by using palladium, copper, and the 2-(methylthio)amide directing group. This chelation-assisted direct selanylation method is also applicable for mono and double ortho functionalization of arenes.
JOURNAL OF ORGANIC CHEMISTRY
(2023)
Review
Chemistry, Multidisciplinary
Pablo A. A. Nogara, Meire E. Pereira, Claudia S. Oliveira, Laura Orian, Joao B. T. Rocha
Summary: Organoselenium compounds (OSeCs) have significant therapeutic applications, but their mechanisms are still unclear. By using models and analytical methods, it is possible to elucidate the metabolism, reactivity, and specificity of OSeCs in vivo, leading to further advancements in their pharmacological applications.
NEW JOURNAL OF CHEMISTRY
(2023)
Article
Chemistry, Physical
Marcelo M. Vieira, Bianca T. Dalberto, Nathalia B. Padilha, Henrique C. S. Junior, Fabiano S. Rodembusch, Paulo H. Schneider
Summary: In this report, we synthesized substituted indolizines using ultrasound irradiation in a one-pot and multicomponent strategy, and studied their photophysical properties. The compounds exhibited absorption maxima in the UV-A-violet region and their electronic transitions were related to allowed 1 pi ->pi* transitions. Indolizines showed fluorescence in the violet-to-green region, and the ground and excited states were influenced by the substituents in the indolizine core. The role of solvent in the deactivation of excited states was critical for exploring these compounds as optical sensors for benzene.
JOURNAL OF MOLECULAR STRUCTURE
(2024)
Article
Clinical Neurology
Nadia Deflorin, Ulrike Ehlert, Rita T. Amiel Castro
Summary: Changes in the gut microbiome of infants have been associated with maternal psychological symptoms during pregnancy. This study found that maternal prenatal depressive symptoms are associated with lower diversity of the infant's microbiome, while maternal saliva cortisol levels are linked to increased diversity and changes in specific bacterial groups. Further research is needed to understand the implications of these microbiota alterations for child health.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Zheng Ma, Hui-Xia Zhou, Da-Chun Chen, Dong-Mei Wang, Xiang-Yang Zhang
Summary: The impaired glucose metabolism in drug-na & iuml;ve schizophrenia patients is strongly associated with suicidal behavior, suggesting that glucose metabolism abnormalities may be potential biomarkers of suicide in schizophrenia patients. Regular monitoring of glucose metabolism variables is essential for suicide prevention.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Katie M. Lavigne, Jiaxuan Deng, Delphine Raucher-Chene, Adele Hotte-Meunier, Chloe Voyer, Lisa Sarraf, Martin Lepage, Genevieve Sauve
Summary: Psychiatric disorders are characterized by cognitive deficits and cognitive biases, which are associated with specific symptoms. While cognitive biases are present across diagnoses, their severity varies.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Yong-Yu Yin, Jiao-Zhao Yan, Shi-Xin Lai, Qian-Qian Wei, Si-Rui Sun, Li-Ming Zhang, Yun-Feng Li
Summary: This study found that gamma oscillations are closely associated with depression and may serve as predictive biomarkers of depression. Chronic restraint stress and lipopolysaccharide induced significant depression-like behaviors in mice and reduced gamma oscillations in the medial prefrontal cortex. Administration of ketamine, scopolamine, or fluoxetine increased gamma oscillations and exhibited rapid-acting antidepressant effects.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Veronica Begni, Moira Marizzoni, Kerstin Camile Creutzberg, Diana Morena Silipo, Mariusz Papp, Annamaria Cattaneo, Marco Andrea Riva
Summary: Exposure to stressful experiences is a significant risk factor for mental disorders, and pharmacological interventions targeting stress-induced alterations can help restore brain function. Lurasidone, an antipsychotic drug, has been shown to normalize the impairments caused by stress exposure and could be a valuable treatment for stress-induced mental illnesses. However, the mechanisms underlying the therapeutic effects of lurasidone are not well understood. This study found that chronic lurasidone treatment counteracted some of the transcriptional changes induced by chronic mild stress exposure, providing new insights into the potential therapeutic effects of lurasidone.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Esther E. Palacios-Barrios, Kunal Patel, Jamie L. Hanson
Summary: This review examines the association between early life interpersonal stress (ELIS) and depression, as well as the underlying mechanisms. The research shows that ELIS affects how youth respond to social rewards, and similar impairments in social reward processing are observed in youth with depression. The authors propose a preliminary model that suggests neurobehavioral disruptions in social reward processing as a mediating factor in the connection between ELIS and depression.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Rui Li, Jiaming Tang, Yizhuo Wang, Ying Wang, Hua Yang, Hongen Wei
Summary: Restricted and repetitive behaviors (RRBs) are characteristic features of neuropsychiatric disorders. This study focused on repetitive self-grooming behavior and investigated the involvement of the Pax2 gene in its control. Through the use of Pax2 neuron-specific deletion mice, the study found that the deletion of Pax2 gene affects the expression of the Arc gene in the prefrontal cortex, leading to impaired synaptic plasticity and excitatory/inhibitory imbalance, thereby contributing to the occurrence of repetitive self-grooming behavior.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Sara Derosa, Paulina Misztak, Jessica Mingardi, Giulia Mazzini, Heidi Kaastrup Muller, Laura Musazzi
