期刊
JOURNAL OF MEDICINAL CHEMISTRY
卷 63, 期 4, 页码 1473-1489出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.jmedchem.9b01152
关键词
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资金
- Department of Pharmacology
- Penn State Cancer Institute of the Penn State College of Medicine
- Plan de Investigacion de la Universidad de Navarra, PIUNA
- AsociacioSn de Amigos de la Universidad de Navarra
- Caixabank
- Spanish Government (Ministerio de Education y Formacion Profesional)
Incorporation of selenium (Se) atom into small molecules can substantially enhance their antioxidant, anti-inflammatory, antimutagenic, antitumoral or chemopreventive, antiviral, antibacterial, antifungal, antiparasitic, and neuroprotective effects. Specifically, selenazo compounds have received great attention owing to their chemical properties, pharmaceutical applications, and low toxicity. In this Perspective, we compile extensive literature evidence with the description and discussion of the most recent advances in different selenazo and selenadiazo motifs as potential pharmacological candidates. We also provide some perspectives on the challenges and future directions in the advancement of these selenazo compounds, each of which could generate drug candidates for various diseases.
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