Summary: This study investigated the involvement of neurotrophic signaling pathways in stress vulnerability/resilience and fast antidepressant response/non-response to ketamine in a rat model of depression. The findings showed that stress and ketamine induced specific changes in these pathways in different brain areas and subcellular fractions.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Review
Clinical Neurology
Georgia F. Caruana, Sean P. Carruthers, Michael Berk, Susan L. Rossell, Tamsyn E. Van Rheenen
Summary: Cognitive impairment is related to both white matter macrostructure and microstructure in bipolar disorder patients. However, there is inconsistency in the results of the studies examining this relationship. Some studies have found an association between higher fractional anisotropy in white matter and better complex attention skills and executive functioning in bipolar disorder patients, while others have found no associations. Further research with increased statistical power and standardized methods is needed.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Review
Clinical Neurology
Alberto Galimberti, Martin Tik, Giovanni Pellegrino, Anna-Lisa Schuler
Summary: This study provides a systematic review and meta-analysis on the effectiveness of repetitive transcranial magnetic stimulation (TMS) and transcranial direct current stimulation (tDCS) for post-traumatic brain injury (TBI) symptoms. The results show that non-invasive brain stimulation techniques have a small overall effect on TBI sequelae, with significant effects observed for anxiety and headache. However, larger randomized controlled trials with longer follow-ups, optimized stimulation parameters, and standardized methodology are needed to establish the efficacy of these techniques in addressing TBI sequelae.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Amanda J. Sales, Pedro H. Gobira, Joa F. C. Pedrazzi, Joao R. Silveia, Elaine Del Bel, Felipe V. Gomes, Francisco S. Guimaraes
Summary: The study found that doxycycline can inhibit metalloproteinase in the brain and attenuate the rewarding effects and locomotor sensitization of drug abuse. This suggests that doxycycline could be repurposed for the treatment of substance use disorders.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Alejandro Borrego-Ruiz, Juan J. Borrego
Summary: There is substantial evidence that the development of the nervous system is related to the composition and functions of the gut microbiome. The communication between the central nervous system (CNS) and the gut microbiota is bidirectional, with various routes such as immune, endocrine, and neural circuits. Dysbiosis of the gut microbiota has been associated with neuropsychiatric diseases and psychological disorders. Fecal microbiota transplantation (FMT) therapy has shown a causal-effect relationship between the gut microbiota and behavioral features. Interventions based on prebiotics, probiotics, or synbiotics have demonstrated their influence on neurological disorders through the synthesis of neuroactive compounds and regulation of inflammatory and endocrine processes. Further research is needed to explore the impact of gut microbiota dysbiosis on psychiatric and psychological disorders and the potential therapeutic role of microbiota-based interventions.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Zhinan Li, Zhuang Kang, Xiaowei Xia, Leijun Li, Junyan Wu, Jiamin Dai, Tong Liu, Cai Chen, Yong Qiu, Ming Chen, Yanxi Liu, Ziyi Zhang, Zili Han, Zhengjia Dai, Qinling Wei
Summary: This study found that patients with schizophrenia showed lower levels of resilience and cognitive functions compared to healthy controls, as well as abnormal global properties and nodal metrics in brain networks. Furthermore, characteristic path length might moderate the relationship between resilience and working memory in these patients.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
David H. Adamowicz, Tsung-Chin Wu, Rebecca Daly, Michael R. Irwin, Dilip Jeste, Xin M. Tu, Lisa T. Eyler, Ellen E. Lee
Summary: This study aimed to explore the relationship between executive functioning and inflammatory biomarkers in people with schizophrenia. The results showed that systemic inflammation did not predict long-term declines in executive functioning. This suggests the need for further research to better understand the relationship and mechanisms between inflammation and cognition in schizophrenia.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Nina Walter, Julian Wenzel, Shalaila S. Haas, Letizia Squarcina, Carolina Bonivento, Anne Ruef, Dominic Dwyer, Theresa Lichtenstein, Oeznur Bastruek, Alexandra Stainton, Linda A. Antonucci, Paolo Brambilla, Stephen J. Wood, Rachel Upthegrove, Stefan Borgwardt, Rebekka Lencer, Eva Meisenzahl, Raimo K. R. Salokangas, Christos Pantelis, Alessandro Bertolino, Nikolaos Koutsouleris, Joseph Kambeitz, Lana Kambeitz-Ilankovic
Summary: Clinical and neuroimaging data can be used to predict the potential of cognitive training to improve social functioning in recent onset psychosis patients. The use of multivariate pattern analysis and support vector machine classifier allows for the prediction of social functioning improvement based on baseline cognitive data. The findings suggest that cognitive data can provide a robust individual estimate of future social functioning for patients with recent onset psychosis.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)